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Graphene-modified biological ceramic support material and preparing method and application thereof

A technology of bioceramics and scaffold materials, applied in wave energy or particle radiation treatment materials, medical preparations containing active ingredients, pharmaceutical formulas, etc., to achieve good anti-tumor ability, promote osteogenesis, and good repeatability

Inactive Publication Date: 2016-11-23
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, how to develop biomaterials with both bone repair and antitumor capabilities remains a major challenge

Method used

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  • Graphene-modified biological ceramic support material and preparing method and application thereof
  • Graphene-modified biological ceramic support material and preparing method and application thereof
  • Graphene-modified biological ceramic support material and preparing method and application thereof

Examples

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example 1

[0059] (1) 4.5g of pure β-tricalcium phosphate powder, after fully mixing with 3g of PVA, use three-dimensional printing technology to prepare scaffold materials;

[0060] (2) Calcining the printed scaffold at 1100°C for 3 hours to obtain pure β-tricalcium phosphate ceramics;

[0061] (3) Soak the pure β-tricalcium phosphate scaffold in 1 mg / mL graphene for 10 min, and coat it 3 times;

[0062] (4) drying in an oven at 120°C to obtain β-TCP-GRA;

[0063] Then the evaluation of biological activity, osteogenicity and antitumor activity was carried out by the above-mentioned methods.

example 2

[0065] (1) 4.5g of pure β-tricalcium phosphate powder, after fully mixing with 2g of PVA, use three-dimensional printing technology to prepare scaffold materials;

[0066] (2) Calcining the printed scaffold at 1150°C for 3 hours to obtain pure β-tricalcium phosphate ceramics;

[0067] (3) soak the pure β-tricalcium phosphate scaffold in 0.5 mg / mL graphene for 10 min, and coat it 6 times;

[0068] (4) Dry in an oven at 120°C to obtain β-TCP-GRA; for the structural characterization results, see figure 1 ;

[0069] Then use the above method to evaluate biological activity, degradability and cytocompatibility, the results can be found in Figure 2 to Figure 7 .

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Abstract

The invention relates to a graphene-modified biological ceramic support material and a preparing method and application thereof. The graphene-modified biological ceramic support material comprises a beta-tricalcium phosphate support and a graphene layer with which the surface of the beta-tricalcium phosphate support is evenly covered. The graphene-modified biological ceramic support material has the quite good anti-tumor capacity and the osteogenesis promoting characteristic, and can serve as a repairing material for excising bone tumor; meanwhile, the photo-thermal performance of the graphene-modified biological ceramic support material is used, residual tumor cells are killed, and the dual effects of treating and repairing are achieved.

Description

technical field [0001] The invention relates to a graphene-modified bioceramic support, a preparation method and application thereof, and belongs to the field of biomaterials. Background technique [0002] Cancer is one of the greatest threats to human health in the new century. The special microenvironment of bone can easily cause other cancers to metastasize to bone, and breast cancer, prostate cancer, and lung cancer can easily metastasize to bone[1]. Therefore, the treatment of bone cancer has also received great attention. At present, the most commonly used method is the combination of chemotherapy and surgery, through the resection of tumor lesions, and then the use of bone graft materials to repair the damage [2]. However, surgical treatment is usually unable to cure advanced patients with metastatic tumors, and radiotherapy and chemotherapy will cause serious side effects to patients [3]. Photothermal therapy has received widespread attention as a relatively safe ...

Claims

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Application Information

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IPC IPC(8): A61L27/12A61L27/08A61L27/54A61K41/00A61P35/00
Inventor 吴成铁马红石常江
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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