Preparation method of biodegradable polyurethane film material

A polyurethane film and biodegradation technology, which is applied in non-active ingredients medical preparations, pharmaceutical formulations, pharmaceutical sciences, etc., can solve the problems of high raw material cost, many raw materials, and inability to adjust, and achieves simple and easy-to-control process and simple operation. , cheap effect

Active Publication Date: 2015-07-22
南通药享科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation method and technological process of this medical material are extremely complicated, and it is not suitable for industrial production. At the same time, more raw materials are used, which relatively increases the cost.
[0005] Patent ZL03121886.5 introduces a kind of polysaccharide copolymerization product, which has good absorption, hemostasis, anti-adhesion and biodegradation ability compared with other products in the current market, but its processing performance, degradation time and elasticity are not good enough, so it cannot Adjust according to the specific needs of surgery
[0006] Introduced in CN1515323A is a kind of prepolymer obtained by copolymerization of polyethylene glycol, polylactic acid and ε-caprolactone, and then copolymerized or blended with chitosan or hyaluronic acid, which has better water absorption Although there is some flexibility, it is still at a low level, and the cost of raw materials is high, and there are animal sources

Method used

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  • Preparation method of biodegradable polyurethane film material
  • Preparation method of biodegradable polyurethane film material
  • Preparation method of biodegradable polyurethane film material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0091] 1) Synthesis of double-terminated hydroxyl prepolymer

[0092] Put 12.0g (0.02mol) of PEG 600 in a vacuum reaction flask, stir with a magnet, remove water under vacuum (20Pa) for 4 hours at a reaction temperature of 100°C, cool to room temperature, and balance nitrogen into the vacuum reaction flask. Then, 18 g of L-lactide, 18 g of ε-caprolactone and 80 μL of stannous octoate (0.2% of the raw material mass) were added into the vacuum reaction flask. Then vacuumize the vacuum reaction bottle, and then pass dry nitrogen to balance, repeat three times. Finally, the vacuum was evacuated to 20 Pa, the vacuum reaction bottle was sealed, and the oil bath was heated to 140° C., and the double-terminated hydroxyl prepolymer was obtained after 48 hours of reaction.

[0093] 2) Preparation of double-terminated isocyanate-based prepolymer

[0094] Add 20.16g (0.12mol) of HDI to the reaction flask, and add the double-terminated hydroxyl prepolymer synthesized in step 1 dissolved ...

Embodiment 2

[0100] 1) Preparation of double-terminated hydroxyl prepolymer: put 16.0g (0.02mol) PEG 800 in a vacuum reaction bottle, stir with a magnet, remove water at a reaction temperature of 100°C under vacuum (30Pa) for 4 hours, then cool to room temperature, Into the vacuum reaction vial nitrogen balance. Then 18 g of L-lactide, 18 g of ε-caprolactone and 0.14 g of dibutyltin diacetate were added into the vacuum reaction flask. Then vacuumize the vacuum reaction bottle, and then pass dry nitrogen to balance, repeat three times. Finally, the vacuum was evacuated to 30 Pa, the vacuum reaction bottle was sealed, and the oil bath was heated to 150° C., and the double-terminated hydroxyl prepolymer was obtained after 24 hours of reaction.

[0101] 2) Preparation of double-ended isocyanate-based prepolymers:

[0102] Add 23.52g (0.14mol) of HDI to the reaction flask, and add the double-terminated hydroxyl prepolymer synthesized in step 1 dissolved in dioxane (dissolving 1g of prepolymer...

Embodiment 3

[0108] 1) Preparation of double-terminated hydroxyl prepolymer:

[0109] Put 20.0g (0.02mol) of PEG 1000 in a vacuum reaction flask, stir with a magnet, remove water in a vacuum (30Pa) at a reaction temperature of 100°C for 4 hours, cool to room temperature, and pass nitrogen gas into the vacuum reaction flask to balance. Then, 10 g of glycolide, 25 g of ε-valerolactone and 0.14 g of dibutyltin diacetate were added into the vacuum reaction flask. Then vacuumize the vacuum reaction bottle, and then pass dry nitrogen to balance, repeat three times. Finally, the vacuum was evacuated to 20 Pa, the vacuum reaction bottle was sealed, and the oil bath was heated to 120° C., and the double-terminated hydroxyl prepolymer was obtained after 72 hours of reaction.

[0110] 2) Preparation of double-ended isocyanate-based prepolymers:

[0111] Add 16.8g (0.12mol) of BDI into the reaction flask, and add the double-terminated hydroxyl prepolymer synthesized in step 1 dissolved in dioxane (d...

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Abstract

The invention relates to a preparation method of a biodegradable polyurethane film material. The preparation method comprises the following steps: (1) synthesizing a dihydroxyl-terminated prepolymer: mixing cyclic lactide or cyclic lactone or a mixture of the two with an initiator and a catalyst, performing vacuum ring-opening reaction on the cyclic lactide or the cyclic lactone, and then performing polymerization reaction on a system to prepare the dihydroxyl-terminated prepolymer; (2) synthesizing a diisocyanate-terminated prepolymer: dropping the dihydroxyl-terminated prepolymer into excess diisocyanate, and performing reaction to remove excess diisocyanate to obtain the diisocyanate-terminated prepolymer; (3) preparing polyurethane: dissolving a chain extender in a solvent, then dropping into the dihydroxyl-terminated prepolymer and performing reaction to obtain a polyurethane material; and (4) preparing the film material. The film has uniform thickness distribution and high tensile strength and elongation at break, wherein the elongation at break of the film is more than 1000%, and the breaking strength is more than 10MPa. The film material can ensure that the film is not broken under high-strength motion of an organ performing continuous motion of a human body.

Description

technical field [0001] The invention belongs to the field of biodegradable polymer materials, and in particular relates to a preparation method of a biodegradable polyurethane film material. Background technique [0002] During clinical operations, if the adhesion of tissues and organs is not handled correctly, it may cause medical accidents such as organ friction damage, surgical wound infection, and wound bleeding. In order to prevent tissue adhesion, the surgical organs are usually wrapped or covered with anti-adhesion materials at the end of the operation. The earliest materials used are non-degradable materials such as cotton gauze, which need to be taken out after healing. With the development of polymer science, polylactic acid and other organic polymer materials with degradability and compatibility have been developed. [0003] In surgery, the "temporary barrier" function of the polymer film can be used to isolate between the wound and surrounding tissues to prevent...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J5/18C08L75/06C08G18/75C08G18/66C08G18/42C08G18/32C08G18/12C08G63/664A61L31/06A61L31/14A61K47/34
Inventor 侯昭升张浩许振李健羽韩正
Owner 南通药享科技有限公司
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