9results about How to "Reduce colonization" patented technology

The invention relates to a microbial preparation for regulating oral flora and application of the microbial preparation. A bacterial strain in the microbial preparation for regulating the oral flora consists of a lactobacillus reuteri LR108 bacterial strain and a lactobacillus plantarum LP194 bacterial strain, and the bacterial strain in the microbial preparation for regulating the oral flora consists of a lactobacillus reuteri LR108 bacterial strain and a lactobacillus plantarum LP194 bacterial strain. The microbial preparation can regulate oral flora, has good copolymerization ability and inhibition effect on porphyromonas gingivalis bred in the oral cavity, reduces colonization of the porphyromonas gingivalis in the oral cavity, and reduces inflammatory factors, thereby promoting oral health. Wherein the LR108 strain and the LP194 strain have excellent self-agglutination and hydrophobicity, and have a positive effect on adhesion with intestinal tracts.

The invention provides bifidobacterium bifidum and application thereof, and relates to the technical field of microorganisms. The invention provides Bifidobacterium bifidum NKU FB3-13, which is preserved in the Guangdong Microbial Culture Collection Center, the preservation number of which is GDMCC No: 64747, and the preservation number of which is GDMCC No: 64747. The invention also provides a preparation method of the Bifidobacterium bifidum NKU FB3-13. The strain has good acid resistance and can well adapt to the stomach environment; the strain can effectively reduce the colonization number of helicobacter pylori on gastric epithelium, can greatly reduce the colonization number of helicobacter pylori in animal experiments, relieves inflammation caused by helicobacter pylori infection, and reduces stomach intestinal metaplasia. The preparation method has a wide application prospect in the fields of clinical prevention, treatment and alleviation of diseases related to helicobacter pylori infection, gastrointestinal health-care food and the like.

The invention relates to a pig immunity-enhancing feed containing natural plant extracts, and belongs to the technical field of feeds. On the basis of basic components, a plantain herb and selfheal composite extract, a purslane and sweet potato vine and leaf composite extract and a folium cortex eucommiae extract are also added into the feed, so that the immunity-enhancing feed is prepared. The plantain herb and selfheal composite extract is obtained by sequentially fermenting a plantain herb whole plant and a selfheal whole plant through lactobacillus cellobiosus and pediococcus acidilactici and then sequentially carrying out step-by-step enzymolysis through trypsin and nattokinase; the herba portulacae and sweet potato vine compound extract is obtained by sequentially fermenting a whole plant of herba portulacae and leaves of sweet potato vines with lactobacillus cellobiosus and bacteroides ruminalis and then sequentially carrying out step-by-step enzymolysis with snail protease and trypsin; the folium cortex eucommiae extract is obtained by sequentially carrying out step-by-step enzymolysis on folium cortex eucommiae through hemicellulase, bromelain and nattokinase. The extract prepared by the invention contains immunological enhancement effective components, and can enhance the immunity of pigs, effectively reduce diarrhea and reduce the risk of illness when being matched with basal feed for use.

The present invention discloses a bacteriophage A155 and its application in antagonizing vancomycin-resistant Enterococcus faecalis, and relates to the technical field of phage screening for antagonizing vancomycin-resistant Enterococcus faecalis. The bacteriophage (Enterococcus phage) A155 has a deposit number of CCTCC NO: M20241805, and was deposited in the China Center for Type Culture and General Microorganisms on August 16, 2024, and the deposit address is Wuhan University, Wuhan, China. The present invention screens out a virulent phage against vancomycin-resistant Enterococcus faecalis, performs biological characteristics and whole genome sequencing analysis on it, and evaluates its antibacterial ability in vitro and in vivo, laying a foundation for the development of phage therapy for vancomycin-resistant Enterococcus faecalis infection.

This invention discloses a low-infection-risk detachable fixation wing and grooveless stop clamp hemodialysis catheter system, belonging to the field of medical device technology. This invention addresses two core pain points of existing long-term hemodialysis catheters: first, it redesigns the traditional one-piece fixation wing as a detachable structure, allowing for quick assembly and disassembly by external force without damaging the catheter, facilitating skin cleaning and reducing the risk of local infection and mechanical damage; second, it optimizes the separate stop clamp into a grooveless structure integrated with the connector, employing a full, smooth inner lumen to completely eliminate dead zones for bacterial residue, reducing catheter-related bloodstream infections at the source. This invention has a simple structure, strong clinical adaptability, and can be widely applied in the field of long-term hemodialysis treatment, demonstrating significant clinical application value.

The utility model discloses a medullary cavity flushing device which comprises a flushing pipe, a water absorption piece, dressing, a water outlet pipe, a positive pressure device and a negative pressure device, the water absorption piece is used for covering a wound, the dressing is used for being pasted on human body soft tissue around the wound to seal the water absorption piece, and one end of the flushing pipe penetrates through the dressing and the water absorption piece to be placed in a patient body. One end of the water outlet pipe is communicated with the water absorption piece, and the other end of the water outlet pipe is connected with the negative pressure device. A wound is covered with the water absorption part, the negative pressure device and the positive pressure device are opened at the same time, the water absorption part can absorb a large amount of seepage and blood flushed out of a marrow cavity, continuous drainage is achieved, soft tissue bacterial colonization is reduced, and soft tissue healing is facilitated; the water absorption piece can relieve edema of a wound surface except for osteomyelitis, improve local blood perfusion, reduce physical stimulation on the wound surface and draw and shrink the cavity; the water absorption piece can stretch soft tissue cells, promote granulation tissue production and promote blood vessel growth; the water absorption piece prevents the water outlet pipe from being blocked.

This invention relates to the technical field of fresh air humidifier units, and discloses a modularly assembled ceiling-mounted fresh air humidifier indoor unit structure, including a fresh air unit, which includes an air intake disinfection component, a filter component, and an exhaust fan component. The air intake disinfection component is equipped with an LED disinfection lamp, and the filter component has a secondary return air duct inside. The LED disinfection lamp disinfects the fresh air inside the filter component and the water in the air intake disinfection component. This invention can add a multi-directional radiation-type collaborative disinfection module to the airflow channel between the filter element and the atomizer, and with an adjustable-angle UV-C LED array, achieve dual-function disinfection of direct water injection and airflow radiation, eliminating the disinfection blind spot between the filter element and the atomizer, and realizing integrated collaborative disinfection of humidification water, filter element, atomizer, and intermediate air duct without dead angles, blocking the path of bacterial growth and transmission from the source, and completely avoiding the risk of secondary pollution of the supply air.

The invention discloses a composition for treating diarrhea caused by rotavirus infection in pet dogs and cats. The composition comprises the following components: 5-18 parts by weight of echinacea extract, 1-6 parts by weight of bacillus subtilis spore powder, 10-35 parts by weight of beta-glucan, 5-18 parts by weight of sodium chondroitin sulfate, 2-10 parts by weight of N-acetylglucosamine, 2-10 parts by weight of gamma-aminobutyric acid, 10-35 parts by weight of lactobacillus plantarum fermentation product, 5-18 parts by weight of D-mannitol, and 5-18 parts by weight of magnesium hydroxide. A preparation method and application of the composition in preparing a medicament for treating rotavirus diarrhea in pet dogs and cats are also disclosed. The composition cleverly utilizes the synergistic effects of the components in anti-virus, immune regulation, intestinal mucosal repair, diarrhea improvement, etc., and exhibits an excellent effect of treating rotavirus diarrhea in pets through comprehensive regulation of multiple links such as immunity, barrier, flora, mucosa, etc.

This application relates to a modified chitosan coating for enhancing adhesion to fruit surfaces and resisting fungal spores, and a method for preparing the same. The modified chitosan coating comprises a chitosan-tannic acid-stearic acid copolymer, a plasticizer, and water. The copolymer is modified by grafting tannic acid and stearic acid onto a chitosan backbone. The modified chitosan coating exhibits enhanced adhesion and hydrophobicity to hydrophobic fruit surfaces, improves wettability, reduces swelling under high humidity, enhances gas barrier properties, displays significant antioxidant activity, reduces enzymatic browning and scavenges free radicals, exhibits anti-adhesion against fungi and bacteria, and possesses excellent biocompatibility. It provides a promising, safe, and sustainable solution for extending the shelf life and quality of fresh agricultural products.