Intrauterine adhesion prevention material

A technology of intrauterine adhesion and gel material, which is applied in the field of medical materials to achieve the effect of good fluidity, comprehensive wound coverage and uniform coating

Active Publication Date: 2015-05-27
广州市弘健生物医用制品科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004]The purpose of the present invention is to overcome the defects of the existing anti-uterine adhesion materials which are complicated to operate and difficult to fully cover the wound surface, and provide people with a good fluidity and uniform coating , an anti-uterine adhesion material that can quickly and comprehensively cover the wound surface

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The anti-uterine adhesion material in this example is a temperature-sensitive gel, and the phase transition temperature of the temperature-sensitive gel is 25°C to 40°C.

[0029] The temperature-sensitive gel is composed of a gel body, a humectant, a gelling temperature regulator and pure water. The gel body is poloxamer 407, which accounts for 20% of the total temperature-sensitive gel. The moisturizer is glycerin, which accounts for 20% of the temperature-sensitive gel The mass fraction of the total gel is 5%, the gelling temperature regulator is poloxamer 188, which accounts for 5% of the total temperature-sensitive gel, and the rest is pure water.

[0030] The preparation method of the anti-uterine adhesion material in this example is as follows:

[0031] Disperse Poloxamer 407 and Poloxamer 188 in a container filled with a certain amount of pure water and stir until dissolved; add glycerin to the remaining amount of pure water and dissolve to obtain a glycerin solu...

Embodiment 2

[0033] The anti-uterine adhesion material in this example is a temperature-sensitive gel, and the phase transition temperature of the temperature-sensitive gel is 25°C to 40°C.

[0034] The temperature-sensitive gel is composed of a gel body, a tissue affinity agent, a moisturizing agent, a gelling temperature regulator and pure water; the gel body is poloxamer 407, which accounts for 15% of the total temperature-sensitive gel; The mixture is sodium hyaluronate, which accounts for 0.2% of the total temperature-sensitive gel; the moisturizing agent is glycerin, which accounts for 5% of the total temperature-sensitive gel; the gelling temperature regulator is poloxamer 188, which accounts for The mass fraction of the total amount of glue is 10%, and the rest is pure water.

[0035] The preparation method of the anti-uterine adhesion material in this example is as follows:

[0036] Disperse Poloxamer 407 and Poloxamer 188 in a container filled with a certain amount of pure water...

Embodiment 3

[0038] The anti-uterine adhesion material in this example is a temperature-sensitive gel, and the phase transition temperature of the temperature-sensitive gel is 25°C to 40°C.

[0039] The temperature-sensitive gel is composed of a gel body, a tissue affinity agent, a moisturizing agent, a gelling temperature regulator, and pure water; the gel body is poloxamer 407, which accounts for 25% of the total temperature-sensitive gel; The mixture is hyaluronic acid, accounting for 0.1% of the total temperature-sensitive gel; the moisturizing agent is glycerin, accounting for 10% of the total temperature-sensitive gel; the gelling temperature regulator is Poloxamer 188, accounting for 10% of the total temperature-sensitive gel The mass fraction of the total amount is 10%, and the rest is pure water.

[0040] The preparation method of the anti-uterine adhesion material in this example is as follows:

[0041] Disperse Poloxamer 407 and Poloxamer 188 in a container filled with a certai...

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Abstract

The invention discloses an intrauterine adhesion prevention material, and belongs to the field of medical materials. The intrauterine adhesion prevention material is characterized in that the intrauterine adhesion prevention material is a temperature-sensitive gel; the phase transition temperature of the temperature-sensitive gel is 25-40 degrees; the temperature-sensitive gel consists of a gel main body, a tissue affinity agent, a humectant, a gelling temperature regulation agent and pure water; the gel main body is one or several of poloxamer 407, a polylactide acid / glycolic acid / polyethylene glycol copolymer, poly(N-isopropylacrylamide), chitosan, sodium beta-glycerophosphate, methoxy polyethylene glycol-(sebacic acid-D,L-lactic acid)polyester anhydride-methoxy polyethylene glycol triblock copolymer, cellulose, a cellulose derivative, and polyethylene glycol / polycaprolactone block copolymer; the tissue affinity agent is hyaluronic acid or sodium hyaluronate; the humectant is glycerol or sodium alginate; and the gelling temperature regulation agent is poloxamer 188 or polyethylene glycol. The intrauterine adhesion prevention material provided for people is good in liquidity and can be coated uniformly, and the surface of a wound can be covered quickly and completely.

Description

[0001] Technical field: [0002] The invention belongs to the field of medical materials, and in particular relates to an anti-uterine cavity adhesion material. [0003] Background technique: [0004] Intrauterine adhesions are a disease that endangers women's health. It mainly causes abdominal pain, infertility, menstrual disorders and other diseases. In addition to natural factors, many human interventions can lead to the occurrence of intrauterine adhesions: such as induced abortion, uterine Intracavitary surgery, etc., and the hysteroscopic surgery that is currently being widely implemented also increases the risk of intrauterine adhesions to a greater extent. Therefore, prevention of intrauterine adhesions is very necessary. [0005] Because intrauterine adhesions are more harmful to women, many materials have been used to prevent intrauterine adhesions: water bags or air bags are used to put them into the uterine cavity after intrauterine surgery. The water or gas in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/14A61L31/06A61L31/04
Inventor 朱晓明
Owner 广州市弘健生物医用制品科技有限公司
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