6 results about "Molecular distribution" patented technology

The application provides a particle surface target molecule analysis method and application thereof, and the analysis method comprises the following steps: mixing and incubating metal-containing nanoparticles containing functional molecules on the surface with particles to be detected, then performing single particle inductively coupled plasma mass spectrometry detection, and analyzing and calculating the surface target molecule distribution of the particles to be detected according to the detection result. The method provided by the application realizes quantitative analysis of target molecules such as biomarkers on the surface of particles at the single particle level, can effectively quantify the number concentration of labeled particles, the content of particles with specific copy number, the number concentration and the total number concentration of measured particles, and realizes high-throughput testing, in which signals of tens of thousands of measured nanoparticles are collected within a few minutes, and reliable statistical distribution information is obtained.

The invention discloses a method for predicting the performance of a GO separation membrane based on molecular simulation and a preparation method of the GO separation membrane. Based on a molecular dynamics simulation technology, revealing a relationship among a GO interlayer water distribution state, an interlayer spacing and a chemical environment, and obtaining an interlayer water distribution state beneficial to ion transmission and corresponding geometric and chemical parameters of the membrane; the GO ion separation membrane is prepared under the guidance, a suspension of single-layer GO is prepared, a polyethersulfone membrane is adopted as a substrate, and thermal reduction treatment is performed after vacuum filtration and membrane formation. By reasonably regulating and controlling the interlayer spacing and the chemical environment of the GO membrane, fine regulation and control are carried out on the distribution state of water molecules containing interface bound water and non-interface free water in a confinement channel, and selective transmission of Li < + > relative to Na < + > and Mg < 2 + > by the GO membrane can be realized.

The application provides a marker screening system and method based on spatial omics, equipment and medium thereof. Through a spatial mapping module and a spatial analysis module, the spatial mapping module is used to obtain a target molecule type, a spatial omics data set and a spatial position data set of a target sample, and perform spatial mapping on the target sample according to the target molecule type, the spatial omics data set and the spatial position data set, so as to obtain molecular distribution data of the target sample and draw a molecular distribution map. The spatial analysis module is used to obtain pathological information of a target research disease and a plurality of molecular distribution maps, determine a target analysis area in each molecular distribution map according to the pathological information, then perform differential analysis on molecules in each target analysis area according to a statistical test method, obtain differential molecules and determine the differential molecules as candidate markers of the target research disease, and further detect low-abundance markers hidden due to homogenization, so as to provide rich potential markers for the research disease.

The application discloses a method for identifying the source of crude oil organic matter and a chart thereof. The method comprises the following steps: separating an aromatic hydrocarbon component from a sample; obtaining a characteristic ratio for characterizing dimethylphenanthrene isomer distribution by gas chromatography-mass spectrometry, and the ratio is denoted as R value; determining the carbon isotope value of 1,7-DMP by gas chromatography-isotope ratio mass spectrometry, and calculating the logarithm value with 2 as the base, and the value is denoted as L value; constructing a two-dimensional identification chart by using the R value and the L value of standard samples with known sources; and finally, projecting the measured value of the sample to be measured into the chart, and identifying the source type of the parent material according to the region where the sample falls. The stable carbon isotope information and the molecular distribution information of 1,7-DMP are combined, the defects that the traditional biomarkers are interfered by thermal maturity and biodegradation are effectively overcome, different organic parent materials such as aquatic algae, angiosperms, herbaceous plants and gymnosperms can be finely distinguished, and a reliable technical means is provided for oil-source correlation under complex geological conditions.

The present invention relates to an integrated method to identify the reservoir compartmentalization and characterize samples of different compositional gradations and types of operation (PVT and DST) through the ESI (−) and APPI (+) FT-ICR-MS techniques in combination with the application of machine learning algorithms. In this way, the present invention presents an integrated method for compositional evaluation in oil wells to: (i) analyze the compositional variation of the polar components in reservoirs; (ii) study the molecular distribution in reservoirs with varied thicknesses; and (iii) explore the composition of the polar components as molecular indicators for understanding compartmentalization and lateral and vertical connectivity between the fluids in reservoirs.

The application discloses a crude oil cutting simulation method and device, computer equipment and a readable storage medium. The method comprises the following steps: based on the molecular composition data of crude oil, simulating the dispersity curve of crude oil molecules and the overlapping degree curve of the cutting point in the preset cutting temperature section; according to the dispersity curve and the overlapping degree curve, determining the proportion of molecules falling into the preset cutting temperature section, so as to determine the simulation side line data of crude oil; comparing the simulation side line data of crude oil with the actual side line data of crude oil, if the deviation between the two is greater than a preset value, adjusting the overlapping degree of the cutting point, until the deviation between the two is less than or equal to the preset value, generating a crude oil cutting model; and using the crude oil cutting model to simulate the crude oil cutting. The dispersity of crude oil molecules and the overlapping degree at the cutting point are considered in the cutting simulation process, so that the cutting simulation result is more in line with the molecular distribution in the actual production process, and the cutting effect is better.