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Bioactive ceramic material and preparation method thereof

A technology of bioactive ceramics and bioceramic materials, used in medical science, prosthesis, etc., to achieve the effect of promoting osteogenic differentiation, fast degradability, and low synthesis temperature

Inactive Publication Date: 2012-07-18
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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Problems solved by technology

[0003] Calcium diorthosilicate phosphate is a compound containing a ternary component of Ca, Si and P. There has been no literature report on its chemical synthesis and research on its use in hard tissue repair. Therefore, calcium diorthosilicate phosphate ceramics The research and application of biomaterials have certain significance

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  • Bioactive ceramic material and preparation method thereof
  • Bioactive ceramic material and preparation method thereof
  • Bioactive ceramic material and preparation method thereof

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Embodiment Construction

[0027] The present invention will be further described with reference to the accompanying drawings and the following embodiments. It should be understood that the accompanying drawings and the following embodiments are only used to illustrate the present invention rather than limit the present invention.

[0028] The purpose of the present invention is to synthesize di-orthosilicate calcium phosphate powder through a sol-gel method, and sinter it into di-orthosilicate calcium phosphate ceramics at a certain temperature. Then the novel bioactive implant material was evaluated by the in vitro bioactivity, degradability and cell compatibility of periodontal ligament cells and bone marrow stromal stem cells.

[0029] The steps for preparing calcium diorthosilicate phosphate ceramics of the present invention are illustrated below, and it should be understood that one of the following steps can also be omitted or other alternative processes that can achieve the same effect can be use...

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Abstract

The invention discloses a bioactive ceramic material with degradability. The chemical formula of the bioactive ceramic material is Ca7Si2P2O16. A preparation method for the bioactive ceramic material comprises the following procedures: A) synthesizing pure Ca7Si2P2O16 powder by using a sol-gel method; and B) adding polyvinyl alcohol into the Ca7Si2P2O16 powder for granulation, dry pressing to obtain a blank, and calcining the blank at high temperature to obtain the Ca7Si2P2O16 bioactive ceramic material. The nagelschmidtite ceramic can support adherence and proliferation of bone marrow stromal cells. Compared with the traditional beta-tricalcium phosphate ceramics, the bioactive ceramic material can better promote osteogenic differentiation of the bone marrow stromal cells and has higher degradability.

Description

technical field [0001] The present invention relates to a novel bioactive calcium diorthosilicate (Ca 7 Si 2 P 2 o 16 ) The preparation and application of ceramic materials belong to the field of biological materials. Background technique [0002] The main inorganic mineralization component of human hard tissue bones and teeth is apatite. In order to simulate the composition of human hard tissue, calcium phosphate bioactive ceramics are mostly used clinically in hard tissue repair, mainly including hydroxyapatite and β - Tricalcium phosphate ceramic. Studies have shown that calcium phosphate bioceramics have good bioactivity and compatibility, but recently, more and more studies have found that the degradation of hydroxyapatite and β-tricalcium phosphate ceramics is slow, and it is also harmful to tissue cells. No apparent facilitation. Silicon is an important element in the human body and has been reported to promote early bone development and mineralization. The stu...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C04B35/447C04B35/622A61L27/12
Inventor 吴成铁常江
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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