Neural restoration bracket and preparation method thereof

A nerve repair and amino modification technology, applied in the field of nerve repair scaffolds, can solve the problems of failure to effectively maintain the spatial position between cells, low biocompatibility and antigenicity, lack of physical strength, etc., and achieves low preparation cost and improved mechanical mechanics. Excellent performance and mechanical properties

Inactive Publication Date: 2020-01-10
张鹏 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are three types of scaffold materials for nerve repair: 1. Natural scaffold materials; mainly autologous or allogeneic nerves, veins, skeletal muscle, and amniotic membrane, etc., but the above materials are difficult to obtain due to their limited sources, and there is a risk of cross-transmission of pathogenic microorganisms , difficult to mass-produce
2. Natural biomaterials: mainly collagen, gelatin, chitosan, alginate, cellulose, hyaluronic acid, aminodextran, liposome, decellularized extracellular matrix, etc. The advantages

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A nerve repair bracket, characterized in that it is made from the following raw materials in parts by weight: 25 parts of vinyl-modified hydroxyl-terminated poly(lactic acid-glycolic acid 75 / 25) copolymer, 0.2 part of pearl powder, amino-modified dextran 0.1 part of sugar-modified carboxylated fullerene, 1 part of amino-modified dextran-modified graphene oxide, 0.8 part of polyethylene glycol, and 3 parts of decellularized nerve matrix.

[0030]The preparation method of described vinyl modified poly(lactic acid-glycolic acid 75 / 25) copolymer, comprises the steps: poly(lactic acid-glycolic acid 75 / 25) copolymer, 3-butenoic acid, 4-dimethyl Aminopyridine and N,N'-dicyclohexylcarboimide were added to tetrahydrofuran, stirred and reacted at 25°C for 3 hours, then the solvent was removed by rotary evaporation, the product was washed with methanol for 3 times, and methanol was removed by rotary evaporation to obtain ethylene Modified poly(lactic acid-glycolic acid 75 / 25) copo...

Embodiment 2

[0035] A nerve repair bracket, characterized in that it is made of the following raw materials in parts by weight: 25-35 parts of vinyl-modified hydroxyl-terminated poly(lactic acid-glycolic acid 75 / 25) copolymer, 0.3 part of pearl powder, amino-modified 0.15 parts of dextran-modified carboxylated fullerene, 2 parts of amino-modified dextran-modified graphene oxide, 1 part of hydroxypropyl cellulose, and 4 parts of decellularized neural matrix.

[0036] The preparation method of described vinyl modified poly(lactic acid-glycolic acid 75 / 25) copolymer, comprises the steps: poly(lactic acid-glycolic acid 75 / 25) copolymer, 3-butenoic acid, 4-dimethyl Add aminopyridine and N,N'-dicyclohexylcarboimide to dichloromethane, stir and react at 27°C for 3.5 hours, then remove the solvent by rotary evaporation, wash the product with methanol 4 times, and then remove methanol by rotary evaporation. Obtain vinyl-modified poly(lactic acid-glycolic acid 75 / 25) copolymer; Said poly(lactic acid...

Embodiment 3

[0041] A nerve repair bracket, characterized in that it is made from the following raw materials in parts by weight: 30 parts of vinyl-modified hydroxyl-terminated poly(lactic acid-glycolic acid 75 / 25) copolymer, 0.35 part of pearl powder, amino-modified dextran 0.2 parts of sugar-modified carboxylated fullerene, 2.5 parts of amino-modified dextran-modified graphene oxide, 1.3 parts of urea, and 5.5 parts of decellularized neural matrix.

[0042] The preparation method of described vinyl modified poly(lactic acid-glycolic acid 75 / 25) copolymer, comprises the steps: poly(lactic acid-glycolic acid 75 / 25) copolymer, 3-butenoic acid, 4-dimethyl Add aminopyridine and N,N'-dicyclohexylcarboimide to acetone, stir and react at 30°C for 4 hours, then remove the solvent by rotary evaporation, wash the product 4 times with methanol, and remove methanol by rotary evaporation to obtain ethylene Modified poly(lactic acid-glycolic acid 75 / 25) copolymer; said poly(lactic acid-glycolic acid 75...

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PUM

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Abstract

The invention discloses a neural restoration bracket. The neural restoration bracket is characterized in that the neural restoration bracket is prepared from the following raw materials in parts by weight: 25-35 parts of a vinyl modified hydroxyl terminated poly (lactic acid-glycolic acid 75/25) copolymer, 0.2-0.5 part of pearl powder, 0.1-0.3 part of amino-modified dextran modified carboxylated fullerenes, 1-4 parts of amino-modified dextran modified oxidized graphene, 0.8-2 parts of a pore-foaming agent and 3-8 parts of a decellularized neural substrate. The invention further discloses a preparation method of the neural restoration bracket. The neural restoration bracket is large in porosity, uniform in pore diameter, good in biocompatibility, excellent in antisepsis and anti-inflammation performance, excellent in mechanical performance, capable in biodegradation and assisting the neural restoration function, high in reliability and high in clinical practicability.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to a nerve repair bracket and an ester method thereof. Background technique [0002] The nervous system is the leading functional regulation system in the human body, and plays a very important role in human life activities. Due to the limited repair ability of the damaged nervous system, the treatment of nerve injury and degenerative diseases has become a major medical problem. Nerve injury is commonly seen in partial or complete damage to nerve cells caused by various traumas and other conditions. It is one of the common and frequently occurring types of injury in clinical practice. It often leads to sensory and motor dysfunction or loss in patients, seriously affecting patients' daily life. live and work. It is very necessary to perform nerve repair on patients. [0003] Among nerve repair options, nerve scaffold repair is the most common. The basic strategy of human ...

Claims

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Application Information

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IPC IPC(8): A61L27/08A61L27/18A61L27/20A61L27/36A61L27/50A61L27/58
CPCA61L27/08A61L27/18A61L27/20A61L27/3604A61L27/3633A61L27/50A61L27/58A61L2430/32C08L67/04C08L5/02
Inventor 张鹏綦磊
Owner 张鹏
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