86 results about "Calcium phosphate ceramics" patented technology

A porous composite comprising a porous layer containing a calcium phosphate ceramic, and a dense layer formed on part of the porous layer and having a smaller average pore size than that of the porous layer. The porous composite can be produced by (1) introducing a slurry containing a calcium phosphate ceramic/collagen composite and collagen into a molding die having a high thermal conductivity, (2) rapidly freezing and drying the slurry in the molding die, to form a porous body comprising a porous layer and a dense layer formed on the porous layer, (3) cross-linking collagen in the porous body, and (4) removing the dense layer except for a portion thereof on a surface coming into contact with a soft tissue when implanted in a human body, so that the porous layer is exposed.

The invention relates to a CaP (Calcium Phosphate)/collagen composite biologic ceramic material and a preparation method thereof. The composite biologic ceramic is prepared by adopting a porous calcium phosphate ceramic as the substrate and I-type collage as the toughening reinforcing phase in a vacuum negative pressure pouring and crosslinking mode. The process is as follows: firstly, preparing the first type through porous calcium phosphate ceramic, wherein the porosity is 60-95%; dipping the porous calcium phosphate ceramic into a collagen solution of which the concentration is 5-20mg/ml; and vacuuming to 0-10Pa at normal temperature and pouring, keeping the pressure for 1-3 hours and carrying out ultrasonic oscillation. The vacuum negative pressure pouring process can be repeated according to demands. The calcium phosphate ceramic poured with the collagen is frozen and dried to prepare the composite biologic ceramic after being subjected to crosslinking. The prepared biologic ceramic has good biocompatibility and biological activity, and at the same time has a mechanical strength better than that of a pure calcium phosphate ceramic material, so that the biologic ceramic can be used as artificial bones and bone tissue engineering bracket materials, and has wide clinical application prospects in orthopedics.

The present invention discloses a mineralized collagen/bioceramic composite useful as a hard tissue replacement material or substitute material, comprising about 10% to 95% by weight of mineralized collagen and about 5% to 90% by weight of bioceramics, and a method of manufacturing the same. Wherein, the mineralized collagen is used as a binder for the bioceramics, such as calcium phosphate ceramics, calcium sulfate ceramics, calcium carbonate ceramics, and other biocompatible ceramics. The bioceramic used in the mineralized collagen/bioceramic composite can be either in powder form or in granular form.

A porous calcium phosphate ceramic comprising a support portion having pores, and ring-shaped portions formed in the pores, the ring-shaped portions having pluralities of fine pores so that they have a network structure. A method for producing a porous calcium phosphate ceramic comprising stirring a slurry containing coarse calcium phosphate particles, fine calcium phosphate particles, a nonionic surfactant and a water-soluble high-molecular compound to foam the slurry; gelling the foamed slurry; and then drying the resultant get to obtain a sintered porous calcium phosphate ceramic; the nonionic surfactant being malamide and/or polyoxyethylene lauryl ether.

The invention discloses a three-dimensional connected honeycomb porous calcium phosphate ceramic artificial bone material. A plurality of longitudinal straight-through holes are distributed in the calcium phosphate ceramic artificial bone material in a honeycomb manner; and a plurality of transverse through holes are distributed in the hole walls of the straight-through holes to connect the adjacent straight-through holes. The invention also discloses a preparation method of the three-dimensional connected honeycomb porous calcium phosphate ceramic artificial bone material. The three-dimensional connected honeycomb porous calcium phosphate ceramic artificial bone material is prepared once through an extrusion molding technology and a pore forming agent adding technology. The straight-through holes are helpful for growing newborn bone tissues and forming blood vessels, and the three-dimensional connected holes are helpful for connecting cells into pieces and facilitate transportation of nutrient substances and discharging of metabolites. The preparation method is simple and can realize continuous production; and the prepared porous calcium phosphate ceramic has the advantages of high porosity, high connectivity and good mechanical performances.

In the invention, calcium phosphate ceramics is soaked by 1-12 mole sodium hydroxide solution, then is soaked and processed by iimitate body fluid with different density to form bone-like kietyoite layer on the surface of calcium phosphate ceramics.

A preparation method for calcium polyphosphate-tricalcium phosphate bone bracket comprises the steps of proportionally ball-milling and mixing calcium phosphate ceramic powder, size stabilizer methylcellulose, surfactant polyvinyl alcohol, foaming agent hydrogen peroxide and de-ionized water in order to prepare compound ceramic slurry, pouring the slurry into a mould, drying in an oven with four-step drying method, and then sintering the dried green body under high temperature in order to acquire porous calcium phosphate ceramic bracket. The big aperture of a big pore of the acquired porous calcium phosphate ceramic bracket of the invention is 200 to 600 microns, the micro-pore aperture thereof is 2 to 5 microns, the whole porosity thereof is from 60 to 90 percent and the compressive strength thereof is 0.5 to 7.0 Mpa. Furthermore, the method has low cost and high efficiency and can be applied to large-scale production.

The invention discloses a HA (hydroxylapatite) micro-nano whisker reinforced calcium phosphate ceramic material which is characterized by using calcium phosphate as a material matrix phase and mixing hydroxyapatite (HA) micro-nano whisker as a reinforcing phase for improving material mechanical properties. The preparation process is as follows: respectively synthesizing a calcium phosphate matrix phase precursor powder material and a hydroxyapatite micro-nano whisker reinforced phase material; then doping 3 ~ 10% of the hydroxyapatite micro-nano whisker to composite into ceramic body powder for preparing a porous ceramic body, finally calcining by a muffle furnace to obtain the reinforced porous bioactive calcium phosphate ceramic. Biological materials are a calcium phosphate component and a hydroxyapatite component which have similar chemical compositions with natural bones, the ceramic has excellent bioactivity due to a finely specially made porous structure, the mechanical properties of the ceramic are reinforced by doping of the micro-nano hydroxyapatite whisker, and the porous ceramic used as a bone repair material has the excellent bioactivity and good mechanical properties and has a wide application prospect in clinical departments of orthopedics.

The invention discloses a two-phase calcium phosphate material, a preparation method thereof, and a two-phase calcium phosphate artificial bone ceramic, and belongs to the field of biological ceramic materials. The two-phase calcium phosphate artificial bone ceramic is prepared through preparing a beta phase tricalcium phosphate (beta-TCP) and hydroxy apatite (HA) mixture (the two-phase calcium phosphate material) from egg shells and carrying out a sintering process. The beta-TCP and the HA are prepared from the egg shells with abundant sources through a one-step chemical synthesis process, the mass proportions of the beta-TCP and the HA in the two-phase calcium phosphate are controlled through changing the particle dimensions of the egg shells in the hydrothermal synthesis process, and the preparation cost of the two-phase calcium phosphate material is low. The two-phase calcium phosphate ceramic is prepared through a template process under pressureless sintering conditions, and the two-phase calcium phosphate ceramic with different degradation speeds can be prepared through controlling the mass proportions of the beta-TCP and the HA, so different demands of bone defect patients on the degradation period of artificial bone scaffold materials due to individual difference are met.

The invention provides a method for preparing a calcium phosphate ceramics/chitosan-hydroxyapatite composite coating porous material, which comprises steps of: selecting porous calcium phosphate ceramics with hole size of 300-600 microns and of a net-shaped hole structure, adding nano-hydroxyapatite in chitosan acetum with the mass percent of 0.5-5 percent to prepare a suspension, coating the surface of the porous calcium phosphate ceramics, and carrying out crosslinking process to obtain the calcium phosphate ceramics/chitosan-hydroxyapatite composite coating porous material, wherein the mass ratio of the hydroxyapatite to the chitosan in the chitosan-hydroxyapatite suspension is (6-1):(1-5). The invention has the technical scheme that a chitosan-hydroxyapatite coating is prepared on the porous calcium phosphate ceramics, thereby enhancing the surface bioactivity of the porous material; the coating is an organic-inorganic composite material and integrates the advantages of the chitosan and the hydroxyapatite, and the constitution of the surface of the material can be conveniently adjusted according to the actual need, thereby endowing the porous material with better combination property.

This invention provides a process for the preparation of protein mediated calcium hydroxyapatite (HAp) coating on metal substrates particularly on stainless steel (316 L) by biomimetic route, capable of rapid and effective osteointegration with the host tissue following controlled interfacial reactions. For the purpose, calcium deficient, carbonated hydroxyapatite (HAp) coating was developed on metal substrates particularly on stainless steel (316L) alloy through biomimetic route after a surface treatment step using aqueous solution (4-10 wt %) of BSA at room temperature. The coating was characterised with respect to phase composition, crystallinity, morphology and thickness. The protein mediated calcium phosphate ceramic coating is porous (pore dia—100-200 μm) having uniform pore distribution and coverage. There is multifold enhancement in thickness and crystallinity (data provided) of the as-prepared coating. The process in the present invention is designed to mimic the structural and characteristic properties of the biological apatite to expedite osteointegration kinetics and to further improve biocompatibility of the metallic implant.

The invention discloses surface nano-scale modified calcium phosphate bioactive ceramic and a preparation method thereof. The surface nano-scale modified calcium phosphate bioactive ceramic comprises a porous calcium phosphate ceramic base body and a nano modifying layer. The preparation method of the surface nano-scale modified calcium phosphate bioactive ceramic comprises the following steps: carrying out surface nano-scale modification onto the porous calcium phosphate ceramic base body by a hydrothermal method in acid liquor; and self-assembling the material surface to form a layer of nano calcium phosphate by modification treatment. Therefore, the material surface/interface has a relatively large specific surface area and is beneficial to adsorbing osteogenesis-associated proteins and cells; after being planted into a body, the material can quickly release calcium and phosphor ions to promote osteogenesis, so that the material has better biological activity and osteoconduction; meanwhile, the ceramic has better mechanical performance.

The invention discloses a three-dimensional printing porous bredigite biological ceramic bracket, and a preparation method and application thereof. The method comprises the following steps: firstly, obtaining a sizing agent by blending bredigite powder, sintering aids and a binder aqueous solution at a certain ratio, then utilizing a three-dimensional printing technique to prepare a ceramic bracket blank with a controllable porous structure, and then sintering at high temperature, thereby obtaining a bredigite biological ceramic bracket material with a porous structure and excellent mechanical properties. The three-dimensional printing porous bredigite biological ceramic bracket prepared according to the preparation method has controllable pore diameter and porosity, high biocompatibility, excellent mechanical properties obviously better than the mechanical properties of a calcium phosphate ceramic bracket with the same structure, and excellent induced osteogenesis activity and angiogenesis activity, and is expected to be used for boosting the regeneration repairing of various defected bone tissues.

The invention relates to a composite material containing microelement for hard tissue repair and reconstruction and a preparation method thereof. The composite material further contains at least one of three microelements of strontium, zinc and copper acceptable in human body with the calcium mole ratio of 0.01-0.5% in ceramic component of calcium phosphate in the ceramic component containing the calcium phosphate and the substrate material of multi-amino acid polymer, wherein the mass ratio of the ceramic component of calcium phosphate is 30-65%, and the balance of multi-amino acid polymer polymerized by epsilon-aminocaproic acid and other amino acids. The process for preparing the calcium phosphate ceramic comprises the following steps of: adding microelement, then mixing the amino acid components evenly, removing water of various forms in the mixture at a temperature lower than or equal to 200 DEG C under the protection of inert gas, then composing in situ polymerization under the condition of 210-250 DEG C and pH of 6.5-7.5. The composite material is a bionic biomedical and tissue engineering material which has controllable degradation speed, good bioactivity and compatibility and overcomes deficiencies and problems of similar repair materials at present.

The invention relates to a magnetic nanoparticle/calcium phosphate ceramic composite porous material. Calcium phosphate ceramic serves as a matrix; the calcium phosphate ceramic matrix has a porous structure; superparamagnetic Fe3O4 magnetic nanoparticles are distributed on the calcium phosphate ceramic matrix uniformly; the superparamagnetic Fe3O4 magnetic nanoparticles are hydrophobic Fe3O4 or hydrophilic Fe3O4; the average particle size of the superparamagnetic Fe3O4 magnetic nanoparticles is 4 to 20 nm; and the content of the superparamagnetic Fe3O4 magnetic nanoparticles is 1 to 10 percent of the mass of the calcium phosphate ceramic matrix. A preparation method for the magnetic nanoparticle/calcium phosphate ceramic composite porous material comprises the following steps of: (1) preparing Fe3O4 magnetic fluid; (2) preparing composite powder; (3) preparing green bodies; and (4) performing vacuum sintering, namely calcining the green bodies subjected to compression moulding at thetemperature of between 300 and 400 DEG C for 20 to 40 minutes by using a vacuum sintering furnace, heating to 1,000 to 1,200 DEG C, calcining for 1 to 2 hours, and cooling to room temperature along with the furnace to obtain the magnetic nanoparticle/calcium phosphate ceramic composite porous material.

The invention relates to a low over-cured calcium phosphate ceramic slurry for light curing molding and a preparation method thereof. The low over-cured calcium phosphate ceramic slurry for light curing molding mainly comprises the following components by mass percentage: 70-80wt% of ceramic powder, 0.5-2wt% of a dispersant, 10-25wt% of a light curable resin monomer and 0.05-0.5wt% of assistants.The preparation method mainly includes: conducting ball-milling and stirring on calcium phosphate ceramic powder, light curable resin, the dispersant, a photoinitiator and an ultraviolet absorber to obtain the slurry. The slurry has the characteristics of low viscosity, high solid content and low over-cured content, and can be used in the field of additive manufacturing of bioceramics.

The invention provides calcium phosphate bioceramics compounded with collagen as well as a preparation method and a usage method thereof. The preparation method of the calcium phosphate bioceramics compounded with collagen comprises the following steps: forming cross-linked collagen coating on surfaces of calcium phosphate bioceramics by using collagen solutions of which the concentrations are from low to high, thereby obtaining cross-linked collagen coating with which the surfaces of the calcium phosphate bioceramics are wrapped; carrying out mixing with a collagen solution, and carrying outfreeze-drying so as to obtain precursors of the calcium phosphate bioceramics compounded with collagen; and then, soaking the coating with a collagen solution, and carrying out freeze-drying so as toobtain the calcium phosphate bioceramics compounded with collagen which comprise collagen wrapping layers. The calcium phosphate bioceramics compounded with collagen prepared according to the technical scheme of the invention have improved repair ability and degradation performance, so that, aseptic inflammation caused by falling off of calcium phosphate ceramic particles in clinical use can be avoided; moreover, the calcium phosphate bioceramics compounded with collagen are plastic in shape and size as well as convenient to use, so that, many problems of bioceramics in clinical application can be solved.

The invention relates to the field of bioceramic materials, in particular to a biphasic calcium phosphate porous bioceramic bone scaffold material which is prepared from salmon spine as a raw material, is composed of main ingredients hydroxyapatite and beta-tricalcium phosphate , has high porosity, reserves a natural three-dimensional pore structure, has a particle size of 500-1000 [mu]m, and is prepared through steps of washing and drying, high temperature calcination, grinding, sieving and sterilization. The biphasic calcium phosphate porous bioceramic bone scaffold material is rich in sources of raw materials and low in preparation cost, high purity biphasic calcium phosphate ceramic can be prepared without artificial addition of compounds, and the content of hydroxyapatite and beta-tricalcium phosphate can be changed by controlling the calcination temperature in the preparation process, and the biphasic calcium phosphate porous bioceramic bone scaffold material contains a small amount of carbonated hydroxyapatite and various trace elements such as magnesium, potassium and strontium, with the content close to the content in the human body. The calcium phosphate ceramic prepared through the method can serve as a good bone scaffold material to be applied to clinical bone defect repair.

The invention relates to a medical biological MgCa alloy which can be degraded and a preparation method thereof. The components of the alloy includes 0.5 to 2.0 percent of calcium, and marginal magnesium; the alloy is made by fire melting, and the process of melting and pouring adopts argon shield; the melting temperature is 700 to 800 DEG C, and the pouring temperature is 650 to 750 DEG C. The thermal treatment process uses nitrogen as the protective atmosphere, with the heating temperature being 450 to 510 DEG C for 1.5 to 3.0 hours. The alloy can degrade by corrosion in physical environment, and induce the deposition of calcium phosphate ceramics; the changing of calcium content can control the degradation speed. The alloy can be used as the material for hard tissue replacement and intervening treatment, can be degraded fully after being implanted in human body for certain time and can transform into natural bone tissue. The medical biological MgCa alloy has the advantages of simple production process, no need of special equipment and low production cost.

The invention discloses strontium-doped calcium phosphate ceramic particles for repairing defective alveolar bone, and a preparation method of the strontium-doped calcium phosphate ceramic particles,and solves the problems that calcium phosphate ceramics in the prior art are irregular in morphology, poor in uniformity, low in porosity and poor in bone repair capability. The preparation method comprises the following steps: uniformly mixing calcium phosphate powder, a sodium alginate solution, a binder solution and water to obtain a calcium phosphate mixed slurry; adding a foaming agent solution into the calcium phosphate mixed slurry, and carrying out heating and stirring to obtain foamed slurry; dropwise adding the foamed slurry into a soluble strontium salt solution to form composite hydrogel microspheres, and continuing soaking until the composite hydrogel microspheres are completely cured, and then carrying out washing and drying to obtain composite microspheres; and sintering thecomposite microspheres at a high temperature to obtain the strontium-doped calcium phosphate ceramic particles. According to the invention, strontium ions are uniformly distributed, so that improvement of biological activity and bone induction capability of the calcium phosphate ceramic particles is facilitated, and requirements for regeneration repair of defective alveolar bone are met. The strontium-doped calcium phosphate ceramic particles are regular in morphology and controllable in size.