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Double-component medical adhesive based on glucan and chitosan and preparation method of double-component medical adhesive

A technology of aldylated dextran and carboxymethyl chitosan, which is applied in the field of chemical modification and medical materials, can solve the problems of high bonding strength, virus infection, low bonding strength, etc., and achieve good bonding strength , good bonding ability, low price effect

Active Publication Date: 2017-12-22
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Cyanoacrylate cures quickly and has high strength, but the hydrolysis of the polymer will produce formaldehyde which is harmful to the human body; the bonding strength of biopolymer-aldehyde is high, because the use of aldehydes as cross-linking agents is also toxic to the human body, and fibrin is Formed in the final stage of blood coagulation, although it has affinity for human tissues, its bonding strength is relatively low, and because it is a blood preparation, there is a risk of viral infection

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] (1) Accurately weigh 5g of dextran and dissolve it in 400mL deionized water to form a uniform solution, weigh 9.9g of sodium periodate in the dark and dissolve it in 400mL of deionized water to form an aqueous solution of sodium periodate, then add periodate Sodium solution was added dropwise to the homogeneous dextran solution in the dark, and the aldylation reaction was carried out in the dark at room temperature for 4 hours; then the product was put into a dialysis bag (molecular weight cut-off: 14000) and dialyzed for 3 days, changing times every 4 hours water; then pour the product into a plate and freeze it at -80°C for 6 hours, and then put it into a vacuum freeze dryer for freeze-drying to finally obtain formaldehyde-glucan, wherein the molecular weight of formaldehyde-glucan is 70,000.

[0029] (2) Accurately weigh 5g of carboxymethyl chitosan and dissolve it in 100mL of aqueous solution, add 30mL of ethylenediamine, adjust the pH to 5.0, then add 8.76g of water...

Embodiment 2

[0033] (1) the formylation dextran that embodiment 1 step (1) is obtained is made into the solution that concentration is 20%, and the aminated carboxymethyl chitosan that embodiment 1 step (2) is obtained is made into concentration as 6% solution, then mixed in equal volumes, and formed a hydrogel by Schiff base reaction at room temperature to obtain a two-component medical adhesive based on dextran and chitosan.

[0034](2) Test the cohesive strength and gel time of the medical adhesive obtained in this embodiment. The specific operation is as follows: take 1mL of aminated carboxymethyl chitosan solution with a 2mL needle tube, and take 1mL of the aldehyde-formylated chitosan solution with a 2mL needle tube. Dextran solution, through a Y-shaped connection, inject the aminated carboxymethyl chitosan solution and the aldehylated dextran solution into two pieces of 1cm×3cm pig skin at the same time through a needle, so that the two pieces of skin are bonded up, the test bond st...

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Abstract

The invention relates to a double-component medical adhesive based on glucan and chitosan and a preparation method of the double-component medical adhesive. The double-component medical adhesive comprises formylated glucan and aminated carboxymethyl chitosan, wherein the mass ratio of the formylated glucan to the aminated carboxymethyl chitosan is (1.67-3.33):1. The preparation method includes: adding a sodium periodate solution into a glucan solution under a dark condition to perform dialysis, and performing freeze drying to obtain the formylated glucan; mixing carboxymethyl chitosan, ethylenediamine and water-soluble carbodiimide, and performing dialysis and freeze drying to obtain the aminated carboxymethyl chitosan; mixing the formylated glucan and aminated carboxymethyl chitosan which are identical in volume, and performing Schiff base reaction to form hydrogel to obtain the medical adhesive. The double-component medical adhesive and the preparation method thereof have the advantages that the raw materials of the double-component medical adhesive are nontoxic and odorless, cheap and good in biocompatibility; the preparation method is simple; the prepared medical adhesive is good in adhesive strength and capable of shortening gelation time, the medical adhesive can act on any body parts through simple local spraying or injection, and the medical adhesive is an ideal replacement product of commercially available fibrin glue.

Description

technical field [0001] The invention belongs to the technical field of chemical modification and medical materials, in particular to a two-component medical adhesive based on dextran and chitosan and a preparation method thereof. Background technique [0002] With the rapid progress of modern medicine, the clinical requirements for surgical effects are getting higher and higher. While reducing the pain of the patient as much as possible and recovering as quickly as possible, it is also hoped to restore the appearance to the greatest extent. For many years, in trauma surgery, the traditional method is to use mechanical connectors (such as: sutures, bone nails, etc.). Although the above-mentioned mechanical connectors are widely used, there are many deficiencies. For example, the use of suture thread itself will cause damage to the surrounding tissue, and it is not suitable for complicated operations (such as preventing the outflow of fluid). When the method of suturing is ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/08A61L24/00
CPCA61L24/001A61L24/0031A61L24/0042A61L24/043A61L2400/04A61L2400/06C08L5/08C08L5/02
Inventor 莫秀梅吴俣袁柳沈乃安
Owner DONGHUA UNIV
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