54results about How to "Prevent ingrown" patented technology

The invention provides a drug-loading type guided tissue regeneration membrane and preparation method thereof. Polycaprolactone and other biodegradable aliphatic polyesters are used as raw materials and added with an antibacterial drug, and the materials are prepared into a single-layer guided tissue regeneration membrane through an electrospinning method. Or, polycaprolactone and degradable aliphatic polyester material are used as a dense layer, degradable natural polymer material and bio active particles are used as a loose layer, and an antibacterial drug is added to the dense layer; and the layers are prepared into a double-layer guided tissue regeneration membrane with different pore structures and biological activity through a layer by layer electrostatic spinning method. The membrane material provided by the invention has excellent biocompatibility, mechanical properties and degradation property consistent with tissue repair process, can effectively prevent the growth of fibroblasts towards tissue defects, at the same time promote the regeneration repair of tissue, does not have to taken out through a secondary operation; and the membrane material can effectively inhibit bacteria infection and inflammation after the operation, can be widely used in medical fields, such as guided tissue regeneration, postoperative adhesion prevention and drug delivery membrane.

The invention relates to a preparation method of an oral biofilm. The preparation method comprises the following steps: adding type I collagen protein into an acetic acid solution to prepare a collagen-acetic acid swelling solution; adding chondroitin sulfate and stirring to prepare a collagen-chondroitin sulfate serous fluid; carrying out vacuum freeze-drying; pressing to prepare a collagen composite film; spraying the collagen-chondroitin sulfate serous fluid between two layers of the collagen composite film, and carrying out vacuum freeze-drying; carrying out high temperature vacuum crosslinking; and sterilizing after crosslinking to obtain a collagen-chondroitin sulfate composite oral biofilm. The invention has the following beneficial effects: the oral biofilm prepared by the above method has good histocompatibility, suitable controllable degradability and absorbability, low antigenicity and good plasticity and mechanical property; the oral biofilm is used in oral operation; and the three-dimensional porous structure of the oral film provides a tissue engineering scaffold for repairing of wounded tissues, is beneficial to invasion of cells and differential growth and can induce reparative regeneration of defective tissues, and specific thickness of the biofilm can effectively prevent ingrowth of soft tissue.

Collagen and hyaluronic acid or its sodium salt as main material are prepared into double layer composite material with compact layer and loose layer. The mass composition of the compact layer includes malonic acid swelling solution in 0.6-0.8 wt%; and the mass composition of the loose layer includes malonic acid swelling solution in 0.2-0.4 wt% and hyaluronic acid or its sodium salt in 5-20 wt% of dry collagen. The present invention has loose structure in one side and compact structure in the other side, and thus excellent biocompatibility capable of resisting the growth of fibroblast and other cell to the damaged part while promoting the regeneration and repairing of tissue in the damaged part. The double layer composite material has corresponding biodegrading function and may be degraded and absorbed without needing secondary operation to take out the implanted material. The present invention is suitable for repairing tissue damage.

The invention discloses a 3D printed digital artificial bone. The artificial bone consists of a cortical bone, a cancellous bone and a marrow cavity, wherein the cortical bone is composed of poly-L-lactic acid or polyester-ester-ketone; the cancellous bone is formed by mixing poly-L-lactic acid and hydroxyapatite; the molecular weight of the poly-L-lactic acid of which the cortical bone is composed higher than that of which the cancellous bone composed; the cortical bone and the cancellous bone are simultaneously prepared by a 3D printing technology. The invention also discloses a 3D printing method for the digital artificial bone. According to the artificial bone disclosed by the invention, in micrometer and millimeter scales, the porosity of the cortical bone is 10 percent; the porosity of the cancellous bone is 60-80 percent, and the pore size of the cancellous bone is 120-220 micrometers. The 3D printed digital artificial bone has the porosity, the pore size and the mechanical property as those of a bone structure of human beings.

A bone tissue regeneration guiding membrane. The invention employs an antigen-extracted mammal tissue membrane, which has a double layer structure of a compact layer and a loosening layer. The compact layer is formed by tightly arranged collagen fibers, and an external side of the compact layer is composited with a collagen coating containing active polypeptides; the loosening layer is formed by interlaced collagen fibers and is composited with ossification active factors. The prepared guiding membrane can prevent soft tissue from evolving and promote new bone formation, has good biological compatibility, hydrophilism and bone induction capability, and can be completely degraded in body without generation of harmful substances. Besides, the guiding membrane has an effect of isolating cell evolving, a characteristic of slow degradation and a longer retaining time in body than a current guiding membrane prepared from natural high-molecular polymer, and can provide enough time and space for new bone growth. The method of the invention is simple, and raw materials have wide sources and low prices, so that the method is suitable for large-scale industrial production and beneficial to lowering medical costs and mitigating patient burdens.

The invention discloses an oral implant with appropriate initial-stage load stimulation. The oral implant is designed into an integrated structure and is divided into a gingival penetration section, a cortical bone fixing section, a spongy bone fixing section and a lead-in fixing section from top to bottom, wherein the center of the oral implant is a composite cavity; the outer surface of the cortical bone fixing section is provided with growing grooves which are staggered longitudinally and transversely; and the lead-in fixing section is 1 / 3 of a segment, and a cross groove is formed at the bottom of the lead-in fixing section. After the implant disclosed by the invention is implanted, an appropriate stress environment is generated in an alveolar ridge crest region, thereby effectively avoiding bone injury and bone absorption, and being favorable for exciting bone remodeling and promoting bone integration. In addition, the growing grooves which are staggered longitudinally and transversely can induce the growth of new bones to form a stable mechanical mosaic structure, thereby being suitable for complex oral occlusion mechanical environments.

The invention relates to a biological membrane stent material with gradient degradation effect and a preparation method thereof. The biological membrane stent material is provided with an inner layer,a middle layer and an outer layer which are mutually combined, wherein the inner layer is an electrospinning fiber membrane and is prepared by mixing composite polyurethane of polyoxyethylene and nanometer hydroxyapatite into medical polyurethane material, the mass of the composite polyurethane is equal to 2.5 to 10wt% of the mass of the medical polyurethane material, and the mass of the nanometer hydroxyapatite is equal to 0 to 60wt% of the mass of the stent material; the middle layer is coated to the surface of the inner surface, and is a mixed electrospinning fiber membrane, and the mixedelectrospinning fiber membrane is formed by weaving the electrospinning fiber of polycaprolactone containing 0.2 to 0.5wt% of calcium salt component and the electrospinning fiber of composite polyurethane; the outer layer is coated to the surface of the middle layer, and is an electrospinning fiber membrane which is formed by the polycaprolactone containing 0.2 to 0.5wt% of calcium salt component.The biological membrane stent material has the advantages that the functions of the natural biological membrane can be simulated to promote the tissue regeneration, and the biological membrane stentmaterial can be widely applied to the fields and industries of biology and medicines.

The invention discloses a cervical vertebra uncovertebral joint fusion cage which comprises uncovertebral joint fusion components and a vertebrae inter elastic supporting body. The cross section of the vertebrae inter elastic supporting body is trapezoidal, and the front end of the vertebrae inter elastic supporting body is a small end. The two uncovertebral joint fusion components are connected to two waist outer side surfaces of the vertebrae inter elastic supporting body respectively and are of a cylindrical mesh structure, and baffles are connected to the side faces, away from the vertebrae inter elastic supporting body, of the uncovertebral joint fusion components. The cervical vertebra uncovertebral joint fusion cage can reduce cost, the fusion time is short, the wearing time of a neck collar is shortened, the comfort level of a patient is improved, an end plate does not need to be ground, the surgical time is shortened, and the sinking risk of prostheses after an operation is reduced.

The invention relates to a PEEK alveolar bone repairing material and an individualization producing method, and belongs to the field of polymer materials and biological medicine engineering. The PEEKalveolar bone repairing material is a polymer material which is composed of an outer compact layer and an inner loose layer, the compact layer can prevent peripheral soft tissues from growing into a bone defect area to form fibrous connective tissues, a bottom loose layer is provided with a through sponge porous structure, the hole structure gradually becomes larger from outside to inside, and thestructure can absorb and release active substances sustainably to promote the growth of bone tissues. A 3D printing technology is adopted by the material to form a repairing material which is highlymatched with the height of an alveolar bone. The PEEK alveolar bone repairing material has the advantages that the PEEK alveolar bone repairing material has better biological compatibility, the PEEK alveolar bone repairing material does not easily drop in the using process, can adapt to cold and hot environments in an oral cavity and can be individually produced according to the demands of a patient, the surgical operation time is greatly shortened, and the PEEK alveolar bone repairing material has good application prospects in alveolar bone regeneration of the department of stomatology.

The invention discloses a complex type tissue engineering nerve damage renovation material, which comprises type I collagen, heparitin sulfate, type IV collagen and gelatin. The material has simple adjusting inner diameter and uniform single orientation axial bore, it is easy to be made into different external forms, e.g. cylinder or rectangle.

The invention relates to the technical field of bone tissue engineering, and discloses a step-by-step tissue engineering bone building method. The method comprises the following steps of: (1) stent repair and pre-vascularization: building a tissue engineering bone sent at a bone defect part, and performing pre-vascularization; (2) later embedding of bone tissue engineering seed cells: after inflammatory reaction stage, embedding the seed cells, subjected to osteogenic induction, into the tissue engineering bone sent at the bone defect part based on growth-in time of capillaries, wherein the later embedding of bone tissue engineering seed cells in the step (2) is carried out 7-14 days later after the stent repair and pre-vascularization in the step (1). In the method provided by the invention, the sent promoting growth of vessels is firstly embedded, the seed cells for osteogenesis are embedded later, thus, a great segment of tissue engineering bone can be built quickly, application amount of the bone tissue engineering seed cells needed for repairing per unit volume of bone tissue is reduced greatly, and utilization rate of the seed cells is improved.

The invention relates to a bionic type artificial intervertebral disc and a forming method thereof. The bionic type artificial intervertebral disc is composed of an upper rigid end plate, a lower rigid end plate, an elastic nucleus pulposus arranged between the upper rigid end plate and the lower rigid end plate and a film body arranged at the outer side of the elastic nucleus pulposus; the elastic nucleus pulposus is constituted by adopting two or more polyurethane materials with different elasticity moduli, and the polyurethane materials with the different elasticity moduli are integrally connected. When the bionic type artificial intervertebral disc is molded, the center of the nucleus pulposus is firstly formed to connect the upper rigid end plate-polyurethane material workpiece and the lower rigid end plate-polyurethane material workpiece, and then the outer side is injected with the polyurethane materials. The bionic type artificial intervertebral disc is of an integral structure, and when the bionic type artificial intervertebral disc is loaded, through elastic deformation of the elastic nucleus pulposus, physiological activities of the artificial intervertebral disc in all directions are achieved.

The invention relates to a functional integrated absorbable guided tissue regeneration membrane and a preparation method thereof. The regenerated membrane comprises a degradable artificially synthesized high-molecular material, a natural degradable high-molecular polymer and inorganic nanoparticles. The method comprises the following steps: dissolving the degradable artificially synthesized high-molecular material and the natural degradable high-molecular polymer in an organic solvent, stirring, adding inorganic nanoparticles, stirring, carrying out ultrasonic treatment, and carrying out electrostatic spinning. The regeneration membrane has good mechanical properties, biocompatibility, antibacterial property and osteogenic activity, and also has an obvious periodontal repair effect. The method has the advantages of wide material sources and low preparation cost, and has potential clinical application prospects.

The invention relates to an interface-friction-free artificial intervertebral disc and a forming method thereof. The interface-friction-free artificial intervertebral disc is composed of an upper rigid end plate, a lower rigid end plate, an elastic nucleus pulposus arranged between the upper rigid end plate and the lower rigid end plate and a membrane arranged on the outer side of the elastic nucleus pulposus. The elastic nucleus pulposus is made from two or more polyurethane materials different in elasticity modulus, and the polyurethane materials different in elasticity modulus are connected together. During forming, an upper rigid end plate-polyurethane material workpiece, a lower rigid end plate-polyurethane material workpiece are prepared firstly, and finally the middle is filled with the polyurethane material low in elasticity modulus to achieve connection of the upper and lower workpieces. The interface-friction-free artificial intervertebral disc is of an integrated structure and achieves physiological activities in all directions through elastic deformation of the elastic nucleus pulposus when being subject to a load.

The invention discloses a multilayer gradient biofilm and a preparation method thereof. The biofilm is prepared by electrospinning and then processes such as drying, cross-linking, and sterilization.The nanofiber biofilm has a gradient change in composition and structure, and the biofilm having a gradient structure is constructed by changing the ratio of gelatin to polycaprolactone. The mechanical properties and degradation behavior can be controlled, and the upper and lower layers of the biofilm are provided with the function of synchronously guiding soft and hard tissue regeneration. The gradient biofilm has controllable mechanical properties, degradation behavior and good biocompatibility, can simultaneously induce soft and hard tissue regeneration, and has application prospects in guiding tissue regeneration.

The invention discloses a composite membrane for guided bone regeneration and a preparation method of the composite membrane. The preparation method of the composite membrane includes the operation steps: treating pig jejuna by a mechanical method to obtain small intestinal submucosa; performing multilayer horizontal-vertical overlapping after processes such as acid, decontaminant and alkali treatment to obtain a compact layer; uniformly spinning prepared collagen solution on the compact layer by an electrospinning technique, and performing compounding and vacuum freeze-drying to obtain the composite membrane. The composite membrane prepared by the method has excellent biocompatibility and bioactivity and is easily absorbed by tissues, the compact layer in a structure can selectively stopsoft tissues from growing into a bone defect area, a loose layer is of a loose porous structure and large in specific surface area by the aid of the electrospinning technique, combination of two membranes, cell adhesion and growing into pores are facilitated, new tissue regeneration can be supported by the aid of bioactive factors or medicines, and wound healing is promoted. By combination, the composite membrane achieves excellent mechanical performance and can keep a regeneration space stable within a certain time.

The invention provides a tissue engineering biological stent system for regenerating complete intervertebral disks. The system comprises a nucleus pulposus stent, an annulus fibrosus stent, end platestents and a peripheral elastic support ring; the nucleus pulposus stent is located at the center of the whole biological stent system, the annulus fibrosus stent is circumferentially arranged aroundthe nucleus nucleus stent, the end plate stents are arranged in the axial direction of the annulus fibrosus stent and cover the two ends of the annulus fibrosus stent, and the peripheral elastic support ring circumferentially wraps the annulus fibrosus stent and the end plate stents; the nucleus pulposus stent is made of biodegradable hydrogel; the annulus fibrosus stent is of a multi-layer structure formed by coaxially winding biodegradable elastic membranes; the end plate stents are made of a biodegradable porous material; the peripheral elastic support ring is a biodegradable non-porous elastic ring. The invention further provides a complete biological artificial intervertebral disk regenerated based on the biological stent system and a preparation method thereof. The biological artificial intervertebral disk has a complete mammalian intervertebral disk structure and has biomechanical properties close to those of a natural intervertebral disk.

The invention specifically relates to a base station component for an individualized implant. The mounting in the manner of adopting an external octagon of a subperiosteal implant for connecting the individualized implant is limited. The base station component comprises a base station main body and a central fixing bolt; an internal octagonal counter bore is formed in a lower end face of the base station main body; a through hole and a stepped hole are formed at the center of the base station main body; the through hole, the stepped hole and the internal octagonal counter bore are communicated with each other. In a mounting process, after the internal octagonal counter bore is nested and fixed with an external octagonal prism arranged at the center of a neck platform of the individualized implant, the central fixing bolt passes through the through hole, the stepped hole and the internal octagonal counter bore in the base station, the lower part of a screw rod is screwed into alveolar bone and is fixedly connected with the alveolar bone and the upper part of the screw rod is screwed into the neck platform of the individualized implant. Due to the dual fixing of the central fixing bolt and the implant as well as the alveolar bone, the connecting strength between the base station and the implant as well as the alveolar bone is increased, the connecting stability is increased, the positioning and anti-rotating properties of the implant are better and bacteria growth is prevented so that the postoperative complication can be effectively reduced.

The invention discloses bone regeneration guiding collagen membrane for dental use and a preparation method thereof, and belongs to the technical field of regenerative medical materials. The preparation method of the bone regeneration guiding collagen membrane for dental use comprises the following steps: S1, preparing a raw material and carrying out pretreatment, including: S1-1, dissolving type-I collagen in an acidic solvent and carrying out homogenization so as to obtain collagen slurry, S1-2, filtering the collagen slurry, and S1-3, performing negative-pressure pumping on the collagen slurry filtered in S1-2 until no obvious bubbles exist; S2, carrying out freeze-drying, namely freeze-drying the collagen slurry prepared in S1 so as to obtain collagen sponge; S3, pressing the collagensponge into a thin piece, namely pressing the collagen sponge into a thin piece under a pressure of 1-5 MPa; and S4, performing severe dehydration and cross-linking on the thin piece in vacuum so as to obtain the bone regeneration guiding collagen membrane for dental use, and carrying out sterilizing and storing. The bone regeneration guiding collagen membrane for dental use disclosed by the invention can be used to stop bleeding and guide bone regeneration after dental implantation, and has the advantages of being low in immunogenicity, excellent in biocompatibility and capable of effectivelypromoting bone regeneration. Moreover, the preparation method of the bone regeneration guiding collagen membrane for dental use has the advantages of being efficient and easy in operation, non-toxicand harmless.

The invention relates to a preparation method of an oral biofilm. The preparation method comprises the following steps: adding type I collagen protein into an acetic acid solution to prepare a collagen-acetic acid swelling solution; adding chondroitin sulfate and stirring to prepare a collagen-chondroitin sulfate serous fluid; carrying out vacuum freeze-drying; pressing to prepare a collagen composite film; spraying the collagen-chondroitin sulfate serous fluid between two layers of the collagen composite film, and carrying out vacuum freeze-drying; carrying out high temperature vacuum crosslinking; and sterilizing after crosslinking to obtain a collagen-chondroitin sulfate composite oral biofilm. The invention has the following beneficial effects: the oral biofilm prepared by the above method has good histocompatibility, suitable controllable degradability and absorbability, low antigenicity and good plasticity and mechanical property; the oral biofilm is used in oral operation; and the three-dimensional porous structure of the oral film provides a tissue engineering scaffold for repairing of wounded tissues, is beneficial to invasion of cells and differential growth and can induce reparative regeneration of defective tissues, and specific thickness of the biofilm can effectively prevent ingrowth of soft tissue.

The invention relates to a bone rehabilitating material and a preparation method of the material. The invention provides a bone rehabilitating material, the effective components of which are prepared by the following weights and portions of raw materials: 40 of a PLGA; 20 to 80 of a semi-hydrated calcium sulphate; 2 to 8 of a rifampicin. The invention also provides the preparation method of the bone rehabilitating material. The invention mixes and solidifies the semi-hydrated calcium sulphate, the PLGA, the rifampicin and a sodium chloride granule and digests the sodium chloride granule to make a novel multi-hole bone rehabilitating material with a function of anti-bacillus tuberculosis.

The invention discloses a reducible uterine tube umbrella mouth implanted type combined birth control device and belongs to the technical field of uterine tube blockage. The device has a key technical point that the device mainly comprises a sack body, wherein one side of the sack body is communicated with a water injection valve through a pipeline and the other side of the sack body is connected with a solid metal needle through a traction fixing thread. The device is simple in structure, convenient in installation and use, ideal in birth control effect and good in reducibility, and is used for reducible birth control of the female.

The invention provides an auto-locking intramedullary nail for the thighbone and relates to the technical field of medical equipment for the department of orthopedics. The auto-locking intramedullary nail comprises a main nail, an auxiliary nail, a screw blade nail, pore channels and a tail cap, wherein a connecting part is arranged at the distal end of the main nail; the screw blade nail is connected onto the connecting part in a sleeving manner and can freely rotate through the connecting part; the pore channels spreading outwards are uniformly arranged in the circumferential direction of the distal end of the main nail; the auxiliary nail is inserted into the main nail and is a bunchy body formed by rigid needles with the number corresponding to the number of the pore channels, and the rigid needles penetrate out of the corresponding pore channels; the proximal end of the main nail adopts an open structure; the tail cap is connected to the open structure of the main nail and connected with the auxiliary nail in the main nail. The auto-locking intramedullary nail can apply sufficient pressure to a fracture line and prevent the bone from rotating malposition effectively.

The invention particularly relates to a double-layer artificial periosteum, a preparation method and application thereof, and belongs to the technical field of biomedical materials. The double-layer artificial periosteum is characterized in that a compact layer is prepared firstly, and then a loose layer is prepared on the compact layer. According to the invention, an artificial periosteum with a double-layer structure is constructed, wherein a compact layer and a loose layer are synergistically combined, the surface of the compact layer is smooth, the compact layer faces soft tissue during use, the physical barrier function of the periosteum can be well utilized, connective tissue is effectively prevented from growing into a bone defect area, and the regeneration function of specific tissue is played to the maximum extent; the coarse loose layer is consistent with the autogenous bone in component and structure, faces bone tissue during use, can be well attached to a bone defect surface, induces generation of new bones, effectively inhibits osteosarcoma and treats bone cancer; and the obtained double-layer artificial periosteum has good mechanical properties and degradation properties, and also has good capabilities of promoting bone healing, inhibiting osteosarcoma and treating bone cancer.

Collagen and hyaluronic acid or its sodium salt as main material are prepared into double layer composite material with compact layer and loose layer. The mass composition of the compact layer includes malonic acid swelling solution in 0.6-0.8 wt%; and the mass composition of the loose layer includes malonic acid swelling solution in 0.2-0.4 wt% and hyaluronic acid or its sodium salt in 5-20 wt% of dry collagen. The present invention has loose structure in one side and compact structure in the other side, and thus excellent biocompatibility capable of resisting the growth of fibroblast and other cell to the damaged part while promoting the regeneration and repairing of tissue in the damaged part. The double layer composite material has corresponding biodegrading function and may be degraded and absorbed without needing secondary operation to take out the implanted material. The present invention is suitable for repairing tissue damage.

The invention particularly relates to a mineralized artificial periosteum, a preparation method and application thereof, and belongs to the technical field of biomedical materials, wherein a compact layer is prepared firstly, and then a loose layer is prepared on the compact layer. According to the invention, a mineralized artificial periosteum with a double-layer structure is constructed, wherein a compact layer and a loose layer are synergistically combined, the surface of the compact layer is smooth, and the compact layer faces soft tissue during use, so that the physical barrier function of the periosteum can be well utilized, connective tissue is effectively prevented from growing into a bone defect area, and the regeneration function of specific tissue is played to the maximum extent; the rough loose layer is consistent with the autogenous bone in component and structure, faces bone tissue during use, and can be well attached to a bone defect surface and induce new bone generation, so that the repair effect is improved; and the mineralized artificial periosteum obtained by the method has good mechanical properties and degradation properties, and also has good bone healing promoting ability.

The invention discloses a 3D printed digital artificial bone, the artificial bone is composed of cortical bone, cancellous bone and bone marrow cavity, the cortical bone is composed of L-polylactic acid or polyether ether ketone, and the cancellous bone is composed of Polylactic acid and hydroxyapatite are mixed, and the molecular weight of the L-lactic acid constituting the cortical bone is higher than that of the L-polylactic acid constituting the cancellous bone. The cortical bone and cancellous bone are simultaneously prepared by 3D printing process. The invention also discloses a 3D printing method of the digitized artificial bone. The artificial bone provided by the present invention has a porosity of cortical bone of 10% on the scale of microns and millimeters; a porosity of cancellous bone of 60-80% and a pore size of 120-220 μm, having pores similar to human bone structure rate, pore size and mechanical properties.

The invention relates to a bone cartilage repairing bracket. The bone cartilage repairing bracket comprises a cartilage lower bone layer, a calcification cartilage layer, a cartilage layer and a cartilage film layer which are sequentially arranged, wherein the cartilage film layer is a compact film layer away from one side surface of the calcification cartilage layer, of the cartilage layer; and the compact film layer can prevent the situation that external fiber cells grow into the cartilage layer. The invention further discloses a preparation method of the bone cartilage repairing bracket. According to the bone cartilage repairing bracket disclosed by the invention, the compact film layer is arranged on one side surface of the cartilage layer, and is used as a screen film of the cartilage layer, so that the condition that the external fiber cells grow into the cartilage layer can be avoided, the repaired cartilage tissue cannot exceed surrounding normal tissue, and cartilage proliferation is avoided.

The invention relates to a method for preparing a guided tissue regeneration membrane by combining electrostatic spinning and electrostatic spraying. The method comprises the following steps: carrying out electrostatic spinning on a PLCL electrostatic spinning solution to prepare a smooth layer; the PLCL electrostatic spinning solution and the I-type collagen electrostatic spinning solution are subjected to electrostatic spinning opposite spinning, and a middle layer is prepared on the surface of the smooth layer; the I-type collagen electrostatic spinning solution is subjected to electrostatic spinning, meanwhile, the mineralized collagen electrostatic spraying solution is subjected to electrostatic spraying, a rough layer is prepared on the surface of the middle layer, and then the guided tissue regeneration membrane is prepared through drying and cross-linking. The prepared guided tissue regeneration membrane can play an isolation barrier role, has certain guided tissue regeneration performance, is beneficial to adhesion, proliferation and differentiation of cells, can provide space for cell crawling along with degradation of collagen, and is excellent in mechanical performance, operability and the like.

The invention provides a drug-loading type guided tissue regeneration membrane and preparation method thereof. Polycaprolactone and other biodegradable aliphatic polyesters are used as raw materials and added with an antibacterial drug, and the materials are prepared into a single-layer guided tissue regeneration membrane through an electrospinning method. Or, polycaprolactone and degradable aliphatic polyester material are used as a dense layer, degradable natural polymer material and bio active particles are used as a loose layer, and an antibacterial drug is added to the dense layer; and the layers are prepared into a double-layer guided tissue regeneration membrane with different pore structures and biological activity through a layer by layer electrostatic spinning method. The membrane material provided by the invention has excellent biocompatibility, mechanical properties and degradation property consistent with tissue repair process, can effectively prevent the growth of fibroblasts towards tissue defects, at the same time promote the regeneration repair of tissue, does not have to taken out through a secondary operation; and the membrane material can effectively inhibit bacteria infection and inflammation after the operation, can be widely used in medical fields, such as guided tissue regeneration, postoperative adhesion prevention and drug delivery membrane.