Mesoporous bioactive glass/polylactic acid-glycolic acid copolymer composite microspheres and preparation method and application thereof

A technology of glycolic acid copolymer and bioactive glass, which is applied in the field of PLGA microspheres, can solve the problems of lack of osteoinductive ability and limit the application of composite microspheres, and achieve good osteoinductive ability, good osteoconductivity, and preparation process easy to control effects

Inactive Publication Date: 2020-11-10
SOUTH CHINA UNIV OF TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, although the microspheres prepared by the prior art have good biocompatibility and certain osteoconductive ability, they do not have osteoinductive ability, which limits the application of composite microspheres in bone and tooth tissue repair.

Method used

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  • Mesoporous bioactive glass/polylactic acid-glycolic acid copolymer composite microspheres and preparation method and application thereof
  • Mesoporous bioactive glass/polylactic acid-glycolic acid copolymer composite microspheres and preparation method and application thereof
  • Mesoporous bioactive glass/polylactic acid-glycolic acid copolymer composite microspheres and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0035] A kind of mesoporous bioactive glass / polylactic acid-glycolic acid copolymer composite microsphere, its preparation method is as follows:

[0036] (1) Preparation steps of mesoporous bioactive glass powder:

[0037] Mesoporous bioactive glass is prepared by microemulsion technology combined with sol-gel template method. The specific synthesis process is as follows: First, 12g of cetyltrimethylammonium bromide (CTAB) is added to 108ml of deionized water, and heated in a 60°C water bath. Stir in the pot until completely dissolved; then add 0.36ml triethanolamine (TEA), then add 2.510g calcium nitrate tetrahydrate and stir until completely dissolved to obtain an aqueous phase solution; then add 12mL tetraethyl orthosilicate (TEOS), 0.921mL triphosphate Mix ethyl ester (TEP) and 48mL cyclohexane evenly to form an oil phase mixture; then use a syringe pump to add the oil phase solution to the water phase solution at a speed of 1.5ml / min, and condense and reflux in a water ba...

Embodiment 2

[0041] A kind of mesoporous bioactive glass / polylactic acid-glycolic acid copolymer composite microsphere, its preparation method is as follows:

[0042] (1) Preparation steps of mesoporous bioactive glass powder:

[0043] Mesoporous bioactive glass is prepared by microemulsion technology combined with sol-gel template method. The specific synthesis process is as follows: First, 8g of cetyltrimethylammonium bromide (CTAB) is added to 108ml of deionized water, and heated in a 60°C water bath. Stir in the pot until completely dissolved; then add 0.36ml triethanolamine (TEA), then add 2.510g calcium nitrate tetrahydrate and stir until completely dissolved to obtain an aqueous phase solution; then add 12mL tetraethyl orthosilicate (TEOS), 0.921mL triphosphate Mix ethyl ester (TEP) and 48mL cyclohexane evenly to form an oil phase mixture; then use a syringe pump to add the oil phase solution to the water phase solution at a speed of 1.5ml / min, and condense and reflux in a water bat...

Embodiment 3

[0047] A kind of mesoporous bioactive glass / polylactic acid-glycolic acid copolymer composite microsphere, its preparation method is as follows:

[0048] (1) Preparation steps of mesoporous bioactive glass powder:

[0049] Mesoporous bioactive glass is prepared by microemulsion technology combined with sol-gel template method. The specific synthesis process is as follows: First, 15g of cetyltrimethylammonium bromide (CTAB) is added to 108ml of deionized water, and heated in a 60°C water bath. Stir in the pot until completely dissolved; then add 0.36ml triethanolamine (TEA), then add 2.510g calcium nitrate tetrahydrate and stir until completely dissolved to obtain an aqueous phase solution; then add 12mL tetraethyl orthosilicate (TEOS), 0.921mL triphosphate Mix ethyl ester (TEP) and 48mL cyclohexane evenly to form an oil phase mixture; then use a syringe pump to add the oil phase solution to the water phase solution at a speed of 1.5ml / min, and condense and reflux in a water ba...

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Abstract

The invention discloses mesoporous bioactive glass / poly(lactic-co-glycolic acid) (PLGA) composite microspheres and a preparation method and application thereof. The mesoporous bioactive glass / poly(lactic-co-glycolic acid) (PLGA) composite microspheres are prepared by the following method of: firstly, preparing mesoporous bioactive glass by using a microemulsion technology in combination with a sol-gel template method, then sequentially adding PLGA, span 80 and the mesoporous bioactive glass into dichloromethane, and carrying out uniform stirring and ultrasonic dispersing to form S / O emulsion;and sequentially adding the S / O emulsion into prepared polyethylene solution W1 and W2 with different concentration, stirring to evaporate a solvent, and carrying out washing, centrifugation, and freeze-drying to obtain the product. The preparation process flow of the composite microspheres is easy to control, and due to the addition of the mesoporous bioactive glass, the bone induction capabilityand the drug loading and slow release capability of the composite microspheres are improved; and the composite microspheres have good application prospect in the fields of bone and tooth tissue repair, tissue engineering and slow release carriers such as drugs, proteins and genes and the like.

Description

technical field [0001] The invention belongs to the field of PLGA microspheres, and in particular relates to a mesoporous bioactive glass / polylactic acid-glycolic acid copolymer composite microsphere and a preparation method and application thereof. Background technique [0002] At present, the clinical treatment of bone defects is still mainly based on autologous bone, xenogeneic or allogeneic bone, and artificially synthesized bone substitute materials for transplantation. However, for people with systemic chronic diseases such as diabetes, hypothyroidism, chronic bone infection, malignant tumors, calcium and phosphorus metabolism disorders, and osteoporosis, the healing of bone defects is particularly difficult. In daily life, dental caries, surgery or trauma may cause tooth defects and expose the pulp, and at the same time, bacterial infection is very easy to occur. Therefore, it is necessary to research and develop bone and tooth repair materials that can load related ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/44A61L27/50A61L27/58
CPCA61L27/446A61L27/50A61L27/58A61L2430/02A61L2430/12C08L67/04
Inventor 陈晓峰陈筱宇王刚
Owner SOUTH CHINA UNIV OF TECH
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