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3D (three-dimensional) printing mesoporous bioactivity glass modified biological ceramic support, and preparation method and application thereof

A technology of bioactive glass and bioceramics, which is applied in medical science, prosthesis, additive processing, etc., can solve the problems of lack of micro-nano structure, lack of multi-functionality, and unsatisfactory interfacial activity, and achieve good mechanical properties and process simple and easy effects

Active Publication Date: 2016-02-10
中科硅诺(太仓)生物材料科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The surface and interface of biomaterials currently used for the repair and replacement of large bone defects lack versatility, such as unsatisfactory interfacial activity, lack of suitable micro-nano structure, and insufficient osteogenic integration in vivo.

Method used

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  • 3D (three-dimensional) printing mesoporous bioactivity glass modified biological ceramic support, and preparation method and application thereof
  • 3D (three-dimensional) printing mesoporous bioactivity glass modified biological ceramic support, and preparation method and application thereof
  • 3D (three-dimensional) printing mesoporous bioactivity glass modified biological ceramic support, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] (1) Mix 6g P123 with 90g ethanol, dissolve and stir for 1 hour, add 2.1g 10.05g ethyl orthosilicate, calcium nitrate tetrahydrate, 1.10g triethyl phosphate, 1.5g hydrochloric acid and stir for 24 hours to obtain mesoporous biological activity glass precursor;

[0067] (2) 4.5g of pure β-tricalcium phosphate powder, after fully mixing with 3g of PVA, use three-dimensional printing technology to prepare scaffold materials;

[0068] (3) Calcining the printed scaffold at 1100°C for 3 hours to obtain a pure β-tricalcium phosphate ceramic scaffold;

[0069] (4) The mesoporous bioactive glass precursor was spin-coated on the surface of the pure β-TCP scaffold for 3 times, and sintered at 650°C for 5 hours to obtain the mesoporous bioactive glass-on-β-TCP ceramic scaffold.

[0070] Mechanical properties, osteogenic activity and angiogenic activity were then evaluated as described above. For the structural and performance characterization of the mesoporous bioactive glass modi...

Embodiment 2

[0072] (1) Mix 6g P123 with 100g ethanol, dissolve and stir for 1 hour, add 10.05g ethyl orthosilicate, 2.1g calcium nitrate tetrahydrate, 1.10g triethyl phosphate, 1.5g hydrochloric acid and stir for 24 hours to obtain mesoporous biological activity glass precursor;

[0073] (2) 4.5g of pure β-tricalcium phosphate powder, after fully mixing with 2g of PVA, use three-dimensional printing technology to prepare scaffold materials;

[0074] (3) Calcining the printed scaffold at 1150°C for 3 hours to obtain a pure β-tricalcium phosphate ceramic scaffold;

[0075] (4) The mesoporous bioactive glass precursor was spin-coated on the surface of the pure β-TCP scaffold for 6 times, and sintered at 600°C for 6 hours to obtain the mesoporous bioactive glass-modified β-TCP ceramic scaffold.

[0076] Mechanical properties, osteogenic activity and angiogenic activity were then evaluated as described above. The results also confirmed that the modification of the mesoporous bioactive glass ...

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Abstract

The invention relates to a 3D (three-dimensional) printing mesoporous bioactivity glass modified biological ceramic support, and a preparation method and application thereof. The biological ceramic support comprises a beta-tricalcium phosphate bioactivity support prepared by using a three-dimensional printing technology and mesoporous bioactivity glass coating the surface of the support uniformly. The biological ceramic support has good mechanical property, mineralization capability and osteogenic and hematopoietic activities, is expected to serve as an effective bone repairing material, and is a potential multifunctional hard tissue bioactivity implanting material.

Description

technical field [0001] The invention relates to a 3D printing bioceramic support modified by mesoporous bioactive glass, a preparation method and application thereof, and belongs to the field of biomaterials. Background technique [0002] For a long time, bone defects caused by trauma, tumors, congenital deformities, aging, sports and accidents have posed a great threat to human bone health. Among them, since the repair of large bone defects exceeds the range of the human body's own bone regeneration capacity, and the gold standard autologous bone graft is limited by the source and surgical risks, bioactive scaffold materials for large bone repair have become a hot spot for researchers . The surface and interface of biomaterials currently used for the repair and replacement of large bone defects lack versatility, such as unsatisfactory interfacial activity, lack of suitable micro-nano structure, and insufficient osteogenic integration in vivo. The new mesoporous bioactive ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12B33Y10/00B33Y80/00
Inventor 吴成铁张亚莉常江
Owner 中科硅诺(太仓)生物材料科技有限公司
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