49results about How to "Short hemostatic time" patented technology

The invention relates to a medical compound micropore polysaccharide and application in hemostasis on wound surface bleeding areas of various wounds and operation tissues. The medical compound micropore polysaccharide is prepared by adopting a method with the following steps: (1) preparing starch fluid; (2) preparing carboxymethyl chitosan solution; (3) mixing the starch fluid and the carboxymethyl chitosan solution, and adding dispersant and emulsifier into the mixture; (4) emulsifying, crosslinking and co-polymerizing; and (5) refining, drying, packing and sterile treatment. The invention also discloses application of the medical compound micropore polysaccharide in preparing a hemostasis medicament used for the wound surface bleeding areas of wounds and operation tissues. The medical compound micropore polysaccharide of the invention has the following characteristics: 1, the hemostasis time is short, namely the hemostasis is generally finished in 3 to 5 minutes; 2, the medical compound micropore polysaccharide has no antigenicity, has polysaccharide components, and has no protein or immune reaction; 3, the medical compound micropore polysaccharide can be fully degraded and absorbed in vivo; 4, the medical compound micropore polysaccharide is a sterile product and is convenient to use by opening; and 5, the tissue reaction is light. Therefore, the medical compound micropore polysaccharide is a comparatively ideal surgical hemostasis product.

The invention provides a preparation method of an oxidized regenerated cellulose hemostatic material with a micro-nano composite structure and relates to a preparation method of an oxidized regenerated cellulose hemostatic material. The invention aims to solve the problems of low hemostatic speed, great effect on environment and uneasiness in decomposition of the existing hemostatic material. The preparation method comprises the following steps: firstly, preparing cellulose solution; secondly, netting fibers in a wet state and reinforcing into a nano layer cellulose non-woven fabric; thirdly, preparing an oxidized nano cellulose non-woven fabric and oxidized viscose staple fibers; and fourthly, cotton-slitting and cotton-carding the oxidized viscose staple fibers prepared in the step 3 and compounding to obtain the oxidized regenerated cellulose hemostatic material with the micro-nano composite structure. The preparation method is applied to the preparation field of the oxidized regenerated cellulose hemostatic material.

The invention discloses a medical antibacterial hydrogel dressing and a preparation method thereof. The hydrogel dressing is prepared from the following raw materials: thiolated chitosan, sodium glycerophosphate hydrate, carbomer, oxidized sodium alginate, L-arginine ethyl ester dihydrochloride, theophylline, glycine fumarate, L-carnitine powder, stachyose, hydroxyethyl methylacrylate, tri(propylene glycol) diacrylate, ginkgo flavonol, polyhexamethylene biguanidine, povidone iodine, alcoholic extract of herba andrographitis, triethanolamine and de-ionized water. The hydrogel dressing prepared by the invention can achieve inhibitory rates 91% and 94% or above on pseudomonas aeruginosa and staphylococcus aureus separately, and the hydrogel dressing has a broad-spectrum antibacterial property and a durable antibacterial effect; and in addition, the hemostasis time of the dressing is just 9-18s and healing time is shorter than 10d, and healed regenerated skin has a smooth and delicate surface; therefore, the hydrogel dressing is excellent in wound healing capacity and quite good in healing effect.

The invention discloses a zeolite tourniquet bandage, which belongs to the technical field of medical supplies. The zeolite tourniquet bandage comprises medical gauze, which adsorbs stanching components, and the stanching components comprise, by weight, 50% to 95% of zeolite powder, 3% to 30% of one or more selected form the group consisting of sodium chloride, potassium nitrate, ammonium salt, urea and sodium bicarbonate and 2% to 20% of a binder. According to the invention, the stanching components and the medical gauze are formed once for all and are subjected to sterile sealing, which enables such problems of conventional stanching products as a high price, nonuniform coating, proneness to external environmental affection, troublesome utilization and the like to be overcome. The zeolite tourniquet bandage provided in the invention has the following advantages: it is convenient to carry, preserve and utilize the zeolite tourniquet bandage; cost is low; a production process is simple; a good stanching effect, low heat release and no side effects are obtained; the zeolite tourniquet bandage can be widely used as a first-aid kit in laboratories, medical stations, household first aids and field works.

The invention relates to a hemostasis patch and a preparation method thereof. The hemostasis patch comprises an upper layer and a lower layer, wherein the upper layer is made of a hemostasis composite material, the lower layer is made of a high-viscosity biological material, the upper layer is smaller than the lower layer, and the upper layer is located in the middle of the lower layer. The high-viscosity biological material can be attached to biological connective tissue around blood vessels tightly so as to limit hemorrhage in a confined tissue cavity. The hemostasis patch has soft texture, high viscosity, low immunogenicity and high biocompatibility, is biodegradable, can stop bleeding in short time and has an excellent hemostasis effect.

A wound-healing and hemostatic sponge of squid ink polysaccharide/chitosan, a preparation method and use thereof are provided. The sponge comprises squid ink polysaccharide and chitosan as carriers and calcium chloride as an initiator for blood coagulation, and the wound-healing and hemostatic sponge of squid ink polysaccharide/chitosan is achieved via a lyophilization technology. Particularly, the preparation method comprises slowly adding a squid ink polysaccharide solution to a chitosan solution to form a uniformly mixed solution, adding a calcium chloride solution to the uniformly mixed solution, forming a gel followed by the gel being frozen and then lyophilized, and achieving the product. The wound-healing and hemostatic sponge has a good absorbing-errhysis effect, a good pro-coagulant effect, fast hemostasis and a complete hemostatic effect, without secondary re-hemorrhage. Moreover, the wound-healing and hemostatic sponge can promote wound healing, re-epithelialization and repair of epidermis and dermis, with strong wound-healing ability, good biocompatibility, weak toxic side effects and irritation, belonging to a novel wound-healing and hemostatic material. Moreover, the preparation method is reliable, fast, and low cost.

The invention discloses a Chinese medicinal composition for treating functional uterine bleeding, which selects the Chinese medicinal herbs with effects of tonifying the kidney, replenishing qi, eliminating of blood stasis and stopping blood, i.e. cassia bark, medlar, largehead atractylodes rhizome, India madder root, poria, himalayan teasel root, garden burnet root, Chinese arborvitae twig, common cephalanoplos herb, Chinese leek root, ginseng and Chinese mugwort leaf, according to the disease causes of the functional uterine bleeding and carries out scientific compatibility. The invention provides capsules for more effectively treating functional uterine bleeding. The clinical application proves that the capsules of the invention have exact curative effect on the patients suffering from functional uterine bleeding, has short administration time, less dosage, quick response, short time of stopping blood and high hemoglobin recovery rate and is valuable to be clinically popularized and applied.

The invention discloses a half-path charge complementary type chiral self-assembled short-peptide nanometer biomedical material and application. The general formula of the amino acid sequence of a chiral self-assembled short peptide provided in the invention is shown as follows: Ac-Pro-X-Phe-Y-Phe-Asn-Phe-Gln-Pro-NH2, wherein X and Y are polar charged amino acids, X is an negatively charged amino acid and Y is an positively charged amino acid, the amino acids of the whole peptide chain are all D-amino acid, and the number of amino acid residues is set as 9. The half-path charge complementary type chiral self-assembled short peptide has a secondary structure with relatively strong stability and is hardly influenced by external environmental factors, the self-assembly morphology of the chiral short peptide can be regulated by adding NaCl or changing the content of NaCl, and nanometer fiber hydrogel, which has rapid bleeding-stopping effect on bleeding wound, can be formed through self assembly. The material is simple and practicable in preparation technology and relatively low in cost, and the application of the material helps to enrich the kinds of nanometer biomedical materials.

The invention relates to injectable and degradable dry hemostatic cryogel with good shape memory and blood coagulation capability as well as a preparation method and an application of the injectable and degradable dry hemostatic cryogel. Chitosan is resuspended in deionized water, glacial acetic acid is dropwise added under stirring, and a CS solution is obtained after uniform mixing; dopamine hydrochloride is added to the deionized water to prepare a DA solution; the CS solution is mixed with the DA solution, an oxidant solution is added simultaneously, and the solutions are uniformly mixed to obtain a mixed solution; and finally, the mixed solution is placed at the temperature of subzero 7-subzero 20 DEG C to react for 12-36 h, a cross-linked cryogel network in a frozen state is obtained, and is placed in the deionized water to be melted, freeze drying is conducted, and the injectable and degradable dry hemostatic cryogel with good shape memory and blood coagulation capability is obtained. The cryogel dressing has high elasticity and ultrafast shape recovery capability, can quickly absorb blood, and has photo-thermal antibacterial performance and the like.

The invention relates to an antibacterial hemostatic membrane as well as preparation and application thereof. According to the antibacterial hemostatic membrane, sodium alginate, carboxymethyl chitosan, collagen and berberine hydrochloride are taken as raw materials, and the biological composite hemostatic membrane is prepared by adding a humectant and adding calcium chloride droplets in an atomizing manner to serve as a cross-linking agent. The hemostatic membrane can quickly stop bleeding of local large-area wounds and prevent bacterial infection of the wounds; and the hemostatic membrane isgood in biocompatibility, free of hemolysis, rapid and efficient in degradation and free of influence on wound healing.

The invention provides a fluid haemostatic adhesive and a preparation method thereof. The fluid haemostatic adhesive comprises cross-linked chitosan or a derivative thereof, cross-linked water-solubleprotein or polypeptide, and a lubricating agent. The haemostatic adhesive does not contain blood coagulation factors, is in a flowable ointment shape, has a proper swelling degree, can be directly used without involving any time-consuming reconstruction step, and has the advantages of short haemostatic time, high wound healing speed, convenience and rapidness in use, in-vivo degradability, good biocompatibility and the like.

The invention provides a bleeding-stopping healing-promoting foam dressing, and a preparation method and application thereof. The method comprises the following steps: (1) mixing and stirring chitosan, frankincense, L-lactic acid oligomer and water; (2) adding a surfactant, a catalyst, a foaming agent and a foam stabilizer, placing the obtained mixture in a foaming mold, and conducting heat preservation, demolding and cutting; (3) conducting immersing in a harba dendrolii nobilis extraction solution, and conducting drying to obtain the foam dressing. The foam dressing prepared by the method ofthe invention adopts an immersing way of immersing in the harba dendrolii nobilis extraction solution, and is simple in process, thus harba dendrolii nobilis is adsorbed for increasing the medicinaleffect of the foam dressing, and also the irritating property of the traditional Chinese medicine extraction solution is avoided. The foam dressing is mild in nature, and has excellent effects of stopping bleeding, diminishing inflammation and promoting healing.

The invention discloses an absorbable medical hemostatic material and a preparation process thereof. The hemostatic material is prepared from the following components: fish scale collagen protein, maltodextrin, oligomannuronate, potassium alginate, D-threitol, polycaprolactone, 0.7 mol/L radix angelicae and alcohol extract, oxaloacetic acid, carboxyl glucan, gamma-polyglutamic acid, glycine ethyl ester, sodium D-glucuronate, microcrystalline cellulose 101, L-pentaguluronic acid pentasodium salt, citric acid and distilled water. The hemostatic material provided by the invention can stop bleeding quickly, is high in hemostasis rate, is higher in degrading speed in vivo, is non-toxic and high in biocompatibility, does not have immunoreactions, is high in capacity of healing and recovering a wound, can be used safely and reliably, and has a good market application prospect.

The application relates to a hemostyptic microsphere containing an antibacterial ingredient berberine as well as a preparation method and application of the hemostyptic microsphere, and a hemostatic agent can be used in human bodies and can be quickly degraded and absorbed. According to the invention, a composite antibacterial hemostyptic microsphere material taking sodium alginate, sodium carboxymethylcellulose, gelatin and the berberine as raw materials is adopted, the characteristics of bacteria resistance and adhesion of the berberine are utilized, so that the material is endowed with an antibacterial property, and a hemostyptic effect of the material is further enhanced. Meanwhile, in a simulated body fluid environment after hemostasis, hemostyptic antibacterial effective ingredientsincluding the sodium alginate, the sodium carboxymethylcellulose, the gelatin and the berberine are degraded, so that an effect that the hemostyptic material can be quickly degraded and absorbed in human bodies is achieved.

The invention relates to a preparation method of a starch microsphere and human recombinant tissue factor lipid composite hemostatic material. The preparation method comprises the following steps: dissolving potato starch in deionized water, mixing with emulsified soybean oil according to the mass ratio of water phase to oil phase solution of 1: 2.0-1: 2.5, and forming starch microspheres with mutually condensed hydroxyl groups under the action of an initiator; further dispersing the obtained starch microspheres in anhydrous 1,4-dioxane, modifying with N,N'-disuccinimido carbonate (DSC), adding human recombinant tissue factor lipids, and combining the tissue factors with the starch microspheres in a covalent bonding manner. The starch microsphere and human recombinant tissue factor lipid composite hemostatic material is obtained through centrifugation, cleaning and vacuum drying, and a rapid blood coagulation effect is achieved by utilizing the starting blood coagulation function of tissue factors.