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Biodegradable polyurethane material based on piperazine block D, L-polylactic acid and preparation method thereof

A polyurethane material, polylactic acid technology, applied in the field based on piperazine block D, can solve the problems of difficult control of polyurethane synthesis process, lack of mechanical strength, aseptic inflammation, etc. Mechanical properties, the effect of improving mechanical properties

Inactive Publication Date: 2010-11-17
CHONGQING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when the existing biodegradable polyurethane biomaterials are used as tissue engineering repair materials, their mechanical strength is still lacking. At present, the solution to this problem is to introduce benzene rings into the main chain of polyurethane materials, such as using isocyanate synthetic materials with benzene rings (Monika.Bil , Acta Biomaterialia, 2009), increase the mechanical properties of the material, but cause the material to be carcinogenic; at the same time, as an ideal tissue engineering scaffold material, its biodegradation rate should be controllable. Currently, the degradable polyurethane material uses macromolecular diols 1. Isocyanate is a fixed synthetic raw material, and dibasic alcohol is selected as a chain extender, so when the material is biodegraded, acid will aggravate the degradation phenomenon, and at the same time it will cause aseptic inflammation; Relieve the problem of acid degradation, but the two hydrogens on -NH2 in the synthesis are easy to react with -NCO, resulting in crosslinking, which makes the polyurethane synthesis process difficult to control, and high molecular weight polyurethane can be obtained, which affects the performance

Method used

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  • Biodegradable polyurethane material based on piperazine block D, L-polylactic acid and preparation method thereof
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  • Biodegradable polyurethane material based on piperazine block D, L-polylactic acid and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Weigh 5.000 g (0.03472 mol, molecular weight: 144) of D,L-lactide that has been distilled and recrystallized from ethyl acetate three times according to the molar ratio of the substance at about 10:1, and the anhydrous piperine after vacuum drying. Zine 0.2988g (0.00347mol, molecular weight: 86.1) was added to a 25ml round-bottomed flask, 1 / 5000 of the molar amount of D, L-lactide substance was added with stannous octoate as an initiator, and then vacuumed for 2 ~3 times, pumped for 15min respectively, sealed the flask, placed in an oil bath to heat, controlled the temperature to 150°C, and reacted for 24h. The reaction product was dissolved in dichloromethane, purified with n-hexane, and dried at room temperature to obtain 3.823 g of polylactic acid with a hydroxy-terminated piperazine block.

Embodiment 2

[0031] Weigh 5.000 g (0.03472 mol, molecular weight: 144) of D, L-lactide that has been distilled and recrystallized from ethyl acetate three times according to the molar ratio of the substance at about 20:1, and anhydrous piperine after vacuum drying. Zine 0.1495g (0.00173mol, molecular weight: 86.1) was added to a 25ml round-bottomed flask respectively, and stannous octoate was added as an initiator by 1 / 5000 of the molar amount of D, L-lactide substance, and then vacuumed for 2 ~3 times, pumped for 15min respectively, sealed the flask, placed in an oil bath to heat, controlled the temperature to 150°C, and reacted for 24h. The reaction product was dissolved in dichloromethane, purified with n-hexane, and dried at room temperature to obtain 3.901 g of polylactic acid with a hydroxy-terminated piperazine block.

Embodiment 3

[0033] Weigh 5.000 g (0.03472 mol, molecular weight: 144) of D,L-lactide that has been distilled and recrystallized from ethyl acetate three times according to the molar ratio of the substance at about 30:1, and anhydrous piperine after vacuum drying. Zine 0.0996g (0.00116mol, molecular weight: 86.1) was added to a 25ml round-bottomed flask, 1 / 5000 of the molar amount of D, L-lactide substance was added with stannous octoate as an initiator, and then vacuumed for 2 ~3 times, pumped for 15min respectively, sealed the flask, placed in an oil bath to heat, controlled the temperature to 150°C, and reacted for 24h. After the reaction product was dissolved in dichloromethane, it was purified with n-hexane and dried at room temperature to obtain 4.147 g of polylactic acid with a hydroxy-terminated piperazine block. Its infrared spectrum see figure 1 , whose NMR images are shown in figure 2 .

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Abstract

The invention relates to a biodegradable polyurethane material based on piperazine block D, L-polylactic acid and a preparation method thereof. The polyurethane material takes piperazine block end hydroxyl D, L-polylactic acid as a prepolymer, is prepared by taking diisocyanate and active double-amine functional group piperazine as a chain extender and belongs to the degradable polyurethane material containing a contain quantity of rapid piperazine rings. The biodegradable polyurethane material based on the piperazine block D, L-polylactic acid is a high polymer material which integrates favorable biocompatibility, biodegradability and high mechanical strength as a whole. The invention can control the material performance by regulating the compositions of the polymer and has wide application potential in the biomedical engineering field.

Description

technical field [0001] The invention belongs to the technical field of polymer materials, in particular to a biodegradable polyurethane material based on piperazine block D, L-polylactic acid and a preparation method thereof Background technique [0002] Polyurethane (PU) is a kind of polymer containing many carbamate groups (-NHCOO-) in the main chain of the polymer, and has a development history of more than 80 years. Polyurethane has excellent molecular designability. By choosing different raw materials and adopting different synthesis processes, polyurethane products with different properties and various forms of expression can be prepared. These products involve various fields such as light industry, chemical industry, electronics, textile, medical treatment, construction, building materials, automobile, national defense, aerospace, aviation and so on. [0003] In the field of biomedicine, degradable polyurethane has attracted more and more attention from scientists. ...

Claims

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Application Information

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IPC IPC(8): C08G18/66C08G18/46C08G18/32C08G63/685
Inventor 王远亮阮长顺魏小娅罗彦凤吴扬兰张茂兰胡承波张徭尧
Owner CHONGQING UNIV
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