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Method for preparing bioceramic in complex phase of hydroxyapatite and beta triealcium phosphate

A technology of tricalcium phosphate composite phase and hydroxyapatite, which is applied in the field of preparation of degradable biomedical materials, can solve the problems of poor degradability, high sintering temperature, and low biological activity of materials, and achieve easy degradation, good biological activity, Uniformity and Quality Assurance Effects

Inactive Publication Date: 2005-01-12
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantages are that the two-phase mixing is uneven, the sintering temperature is high, the bioactivity of the prepared material is low, and the degradation is poor after implantation, which is not conducive to the reconstruction and growth of human new bone.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] (1) The percentage by weight (the same below) is 15.2% potassium oxide (K 2 O), 10.8% magnesium oxide (MgO), 11.2% magnesium fluoride (MgF 2 ), 50.5% silicon dioxide (SiO 2 ), 4.5% zirconia (ZrO 2 ), 5.2% phosphorus pentoxide (P 2 o 5 ), 2.6% boron trioxide (B 2 o 3 ) are evenly mixed, and after dry pressing, they are melted at 1050°C, quenched in water, and then pulverized into biological glass powder by ball milling;

[0015] (2) The above-mentioned biological glass powder is added to 90% hydroxyapatite powder in a proportion of 10% by weight, ball milled and mixed for 6 hours, and dry-pressed at a pressure of 20 MPa;

[0016] (3) Sintering the green body formed by dry pressing in step (2) at 1150° C. to obtain a biodegradable hydroxyapatite and β-tricalcium phosphate composite bioceramic with a weight percentage of β-tricalcium phosphate of 60% .

Embodiment 2

[0018] (1) The percentage by weight (the same below) is 15.7% potassium oxide (K 2 O), 10.6% magnesium oxide (MgO), 10.5% magnesium fluoride (MgF 2 ), 51.3% silicon dioxide (SiO 2 ), 4.3% zirconia (ZrO 2 ), 5.4% phosphorus pentoxide (P 2 o 5 ), 2.2% boron trioxide (B 2 o 3 ) are evenly mixed, and after dry pressing, they are melted at 1080°C, quenched in water, and then pulverized into biological glass powder by ball milling;

[0019] (2) The above-mentioned biological glass powder is added to 95% hydroxyapatite powder in a proportion of 5% by weight, ball milled and mixed for 4 hours, and dry-pressed at a pressure of 10 MPa;

[0020] (3) Sinter the green body formed by dry pressing in step (2) at 1050° C. to obtain a biodegradable hydroxyapatite and β-tricalcium phosphate composite biomaterial with a weight percent of β-tricalcium phosphate of 40% ceramics.

Embodiment 3

[0022] (1) The percentage by weight (the same below) is 16.5% potassium oxide (K 2 O), 10.5% magnesium oxide (MgO), 10.2% magnesium fluoride (MgF 2 ), 51.8% silicon dioxide (SiO 2 ), 3.2% zirconia (ZrO 2 ), 5.1% phosphorus pentoxide (P 2 o 5 ), 2.7% boron trioxide (B 2 o 3 ) are uniformly mixed, and after dry pressing, they are melted at 1100°C, quenched in water, and then pulverized into biological glass powder by ball milling;

[0023] (2) adding the above-mentioned biological glass powder to a ratio of 15% by weight in 85% hydroxyapatite powder, ball milling and mixing for 5 hours, and dry pressing at a pressure of 30 MPa;

[0024] (3) Sinter the green body formed by dry pressing in step (2) at 1250° C. to obtain a biodegradable hydroxyapatite and β-tricalcium phosphate composite with 80% by weight of β-tricalcium phosphate ceramics.

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Abstract

In the invention, biological glass powder (weight percentage is 5-15) is added in oxhydryl kietyoite powder to be formed by dry pressing on pressure 10-30 Mpa, then to be fired in temp. 1050-1250 deg.C to produce compound biological ceramics of oxhydryl kietyoite and beta-tricalcium phosphate that content can be controlled.

Description

technical field [0001] The invention belongs to the technical field of preparation of degradable biomedical materials, and in particular relates to a preparation method of a degradable hydroxyapatite and β-tricalcium phosphate composite bioceramic material. Background technique [0002] The chemical composition of hydroxyapatite and β-tricalcium phosphate is similar to the inorganic composition of human bone. They are two important bone repair materials. The research on their preparation process and properties has always been one of the hot spots in the field of biomedical materials. Hydroxyapatite has high strength but poor degradability, while β-tricalcium phosphate has good degradability and low strength. Therefore, it is important to combine the two to prepare a composite material with both advantages. use value. The traditional method of preparing hydroxyapatite and β-tricalcium phosphate composite materials is to firstly prepare pure single-phase hydroxyapatite powder...

Claims

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Application Information

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IPC IPC(8): A61F2/28A61K6/04C04B35/447C04B35/626
Inventor 王晨董利民田杰谟
Owner TSINGHUA UNIV
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