Neural restoration bracket and preparation method thereof

Abstract

The invention discloses a neural restoration bracket. The neural restoration bracket is characterized in that the neural restoration bracket is prepared from the following raw materials in parts by weight: 25-35 parts of a vinyl modified hydroxyl terminated poly (lactic acid-glycolic acid 75 / 25) copolymer, 0.2-0.5 part of pearl powder, 0.1-0.3 part of amino-modified dextran modified carboxylated fullerenes, 1-4 parts of amino-modified dextran modified oxidized graphene, 0.8-2 parts of a pore-foaming agent and 3-8 parts of a decellularized neural substrate. The invention further discloses a preparation method of the neural restoration bracket. The neural restoration bracket is large in porosity, uniform in pore diameter, good in biocompatibility, excellent in antisepsis and anti-inflammation performance, excellent in mechanical performance, capable in biodegradation and assisting the neural restoration function, high in reliability and high in clinical practicability.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to a nerve repair bracket and an ester method thereof. Background technique [0002] The nervous system is the leading functional regulation system in the human body, and plays a very important role in human life activities. Due to the limited repair ability of the damaged nervous system, the treatment of nerve injury and degenerative diseases has become a major medical problem. Nerve injury is commonly seen in partial or complete damage to nerve cells caused by various traumas and other conditions. It is one of the common and frequently occurring types of injury in clinical practice. It often leads to sensory and motor dysfunction or loss in patients, seriously affecting patients' daily life. live and work. It is very necessary to perform nerve repair on patients. [0003] Among nerve repair options, nerve scaffold repair is the most common. The basic strategy of human ...

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Problems solved by technology

[0004] At present, there are three types of scaffold materials for nerve repair: 1. Natural scaffold materials; mainly autologous or allogeneic nerves, veins, skeletal muscle, and amniotic membrane, etc., but the above materials are difficult to obtain due to their limited sources, and there is a risk of cross-transmission of pathogenic microorganisms , difficult to mass-produce

2. Natural biomaterials: mainly collagen, gelatin, chitosan, alginate, cellulose, hyaluronic acid, aminodextran, liposome, decellularized extracellular matrix, etc. The advantages of these materials are mainly reflected in biological Good compatibility, low antigenicity, some materials have a natural pore structure system, which is conducive to cell adhesion, growth and proliferation, but the mechanical properties are poor and lack sufficient physical strength

Patent CN 108187147A discloses an electrospun three-layer stent catheter, which has a corresponding response mechanism after conductive electrical stimulation, but when a variety of cells are assembled in the biomaterial, it cannot effectively maintain the space between cells