Chitosan-based self-healing gel and preparation method thereof

A chitosan and self-healing technology, which is applied in the field of chitosan-based self-healing gel and its preparation, can solve the problems of less research on natural polymer self-healing gel, and achieve good self-healing properties , mild reaction and simple method

Inactive Publication Date: 2016-09-28
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the research on self-healing gels mainly focuses on synthetic polymers, but less research on natural polymer

Method used

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  • Chitosan-based self-healing gel and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A certain amount of chitosan was dispersed in a mixed solution of 50 wt% NaOH and 12 wt% urea at -30 o Ice was formed at ℃, placed for 12 hours, and then thawed into a solution at room temperature with a concentration of 0.5 wt%. Adding acrylamide to the chitosan solution at a molar ratio of chitosan unit and acrylamide was 1:1, and the 0 o C for 1 h to obtain acrylamide chitosan with a degree of substitution of 0.12. Dissolve acrylamide chitosan with a substitution degree of 0.12 in ultrapure water to prepare a solution with a concentration of 0.5 wt%, and add an oxidation degree of 5 % oxidized natural polysaccharides, mixed well at room temperature, and after the gel was prepared, it was stored in a desiccator containing saturated sodium chloride to maintain a humidity of 75%. Cut the prepared gel and stick it together. After a certain period of time, take pictures with a camera and observe the healing condition of the gel with an optical microscope.

Embodiment 2

[0026] A certain amount of chitosan was dispersed in a mixed solution of 15 wt% KOH, 8 wt% NaOH, and 12 wt% thiourea at -30 o It was frozen under ℃, placed for 12 hours, then thawed into a solution at room temperature, the concentration was 8 wt%, and the molar ratio of chitosan unit and acrylamide was 1:25 to add acrylamide to the chitosan solution. 15 o C for 72 h to obtain acrylamide chitosan with a degree of substitution of 0.96. Dissolve acrylamide chitosan with a substitution degree of 0.96 in ultrapure water to prepare a solution with a concentration of 0.5 wt%, and add acrylamide chitosan with an oxidation degree of 5 % oxidized natural polysaccharides, mixed well at room temperature, after gel preparation, stored in a desiccator containing saturated sodium chloride to maintain a humidity of 75%. Cut the prepared gel and stick it together. After a certain period of time, take pictures with a camera and observe the healing condition of the gel with an optical microsco...

Embodiment 3

[0028] A certain amount of chitosan was dispersed in a mixed solution of 20 wt% LiOH, 8 wt% NaOH, and 12 wt% urea at -30 o Ice was formed under the temperature of C, placed for 12 hours, and then thawed into a solution at room temperature, the concentration was 3 wt%, and the molar ratio of chitosan unit and acrylamide was 1:25 to add acrylamide to the chitosan solution. 15 o C for 72 h to obtain acrylamide chitosan with a degree of substitution of 0.96. Dissolve acrylamide chitosan with a substitution degree of 0.96 in ultrapure water to prepare a solution with a concentration of 3 wt%, and add acrylamide chitosan with an oxidation degree of 5 % oxidized natural polysaccharides, mixed well at room temperature, after gel preparation, stored in a desiccator containing saturated sodium chloride to maintain a humidity of 75%. Cut the prepared gel and stick it together. After a certain period of time, take pictures with a camera and observe the healing condition of the gel with ...

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Abstract

The invention discloses chitosan-based self-healing gel and a preparation method of the chitosan-based self-healing gel. The preparation method comprises the following steps: putting chitosan in a mixed solvent of KOH, LiOH, NaOH, urea and thiourea, thus obtaining a chitosan solution through a freezing-defreezing process; adding acrylamide in the chitosan solution, thus preparing acrylamide chitosan; oxidizing by sodium periodate, thus preparing oxidized natural polysaccharide; mixing the acrylamide chitosan with the oxidized natural polysaccharide according to a certain proportion, thus preparing a gel material, wherein self repairing on damage after gel is damaged can be realized. According to the preparation method disclosed by the invention, the chitosan gel with good self-healing performance, good biocompatibility and good biodegradability can be obtained, and a wide application prospect in many fields of biomedical materials, tissue engineering, medical packaging materials and the like is obtained.

Description

technical field [0001] The invention belongs to the field of natural polymer materials, and in particular relates to a chitosan-based self-healing gel and a preparation method thereof. Background technique [0002] In recent years, self-healing polymer gels have attracted extensive attention. Self-healing refers to the ability of a material to restore itself to its original state after being damaged (Burattini et al., 2010). Dynamic chemistry is a way to prepare self-healing gels, such dynamic chemistry includes dynamic covalent chemistry and non-covalent chemistry (Wei et al., 2014). Most of the physical self-healing gels are achieved through non-covalent chemistry, such as hydrogen bonding, hydrophobic aggregation, and host-guest interactions, which do not require external stimulation (Urban, 2009). However, self-healing gels based on dynamic covalent bonds usually require external stimuli, such as adjustments in pH, light, or temperature, to induce covalent bond reacti...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08J3/24C08L5/08C08L5/04C08B37/08
CPCC08J3/075C08B37/003C08J3/246C08J2305/04C08J2305/08C08J2405/04C08J2405/08C08L5/04C08L5/08C08L2201/06C08L2205/02
Inventor 丁福源黎厚斌施晓文杜予民
Owner WUHAN UNIV
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