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Artificial bone containing hydroxyapatite whiskers and diphasic calcium phosphate and preparation method of artificial bone

A technology of hydroxyapatite and biphasic calcium-phosphorus, applied in the medical field, can solve the problems of increasing the infection rate of patients, the pain of secondary surgery, the economic burden, and the lack of biocompatibility, so as to promote the growth and healing of bone cells, improve The effect of mechanical properties and uniform particle size

Inactive Publication Date: 2019-01-04
迈海新型材料科技(固安)有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these enhancers generally have a certain degree of cytotoxicity, lack of excellent biocompatibility, and will not degrade in the human body. After implantation, remaining in the body will have adverse effects on humans. If they are removed by surgery again, it will increase the number of patients Infection rate, secondary surgery pain and financial burden

Method used

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  • Artificial bone containing hydroxyapatite whiskers and diphasic calcium phosphate and preparation method of artificial bone
  • Artificial bone containing hydroxyapatite whiskers and diphasic calcium phosphate and preparation method of artificial bone
  • Artificial bone containing hydroxyapatite whiskers and diphasic calcium phosphate and preparation method of artificial bone

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preparation example Construction

[0039] The invention discloses an artificial bone comprising hydroxyapatite whiskers and biphasic calcium-phosphorus, the artificial bone is composed of hydroxyapatite whiskers, hydroxyapatite powder and beta-tricalcium phosphate; In terms of parts, the ratio of hydroxyapatite whiskers, hydroxyapatite powder and β-tricalcium phosphate is X:(60-X):40, and X is 5-20. Hydroxyapatite whiskers, hydroxyapatite powder and β-tricalcium phosphate are all nanoscale materials, and the preparation method of the artificial bone comprises the following steps:

[0040] Step A, Synthesis of High Aspect Ratio Hydroxyapatite Whiskers

[0041] see figure 1 , using hydrothermal method to prepare hydroxyapatite whiskers, the obtained hydroxyapatite whiskers not only have excellent biocompatibility, bioactivity and good mechanical properties, but also safe and simple to operate, the aspect ratio of the whiskers is stable, and the yield High; preparation process of the present invention specifical...

Embodiment 1

[0069] Example 1: The ratio of HA whiskers: HA powder: β-TCP is 5:55:40

[0070] 1. Preparation of HA whiskers by hydrothermal method

[0071] The same volume of 0.5mol / L CaCl 2 solution and 0.2mol / L (NH 4 ) 2 HPO 4 The solution was slowly added dropwise to CaCl 2 In the solution, stir continuously during the dropwise addition, and continue to stir for 2 hours after the dropwise addition is completed; add urea, and continue to stir for 1 hour to obtain a mixed solution B; slowly add 0.2mol / L HCl solution dropwise into the mixed solution B, Continue to stir for 1 hour until the solution is colorless and transparent. At this time, the pH value of the mixed solution C is 3; the mixed solution C is subjected to a hydrothermal reaction at a heating rate of 2°C / min, and the temperature is raised to 120°C and kept for 24 hours. Product D; Process Product D was subjected to suction filtration, washed 3 times with deionized water, then washed 2 times with absolute ethanol, put in ...

Embodiment 2

[0080] Embodiment 2: HA whiskers: HA powder: β-TCP ratio is 10:50:40

[0081]1. Preparation of HA whiskers by hydrothermal method

[0082] The same volume of 0.5mol / L CaCl 2 solution and 0.2mol / L (NH 4 ) 2 HPO 4 The solution was slowly added dropwise to CaCl 2 In the solution, stir continuously during the dropwise addition, and continue to stir for 2 hours after the dropwise addition is completed; add urea, and continue to stir for 1 hour to obtain a mixed solution B; slowly add 0.2mol / L HCl solution dropwise into the mixed solution B, Continue stirring for 1 hour until the solution is colorless and transparent. At this time, the pH value of the mixed solution C is 4; the mixed solution C is subjected to a hydrothermal reaction at a heating rate of 3°C / min. Product D; Process Product D was subjected to suction filtration, washed 3 times with deionized water, then washed 2 times with absolute ethanol, put in an oven, dried at 70°C for 8 hours, and was ground to obtain HA w...

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Abstract

The invention discloses an artificial bone containing hydroxyapatite whiskers and diphasic calcium phosphate and a preparation method of the artificial bone. The hydroxyapatite whiskers, hydroxyapatite powder and beta-tricalcium phosphate are used as raw materials of the artificial bone, the artificial bone has an induction effect on growth of osteocytes, and growth and healing of the osteocytes are promoted; by controlling the ratio of the hydroxyapatite whiskers, the hydroxyapatite powder and the beta-tricalcium phosphate, the strength of the artificial bone is increased; the preparation method of the artificial bone is a 3D printing technology, on the one hand, the 3D printing technology can customize a stent according to the shape of a bone defect portion, and the shortcomings that bymanufacturing through a traditional mold, molding is required at first, then size is limited after molding, and the cost of the mold is high are overcome; and on the other hand, by the method, the aperture, the porosity and the connectivity of the stent can be controlled precisely, and an open porous structure and an interconnected network are of great important on cytotrophy supply, proliferationand differentiation and formation of tissues and blood vessels.

Description

【Technical field】 [0001] The invention belongs to the technical field of medicine, and in particular relates to an artificial bone containing hydroxyapatite whiskers and two-phase calcium-phosphorus and a preparation method thereof. 【Background technique】 [0002] The repair of large bone defects has always been a difficult problem for orthopedic surgeons. The current repair strategies include autologous bone, allogeneic bone, and synthetic substitutes. At present, factors such as limited sources, infection, complications, and risk of immune rejection limit the research, development and clinical application of autologous and xenograft bones, while the rapid development of bone tissue engineering provides a basis for the repair of large bone defects. a more feasible method. Bone tissue engineering scaffolds are usually porous structures with good biocompatibility and degradability, which can provide mechanical support and physical and biochemical stimulation for cell growth ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C04B35/447C04B35/634C04B38/00C04B35/81B28B1/00B33Y10/00B33Y70/00C30B29/14C30B29/62C30B7/10A61L27/12
CPCA61L27/12B28B1/001B33Y10/00B33Y70/00C04B35/447C04B35/63416C04B35/803C04B38/00C04B2235/5276C04B2235/6026C04B2235/96C30B7/10C30B29/14C30B29/62C04B38/0074C04B38/0054
Inventor 曾庆丰于树印常文辰刘宁薛航
Owner 迈海新型材料科技(固安)有限公司
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