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Medical polycaprolactone membrane as well as preparation method and application of medical polycaprolactone membrane

A polycaprolactone and membrane technology, which is used in medical science, prosthesis, etc., to prevent the growth of surrounding muscle fibers, increase the contact area, and reduce the residence time.

Inactive Publication Date: 2015-07-08
SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Using 3D printing fusion rapid prototyping technology to prepare guided bone regeneration membrane has not been reported yet

Method used

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  • Medical polycaprolactone membrane as well as preparation method and application of medical polycaprolactone membrane
  • Medical polycaprolactone membrane as well as preparation method and application of medical polycaprolactone membrane
  • Medical polycaprolactone membrane as well as preparation method and application of medical polycaprolactone membrane

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Embodiment 1

[0031] The medical polycaprolactone diaphragm related to the first embodiment of the present invention, its microscopic display diagram is as attached figure 1 shown. The composition of the medical polycaprolactone diaphragm is polycaprolactone, and the thickness of the diaphragm is 0.6 mm. In addition, the medical polycaprolactone diaphragm has a planar network structure, and the meshes of the planar network structure are evenly distributed. The mesh shape of the planar network structure in this embodiment is a square, and the side length of the square is 200 microns.

Embodiment 2

[0033] The medical polycaprolactone diaphragm related to the second embodiment of the present invention has a microscopic display as shown in the attached figure 2 As shown, in terms of mass percentage, the composition of the medical polycaprolactone diaphragm is 80% polycaprolactone and 20% BETA-tricalcium phosphate, and the thickness of the medical polycaprolactone diaphragm is 2 mm, the medical polycaprolactone diaphragm is a planar mesh structure, and the mesh of the planar mesh structure is evenly distributed, the shape of the mesh of the planar mesh structure in the present embodiment is rhombus, and the side length of the rhombus is 100 Microns.

Embodiment 3

[0035] The medical polycaprolactone diaphragm related to the third embodiment of the present invention, its microscopic display is as shown in the attached image 3 shown. In terms of mass percentage, the composition of the medical polycaprolactone diaphragm is 90% polycaprolactone and 10% hydroxyapatite, and the thickness of the medical polycaprolactone diaphragm is 1 mm. The medical polycaprolactone diaphragm is a planar network structure, and the meshes of the planar network structure are evenly distributed. The shape of the meshes of the planar network structure in this embodiment is a rectangle, and the length of the rectangle is 200 microns, and the width is 150 microns. Microns.

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Abstract

The invention relates to the technical field of medical high polymer materials and discloses a medical polycaprolactone membrane as well as a preparation method and an application of the medical polycaprolactone membrane. The constituents of the membrane include polycaprolactone; the membrane is 0.5-2mm thick; and the membrane is of a planar mesh structure and the mesh aperture of the planar mesh structure is 100-300 microns. Besides, composite additive materials, such as BETA-tricalcium phosphate, hydroxylapatite and coral, also can be added to the membrane. The invention also provides a method for preparing the medical polycaprolactone membrane by use of the 3D printing technology; the membrane is applicable to the field of bone tissue engineering; and the medical polycaprolactone membrane is used for covering a bone defect part and then repairing the bone defect, and therefore, the effects of surrounding and protecting the bone defect part, reducing stem cell loss, preventing surrounding fiber tissue ingrowth and guiding bone regeneration can be achieved.

Description

technical field [0001] The invention relates to the technical field of medical polymer materials, in particular to a medical polycaprolactone diaphragm and its preparation method and application. Background technique [0002] Bone damage and bone defects caused by tumors, inflammation, and trauma are usually treated by surgically implanting artificial substitutes. However, because the growth rate of fibroblasts around the injury site is faster than the crawling and replacement speed of bone cells in the injury site, and the inflammatory response at the injury site exists, connective tissue occupies the bone defect repair site and hinders the growth and formation of new bone, resulting in uneven repair effects. together. [0003] Guided Bone Regeneration (Guided Bone Regeneration) is a technology that uses a membrane to form a space between soft tissue and bone tissue, thereby blocking the space occupied by fibroblasts and providing space for bone cells to crawl and repair t...

Claims

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Application Information

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IPC IPC(8): A61L27/50A61L27/18
Inventor 汪振星张智勇吴鼎宇张占召李昱王进兵周权金鑫谢慧周广东张文杰刘伟曹谊林
Owner SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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