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Preparation method of calcium phosphate nanopowder with controllable length-to-diameter ratio and calcium-to-phosphorus ratio

A nano-powder and calcium phosphate technology, which is applied in the field of calcium phosphate materials and its preparation, can solve problems such as limited application, serious product agglomeration, and poor economy, and achieve improved conversion rate and selectivity, efficient control of nucleation process, The effect of reducing size and weight

Active Publication Date: 2018-01-09
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main defect of this kind of preparation method is that the product is seriously agglomerated, the particle size is large, and the calcium-phosphorus ratio and aspect ratio of the product cannot be controlled at the same time, which limits its application in the field of biomedical materials.
And additional materials such as other surfactants and crystal form regulators need to be added, which increases its preparation cost and is economical. At the same time, other substances will be introduced to affect its application performance

Method used

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  • Preparation method of calcium phosphate nanopowder with controllable length-to-diameter ratio and calcium-to-phosphorus ratio
  • Preparation method of calcium phosphate nanopowder with controllable length-to-diameter ratio and calcium-to-phosphorus ratio
  • Preparation method of calcium phosphate nanopowder with controllable length-to-diameter ratio and calcium-to-phosphorus ratio

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] 1) Dissolve 4.72g of calcium nitrate tetrahydrate in 100ml of deionized water to prepare an aqueous solution of calcium nitrate, add 6g of urea to 20ml of deionized water to prepare a 5mol / L urea solution, prepare a 5mol / L ammonia solution, and add 2ml of the prepared ammonia solution is used as raw material A.

[0065] 2) Dissolve 1.584g of diammonium hydrogen phosphate in 60ml of water to prepare an aqueous solution of diammonium hydrogen phosphate, so that the ratio of calcium to phosphorus is 1.67, as raw material B.

[0066]3) Turn on the supergravity rotation device and adjust the rotation speed to 2500rpm;

[0067] 4) Turn on the peristaltic pump, control the flow rate to be 0.2L / min and 0.12L / min respectively, and feed the two raw materials A and B into the high-gravity rotating bed by using the peristaltic pump, and keep the calcium-phosphorus ratio at 1.67 at the two feeding rates. Control the temperature of the reaction system at 25° C. to carry out the reac...

Embodiment 2

[0074] 1) Dissolve 4.72g of calcium nitrate tetrahydrate in 100ml of deionized water to prepare an aqueous solution of calcium nitrate, add 6g of urea to 20ml of deionized water to prepare a 5mol / L urea solution, prepare a 5mol / L ammonia solution, and add 1.5ml of prepared ammonia solution and 0.5ml of urea solution are used as raw material A.

[0075] 2) Dissolve 1.584g of diammonium hydrogen phosphate in 60ml of water to prepare an aqueous solution of diammonium hydrogen phosphate, so that the ratio of calcium to phosphorus is 1.67, as raw material B.

[0076] 3) Turn on the supergravity rotation device and adjust the rotation speed to 2500rpm;

[0077] 4) Turn on the peristaltic pump, control the flow rate to be 0.2L / min and 0.12L / min respectively, and feed the two raw materials A and B into the high-gravity rotating bed by using the peristaltic pump, and keep the calcium-phosphorus ratio at 1.67 at the two feeding rates. Control the temperature of the reaction system at 2...

Embodiment 3

[0083] 1) Dissolve 4.72g of calcium nitrate tetrahydrate in 100ml of deionized water to prepare an aqueous solution of calcium nitrate, add 6g of urea to 20ml of deionized water to prepare a 5mol / L urea solution, prepare a 5mol / L ammonia solution, and add 1ml of prepared ammonia solution and 1ml of prepared urea solution are used as raw material A.

[0084] 2) Dissolve 1.584g of diammonium hydrogen phosphate in 60ml of water to prepare an aqueous solution of diammonium hydrogen phosphate, so that the ratio of calcium to phosphorus is 1.67, as raw material B.

[0085] 3) Turn on the supergravity rotation device and adjust the rotation speed to 2500rpm;

[0086] 4) Turn on the peristaltic pump, control the flow rate to be 0.2L / min and 0.12L / min respectively, and feed the two raw materials A and B into the high-gravity rotating bed by using the peristaltic pump, and keep the calcium-phosphorus ratio at 1.67 at the two feeding rates. Control the temperature of the reaction system...

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Abstract

The invention discloses a preparation method of calcium phosphate nanopowder with a controllable length-to-diameter ratio and calcium-to-phosphorus ratio. The method comprises the step: carrying out areaction by mixing phosphate or phosphoric acid with a calcium salt to prepare the calcium phosphate nanopowder, wherein the one-dimensional size of a calcium phosphate nanoparticle can be regulatedto be 50nm-5mu m and the length-to-diameter ratio can be regulated to be 2-50 by adding a pH regulator into a reactant, components and proportions of the calcium phosphate nanopowder serving as a product can be regulated by controlling the feeding ratio of the phosphate or phosphoric acid to the calcium salt to be 1.5-1.67, and the calcium phosphate nanopowder is beta-tricalcium phosphate and / or hydroxyapatite. According to the method disclosed by the invention, the length-to-diameter ratio of the product is regulated by controlling the proportion of weak bases and relatively strong bases in the pH regulator; the calcium-to-phosphorus ratio of the product is controlled by changing the feeding ratio of a calcium source to a phosphorus source; a supergravity technology is combined to enhancea micromixing effect, so that the calcium phosphate nanopowder is prepared; and the preparation method is low in production cost, simple in operation, good in repeatability, better in application performance and wider in application range.

Description

technical field [0001] The invention relates to the field of calcium phosphate materials and their preparation. More specifically, it relates to a preparation method of calcium phosphate nanopowder with controllable aspect ratio and calcium-phosphorus ratio. Background technique [0002] Calcium phosphate biomaterial is a kind of biological material that can produce structural or material decay in a physiological environment, and its products are absorbed and utilized by the body or excreted through the circulatory system, undergo biodegradation, and simultaneously fulfill specific functional requirements. It has good biocompatibility, biodegradability, no toxic side effects, harmless to human body, etc. These excellent properties make it widely used. [0003] As we all know, the excellent properties of many nanomaterials depend on the particle size, preparation process and other factors of nanomaterials. Current research focuses on controlling crystal size, morphology, an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B25/32B82Y30/00B82Y40/00
Inventor 王洁欣吕博杨乐园曾晓飞陈建峰
Owner BEIJING UNIV OF CHEM TECH
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