186 results about "Beta-tricalcium phosphate" patented technology

A composition of porous material and gel for preparing artificial bone is prepared from collagen and porous material chosen from alpha-tricalcium phosphate/hydroxy apatite, beta-tricalcium phosphate/hydroxy apatite-coral, calcium phosphate/hydroxy apatite, calcium carbonatel tricalcium phosphate, etc.

The present invention is one kind of new inorganic bone grafting material and belongs to the field of medical material. The inorganic bone grafting material consists of beta-tricalcium phosphate grain in 20-80 wt% and alpha-calcium sulfate semihydrate powder in 20-80 wt%, and the alpha-calcium sulfate semihydrate powder form layered structure in the surface and/or pores of beta-tricalcium phosphate grain. Both beta-tricalcium phosphate and alpha-calcium sulfate semihydrate have excellent biocompatibility and excellent in vivo degrading performance, and the composite artificial bone grain may be used in repairing bone defect of different shapes. The composite artificial bone grain has wide material source, convenient use, excellent performance, simple preparation process, low cost and other advantages.

The invention discloses a pre-mixing typed plaster calcium phosphate bone cement in the biological medical bone tissue material technology, which is characterized by the following: the solid powder and liquid powder with quality rate at 2.5-3.7: 1 are sealed container, the solid powder is beta-tricalcium phosphate and hydrated acid calcium phosphate with molar rate at 1:1, the liquid material is medical glycerin or polietilenglicol with molecular quantity at 400-800.

The invention relates to an artificial bone with a porous laminated structure and passages, which belongs to the technical field of biomedical materials. The artificial bone is alternately laminated and formed by compact layers and porous layers which are made of calcium phosphate base biological ceramic materials, and in addition, passages for conveying cells and body fluid are arranged in the direction which forms a set angle with the laminated layers. The preparation method comprises the following step: mixing powder such as hydroxylapatite, beta-tricalcium phosphate and the like through using deionized water as medium to be prepared into pulp. A three-dimensional gel laminated forming system is adopted for preparing ceramic blanks formed by the compact layers, the porous layers and the passages, and then the ceramic blanks are sintered at a high temperature for preparing the artificial bone. The invention has the characteristics that the artificial bone has high mechanical strength, has the porous structure with the effects of osteoplast adhesion, propagation, growth and vascularization, can be used as the artificial bone, can also be used as a bone tissue engineering support frame, and has wide application prospects in clinics in the orthopedics department.

The invention relates to a 3D (three-dimensional) printing mesoporous bioactivity glass modified biological ceramic support, and a preparation method and application thereof. The biological ceramic support comprises a beta-tricalcium phosphate bioactivity support prepared by using a three-dimensional printing technology and mesoporous bioactivity glass coating the surface of the support uniformly. The biological ceramic support has good mechanical property, mineralization capability and osteogenic and hematopoietic activities, is expected to serve as an effective bone repairing material, and is a potential multifunctional hard tissue bioactivity implanting material.

The invention discloses a beta-tricalcium phosphate/alginic acid composite microsphere and a preparation method and an application of the beta-tricalcium phosphate/alginic acid composite microsphere. The method comprises the following steps: dropwise adding a mixed solution of beta-tricalcium phosphate and sodium alginate into a calcium chloride solution of which the pH value is 4.5 to 5.0 by virtue of an electrostatic liquid dropping device, and continuing to calcify for a period of time after dropwise adding; pouring out the calcium chloride solution after reaction, then washing a calcified crosslinked microsphere with deionized water, and airing, so as to obtain the beta-tricalcium phosphate/alginic acid composite microsphere. The method is carried out at normal temperature without heating or reference to poisonous and harmful liquid and other volatile solids and gases. The beta-tricalcium phosphate/alginic acid composite microsphere prepared by using the preparation method has the advantage of wide particle size adjusting range and can be widely applied to tissue repair and drug carriers, and a plurality of micropores are formed in the surface of the beta-tricalcium phosphate/alginic acid composite microsphere, so as to be easy for cells to adhere, for tissue fluid to permeate and for loading of drugs, growth factors and cells, and therefore, the beta-tricalcium phosphate/alginic acid composite microsphere can be widely applied to tissue repair and drug carriers.

The invention relates to a method for preparing mesh-shaped bionic bone porous stent material, comprising the following steps: taking a multi-cellular marine animal natural sponge processed by organic acid and inorganic alkali solution as a template, impregnating with sol or water based slurry of hydroxylapatite, 45S5 bioactive glass, beta-tricalcium phosphate or calcium silicate, drying, oxidizing, demoulding and sintering at high temperature, thereby preparing the bone tissue engineering stent material in a mesh-shaped pore structure. The pore structural parameters and degradation performance of a porous stent are controlled by adjusting the solid content in the sol or the slurry, impregnation frequency and parameters in the process of oxidizing and demoulding as well as sintering at high temperature. Pore size of the mesh-shaped porous stent produced by adopting the invention is 100-300Mum, porosity is 68-94%, and the porous stent is highly similar to a natural cancellous bone in the shape and pore size. The product prepared by adopting the invention has the characteristics that bionic degree of the porous structure is high, adaptation to materials is high, process is simple and cost is low and the product has a great application potential in the regeneration repairing technology of hard tissue engineering, such as bone, basibranchial bone and teeth.

The invention relates to the technical field of medical high polymer materials and discloses a medical polycaprolactone membrane as well as a preparation method and an application of the medical polycaprolactone membrane. The constituents of the membrane include polycaprolactone; the membrane is 0.5-2mm thick; and the membrane is of a planar mesh structure and the mesh aperture of the planar mesh structure is 100-300 microns. Besides, composite additive materials, such as BETA-tricalcium phosphate, hydroxylapatite and coral, also can be added to the membrane. The invention also provides a method for preparing the medical polycaprolactone membrane by use of the 3D printing technology; the membrane is applicable to the field of bone tissue engineering; and the medical polycaprolactone membrane is used for covering a bone defect part and then repairing the bone defect, and therefore, the effects of surrounding and protecting the bone defect part, reducing stem cell loss, preventing surrounding fiber tissue ingrowth and guiding bone regeneration can be achieved.

The invention discloses a bioactive multilayer multiphase ceramic microsphere material and its preparation method and use. The bioactive multilayer multiphase ceramic microsphere material comprises multilayer microspheres obtained by alternate wrapping of beta-tricalcium phosphate and calcium silicate respectively doped with foreign ions. The preparation method comprises the following steps of respectively dispersing the beta-tricalcium phosphate and calcium silicate powder respectively doped with the foreign ions into alginate hydrosol to obtain two types of paste, putting the two types of paste respectively into liquid storage tanks connected to two layers of coaxial tubular nozzles, synchronously injecting the paste in the liquid storage tanks to outlets of the two layers of coaxial tubular nozzles to obtain concentric multilayer paste liquid drops, and receiving the concentric multilayer paste liquid drops by an inorganic calcium salt aqueous solution, and carrying out drying and calcination. The bioactive multilayer multiphase ceramic microsphere material has the fast-slow alternative degradation rate characteristic in the normal liquid, and can release an inorganic ion composition with layer-by-layer degradation. Granularity, each-layer thickness and an inorganic ion release rate of the bioactive multilayer multiphase ceramic microsphere material can be controlled easily. The bioactive multilayer multiphase ceramic microsphere material can be used for bone defect repair and bone regeneration medical science.

The invention provides construction and preparation of a three-dimensional bionic electropolarized gradient pore nerve conduit. The nerve conduit is an electropolarized beta-tricalcium phosphate/polylactic acid/hyaluronic acid/chitosan/nerve growth factor nerve conduit, and is prepared by the steps of: preparing a uniformly dispersed electropolarized beta-tricalcium phosphate and polylactic acid core material by using polylactic acid as a substrate material and adding the electropolarized beta-tricalcium phosphate; and preparing a three-dimensional bionic electropolarized gradient pore nerve conduit with component and pore structure double gradient by attaching the hyaluronic acid, the chitosan and the nerve growth factor to the surface of the core material by virtue of electrostatic self-assembly and coupling crosslinking, wherein the length is between 10 and 100mm, the inner diameter is between 1 and 6mm, the wall thickness is between 0.5 and 2mm, and the outer tube wall is of a three-dimensional network structure. The nerve conduit is applied to repairing of a peripheral nervous system, induction of peripheral nerve regeneration and in-vitro culture of nerve cells in tissue engineering. The three-dimensional bionic electropolarized gradient pore nerve conduit has the advantages of simple preparation method, low cost, environmental friendliness and high economical benefit, and is applicable to industrial production.

In the invention, biological glass powder (weight percentage is 5-15) is added in oxhydryl kietyoite powder to be formed by dry pressing on pressure 10-30 Mpa, then to be fired in temp. 1050-1250 deg.C to produce compound biological ceramics of oxhydryl kietyoite and beta-tricalcium phosphate that content can be controlled.

The invention discloses a preparation method of calcium phosphate nanopowder with a controllable length-to-diameter ratio and calcium-to-phosphorus ratio. The method comprises the step: carrying out areaction by mixing phosphate or phosphoric acid with a calcium salt to prepare the calcium phosphate nanopowder, wherein the one-dimensional size of a calcium phosphate nanoparticle can be regulatedto be 50nm-5mu m and the length-to-diameter ratio can be regulated to be 2-50 by adding a pH regulator into a reactant, components and proportions of the calcium phosphate nanopowder serving as a product can be regulated by controlling the feeding ratio of the phosphate or phosphoric acid to the calcium salt to be 1.5-1.67, and the calcium phosphate nanopowder is beta-tricalcium phosphate and/or hydroxyapatite. According to the method disclosed by the invention, the length-to-diameter ratio of the product is regulated by controlling the proportion of weak bases and relatively strong bases in the pH regulator; the calcium-to-phosphorus ratio of the product is controlled by changing the feeding ratio of a calcium source to a phosphorus source; a supergravity technology is combined to enhancea micromixing effect, so that the calcium phosphate nanopowder is prepared; and the preparation method is low in production cost, simple in operation, good in repeatability, better in application performance and wider in application range.

The invention relates to a graphene-modified biological ceramic support material and a preparing method and application thereof. The graphene-modified biological ceramic support material comprises a beta-tricalcium phosphate support and a graphene layer with which the surface of the beta-tricalcium phosphate support is evenly covered. The graphene-modified biological ceramic support material has the quite good anti-tumor capacity and the osteogenesis promoting characteristic, and can serve as a repairing material for excising bone tumor; meanwhile, the photo-thermal performance of the graphene-modified biological ceramic support material is used, residual tumor cells are killed, and the dual effects of treating and repairing are achieved.

The medical composite beta-tricalcium phosphate/collagen material consists of nano level beta-tricalcium phosphate in 50-67 wt% and collagen 33-50 wt%. Through in-situ complexing of collagen and beta-tricalcium phosphate, nanometer level beta-tricalcium phosphate powder is deposited on collagen substrate, and under the action of glutaraldehyde, the composite material has raised mechanical strength. The composite beta-tricalcium phosphate/collagen material of the present invention has homogeneous components, close combination, excellent biocompatibility, proper pore size and other features, and is suitable for use as the medical bone repairing material.

The invention discloses a composite biological active ceramic material of Apatite-Wollastonite/beta-tricalcium phosphate (AW/beta-TCP), which comprises the following steps: adopting sol-gel process to prepare AW former powder; preparing TCP former powder through chemical sediment method; sieving TCP former powder through 60-order standard sieve; putting AW former powder and TCP former particle in the material mixing machine according to different proportion; adding certain rate corresponding to powder weight geoceric acid or naphthalene particle with grain size at 20-30 order; making 5wt% polyvinyl alcohol solution as adhesive; blending completely; moulding; drying; sintering to obtain porous product.

The present invention discloses a method for preparation of a controlled pore size biphasic calcium phosphate composite ceramic scaffold. Firstly, nano-hydroxyapatite and nano-beta-tricalcium phosphate powder are prepared, the nano powder and a surfactant and a pore-forming agent are uniformly mixed, ground and sieved, added dropwise with a foaming agent solution, stirred into stick viscous slurry, and dried in air at room temperature to obtain a ceramic blank, the ceramic blank is foamed at a certain temperature and dehydrated, and sintered at high temperature, and after removal of the surfactant, the pore-forming agent and the foaming agent, the porous biphasic calcium phosphate ceramic composite scaffold can be obtained. The method is simple in process and strongly practical, by regulating of the use amount of the surfactant, the pore-forming agent and the foaming agent, the porous biphasic calcium phosphate ceramic composite scaffold can be controlled in pore size, even in distribution, and conductive to the practical application in biological medicines.

The invention relates to an injection organism repair material and relative production. Wherein, it comprises carrier support and seed cell adhered on the carrier support to form skeleton three-dimension structure and biological active composite; and it uses the injection chitose-beta-tricalcium phosphate composite as carrier support to couple seed cell; the seed cell is bone marrow substrate stem cell. The test has proved that the chitose-beta-tricalcium phosphate composite has better compatibility with BMSCs.

The invention discloses a method for manufacturing biological bone wires useable for FDM (frequency-division multiplexing) 3D (three-dimensional) printer models.The method includes weighing, by weight, 10-90% of PLA (polylactic acid) and 90-10% of hydroxyapatite and beta-tricalcium phosphate; ultrasonically dispersing artificial bone induction and repair substrates by the aid of solvents to obtain dispersion liquid A; dissolving a binder into the dispersion liquid A by the aid of mechanical stirring processes so as to obtain mixtures B; drying the mixtures B and removing redundant solvents to obtain mixtures B for blocks; extruding the mixtures B for the blocks by the aid of double-screw extruders to obtain wires with the diameters of 1.75 millimeters.The PLA is used as the binder, and the hydroxyapatite and the beta-tricalcium phosphate are used as the artificial bone induction and repair substrates.The wires with the diameters of 1.75 millimeters are the biological bone wires.The method has the advantages that the biological bone wires manufactured by the aid of the method are combined with desktop machines and can be used for directly printing absorbable bone repair models, accordingly, the biological printing ranges can be greatly expanded, and biological printing access threshold can be lowered.