120results about How to "Reduce colonization" patented technology

This invention relates to a method for coating a medical device comprising the steps of applying to at least a portion of the surface of the medical device, a bactericidal coating layer, wherein the bactericidal coating layer comprises a bactericidal agent; and applying to at least a portion of the surface of the medical device, a bacteriostatic coating, wherein the bacteriostatic coating layer comprises a bacteriostatic agent wherein the combination of the bactericidal and bacteriostatic agents are in an effective concentration to inhibit growth of microbial organisms relative to an uncoated medical device. The two antimicrobial agents are used to develop a kit comprising these compositions in one container or in separate containers. The kit is used to coat or flush medical devices prior to or after implantation in a mammal.

Provided herein are molecular methods for assessing the state of gastrointestinal microflora of an animal, especially a species of poultry, and methods for identifying probiotic bacteria by comparing certain bacteria present in animals fed a diet not containing antibiotics but absent or present in significantly lower numbers in animals fed a diet containing antibiotics.

The invention describes nanotextured super hydrophobic coatings that contain active agents which can elute from the coating over a period of time.

A method for the augmentation of immune function is described. The invention comprises a combination of β-1,3 (4)-endoglucanohydrolase, β-1,3 (4)glucan, diatomaceous earth, mineral clay and glucomannan, which is fed to or consumed by mammalian or avian species in amounts sufficient to augment immune function. The invention described may be admixed with feeds or foods, incorporated into pelleted feeds or foods or administered orally to mammalian and avian species.

A method for the augmentation of immune function is described. The invention comprises a combination of β-1,3(4)-endoglucanohydrolase, β-1,3(4)glucan, diatomaceous earth, mineral clay and glucomannan, which is fed to or consumed by mammalian or avian species in amounts sufficient to augment immune function. The invention described may be admixed with feeds or foods, incorporated into pelleted feeds or foods or administered orally to mammalian and avian species.

The present application is generally directed to novel pneumococcal polypeptide antigens and nucleic acids encoding such antigens, and immunogenic compositions comprising such antigens for treating and preventing pneumococcal infection. The present invention further provides method of using the antigens to elicits an immune response (e.g., IL-17A response, a T cell-mediated and / or B-cell-mediated immune responses). The present invention also provides methods of prophylaxis and / or treatment of pneumococcal-mediated diseases, such as sepsis, comprising administering an immunogenic composition including one or more of a combination of pneumococcal antigens or functional fragments thereof as disclosed herein. In some embodiments, one or more pneumococcal antigens can be present in a polysaccharide conjugate. The compositions induce an anti-pneumoccocus immune response when administered to a mammal. The compositions can be used prophylactically to vaccinate an individual and / or therapeutically to induce a thereapeutic immune response to an infected individual.

A wound dressing device for use with a transcutaneous medical device such as a cannula or a catheter comprises a polyurethane matrix which may be covered with a film backing. Chlorhexidine di- gluconate and a polyanhydroglucuronic salt are contained in the polymer matrix. The wound dressing device prevents microbial colonization of the dressing and stops bleeding from the insertion site. The device provides combined haemostatic and antimicrobial effects at the insertion site but without adversely affecting wound healing.

A kit for treating an antimicrobial resistant biological contaminate at a treatment site is disclosed which includes a diffuser tip adapted to receive near infrared therapeutic light from a light delivery system and diffuse the light to illuminate at least a portion of the treatment site; a quantity of an antimicrobial; agent; instructions to use the antimicrobial agent in conjunction with the therapeutic light to potentiate the antimicrobial agent to treat the biological contaminate; and suitable packaging.

The invention relates to, in part, secreted proteins of bacterial pathogens and methods for their use. More specifically, the invention provides in part several new common secreted proteins for A / E pathogens. In some embodiments of the invention, these polypeptides and nucleic acid molecules encoding these polypeptides, or portions thereof, are useful as vaccines, diagnostics, or drug screening tools for A / E pathogenic infections, or as reagents.

The invention belongs to the technical field of feed additives, and in particular discloses a feed additive for controlling newborn pig diarrhea. The feed additive is prepared by mixing fructo-oligosaccharide, probiotic bacillus subtilis powder and / or enterococcus faecalis powder in a certain weight ratio. The intestinal regulator and the probiotic living bacteria agent are combined, antibiotics are not contained, medicine resistance is avoided and the feed additive is convenient to use. The feed additive for controlling newborn pig diarrhea can regulate intestinal microflora in vivo, reduce the pH of intestinal tract, enhance reproduction of beneficial bacteria and reduce colonization of harmful bacteria, so that the newborn pig diarrhea is effectively controlled, the feed conversion rate for newborn pigs is improved and the newborn pigs are promoted to grow. The feed additive has an obvious effect of controlling the newborn pig diarrhea, and has the advantages of high efficiency, safety, no pollution, no residue, no medicine resistance and the like.

The present invention provides methods for treating, preventing or ameliorating skin infections, including bacterial and viral infections. In certain embodiments, the invention provides methods to reduce skin infection in a patient with atopic dermatitis (AD). Also provided are methods for improving skin barrier function, and methods for reducing the risk of inflammation due to microbial infection in a patient in need thereof. The methods of the present invention comprise administering to a patient in need thereof a pharmaceutical composition comprising an interleukin-4 receptor (IL-4R) antagonist such as an anti-IL-4R antibody.

This invention relates to oral care compositions comprising a first source of zinc which is zinc citrate, a second source of zinc which is zinc oxide or zinc lactate, a stannous ion source, and a polyphosphate, as well as to methods of using and of making these compositions.

The invention discloses a porcine epidemic diarrhea S1 protein fusion gene, recombinant bacillus megaterium strain and application. An antigen fusion gene shown as SEQ ID No. 1. is obtained by connecting an antigen locus of porcine epidemic diarrhea virus (PEDV) S glycoprotein and a cell wall anchoring sequence. The invention further constructs a secretion expression vector containing the antigen fusion gene, and secretion expression vector is converted into the bacillus megaterium to express recombinant protein on the cell wall or surface of the bacillus megaterium. Immunoblotting experiments indicate that the expressed recombinant protein can react with PEDV immune serum and has the same antigenicity as PEDV natural antigens. Immunofluorescent tests of live bacteria which are subjected to induced expression indicate that the expressed recombinant protein is positioned to the surfaces of the bacteria. Experiment results indicate that the recombinant protein can be prepared into safe and effective mucous immune live vaccines for preventing and treating porcine epidemic diarrhea.

The present invention encompasses protective monoclonal antibodies that bind to peptidoglycan of Gram-positive bacteria. The antibodies also bind to whole bacteria and enhance phagocytosis and killing of the bacteria in vitro and block nasal colonization by Gram-positive bacteria in vivo. The invention also provides human, humanized and chimeric antibodies. The invention also sets forth the heavy chain and light chain variable regions of an antibody within the invention.

Novel bacteriocins produced by novel bacterial strains are used for at least reducing the levels of colonization by at least one target bacteria in animals, especially poultry.

The present invention provides polymer-based slippery liquid-infused porous surfaces (SLIPS) that can prevent adhesion and colonization by fungal and bacterial pathogens and also kill and / or attenuate the colonization and virulence of non-adherent pathogens in surrounding media. The present approach exploits the polymer and liquid oil phases in these slippery materials to sustain the release of small molecules such as a broad-spectrum antimicrobial agent, an antifungal agent, an antibacterial agent, an agent that modulates bacterial or fungal quorum sensing, an agent that attenuates virulence, or a combination thereof. This controlled release approach improves the inherent anti-fouling properties of SLIPS, has the potential to be general in scope, and expands the potential utility of slippery, non-fouling surfaces in both fundamental and applied contexts.

A wound care instrument to be used for measuring, probing, suctioning, cleaning, mechanically debriding, and applying creams or ointments in or onto acute and chronic ulcers or wounds, including but not limited to undermining or tunneling, surgically dehisced wounds, penetrating wounds, and burns.

Comblike, surfactant polymers for changing the surface properties of biomaterials are provided. Such surfactant polymers comprise a polymeric backbone of repeating monomeric units having functional groups for coupling with side chains, a plurality of hydrophobic side chains linked to the backbone via the functional groups, and a plurality of hydrophilic side chains linked to said backbone via the functional groups. Medical devices coated with the surfactant polymers are also provided. The surfactant polymers may be used to decrease the thrombogenic properties, encapsulation, and bacterial colonization of medical devices.

Disclosed are surfaces for resisting and reducing biofilm formation, particularly on medical articles (100). The surfaces include a plurality of microstructures (120) including a plurality of nanofeatures (140) arranged according to at least one unit cell. Also disclosed are methods for creating anti - adherent surfaces.

The invention provides an anti-helicobacter-pylori probiotic composition, which comprises fructo-oligosaccharide, stachyose, orange juice powder, glucose, yam powder, maltodextrin and lactobacillus dry powder. The probiotic composition provided by the invention can inhibit the growth of helicobacter pylori so as to relieve the occurrence of gastric ulcer and stomachache.

The present invention provides methods for treating, preventing or ameliorating skin infections, including bacterial and viral infections. In certain embodiments, the invention provides methods to reduce skin infection in a patient with atopic dermatitis (AD). Also provided are methods for improving skin barrier function, and methods for reducing the risk of inflammation due to microbial infection in a patient in need thereof. The methods of the present invention comprise administering to a patient in need thereof a pharmaceutical composition comprising an interleukin-4 receptor (IL-4R) antagonist such as an anti-IL-4R antibody.

A device delivers light within a patient using an inner cannula, fiber optics, LED along an endotracheal tube, ETT or tracheostomy tube or a strip with embedded LED adhered to an ETT. The inner cannula includes a tubular thin walled device that transmits light by fiber optics or delivers electrical power to an LED. The light passes along one or more fibers placed within the walls of the inner cannula for outward delivery of the light. The light affects the inside of the cannula, the area between the cannula and the ETT, the area outside the ETT, and into the tracheobronchial tree. The light delivers an antimicrobial effect into the upper airway of a patient. Alternatively, the light delivery device involves tubes and cannulas attaching to existing medical tubes and devices. Alternatively, a transparent strip of embedded LED secures to an existing medical tube.

A device delivers light within a patient using an inner cannula, fiber optics, LED along an endotracheal tube, ETT or tracheostomy tube or a strip with embedded LED adhered to an ETT. The inner cannula includes a tubular thin walled device that transmits light by fiber optics or delivers electrical power to an LED. The light passes along one or more fibers placed within the walls of the inner cannula for outward delivery of the light. The light affects the inside of the cannula, the area between the cannula and the ETT, the area outside the ETT, and into the tracheobronchial tree. The light delivers an antimicrobial effect into the upper airway of a patient. Alternatively, the light delivery device involves tubes and cannulas attaching to existing medical tubes and devices. Alternatively, a transparent strip of embedded LED secures to an existing medical tube.

The invention comprises 1) an oral composition, including an oral rehydration composition or solution, comprising an effective amount of a compound selected from epidermal growth factor (EGF) and agonists to the epidermal growth factor receptor, 2) a kit comprising an oral rehydration composition containing an effective amount of a compound selected from epidermal growth factor and agonists to the epidermal growth factor receptor, and 3) methods for the treatment and prevention of dehydration and diarrhea, and enhancing intestinal healing, reducing bacterial colonization, reducing the incidence of weight loss, increasing food uptake, enhancing rehydration, and enhancing mucosal healing in an animal having diarrhea.

The invention provides a control system of an aquarium illuminating system, wherein a motor driver changes the relative inclination degrees of light sources related to ornaments in an aquarium with the passage of time, so that incident light falling onto the ornaments more accurately simulates natural light of the sun which moves every day and moves seasonally. Besides relative change of the inclination degrees, the power setting of the light sources can be further adjusted so as to further simulate the effect caused by changes of climates and / or weather every day. Therefore, the system eliminates regions filled with excessive light (the light further can promote growth of unnecessary algae) from the light sources erected in a single fixed position in the aquarium, and saturation of the excessive light means that light from the light sources in the single fixed position penetrates downward into the deep part of the aquarium. By providing the system which effectively changes the angle of incidence of light, a programmable illuminating level can be obtained in the outward regions of ornaments or the regions below bumps, which can not be realized by the erected light sources in the single fixed position.

Comblike, surfactant polymers for changing the surface properties of biomaterials are provided. Such surfactant polymers comprise a polymeric backbone of repeating monomeric units having functional groups for coupling with side chains, a plurality of hydrophobic side chains linked to the backbone via the functional groups, and a plurality of hydrophilic side chains linked to said backbone via the functional groups. Medical devices coated with the surfactant polymers are also provided. The surfactant polymers may be used to decrease the thrombogenic properties, encapsulation, and bacterial colonization of medical devices.

The present invention relates to a polypeptide based toxin that originates from Clostridium perfringens. The invention further relates to immunogenic compositions comprising the toxin and methods to vaccinate animals, for example chickens, such that they are less susceptible to clostridial diseases. Methods to determine whether an animal has been exposed to the toxin, polynucleotides encoding the toxin and attenuated bacteria that express a reduced or less active form of the toxin are also disclosed.

The invention relates to a trachea cannula capable of removing sputum accumulation and relieving inflammatory reaction. The trachea cannula is provided with a cannula body, a breathing machine connector, an air vent, an airbag, an inflating passage and an inflating tube, wherein hydrophobic and oleophobic layers are arranged on the inner wall and the outer wall of the cannula body as well as on the outer wall of the airbag; a plurality of convex rings are arranged on the airbag, and the convex ring at the nearest end protrudes towards a near end, so that an accommodating groove is formed between a balloon and the cannula body; the edge of the air vent is coiled towards the near end, so that a receiving groove is formed; a sputum suction passage is formed in the inner wall of the cannula body; the sputum suction passage is provided with a first sputum suction hole and a second sputum suction hole; an opening at the far end of the sputum suction passage is a third sputum suction hole; the first sputum suction hole is opened outwards; the second sputum suction hole communicates with the accommodating groove; the third sputum suction hole communicates with the receiving groove; and a sputum suction tube is connected to the near end of the sputum suction passage. With the application of the trachea cannula provided by the invention, sputum can be thoroughly removed, planting and growth of pathogenic bacteria can be relieved, and an infection probability and an occurrence rate of the inflammatory reaction can be reduced; and the trachea cannula is fixed more firmly and cannot cause displacement and air leakage easily.

The invention discloses a mildew proof antibacterial material with a bionic micrometer structure surface. The material comprises the surface, a substrate and a topological feature printed on a surface material in press mode. The surface material of the material contains at least one polymer. Compared with the prior art, the material is capable of preventing bacteria from being planted and adhered to the surface according to the tests on multiple cells such as escherichia coli, staphylococcus aureus, vancomycin-proof enterococcus, pseudomonas aeruginosa and ulva spore and conducted in a laboratory. The material is capable of reducing 85%-99% of bacteria planting and adhesion relative to blank contrast samples with smooth surface and has strong mildew proof antibacterial functions.