239results about How to "To achieve the effect of sustained release" patented technology

The invention discloses medicinal sustained-release hydrogel as well as a preparation method and an application thereof. Monodisperse medicament-containing calcium alginate microspheres are prepared by adopting a high-pressure electrostatic sessile drop method, to realize direct encapsulation of growth factors and keep the activity of medicaments; and the medicament-carrying calcium alginate microspheres are put into the netlike structure of the hydrogel to realize sustained release of the medicaments. The matrix of the hydrogel contains carboxymethyl chitosan and polyvinyl alcohol, the volume ratio of the carboxymethyl chitosan solution to the polyvinyl alcohol solution is n: (6-n), 0<n<=4, and the release rate of the medicaments is controlled through different volume ratios.

The invention provides a temperature-sensitive amphiphilic cyclodextrin polymer PCEC (polycaprolactone-polyethylene glycol-polycaprolactone, PCL-PEG-PCL). The polymer provided by the invention is the amphiphilic cyclodextrin polymer which is obtained by linking a PCL-PEG-PCL molecule with beta-CD (cyclodextrin) through utilizing the temperature-sensitive characteristic of a PCL-PEG-PCL triblock copolymer and the inclusion effect of beta-CD on a hydrophobic medicament, can effectively load and slowly release a hydrophobic or water-soluble medicament on the basis of the traditional hydrogel encapsulated water-soluble medicament, has proper critical gel temperature and can form in situ temperature-sensitive hydrogel after injection. According to the invention, the hydrophobic zone of the polymer is obviously enlarged, thereby effectively improving the loading capacity of the hydrogel on the hydrophobic medicament and obtaining high medicament encapsulation rate and medicament loading amount; and simultaneously, the controlled-release effect of the medicament after local injection delivery is realized by utilizing the temperature-sensitive gel performance of the polymer. The polymer provided by the invention has the following chemical structure shown in the specification.

The invention provides a special slow release fertilizer for sugarcane. The special slow release fertilizer sequentially comprises a first fertilizer layer, a first film coating layer, a second fertilizer layer, a second film coating layer, a third fertilizer layer and a third film coating layer at a weight part ratio of (4-6) to (1-2) to (6-8) to 1 to (10-12) to (2-3) from inside to outside, wherein the first fertilizer layer is a fermented product of animal manure, marine product leftovers and a microorganism fermenting agent; the first film coating layer is a mixture of bentonite and acrylic resin; the second fertilizer layer is a fermented product of sugar filtering mud, molasses, saw dust, straws, traditional Chinese medicine liquid, yeast waste liquid and a fermentation bacterium agent; the second film coating layer is a mixture of zeolite and attapulgite; the third fertilizer layer is a mixture of a nitrogenous fertilizer, a phosphatic fertilizer, a potash fertilizer and traditional Chinese medicine residues; the third film coating layer is beta-cyclodextrin. The fertilizer is enriched with nitrogen, phosphorus, potassium and microelements; fermentation products and traditional Chinese medicine extracts are added into the fertilizer, and the continuous absorption and utilization on nutrition by the sugarcane are increased so that the releasing time of the fertilizer in soil is prolonged.

The invention belongs to the field of fertilizer, and particularly relates to slow release fertilizer comprising fly ash gel and a preparation method of the slow release fertilizer. The slow release fertilizer comprising fly ash gel is characterized in that fly ash which is solid waste of a fuel factory is taken as the raw material, modified through ion beam irradiation, and excited by an active exciting agent to form a gel solution with a three-dimensional network structure; and in a gel forming process, the surface energy of the fly ash is increased, the adsorbability is enhanced, a large amount of chemical fertilizer can be adsorbed after the fly ash is mixed with a chemical fertilizer solution, the chemical fertilizer is fixed in the network structure of the gel after adsorption, so that the release and decomposition speed of the chemical fertilizer is effectively slowed, and the slow release purpose is achieved. The slow release fertilizer can be dispersed in an aqueous solution to form the gel and can be used for irrigation and fertilization with water, water and fertilizer integration is facilitated, the raw material source is wide, the production technology is simple, and the slow release fertilizer has positive significance on increase of crop yield.

The present invention discloses a fertilizer additive for improving acidified soil. The fertilizer additive is prepared from the following raw materials by weight: 3-5 parts of smectite powder, 1-2 parts of peat soil, 1-3 parts of peat soil, 3-6 parts of silt, 5-10 parts of smashed deciduous leaf, 6-15 parts of pomegranate rind, 0.3-0.5 part of dicyandiamide, 0.1-0.2 part of thiourea, 10-12 parts of activated carbon, 40-45 parts of pomace, 3-5 parts of shell powder, 3-5 parts of calcium silicon powder, 1-2 parts of lignin, 0.1-0.2 part of an EM microbial agent, 0.1-0.2 part of Bacillus subtilis microbial agent, and 2-4 parts of a complex deodorant.

The invention discloses a pollution-free paddy rice planting method. The method comprises the following steps: A, planting milk vetch as green manure in a rice field, and applying a basic manure, wherein 500-800 kg of the basic manure is applied to each mu of the rice field; B, after the rice field is subjected to exposure, performing rotary tillage, ridge separation, irrigation and rice transplanting; C, applying a compound fertilizer to seedlings after the seedlings are inserted; D, grazing 8-15 7-10-day-old ducks to each mu of the rice field after 15-20 days of rice transplanting, evicting the ducks from the rice field after 25-40 days, spraying a biological pesticide, draining for 7-10 days, topdressing 30-100 kg of the compound fertilizer used in the step C to each mu of the rice field, irrigating till the depth of water is 8-10 cm, grazing 5-10 7-10-day-old ducks to each mu of the rice field again, and evicting the ducks from the rice field before 15-20 days of rice mature. According to the pollution-free paddy rice planting method, the yield is high, pollution is avoided, produced rice tastes good, and meanwhile, high-quality duck is obtained.

The invention discloses a concrete anti-bleeding inhibitor with a water reducing function and a preparation method thereof. The anti-bleeding inhibitor is mainly prepared by subjecting polyether largemonomer, unsaturated carboxylic acid, unsaturated amide, unsaturated sulfonic acid or sulfonate, a cross-linking agent, an oxidizing agent, a reducing agent, a chain transfer agent and deionized water to free radical polymerization at 15-30 DEG C through an aqueous solution, adding a sodium hydroxide solution to adjust a pH value and then supplementing water. According to the preparation method,production is conducted at normal temperature, no heat sources are needed, the equipment is simple, no pollution is generated, the production efficiency is high, and the anti-bleeding inhibitor can effectively solve the problems that existing polycarboxylic acid water reducers are poor in water retention and water absorption performance and workability, and bleeding and bottom holding are easy tooccur; the inhibitor has excellent thickening and water retention performance, and the degree of construction difficulty can be greatly reduced.

The invention discloses a slow-release additive for a fertilizer of eucalyptus. The slow-release additive is prepared from the following raw materials in parts by weight: 20-25 parts of straw, 14-16 parts of zeolite powder, 1-2 parts of clay, 1-2 parts of guanylthiourea, 1-2 parts of glycine betaine, 1-4 parts of soluble chitosan, 1.4-2.8 parts of fulvic acid, 20-30 parts of pig manure, 4-8 parts of rape seed cake, 1-2 parts of maize meal, 1-2 parts of polyacrylamide, 0.5-1 part of rhizoma arisaematis, 1-2 parts of radix sophorae flavescentis, 1-2 parts of caulis perillae and 1-2 parts of castor root. According to the slow-release additive for the fertilizer of eucalyptus, provided by the invention, positive ions in cavities and channels have a higher selective ion-exchange property, heavy metal ions and cyanide harmful to animals can be removed, and beneficial metal ions are enabled to be released.

The invention discloses an environment-friendly bamboo fiber material which is prepared from the following raw materials in parts by weight: 30-40 parts of polylactic acid, 10-18 parts of poly (butylene succinate), 20-30 parts of modified bamboo fiber, 10-15 parts of a plasticizer and 2-3 parts of an antibacterial agent; the invention further discloses a preparation method of the environment-friendly bamboo fiber material, and the preparation method comprises: step 1, sealing and placing; step 2, mixing; step 3, after being cooled, crushing the mixture into particles through a strong crusher,and pouring the particles into a hot-pressing mold; and step 4, carrying out hot pressing. According to the invention, the polylactic acid and the poly (butylene succinate) are used as a matrix of materials, and are both biodegradable resin, and the mechanical property and the heat resistance of the composite material can be improved by enhancing effect of the modified bamboo fiber; meanwhile, dueto the addition of the plasticizer, the composite material not only has relatively high strength, and the elongation at break and the water resistance are good; due to the addition of the antibacterial agent, the composite material is not easy to mildew, and the service life of the composite material can be effectively prolonged.

The invention discloses a medical antibacterial hydrogel dressing preparation method which comprises the following steps: firstly, utilizing graphene oxide to modify carboxymethyl chitosan and wrapping the graphene oxide with the carboxymethyl chitosan; then spinning, freeze drying and smashing to form fibers; then reacting with oxidized sodium alginate and the carboxymethyl chitosan to form hydrogel dressing. The medical antibacterial hydrogel dressing has an excellent antibacterial effect; furthermore, the mechanical property of the hydrogel dressing is remarkably improved; the hydrogel dressing has good biocompatibility.

The invention discloses a 3D (Three-Dimensional) printing bracket of beta-tricalcium phosphate and calcined pyritum, which is used for bone defect repair. The 3D printing bracket is prepared from thefollowing raw materials in percentage by mass: 55 to 80 percent of the beta-tricalcium phosphate, 10 to 30 percent of the calcined pyritum, 2 to 10 percent of sodium polyacrylate and 2 to 10 percent of hydroxymethylpropyl cellulose, wherein the sodium polyacrylate is a high molecular polymer, and has the molecular weight of one million to ten million; the sum of the percentages (by mass) of the four raw materials is 100 percent. A compound of the 3D printing bracket can be processed into a bone defect filling material, a 3D bracket, a bone screw, a bone rod, a bone repairing fuser and the like; the 3D printing bracket has favorable biocompatibility, can be absorbed and degraded in a human body, and moreover, has bone conduction and bone induction effects; the secondary operation and the side effect of an implant are avoided; the regeneration of bone tissue is promoted and the coalescence of a bone is promoted.

The invention discloses a pear tree fertilizer slow-release additive containing brassinolide. The pear tree fertilizer slow-release additive containing brassinolide comprises, by weight, 20-25 parts of rice straw, 4-6 parts of coal gangue powder, 0.2-0.4 part of brassinolide, 1-2 parts of guanylthiourea, 1-4 parts of glucose, 1-2 parts of polyethylene glycol, 1-2 parts of brown sugar, 1-2 parts of ardealite, 6-8 parts of weathered coal, 1-3 parts of polyacrylamide, 0.2-0.3 part of potassium nitrophenolate, 0.6-0.8 part of polypropylene glycol, 1-3 parts of agricultural rare earth nitrate, 1-2 parts of sodium dodecyl benzene sulfonate, 4-5 parts of alfalfa, 1-2 parts of flos chrysanthemi indici, 1-2 parts of plumeria rubra, 1-3 parts of stellera chamaejasme, 3-5 parts of corn gluten meal, 3-5 parts of cow dung and 0.1-0.3 part of HM decomposition maturing agent.

The invention discloses a method for preparing matrine slow-release tablets by applying attapulgite, which comprises the following steps of: dissolving matrine by using hydrochloric acid with the mass concentration of 0.1 percent to obtain 2-5mg/ml of matrine solution; adsorbing the matrine solution through modified attapulgite for 4-6 hours according to the proportion by weight of 1:2; filtering and drying to obtain the attapulgite loading the matrine; and adding 2 percent by weight of talcum powder into the attapulgite loading the matrine, granulating by a dry method, and tabletting to obtain the matrine slow-release tablets. A modifying method of the attapulgite comprises the following steps of: weighing 20g of attapulgite, placing the attapulgite into 1000ml of aqueous solution, stirring for 12 hours, settling, removing upper water, adding purified water, stirring for 12 hours, settling, taking an intermediate fine particle layer, adding concentrated hydrochloric acid, settling for 24 hours, filtering through suction, washing with water to be neutral, drying at the temperature of 105DEG C, finely grinding and screening with a 120-mesh screen to obtain acid modified attapulgite. The invention adopts the principle of adsorption separation and selects the modified attapulgite which can be taken as an adsorbent for adsorbing the matrine, the matrine slow-release tablets are slowly released under the desorption action of a body fluid, operation steps are simple, and the production period of traditional Chinese medicine preparations is shortened.

The invention discloses a chlorine dioxide disinfection gel and a preparation method thereof. The preparation method comprises the following steps: preparing a mixed solution consisting of 95-100 parts by mass of tetraethyl orthosilicate, 3-6 parts by mass of methyltriethoxysilane and 15-30 parts by mass of hydrochloric acid, and conducting hydrolyzing while stirring, wherein after hydrolysis a byproduct ethanol is generated, and a clarified solution is obtained; adding 5-10 parts of a chelating agent and 0.5-5 parts of a slow release agent into the clarified solution, and continuing to perform stirring for 30 minutes; at a temperature of 40-50 DEG C, partially pumping out the ethanol by adopting a reduced pressure distillation method to obtain a sol solution; adding 1-10 parts of a stabilizer and 1-10 parts of chlorite into the sol solution, and continuing to perform uniform stirring to obtain a sol mixed solution; and adding 2.5-20 parts of an activator and 0.5-4 parts of an alkalinereagent into the sol mixed solution, and conducting stirring until the sol is solidified to obtain the chlorine dioxide disinfection gel. The preparation method of the chlorine dioxide disinfection gel is simple in overall process, easy to operate and low in investment cost, and the prepared chlorine dioxide disinfection gel has the advantages of being long in action period, high in stability, controllable in release rate and the like.

The invention discloses a method for preparing a carbon-based mineralized active fertilizer. The method includes the steps that forestry and agricultural residues and woody brown coal biomass serve as basic materials, the basic materials and a catalyst formed by mixing and blending powdered rock phosphate, pumice stones, serpentine, medical stone and bentonite are crushed respectively, mixed according to a certain proportion for pelleting and then placed into a carbonation reaction kettle for a reaction, output materials are cooled and then crushed again, wood vinegar, a biological agent and humic acid are added, stirred and mixed, and the carbon-based mineralized active fertilizer is obtained through pelleting. The carbon-based mineralized active fertilizer prepared through a simple and effective method is environmentally friendly, microcellular structures are increased by 20% and above compared with traditional charcoal, the fertilizer contains richer nitrogen, phosphorus, potassium and medium trace elements compared with the charcoal obtained just through biomass, the total quantity of nitrogen, phosphorus and potassium available to plants is increased by 15-30%, the total content of N-P-K is larger than or equal to 10% and above, the content of organic matter is larger than or equal to 36%, the fertilizer contains rich organic acid, the fertilizer consumption can be lowered, and fertilizer efficiency can be improved.

The invention discloses a preparation method of a cationic hydrogel. The method comprises the following steps: heating a mixture of polyvinyl alcohol and cationic starch at 90 DEG C for 2-4 h to achieve complete and uniformly mixing, dissolving the obtained mixture in water, and cooling to room temperature to obtain an aqueous polymer solution, wherein the mass ratio of the polyvinyl alcohol to the cationic starch is (1-5):1, and the total mass of the polyvinyl alcohol and the cationic starch is 12% of the total mass of the aqueous polymer solution; freezing the aqueous polymer solution at -25DEG C for 16-20 h, unfreezing at 25 DEG C for 4-8 h, and repeating for 1-5 times to obtain the hydrogel containing cations. The preparation process is simple, the raw materials are cheap and easy toobtain, the polyvinyl alcohol and the cationic starch are used as the raw materials, a cross-linking agent is not introduced, and the physical cross-linked hydrogel can be prepared through a refrigeration cycle method. The hydrogel adhesive tape has positive charges, the slow release effect of a drug is achieved through anion and cation combination in different pH environments, the advantages of the polyvinyl alcohol and cationic starch are combined, and the cationic hydrogel can be widely applied to the field of drug carriers.

The invention belongs to the field of biological preparations and discloses a composite polysaccharide fertilizer synergist and a preparation method thereof. The synergist is prepared from, by weight, 0.1-1 part of xanthan gum, 0.1-1 part of Welan gum and 0.001-1 part of polyglutamic acid. The invention further discloses a preparation method and application of the fertilizer synergist. The synergist is natural and free of pollution, has the effect of regulating growth of crops, stimulates vitality of the crops, increases the absorption rate of the crops, improves nutrient absorption efficiency of the crops, increases the utilization rate of fertilizer, and improves the quality of the crops. Thus, the synergist is mixed with the fertilizer to be used, so the yield of food crops, leafy vegetables, melons, fruits and other crops can be effectively increased, and the quality can also be greatly improved.

The invention relates to the technical field of non-woven fabrics, and provides a non-woven fabric for protective clothing and a preparation method of the non-woven fabric. The non-woven fabric comprises a non-woven fabric substrate, and the non-woven fabric substrate can be applied to the protective clothing after being treated by microcapsule finishing liquid, wherein the microcapsule finishingliquid is prepared from the following raw material in parts by weight: 35 to 60 parts of microcapsule emulsion, 6 to 12 parts of cross-linking agent, 2 to 4 parts of carboxymethyl cellulose and 1.5 to2.5 parts of fatty alcohol-polyoxyethylene ether; the microcapsule emulsion is prepared by taking chitosan and sodium alginate as wall materials and xylitol, N-ethyl-L-menthyl formamide and ammoniumnitrate as core materials by using a complex coacervation method, and the non-woven fabric substrate treated by the microcapsule finishing liquid solves the problems that in the prior art, the medicalprotective clothing non-woven fabric is single in function, a cool feeling cannot be generated, and stuffiness and discomfort are easily caused when a large amount of sweat is sweated.