119results about How to "Reduce colonization" patented technology

A wound dressing device for use with a transcutaneous medical device such as a cannula or a catheter comprises a polyurethane matrix which may be covered with a film backing. Chlorhexidine di- gluconate and a polyanhydroglucuronic salt are contained in the polymer matrix. The wound dressing device prevents microbial colonization of the dressing and stops bleeding from the insertion site. The device provides combined haemostatic and antimicrobial effects at the insertion site but without adversely affecting wound healing.

A kit for treating an antimicrobial resistant biological contaminate at a treatment site is disclosed which includes a diffuser tip adapted to receive near infrared therapeutic light from a light delivery system and diffuse the light to illuminate at least a portion of the treatment site; a quantity of an antimicrobial; agent; instructions to use the antimicrobial agent in conjunction with the therapeutic light to potentiate the antimicrobial agent to treat the biological contaminate; and suitable packaging.

This invention relates to oral care compositions comprising a first source of zinc which is zinc citrate, a second source of zinc which is zinc oxide or zinc lactate, a stannous ion source, and a polyphosphate, as well as to methods of using and of making these compositions.

The invention discloses a porcine epidemic diarrhea S1 protein fusion gene, recombinant bacillus megaterium strain and application. An antigen fusion gene shown as SEQ ID No. 1. is obtained by connecting an antigen locus of porcine epidemic diarrhea virus (PEDV) S glycoprotein and a cell wall anchoring sequence. The invention further constructs a secretion expression vector containing the antigen fusion gene, and secretion expression vector is converted into the bacillus megaterium to express recombinant protein on the cell wall or surface of the bacillus megaterium. Immunoblotting experiments indicate that the expressed recombinant protein can react with PEDV immune serum and has the same antigenicity as PEDV natural antigens. Immunofluorescent tests of live bacteria which are subjected to induced expression indicate that the expressed recombinant protein is positioned to the surfaces of the bacteria. Experiment results indicate that the recombinant protein can be prepared into safe and effective mucous immune live vaccines for preventing and treating porcine epidemic diarrhea.

The present invention encompasses protective monoclonal antibodies that bind to peptidoglycan of Gram-positive bacteria. The antibodies also bind to whole bacteria and enhance phagocytosis and killing of the bacteria in vitro and block nasal colonization by Gram-positive bacteria in vivo. The invention also provides human, humanized and chimeric antibodies. The invention also sets forth the heavy chain and light chain variable regions of an antibody within the invention.

Comblike, surfactant polymers for changing the surface properties of biomaterials are provided. Such surfactant polymers comprise a polymeric backbone of repeating monomeric units having functional groups for coupling with side chains, a plurality of hydrophobic side chains linked to the backbone via the functional groups, and a plurality of hydrophilic side chains linked to said backbone via the functional groups. Medical devices coated with the surfactant polymers are also provided. The surfactant polymers may be used to decrease the thrombogenic properties, encapsulation, and bacterial colonization of medical devices.

Disclosed are surfaces for resisting and reducing biofilm formation, particularly on medical articles (100). The surfaces include a plurality of microstructures (120) including a plurality of nanofeatures (140) arranged according to at least one unit cell. Also disclosed are methods for creating anti - adherent surfaces.

The invention provides an anti-helicobacter-pylori probiotic composition, which comprises fructo-oligosaccharide, stachyose, orange juice powder, glucose, yam powder, maltodextrin and lactobacillus dry powder. The probiotic composition provided by the invention can inhibit the growth of helicobacter pylori so as to relieve the occurrence of gastric ulcer and stomachache.

The invention comprises 1) an oral composition, including an oral rehydration composition or solution, comprising an effective amount of a compound selected from epidermal growth factor (EGF) and agonists to the epidermal growth factor receptor, 2) a kit comprising an oral rehydration composition containing an effective amount of a compound selected from epidermal growth factor and agonists to the epidermal growth factor receptor, and 3) methods for the treatment and prevention of dehydration and diarrhea, and enhancing intestinal healing, reducing bacterial colonization, reducing the incidence of weight loss, increasing food uptake, enhancing rehydration, and enhancing mucosal healing in an animal having diarrhea.

The present invention relates to a polypeptide based toxin that originates from Clostridium perfringens. The invention further relates to immunogenic compositions comprising the toxin and methods to vaccinate animals, for example chickens, such that they are less susceptible to clostridial diseases. Methods to determine whether an animal has been exposed to the toxin, polynucleotides encoding the toxin and attenuated bacteria that express a reduced or less active form of the toxin are also disclosed.

The invention relates to a trachea cannula capable of removing sputum accumulation and relieving inflammatory reaction. The trachea cannula is provided with a cannula body, a breathing machine connector, an air vent, an airbag, an inflating passage and an inflating tube, wherein hydrophobic and oleophobic layers are arranged on the inner wall and the outer wall of the cannula body as well as on the outer wall of the airbag; a plurality of convex rings are arranged on the airbag, and the convex ring at the nearest end protrudes towards a near end, so that an accommodating groove is formed between a balloon and the cannula body; the edge of the air vent is coiled towards the near end, so that a receiving groove is formed; a sputum suction passage is formed in the inner wall of the cannula body; the sputum suction passage is provided with a first sputum suction hole and a second sputum suction hole; an opening at the far end of the sputum suction passage is a third sputum suction hole; the first sputum suction hole is opened outwards; the second sputum suction hole communicates with the accommodating groove; the third sputum suction hole communicates with the receiving groove; and a sputum suction tube is connected to the near end of the sputum suction passage. With the application of the trachea cannula provided by the invention, sputum can be thoroughly removed, planting and growth of pathogenic bacteria can be relieved, and an infection probability and an occurrence rate of the inflammatory reaction can be reduced; and the trachea cannula is fixed more firmly and cannot cause displacement and air leakage easily.

The invention discloses a mildew proof antibacterial material with a bionic micrometer structure surface. The material comprises the surface, a substrate and a topological feature printed on a surface material in press mode. The surface material of the material contains at least one polymer. Compared with the prior art, the material is capable of preventing bacteria from being planted and adhered to the surface according to the tests on multiple cells such as escherichia coli, staphylococcus aureus, vancomycin-proof enterococcus, pseudomonas aeruginosa and ulva spore and conducted in a laboratory. The material is capable of reducing 85%-99% of bacteria planting and adhesion relative to blank contrast samples with smooth surface and has strong mildew proof antibacterial functions.