96 results about "Biodegradable polyurethane" patented technology

A biodegradable and biocompatible polyurethane composition synthesized by reacting isocyanate groups of at least one multifunctional isocyanate compound with at least one bioactive agent having at least one reactive group —X which is a hydroxyl group (—OH) or an amine group (—NH₂). The polyurethane composition is biodegradable within a living organism to biocompatible degradation products including the bioactive agent. Preferably, the released bioactive agent affects at least one of biological activity or chemical activity in the host organism. A biodegradable polyurethane composition includes hard segments and soft segments. Each of the hard segments is preferably derived from a diurea diol or a diester diol and is preferably biodegradable into biomolecule degradation products or into biomolecule degradation products and a biocompatible diol. Another biodegradable polyurethane composition includes hard segments and soft segments. Each of the hard segments is derived from a diurethane diol and is biodegradable into biomolecule degradation products.

The present invention relates to biocompatible, biodegradable polyurethane/urea polymeric compositions that are capable of in-vivo curing with low heat generation to form materials suitable for use in scaffolds in tissue engineering applications such as bone and cartilage repair. The polymers are desirably flowable and injectable and can support living biological components to aid in the healing process. They may be cured ex-vivo for invasive surgical repair methods, or alternatively utilized for relatively non-invasive surgical repair methods such as by arthroscope. The invention also relates to prepolymers useful in the preparation of the polymeric compositions, and to methods of treatment of damaged tissue using the polymers of the invention.

This invention relates to biocompatible, biodegradable thermoplastic polyurethane or polyurethane/ureas comprising isocyanate, polyol and a conventional chain extender and/or a chain extender having a hydrolysable linking group and their use in tissue engineering and repair applications, particularly as stents and stent coating.

The invention provides ABA type triblock biodegradable polyurethane with amino side chains and a preparation method and uses thereof, belongs to the field of biomedical materials and solves the problem that the existing biodegradable polyurethane has molecular weight uncontrollable, wide molecular distribution index and complexity in self-assembly. The ABA type triblock biodegradable polyurethane with amino side chains is shown as in a structural formula I or II. The ABA type triblock biodegradable polyurethane is controllable in polymer molecular weight and wide in molecular weight distribution and can serve as a drug carrier; drug molecules, target molecules or fluorescence molecules are grafted to active side groups of the polyurethane by means of physical encapsulation or chemical bonding, so that a carrier drug system having one or multiple of functions such as being untargeted, being targeted, pH sensitivity, photosensitivity, enzyme sensitivity and fluorescence probing is constructed.

A biodegradable polyurethane scaffold that includes a HDI trimer polyisocyanate and at least one polyol; wherein the density of said scaffold is from about 50 to about 250 kg m−3 and the porosity of the scaffold is greater than about 70 (vol %) and at least 50% of the pores are interconnected with another pore. The scaffolds of the present invention are injectable as polyurethane foams, and are useful in the field of tissue engineering.

Composition for preparing a biodegradable polyurethane-based foam and a biodegradable polyurethane foam, comprising mixtures based on poly(hydroxybutyrate) polymer, polyols of renewable source, isocyanates and additives, with the object of preparing biodegradable polyurethane foams. In the process, the poly(hydroxybutyrate) plus the polyol, the isocyanate and the additives are previously mixed in specific mixers; once the homogenization is reached, the mixture is poured in mold for growing. After curing, the resulting product presents foam characteristics, with its density, toughness and cell size varying according to the proportion of the reagents and allowing the manufacture of several products.

A method of synthesizing of a biocompatible and biodegradable polyurethane foam includes the steps of: mixing at least one biocompatible polyol, water, at least one stabilizer, and at least one cell opener, to form a resin mix; contacting the resin mix with at least one polyisocyanate to form a reactive liquid mixture; and reacting the reactive liquid mixture form a polyurethane foam. The polyurethane foam is preferably biodegradable within a living organism to biocompatible degradation products. At least one biologically active molecule having at least one active hydrogen can be added to form the resin mix.

A biodegradable polyurethane scaffold that includes a HDI trimer polyisocyanate and at least one polyol; wherein the density of said scaffold is from about 50 to about 250 kg m-3 and the porosity of the scaffold is greater than about 70 (vol %) and at least 50% of the pores are interconnected with another pore. The scaffolds of the present invention are injectable as polyurethane foams, and are useful in the field of tissue engineering.

The present invention relates to biodegradable polyurethane capsules for molded product of polyurethane foam and to methods for manufacturing the same, the inventive biodegradable polyurethane capsule comprises a powder made from a biodegradable material, first coating layer of calcium alginate gel formed on the surface of said power and second coating layer of foamable polyurethane resin formed on the surface of said first coating layer. Products manufactured from the biodegradable polyurethane capsule according to the present invention can be widely used as heat isolating materials and heat isolating structural materials because the basic physical properties such as heat insulation are good. And, since the biodegradable material inside the capsule is decomposed by microbes in the nature after a certain period, the efficiency of destruction is considerably improved, so it is possible to minimize the conventional problems of soil, air, and sea pollution caused by fill-in or incineration of the wastes of polyurethane molded foam product.

The invention relates to a biodegradable polyurethane material based on piperazine block D, L-polylactic acid and a preparation method thereof. The polyurethane material takes piperazine block end hydroxyl D, L-polylactic acid as a prepolymer, is prepared by taking diisocyanate and active double-amine functional group piperazine as a chain extender and belongs to the degradable polyurethane material containing a contain quantity of rapid piperazine rings. The biodegradable polyurethane material based on the piperazine block D, L-polylactic acid is a high polymer material which integrates favorable biocompatibility, biodegradability and high mechanical strength as a whole. The invention can control the material performance by regulating the compositions of the polymer and has wide application potential in the biomedical engineering field.

The invention discloses a method for preparing biodegradable rigid polyurethane foam with liquefaction products of bamboo waste, which comprises the following steps: 1 mass portion of crude glycerin/polyethylene glycol liquefying solvent and 0.02-0.04 mass portion of concentrated sulfuric acid are added into a reaction vessel, heated till the temperature reaches 120-180 DEG C after a reflux condensation tube is connected to the reaction vessel; 0.2-0.5 mass portion of crushed and dried bamboo waste is added, reacted for 90-180min with stirring, taken out and cooled and neutralized by MgO till being neutral; 1 mass portion of liquefaction products of bamboo waste, 0.02-0.08 portion of a dibutyl tin dilaurate/triethylene diamine mixed catalyst, 0.02-0.06 portion of silicone oil, 0.02-0.1 portion of water and 0.1-0.15 portion of fire retardant are added into a container, premixed for 20-30s when stirred at 2,000r/min, added with sufficient PAPI with the molar ratio between isocyanato-NCO in PAPI and hydroxyl group-OH in bamboo waste liquefaction products being 0.6-1.2, stirred for 10s-15s at 1,000r/min, put into a mould, foamed with standing at room temperature, placed for slaking and mould separating at room temperature for 24h-72h after reaction. The method fully utilizes resources, reduces liquefaction cost, and has a mild reaction temperature and stable liquefaction products; the performance of obtained foam meets the national standard and biodegradability.

The invention provides a low-melting-point biodegradable polyurethane elastomer. The low-melting-point biodegradable polyurethane elastomer is prepared by adopting the following steps of: step one, weighing the following components: 70-100 parts by weight of polyester polyol, 1-10 parts by weight of polyether polyol and 20-90 parts by weight of diisocyanate; step two, heating and fusing the polyester polyol and the polyether polyol to obtain a fused mixture; step three, fully drying the fused mixture, and adding a catalyst and the diisocyanate for reaction; step four, adding a chain extender, and continuously reacting to obtain the low-melting-point biodegradable polyurethane elastomer. The biodegradable polyurethane elastomer provided by the invention has excellent mechanical property, the temperature of fusion processing is reduced, meanwhile, the relatively fast crystallization speed of the low-melting-point biodegradable polyurethane elastomer is maintained, so that the blending modification processing is facilitated, and therefore, the polyurethane elastomer material provided by the invention is suitable for the modification of biodegradable high polymer materials.

The invention relates to a method for preparing biodegradable polyurethane foam by liquefied modification of bark powder and lignin. The method comprises the following steps: 1. adding phenol into alkaline solution, heating, then adding larch bark powder and the lignin, stirring evenly, carrying out reaction adequately, and cooling for use; 2. heating liquefied product, adding formaldehyde and catalyst to obtain methylolated lignin, phenolic hydroxyl lignin and methylolated tannin; 3. mixing above modified product, polyether, a foam homogenizing agent and catalyst according to a certain proportion, and mixing with isocyanate for foaming. The rigid foam material foamed by mixing, provided by the invention, has an apparent density of 0.03-0.05g/cm<3>, compressive strength greater than 0.15MP, thermal conductivity of 0.023W/(M.K), and water absorption of 3%. The method provided by the invention can improve the utilization of lignin, save resources, does not cause environmental pollution, and is high in production efficiency. The foam is good in lame retardant property.

The present disclosure relates to biodegradable intravaginal rings for the delivery of therapeutic or prophylactic agent, inter alia, antiviral agents. The present disclosure further relates to biodegradable polyurethanes which will allow therapeutic/prophylactic agents to be released in a controlled manner that will not degrade when in use, but will degrade upon disposal.

The invention discloses a method for preparing a biodegradable polyurethane material with pH responsiveness. Diisocyanate compounds and amino derivatives of polyhydroxyl compounds or amino derivatives of polyhydroxyl polymers serve as raw materials, and a conventional in-situ reaction method in solution polymerization is adopted to prepare the material in the presence of a catalyst. The invention has the advantages that: the preparation method is simple, is easy to operate and is suitable for industrial production, the raw materials are readily available, and the product efficiency is high; the prepared multi-block polyurethane material has a special characteristic of pH sensitivity, can be assembled into the needed structure and shape, has an alternating block structure and a plurality of reactivity points, is easily subjected to macromolecular modification, and is introduced with functional groups to realize structural and functional diversity. For instance, the material is combined with targeting molecules in the field of medicines to serve as a targeted release carrier material and the like; meanwhile, the material has biodegradability, meets the environmentally-friendly requirement of society, and can be widely applied to the fields of materials science, biology, medical science and the like.

The invention discloses a peelable and biodegradable polyurethane protective film, a preparation method and application thereof. The protective film comprises the following raw materials by weight: 40-70 parts of thermoplastic polyurethane, 10-30 parts of biodegradable polyester, 0.01-0.5 part of a corrosion inhibitor, 1-10 parts of filler and 5-30 parts of a plasticizer. The preparation method comprises: 1) selecting materials according to the composition and weight part of each component prescribed in the formula; 2) putting the raw materials into a banbury mixer, performing stirring at 140-180DEG C for 5-15min till uniform mixing melting; 3) carrying out extrusion granulation and cooling to obtain an anti-bump and anti-corrosion protective film particle semi-finished product, during use, heating the semi-finished product to 160DEG C to melt it into liquid, then spraying the liquid on a metal component surface, and conducting cooling so as to form a 3-5micrometer protective film. The peelable and biodegradable polyurethane protective film provided by the invention has a simple formula and no pollution, and is especially suitable for temporary protection of metal raw materials and semi-finished products. The peelable and biodegradable polyurethane protective film is convenient to make and use, has no residual protective film after peeling, and can be biodegradable after abandonment.