Preparation method and application of multifunctional GTR gradient barrier membrane

Abstract

The invention discloses a preparation method of a multifunctional GTR gradient barrier membrane. The multifunctional GTR gradient barrier membrane is prepared by a solvent pouring method. The method comprises specific steps as follows: preparing hollow carbonated hydroxyapatite; mixing the hollow carbonated hydroxyapatite with polylysine and agarose, and then preparing the multifunctional GTR gradient barrier membrane by the solvent pouring method. The invention also discloses an application of the multifunctional GTR gradient barrier membrane in regeneration of periodontal tissue and long-term antibiosis in oral environments. The process is simple, the requirement of ideal GTR barrier membrane can be met, the multifunctional GTR gradient barrier membrane can be prepared simply and conveniently by the method on a large scale, the prepared gradient barrier membrane can effectively prevent postoperative infection and promote repair of periodontal defect tissue after being applied to GTRoperation.

Description

technical field [0001] The invention relates to a construction method of an oral GTR gradient barrier membrane and its biological application. In particular, it relates to a preparation method based on an asymmetric agarose hydrogel film loaded with polylysine and hydroxyapatite and its use in oral cavity guided tissue regeneration to achieve periodontal tissue regeneration and oral environment Antibacterial for a long time. Background technique [0002] Chronic periodontitis is a chronic infectious disease that occurs in the periodontal supporting tissue, causing the absorption and destruction of alveolar bone, and is the main cause of tooth loss in adults. Bacterial plaque is the initiating factor of chronic periodontitis, and is most closely related to the occurrence and development of chronic periodontitis. The traditional method of treating periodontitis is basic periodontal treatment, including supragingival scaling, subgingival scaling, root planing and drug treatme...

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Problems solved by technology

And it has the advantages of good histocompatibility, low antigenicity, strong toughness, and easy operation, but it does not have good osteoinduction and conductivity, the manufacturing process is complicated, and the price is relatively expensive

And because the oral cavity is a bacterial environment, in the process of periodontal tissue regeneration and healing, it is easy to make the wound pollution and oral microbial adhesion exposed to the oral environment, resulting in a significant reduction in wound infection or the formation of new periodontal attachments, but at present GTR barrier membrane materials on the market have no antibacterial ability, and postoperative oral bacterial infection is one of the main reasons for the failure of GTR surgery

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