79results about How to "Strong clinical practicability" patented technology

The invention belongs to the technical field of pharmaceutical preparation, in particular to a lansoprazole enteric-coated tablet; wherein, the enteric-coated tablet consists of the following components: a) tablet core consisting of lansoprazole and pharmaceutical excipient; b) a enteric coating layer consisting of castor oil, polyacrylic resin II and pharmaceutical excipient. The enteric coating layer of the invention contains castor oil which is water insoluble plasticizer and has good compatibility with the polyacrylic resin II, thereby effectively preventing the lansoprazole of the raw material from being damaged by the polyacrylic resin II which is the acidic and intestinal-lysis coating material; therefore, an isolated layer is not needed to be packed between an enteric-coated layer and a tablet core, and fatherly allowing the invention has the advantages of simplifying the preparation process, reducing production cost, high dissolution rate of the prepared enteric-coated tablet, high bioavailability and good stability.

The invention discloses a precision improving method for a spinal surgery computer navigation system which comprises a computer host, a video camera, an image acquisition device, a tracer, a fixed clamp, fixed nails, a pointer, a pointed cone, a route opener, a navigation intelligent machine and a register platform. Scanned images and data parameters of the image acquisition device are input into the computer navigation system, flow steps comprising A, system preparation, B, system connection, C, navigation image acquisition, D, navigation image registration, E, precision verification, F surgery operation, and the like are displayed on a computer display by picture prompt software and voice prompt software so as to indicate an operation surgeon to normally operate in real time, the operability of the navigation system and the precision of clinical operations are improved, the operation of the picture prompt software and the voice prompt software is convenient, time for the operation surgeon to suit the navigation system is shortened, and the clinical practicability is strong, thereby the invention is suitable for popularization and application.

A cerebrovascular regulation function monitor system and a method for detection of cerebrovascular circulation critical closing pressure, wherein the cerebrovascular regulation function monitor system includes a signal collection system for in-phase sampling analog signal of transcranial doppler (TCD) signal and continuous artery pressure signal and further converting the analog signals into correspondent digital signals and a signal processing / displaying system connected with the signal collection system via interfaces for processing the digital signals to obtain the cerebrovascular critical closing signal and displaying them. The method and system realize a non-invasion detection and monitor of cerebrovascular autoregulation function in clinical practice.

The invention discloses application of a miRNA (Micro-Ribonucleic Acid) expression profile in predicting the sensibilities of lung cancer patients to the radiotherapy. A preparation method for the invention comprises the following steps of: selecting lung cancer patients who are clinically unusually sensitive and highly tolerant to the radiotherapy, drawing 5ml of peripheral blood, and extracting total RNA by using a TRIZOL kit (Invitrogen); then hybridizing by using a MicroRNA expression profile chip; carrying out data processing, and analyzing the difference of MicroRNA expression profiles of radiotherapy sensitive and non-sensitive patients by using a cluster analysis method; and finally, checking a result by using a Real-time PCR (Polymerase Chain Reaction) method. The inventor finds that an expression profile consisting of 12 miRNA can regulate and control the expression of genes relevant to tumor radiosensitivity and be used for predicting the sensitivity of the lung cancer patients to the radiotherapy and providing an experimental foundation of an early period for the individualized radiotherapy of lung cancer.

The invention relates to method and agent box for detecting mammary gland globulin in the field of biology chemistry. The latex fixation leptospiral method comprises the steps of: a) mixing the mammary gland globulin antibody marked emulsion particle with the tested sample, b) quoting the test result by weather it has agglutination reaction, wherein the mammary gland globulin antibody marked emulsion particle is the emulsion particle which uses mammary gland globulin antibody R028 or R048 marked emulsion particle with the dilemma 2-10um; preserving the marked emulsion particle inside the HEPES buffer solution with pH 8.2. It also discloses a method for using the anti-mammary gland globulin monoclonal antibody and skin factor mark anti-mammary gland globulin monoclonal antibody to quantity test the mammary gland globulin by double clamp heart enzyme immune adsorption method. It also discloses a RT-PCR test mammary gland globulin expressing method and provides the agent box used to test the mammary gland globulin.

The invention discloses a method for making a dental model mold through 3D printing. The method comprises the steps that a three-dimensional tooth model is established through 3D calculation according to Dicom-format CT scanning fault data of patient's teeth, and then a three-dimensional model of the dental model mold is obtained through processing and output to a 3D printer in an appropriate format to obtain the dental model mold of a patient. The gypsum model of the patient's teeth and whole or single / multiple resin or ceramic false teeth and the like clinically used in oral medicine can be obtained by filling gypsum, tooth making resin, ceramic powder and other materials in the obtained mold. A traditional impression taking method is replaced by utilizing the dental model mold made through 3D printing, the discomfort of the patient is greatly decreased, and various failure phenomena in the traditional impression taking operation are decreased. In addition, the dependence on the operator's proficiency of the making quality of traditional dental products is effectively decreased while the designability of the dental model, false teeth and other dental products is enhanced through computer aided design, the clinic practicability is good, the cost is low, and the method is easy to popularize.

A cerebrovascular regulation function monitor system and a method for detection of cerebrovascular circulation critical closing pressure, wherein the cerebrovascular regulation function monitor system includes a signal collection system for in-phase sampling analog signal of transcranial doppler (TCD) signal and continuous artery pressure signal and further converting the analog signals into correspondent digital signals and a signal processing / displaying system connected with the signal collection system via interfaces for processing the digital signals to obtain the cerebrovascular critical closing signal and displaying them. The method and system realize a non-invasion detection and monitor of cerebrovascular autoregulation function in clinical practice.

A safety protector for ensuring that the medical injector can be used only once is composed of a needle holder and a fastening cover. After its needle holder and fastening cover are closed, a sharp object in the push handle can prick the needle holder and injector to destroy it.

The invention belongs to the technical field of surgical robots, and specifically relates to a vascular interventional device control apparatus with dual guide wires or balloons. The purpose of the invention is to solve the problems of low operation work efficiency, high work load, long treatment duration and high doctor labor intensity of the prior art that operation control can only be realizedon a single guide wire by a surgical robot. The vascular interventional device control apparatus with dual guide wires or balloons provided by the invention comprises a main finger assembly, a first sub-finger assembly, a second sub-finger assembly, a driving assembly, and a clamping. One of the dual guide wires or balloons to be operated is clamped by the main finger assembly and the first sub-finger assembly while the other of the dual guide wires or balloons to be operated is clamped by by the main finger assembly and the second sub-finger assembly, so that the the operated dual guide wiresor balloons can respectively carry out axial movement or rotation around their own axial directions. The vascular interventional device control apparatus with dual guide wires or balloons is capableof improving work efficiency and enabling better handling bifurcated lesions, so that the vascular interventional device control apparatus with dual guide wires or balloons is high in practicability and wide in application prospects.

The invention discloses a novel dental glass ionomer cement / fluorinated graphene composite material. Traditional commonly-used dental glass ionomer cement powder and fluorinated graphene are used as raw materials, and uniformly mixed by mechanical ultrasonic blending, the traditional commonly-used dental glass ionomer cement powder and fluorinated graphene are uniformly dispersed in absolute ethanol in a certain proportion, the dispersion is ultrasonically promoted, uniform grinding is performed, and the ethanol is completely evaporated to obtain a new dental material, namely glass ionomer cement and fluorinated graphene mixed powder. The novel dental glass ionomer cement / fluorinated graphene composite material has the advantages of simple preparation method, simple equipment, low price and easy mass promotion. The novel dental material has high microhardness, high compressive strength, high abrasion resistance, and high antibacterial property, and does not affect the color, fluoride ion release property and solubility of the material, the quality of filling materials can be greatly improved, and the clinical application range of glass ionomer cement is expanded.

The invention provides a safety shape destruction medical needle, which comprises a sheath, a needle tube, a needle stand and a protecting cap, characterized in that, the needle stand is provided with a through guiding-tube with two open ports at the front, middle and rear portions, the chamber of the front needle tube fixed section or projection on the inner wall can match with the needle tube containing needle tube positioning arrangement, thus orienting a needle tube inclined surface. The middle destroying segment of the needle stand is provided with a guiding-tube thin wall, the coupling seat on the rear portion needle stand outer wall can match with the sheath connecting arm, thus the sheath can rotate back and forth on the needle stand, the hooking arm on the elastic-wall block can secure the needle tube in the longitudinal groove of the sheath, the thin wall of the guiding tube can be punctured by the tip-shape projection in the sheath, so as to destroy the whole needle.

The invention relates to a medical intervention catheter or guide wire fixing clip. The clip comprises an upper clip body, a lower clip body, a rotating shaft and a torsional spring, wherein the upper clip body and the lower clip body respectively comprise a clamping part at the front end and a handle part at the rear end; the middles of the upper and lower clips are hinged through the rotating shaft; the torsional spring is arranged on the rotating shaft in a sleeving manner; one end of the torsional spring is connected with the handle part at the rear end of the upper clip body, and the other end of the torsional spring is connected with the handle part at the rear end of the lower clip body; a clamping cavity is formed between the clamping parts of the upper and lower clip bodies; front and back parts of the clamping cavity are joint parts of the two clamping parts; an upper half sponge body and a lower half sponge body, which correspond to the upper clip body and the lower clip body, are embedded in the clamping cavity; the two half sponge bodies are compressed together under a normal state; the surfaces, corresponding to sponge body mounting positions, of the clamping parts of the upper and lower clip bodies are provided with a plurality of wetting through holes. The fixing clip is simple in structure and high in clinical practicability, does not damage a catheter or a guide wire, fixes the catheter or the guide wire firmly, can wet the guide wire, provides great convenience for clinical interventional operation, and is suitable for implementation.

The invention provides a recombinant feline parvovirus VP2 protein antigen and application thereof in vaccine preparation and virus diagnosis. A plurality of B cell antigens of the feline parvovirus VP2 protein are subjected to tandem expression by using a prokaryotic expression vector. The expressed recombinant protein is purified and used as a coating antigen for detecting the feline parvovirus antibody. And compared with a whole virus coating method in parallel, the values of detected positive and negative serum are highly consistent. The antigen treatment method provided by the is convenient, the test time is shortened, and the operation steps are simpler. According to the invention, an indirect ELISA method is established for detecting the antibody level of the feline parvovirus in feline serum, which has the characteristics of good repeatability and high specificity, and can be used for feline parvovirus serology investigation. Therefore, the indirect ELISA detection kit for the feline parvovirus based on the tandem expression of the VP2 protein B cell antigens, provided by the invention, is very suitable for the detection of clinical large samples and is suitable for large-scale popularization.

The invention discloses a preparation method of a dialysis membrane for a hemodialyzer. The preparation method comprises the following steps: (I) preparing a diamond alkyl furanyl condensation polymer; (II) preparing a membrane material in a spinning manner; (III) preparing an intermediate product; (IV) preparing a surface modified membrane material; and (V) doping an anticoagulant. The inventionalso discloses a dialysis membrane for a hemodialyzer prepared according to the preparation method of the dialysis membrane for the hemodialyzer. The dialysis membrane for the hemodialyzer disclosed in the invention is good in biocompatibility, blood compatibility, hydrophilicity and smoothness, high in removal rate and hyperfiltration coefficient, and capable of effectively prolonging the life and dialysis age of a patient.

A method for fast clustering a medical sequential images belongs to the technical field of computer aided diagnosis of medical imaging, and comprises the following steps of: preprocessing, forming a feature vector matrix, forming a target vector matrix, computing a linear transformation matrix, measuring a space vector feature space transformation, clustering a feature space, and clustering a measuring space. The method has high image processing speed, high clustering precision and strong clinical utility.

The invention relates to the field of medical apparatus and instruments and in particular to a blood purification therapy oxygen supplying instrument. At present, the clinic oxygen supplying modes comprise catheter nasal oxygen inhalation, mask oxygen inhalation, artificial and mechanical ventilation, ultraviolet radiation blood infusion or high pressure oxygen bins, and the like, which are respectively a single oxygen supplying mode, and have a certain limit. The invention aims to provide the blood purification therapy oxygen supplying instrument. The instrument has a structure in which one end of a connection opening A is connected with an electromagnetic valve in serial, and is then divided into two branches, one branch is communicated with an injector through being connected with a pressure sensor in series, and the other branch is connected with the electromagnetic valve, a protective cover and a connecting opening B in series; and one end of a connecting opening C is sequentially connected with the protective cover, the pressure sensor and the electromagnetic valve through an oxygen catheter; and the other end of the electromagnetic valve is divided into two branches, one branch is communicated with the injector, and the other branch is communicated with the atmosphere after being connected with the electromagnetic valve in series. The purpose of the invention is to make up the problem that in the prior art, the blood purification oxygen therapy method of patients has limits, realize oxygen supply by a new path or two paths, improve the oxygen therapy effect, and relieve the hurt to body tissues due to oxygen deficiency.

The invention discloses an antimicrobial super-smooth material for a medical indwelling catheter. The material is prepared through the following preparation method of (1) polyether amine thiazolidine-2,4-dicarboxylic acylamide preparation; (2) condensation polymer preparation; (3) condensation polymer ionization; (4) catheter material formation. The invention also discloses the medical indwellingcatheter prepared from the antimicrobial super-smooth material for the medical indwelling catheter. The antimicrobial super-smooth material for the medical indwelling catheter disclosed by the invention has the advantages of continuous bacteria resistance and bacteriostasis effects, surface hydrophilic lubrication performance, flexibility, biocompatibility and excellent comfort; the intubatton ofthe medical indwelling catheter prepared from the material is easy; the treatment effect is effectively improved; the pain of patients is reduced.

The invention discloses a vaginal matrix material and a preparation method thereof. The preparation method comprises the following steps: step 1, collection and sterilization of raw materials; step 2,initial treatment of raw materials; step 3, decellularization treatment; step 4, cleaning; and step 5, antimicrobial modification. The decellularizing solution used in the process of decellularization treatment is prepared by evenly mixing the following components in percentages by mass: 0.3%-0.5% of amino trimethylene phosphonic acid-ethylene glycol ether surfactant, 0.1%-0.3% of water-soluble hyperbranched polyamino acid and 0.1% of leucopeptin, with the balance being distilled water. The vaginal matrix material disclosed by the invention retains the biological integrity of the natural vaginal tissue matrix, and id remarkable in curative effects on vaginal tissue loss, pelvic floor injury and function degradation, good in anti-bacterial and anti-infective performance and safe to use.

The invention discloses a pathological complete remission probability prediction method after breast cancer neoadjuvant chemotherapy. The method comprises the following steps: S1, forming a training set; S2, screening out independent prediction factors; S3, obtaining a weight score; S4, analyzing and calculating a probability prediction value of pathological complete remission after breast cancerneoadjuvant chemotherapy. The invention further discloses a computer readable storage medium, a computer program is stored on the computer readable storage medium, and when the program is executed bythe processor, the step S1-S4 is achieved. The invention further discloses a system for predicting the pathological complete remission probability after breast cancer neoadjuvant chemotherapy. The system comprises a training set generation module, a multi-factor regression analysis screening module, a column diagram model construction and display module, a weight score generation module and a netincome analysis module. According to the invention, patients with low profit possibility can be screened out, and the patients are finally free from neoadjuvant chemotherapy.

The invention discloses an intelligent portable traditional Chinese medical science navel treatment moxibustion instrument. The intelligent portable traditional Chinese medical science navel treatmentmoxibustion instrument comprises a housing, as well as an upper cover, a heating structure and a bottom disk which are sequentially arranged from top to bottom, wherein the top of the housing cooperates with the upper cover, and the bottom of the housing cooperates with the bottom disk; a plurality of ventilation holes are formed in the housing; the heating structure comprises an insulating frame, an insulating hood, a heating chamber, a moxibustion cake placing frame and a diversion hood; a first through hole and a second through hole are formed in the insulating frame; an air outlet of a fan mounted on the insulating frame communicates with the first through hole; the insulating hood is arranged below the first through hole; the heating chamber is arranged in the insulating hood; wind inlet holes are formed in the tops of the insulating hood and the heating chamber, and wind outlet holes are formed in the bottoms of the insulating hood and the heating chamber; an opening is formed in the side wall of the heating chamber; the moxibustion cake placing frame can be used for inserting in or drawing out of the heating chamber; the upper part and the lower part of the diversion hood are opened, and the diversion hood is arranged at the lower part of the insulating hood, and is fixed to the bottom disk; and ventilation holes are formed in the upper side wall of the diversion hood;a temperature sensor is arranged on the bottom disk; the temperature sensor and the fan are connected with a control circuit; and the control circuit is connected with a display and a key switch.

The invention discloses a central venous catheter with a wall adherence preventing device for dialysis. The central venous catheter comprises a catheter body, an outlet, a blood inlet and a blood outlet, an air bag which is close to the blood inlet is sleeved at a position of the upper portion of the blood inlet, the air bag comprises an air bag body and an air bag channel which is connected with the air bag body, the other end of the air bag channel extends to a position of the outlet of the upper end of the catheter to form an air vent, and the air bag body comprises at least three same air bag pouches which are uniformly distributed on a same horizontal plane. By means of the central venous catheter with the wall adherence preventing device for the dialysis, the problems that the blood inlet adheres to the wall when a dialysis catheter is placed in vein for a long time, and wall adherence can occur due to conditions of low blood pressure and the like of critically ill patients can be excellently solved, when blood flow is blocked caused by the fact that a fibrin sheath forms and wraps the tip end of the catheter, the air bag is opened to open up the fibrin sheath, thereby a part of space is reserved to enable blood to pass, the manufacturing process is simple, the cost is low, and the clinical practicability is high.

The invention provides a method for detecting inhibition for bacteria by antibiotics through single-cell counting. The method comprises the following steps of: after antibiotics of preset concentration are added into bacteria to be detected, setting into a bacteria antibiotic mixture, and meanwhile, setting bacteria to be detected, which are not added with the above antibiotics, as a positive control; after first preset duration is formed with a moment when the above antibiotics are added, obtaining a current amount of the above bacteria of the above bacteria antibiotic mixture and a current amount of the above bacteria of the above positive control; and determining the minimum inhibition concentration for the above bacteria by the above antibiotics, and determining an inhibition degree ofthe above antibiotics for the above bacteria. On the basis of implementation of drug sensitivity through the single-cell counting, the technical problem that a link between a single-cell counting value and a drug sensitivity experiment result can not be accurately determined is solved, a result is reliable, and therefore, the method disclosed by the invention has the beneficial effects that clinical practicality is high, cost is low and automation is easily realized.

The invention discloses a skin care film. The film is prepared from the following raw materials in parts by weight: 10 to 20 parts of vinyl modified hyperbranched polylysine, 0.1 to 0.3 part of strontium acetylacetonate hydrate, 2 to 4 parts of isopulegol, 3 to 5 parts of glycidyl ether-terminated allyl alcohol random polyether, 5 to 10 parts of ionized imidazolium salt-based polycarbonate-based polyester polycondensate, 1 to 3 parts of hyaluronic acid and 0.02 to 0.05 part of an initiator. The invention further discloses a preparation method of the skin care film. The skin care film disclosedby the invention is good in biocompatibility, sufficient in strength, good in air permeability and remarkable in skin care effect, can effectively prevent wound infection, accelerate wound healing, promote skin growth and reduce scars, and further has multiple functions of whitening, resisting skin aging and the like.

The invention discloses a meniscus injury grading method based on mixed attention weakness supervised transfer learning. The meniscus injury grading method mainly solves the problems that an existing method is large in meniscus injury degree grading difficulty and lacks clinical interpretability. The method comprises the steps of positioning a meniscus area through a target detection network to generate a meniscus area image data set; carrying out two-dimensional histogram equalization enhancement operation on the data; then using a transfer learning pre-training network to extract saliency features of the enhanced image to generate a feature map, and using weak supervision attention learning to generate an attention map of the enhanced image; and finally, through a bilinear attention pooling algorithm, classifying the meniscus injury grades in combination with the feature map and the attention map to obtain a visual meniscus injury grading result. According to the method, the requirement for automatic classification diagnosis of half-month injury clinically is met, the interpretability of deep learning in clinical diagnosis is improved, and the method can be used for image detection and classification of nuclear magnetic resonance lesions.

The invention discloses a multifunctional aseptic protective sleeve for a disposable esophageal ultrasonic probe, includes a packaging bag, a sealing mechanism, a protective sleeve body and a fixing mechanism, wherein the protective sleeve body comprises a pulling belt, a coupling agent adding pipe, a sleeve body, a sleeve head and an ultrasonic probe; one end of the sleeve body is provided with asleeve opening; one side of the sleeve opening is provided with a pulling belt; The outer part of the protective sleeve body is sleeved with a packaging bag, and a sealing mechanism is arranged at the opening of the packaging bag; One side of the packaging bag is provided with a fixing mechanism, As that sterile protective cov of the ultrasonic probe reduces the transmission of disease and iatrogenic cross infection, the most important thing is that part of the air in the stomach can be sucked away through a suction tube when the stomach is full of air, and the coupling agent can be adde through a coupling agent addition tube when the coupling agent is needed, thereby ensuring the clarity of the image to a great extent.

The invention provides inflation pressurizing trousers for facilitating blood vessel puncture of a child. The inflation pressurizing trousers are characterized in that the inflation pressurizing trousers comprise a trouser waist and trouser legs; the middle part of the trouser waist is provided with a trouser waist air bag; two sides of the trouser waist are respectively provided with a trouser waist sticking buckle for closed adhesion of two sides; the middle part of the trouser leg is provided with a trouser leg airbag; two sides of the trouser leg are respectively provided with a trouser leg sticking buckle for closed adhesion of the two sides and is trouser-leg-shaped; the crotch of the pressurizing trousers is provided with a selector valve; the selector valve is connected with one end of a total gas filling pipe; the other end of the total gas filling pipe is connected with an air pressure gauge; the air pressure gauge is connected with an inflating ball; and a total gas fillingpipe valve is arranged between the inflating ball and the air pressure gauge. The inflation pressurizing trousers settle a problem of incapability of increase the internal diameter of the blood vesselat a puncture part of the child in existing clinical blood vessel puncture. Through performing inflation pressuring on the lower limb and the belly part, the internal diameter of the blood vessel atthe puncture part is increased and child blood vessel puncture is assisted.

The invention provides a recombinant feline herpesvirus type 1 gB protein antigen and an application thereof to antibody diagnosis and vaccine preparation. By using a prokaryotic expression vector, dominant epitopes of the feline herpesvirus type 1 gB protein are subjected to tandem expression. The expressed recombinant protein is purified and used as a coating antigen for detecting the feline herpesvirus type 1 antibody. The antigen treatment is convenient, the test time is shortened, and the operation steps are simpler. An indirect ELISA method established by the invention is used for detecting the antibody level of the feline herpesvirus type 1 in feline serum, has the characteristics of good repeatability and high specificity, and can be used for feline herpesvirus type 1 serology investigation. Therefore, an indirect ELISA detection kit for the feline herpesvirus type 1 based on tandem expression of a dominant antigen of the gB protein, provided by the invention, is very suitable for detection of clinical large samples and is suitable for large-scale popularization.

The invention discloses a urethroscope with an urethral dilatation function. The urethroscope comprises a detachable outer sheath and an endoscope system, wherein the outer sheath is prepared by a transparent hard plastic material with one-time application and sterility, is divided into different models, and is hollow (including vertical large and small channels); a head end is rounded in bullet shape (the tip is slightly flat) and a front section is slightly curved; one side of a rear end has a flushing end communicating with the small channel in the outer sheath, and the small channel is open at the head end; an endoscope system mirror body at middle of the rear end enters the large channel, and the large channel to the tip end is lenticular. The endoscope system is flexible, and the same endoscope is suitable for different types of the outer sheaths. The endoscope system has an integrated structure (like an industrial endoscope system), including an objective lens, a light source, fiber optic fiber, and a display, which can be reused and used without disinfection. The mirror body extends from the rear end of the outer sheath into the longitudinal large passage in the outer sheath to a outer sheath tip lens, and has an own light source and a display system. The urethroscope solves the functions of common urethroscope direct vision examination and dilatation of urethral stricture, and has the characteristics of clear intraoperative vision, simple structure, and easy learning and use.

The invention relates to a method for radiolabeling a biological compound. The method comprises the following steps of performing chelation reaction on a bifunctional chelating agent modified with a maleimide group and radionuclide, and directly adding the biological compound to carry out coupling reaction, thereby obtaining the radiolabeled biological compound. The technical scheme adopts the maleimide group with excellent thermal stability, so that the bifunctional chelating agent can be chelated with radioactive metal ions under a high-temperature condition, the chelating reaction time is remarkably shortened, and the labeling efficiency is improved; and the product of the chelation reaction can be subjected to biological compound coupling without purification, and the method has the advantages of simple steps, convenience, high efficiency and high connection efficiency.