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3D (Three-Dimensional) printing bracket serving as bone repairing biological material and preparation method thereof

A 3D printing and biomaterial technology, applied in the new field of traditional Chinese medicine, can solve the problems of cumbersome operation and high cost, and achieve the effect of abundant resources, stable components and guaranteeing integrity

Active Publication Date: 2018-03-16
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the three core elements of tissue engineering bone are scaffold materials, seed cells and cell biological regulators. This method has very good curative effect, but has the disadvantages of high cost and cumbersome operation.

Method used

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  • 3D (Three-Dimensional) printing bracket serving as bone repairing biological material and preparation method thereof
  • 3D (Three-Dimensional) printing bracket serving as bone repairing biological material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1: the preparation of calcined natural copper

[0022] Take 100g of raw natural copper, particle size 9-10mm, bedding thickness 3cm, put it in a crucible, and calcinate it in a muffle furnace at a temperature of 600°C for 2 hours. Take out the calcined natural copper and immediately pour it into rice vinegar. Once, take it out after quenching with vinegar for 5 minutes, dry it in the air, and crush it through a 100-mesh sieve to obtain calcined natural copper. For every 100kg of natural copper, 30kg of vinegar is used.

Embodiment 2

[0024]A method for preparing β-tricalcium phosphate and calcined natural copper composite 3D printing support: the printing slurry is prepared according to the mass ratio of each component, wherein β-tricalcium phosphate is 80%, calcined natural copper is 10%, sodium polyacrylate 6 %, 4% hydroxymethyl propyl cellulose, weighed calcined natural copper in proportion, added 8 times the amount of water, decocted for 1 hour, decocted twice, filtered, and the filtrate was concentrated to 10g / mL, and mixed with other 3 raw materials Mix, add ultra-pure water, adjust the ratio to keep the volume ratio of raw materials and water at 1:0.5, put it into a high-speed ball mill for grinding for 6 hours, stir and mix with a constant temperature magnetic stirrer at 37°C for 20 minutes, and the speed of stirring is 300rpm to obtain a uniform texture Print paste. Turn on the computer, printer and Solidwords2015 modeling software, connect the computer and printer, put the printing paste into the...

Embodiment 3

[0026] A composite 3D printing bracket of β-tricalcium phosphate and calcined natural copper. The printing paste is 70% of β-tricalcium phosphate, 15% of calcined natural copper, 4% of sodium polyacrylate and methylol Propyl cellulose 6%, weigh calcined natural copper in proportion, add 8 times the amount of water, decoct for 1 hour, decoct twice, filter, concentrate the filtrate to 10g / mL, mix with other 3 kinds of raw materials, add super Pure water, adjust the ratio to keep the volume ratio of raw materials and water at 1:0.5, put it into a high-speed ball mill to grind for 8 hours, stir and mix with a constant temperature magnetic stirrer at 37°C for 25 minutes, and the speed of stirring is 400rpm to obtain a uniform printing paste. Turn on the computer, printer and Solidwords2015 modeling software, connect the computer and printer, put the printing paste into the material tray, install the ink cartridge of the nozzle on the drawing device, load the 3D model data to be prin...

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Abstract

The invention discloses a 3D (Three-Dimensional) printing bracket of beta-tricalcium phosphate and calcined pyritum, which is used for bone defect repair. The 3D printing bracket is prepared from thefollowing raw materials in percentage by mass: 55 to 80 percent of the beta-tricalcium phosphate, 10 to 30 percent of the calcined pyritum, 2 to 10 percent of sodium polyacrylate and 2 to 10 percent of hydroxymethylpropyl cellulose, wherein the sodium polyacrylate is a high molecular polymer, and has the molecular weight of one million to ten million; the sum of the percentages (by mass) of the four raw materials is 100 percent. A compound of the 3D printing bracket can be processed into a bone defect filling material, a 3D bracket, a bone screw, a bone rod, a bone repairing fuser and the like; the 3D printing bracket has favorable biocompatibility, can be absorbed and degraded in a human body, and moreover, has bone conduction and bone induction effects; the secondary operation and the side effect of an implant are avoided; the regeneration of bone tissue is promoted and the coalescence of a bone is promoted.

Description

technical field [0001] The invention relates to a 3D printing bracket of a compound of β-tricalcium phosphate and calcined natural copper and its function in bone repair medical parts, belonging to the field of new technology of traditional Chinese medicine. Background technique [0002] Bone defects are clinically more common because of damage to the integrity of bone structure due to diseases such as injury, tumor, infection, and resection. Human bones have the function of reconstruction and self-repair, but for large bone defects, it is difficult to heal by itself. At this time, manual intervention is required, such as bone transplantation, bone handling technology, artificial bone, tissue engineering bone, etc. Among them, the three core elements of tissue engineering bone are scaffold materials, seed cells and cell biological regulators. This method has very good curative effect, but has the disadvantages of high cost and cumbersome operation. The 3D printing scaffold ...

Claims

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Application Information

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IPC IPC(8): A61L27/02A61L27/12A61L27/16A61L27/20A61L27/50A61L27/54A61L27/58A61L31/02A61L31/04A61L31/14A61L31/16
CPCA61L27/025A61L27/12A61L27/16A61L27/20A61L27/50A61L27/54A61L27/58A61L31/028A61L31/042A61L31/048A61L31/14A61L31/148A61L31/16A61L2300/102A61L2300/412A61L2300/604A61L2430/02C08L1/284C08L33/02
Inventor 李伟东陆金兰陈志鹏吴丽刘玲朱星宇
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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