5results about How to "Short hemostatic time" patented technology

This invention belongs to the field of biomedical materials technology, specifically relating to an oxidized hyaluronic acid / carboxymethyl chitosan hemostatic sponge and its preparation method. The preparation method includes: oxidizing hyaluronic acid with sodium periodate to obtain oxidized hyaluronic acid; preparing aqueous solutions of oxidized hyaluronic acid and carboxymethyl chitosan; mixing the two solutions and forming a hydrogel through a Schiff base reaction between aldehyde and amino groups; cryogelatinizing the hydrogel at low temperature and then freeze-drying it under vacuum to obtain an expandable hemostatic sponge with a three-dimensional interconnected porous structure. Upon contact with blood, the sponge of this invention rapidly absorbs water and expands, increasing in volume by more than three times, forming a tight physical seal. Simultaneously, it adsorbs and activates platelets to accelerate coagulation, achieving highly efficient hemostasis. This sponge exhibits excellent biocompatibility, is completely degradable in vivo, and the preparation process is mild and requires no toxic cross-linking agents. It can be used for rapid hemostasis of deep, irregular, and non-compressible bleeding wounds.

The present application belongs to the technical field of medical hemostatic dressings and bandages, and particularly relates to a Duyuwei emergency hemostatic bandage, which comprises a bandage main body, the bandage main body is composed of a tight band and a dressing pad, the dressing pad is fixed to the front end of the tight band, the dressing pad is composed of an absorption area, a tablet area and a pad base layer, the absorption area and the tablet area are fixed on the pad base layer by traditional Chinese medicine glue, the absorption area is composed of Duyuwei gelatin sponge, the tablet area is composed of Duyuwei external-use tablets, and the pad base layer is composed of a medical degreasing cotton pad. A preparation method of the Duyuwei emergency hemostatic bandage comprises the following steps: Duyuwei medicinal material decoction piece component extraction, Duyuwei external-use tablet preparation, traditional Chinese medicine glue preparation, Duyuwei gelatin sponge preparation and Duyuwei hemostatic bandage preparation. The present application has the advantages of rapid hemostasis and remarkable efficacy: the Duyuwei extract, the gelatin sponge and the traditional Chinese medicine glue synergistically act to significantly shorten the hemostasis time. Animal experiments show that the average hemostasis time is short.

The invention provides a preparation method of a biological tissue adhesive, which comprises the following steps: (1) respectively dissolving polyacrylic acid and polyethyleneimine in deionized water to prepare a polyacrylic acid aqueous solution and a polyethyleneimine aqueous solution; (2) blending the polyacrylic acid aqueous solution, the polyethyleneimine aqueous solution and the inorganic hemostatic material, and fully stirring to obtain a copolymer of the three substances; (3) immersing the copolymer into liquid nitrogen for pre-freezing, and then freeze-drying; and (4) taking out the freeze-dried sample, and grinding the sample into powder to obtain the biological tissue adhesive powder. The hemostatic adhesive powder is simple and convenient to apply, has a remarkable hemostatic effect and can be used for effectively stopping bleeding under various bleeding conditions.

The invention discloses hemostatic powder with rapid high-strength imbibition capacity and an antibacterial function and a preparation method thereof.The preparation method includes the steps that chitosan derivatives and deionized water are mixed to be uniform, and a chitosan derivative solution is prepared; the preparation method comprises the following steps: adding acrylic acid and methacryloyloxyethyl trimethyl ammonium chloride into a chitosan derivative solution, uniformly mixing, adding a cross-linking agent and a photoinitiator, carrying out polymerization reaction to obtain a cross-linked product, freeze-drying, and grinding to obtain the hemostatic powder with rapid liquid absorption and antibacterial functions. According to the hemostatic powder disclosed by the invention, a material which is good in biocompatibility, relatively strong in antibacterial function, rapid in imbibition and capable of stopping bleeding in time is obtained by regulating and controlling the proportion of polycations and anions, and the problems that a cationic material is poor in biocompatibility, and the hemostatic powder is poor in imbibition capacity are solved.

The present invention provides a hemostatic material and a preparation method thereof, and belongs to the technical field of biomedical composite materials. The preparation method of the hemostatic material provided by the present invention comprises the following steps: (1) mixing oxidized regenerated cellulose containing a sodium carboxylate structure with dilute hydrochloric acid and then performing an acidification treatment to obtain acidified oxidized regenerated cellulose; (2) impregnating the oxidized nanocellulose into a copper salt solution to obtain a Cu-loaded nanocellulose; 2+ (3) the acidified oxidized regenerated cellulose obtained in step (1) and the loaded Cu obtained in step (2) 2+ The oxidized nanocellulose is added to a PBS solution containing thrombin and mixed, and then washed and dried in sequence to obtain a hemostatic material. The results of the embodiment show that the average hemostatic time of the hemostatic material prepared by the preparation method provided by the present invention is 2.5 to 3.0 minutes, the hemostatic time is short, and the hemostatic effect is good.