Flexible absorbable composite interface screw sheath and preparation method thereof
An interface screw and flexible technology, applied in medical science, surgery, etc., can solve the problems of lack of ductility and impact toughness, easy cracking of the interface screw sheath, decrease in strength, etc., and achieve the effect of excellent ductility, enhanced strength, and improved strength.
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Embodiment 1
[0032] A method for preparing a flexible absorbable composite interface screw sheath, the steps are as follows:
[0033] (1) Adding caprolactone monomer, molecular weight is polyethylene glycol and stannous octoate of 1000g / mol in reaction flask, wherein, the mass ratio of caprolactone monomer and polyethylene glycol is 7:3, and octoate The molar ratio of tin to caprolactone monomer is 1:25000. Before starting the reaction, the reactant was dried under reduced pressure at 50° C. for 0.5 h, and then the gas atmosphere in the reaction bottle was purified with dry nitrogen several times. After that, the oil bath was heated up, and the ring-opening polymerization was carried out at 180°C. After about 5 hours, the viscosity of the product no longer increased significantly. The contents of alcohol segment and polycaprolactone segment are 30wt% and 70wt% respectively.
[0034] (2) Pre-blending L-polylactic acid with a weight average molecular weight of 600,000g / mol and polyethylene...
Embodiment 2
[0042] A method for preparing a flexible absorbable composite interface screw sheath, comprising poly(ethylene glycol)-polycaprolactone copolymer synthesized in the step (1) of Example 1 and L-polylactic acid with a weight average molecular weight of 600,000 g / mol and β-TCP with an average particle size of 500nm was pre-blended, and then melt-blended by a twin-screw extruder and extruded to granulate, and the particles were injection-molded to obtain a flexible absorbable composite interface screw sheath, in which L-polylactic acid and The mass ratio of polyethylene glycol-polycaprolactone copolymer is 8:2, and the mass content of β-TCP is 3% of the sum of the mass content of polylactic acid and polyethylene glycol-polycaprolactone copolymer. During extrusion granulation, the temperature range of each barrel and die in the twin-screw extruder is 190°C to 220°C, the screw speed is 200rpm, the injection temperature during injection molding is 200°C, and the mold temperature is 50...
Embodiment 3
[0046] A method for preparing a flexible absorbable composite interface screw sheath, the steps are as follows:
[0047] (1) Adding caprolactone monomer, molecular weight is polyethylene glycol and stannous octoate of 1000g / mol in reaction flask, wherein, the mass ratio of caprolactone monomer and polyethylene glycol is 9:1, and octoate The molar ratio of tin to caprolactone monomer is 1:25000. Before starting the reaction, the reactant was dried under reduced pressure at 50° C. for 0.5 h, and then the gas atmosphere in the reaction bottle was purified with dry nitrogen several times. After that, the oil bath was heated up, and the ring-opening polymerization was carried out at 180°C. After about 5 hours, the viscosity of the product no longer increased significantly. The contents of alcohol segment and polycaprolactone segment are respectively 10wt% and 90wt%.
[0048] (2) Pre-blending racemic polylactic acid with a weight-average molecular weight of 600,000g / mol, polyethyl...
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