Composite material for porous material and gel use thereof

A technology of porous materials and composite materials, applied in the field of artificial artificial bone, can solve the problems of lowering calcination temperature, blockage of material pores, and excessive calcination temperature.

Inactive Publication Date: 2005-07-27
徐小良
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Chinese patent (application number: 02145493.0) can partially or completely convert the calcined bone into β-TCP by adding diammonium hydrogen phosphate and calcining at a high temperature of 900°C-1300°C once, but the calcining temperature is still too high, so it is necessary to reduce the calcining temperature
Chinese patent (02145493.0) applies collagen coating on the surface of calcined bone, which can significantly improve the cell attachment ability, but it is prone to blockage of material pores

Method used

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  • Composite material for porous material and gel use thereof
  • Composite material for porous material and gel use thereof
  • Composite material for porous material and gel use thereof

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Embodiment Construction

[0080] The invention uses porous material and gel composite as the carrier of bone and cartilage tissue engineering. The composite material can be used as a carrier for seed cells, gene-transfected cells, growth factors, hormones, immunosuppressants, antibiotics, or mixtures thereof, especially for bone morphogenetic protein (BMP) gene-transfected cells, seed cells and BMP, transforming growth factor, vascular endothelial growth factor (VEGF) or fibroblast growth factor (bFGF) mixture carrier. It can be used to construct tissue-engineered artificial bone, repair bone and cartilage damage, bone and cartilage defect, nonunion, periodontal defect, spinal fusion, enhance the stability of artificial prosthesis or enhance the attachment of tendons or ligaments to the bone surface.

[0081] 1. Porous materials can be calcined bone and related materials, coral and related materials after transformation, porous organic polymers (such as PLA, PGA, etc.), artificially synthesized porous ...

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Abstract

A composition of porous material and gel for preparing artificial bone is prepared from collagen and porous material chosen from alpha-tricalcium phosphate/hydroxy apatite, beta-tricalcium phosphate/hydroxy apatite-coral, calcium phosphate/hydroxy apatite, calcium carbonatel tricalcium phosphate, etc.

Description

Technical field [0001] The invention relates to composite material of porous material and gel, preparation method and application in bone and cartilage tissue engineering. In particular, it relates to a simulated artificial bone prepared by combining hydroxyapatite and collagen with an ideal porous structure. The material of the invention can be widely used as a scaffold for bone tissue engineering and as a slow-release carrier for cells and medicines. Background technique [0002] Hydroxyapatite (HAP) has good biocompatibility and osteoconductivity, and can be directly combined with new bone. Therefore, a variety of HAPs with different structures and properties have been developed by different methods to repair damaged bones. or diseased part. But HAP is too stable in the body to be absorbed because it displays a crystal structure similar to bone mineral and tends to be in chemical and biological equilibrium with bone tissue. Tricalcium phosphate (α-TCP or β-TCP) can be ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/24
Inventor 徐小良刘爱红
Owner 徐小良
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