Three-dimensional connected honeycomb porous calcium phosphate ceramic artificial bone material and preparation method thereof

A technology of porous calcium phosphate and calcium phosphate ceramics, applied in ceramic products, other household utensils, applications, etc., can solve the problems of lower mechanical properties of supports, random distribution of pores, and low connectivity of pores, and achieve a high degree of automation and industrialization The effect of simple production and operation

Inactive Publication Date: 2017-03-22
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The pore diameter of the three-dimensional interconnected pores should be large enough to provide sufficient blood supply, but too large apertures will reduce the mechanical properties of the scaffold, and it is generally believed that the three-dimensional interconnected pores should be larger than 50 μm
[0003] There are many methods for preparing porous calcium phosphate ceramics, including adding pore-forming agents, organic templates, freeze-drying, gas foaming, etc. These methods can introduce pores into the calcium phosphate ceramic matrix, but in these pores There are generally problems in the structure such as random distribution of pores, difficulty in controlling the pore size, low connectivity between pores, and low mechanical strength.

Method used

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  • Three-dimensional connected honeycomb porous calcium phosphate ceramic artificial bone material and preparation method thereof
  • Three-dimensional connected honeycomb porous calcium phosphate ceramic artificial bone material and preparation method thereof
  • Three-dimensional connected honeycomb porous calcium phosphate ceramic artificial bone material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Preparation of mud mass: Mix 100g of β-phase tricalcium phosphate powder, 10g of paraffin microspheres (with a particle size of 400-500μm) and 5g of methyl cellulose in a high-speed mixer to make a solid phase; mix 10g of ethylene glycol, 1g Liquid paraffin and 20mL deionized water were mixed evenly, and then added dropwise to the solid phase to make a mud mass.

[0036] Practicing mud and stale: use a mud training machine to refine the mud balls for 3 times, and then seal and stale for 12 hours to obtain plastic mud balls.

[0037] Extrusion molding: put the stale mud into the mold (the width of the discharge groove is 0.6mm, and the center distance of the discharge groove is 1.0mm) for extrusion molding. The extrusion die in the mold is a square hole. Extrusion The speed is 2mm / min.

[0038] Drying: Dry in an oven at 30°C for 72h.

[0039] Sintering: The dried green body is fired in an air atmosphere furnace at 1100°C for 2 hours to obtain a three-dimensionally conn...

Embodiment 2

[0042] Preparation of mud mass: Mix 100g of hydroxyapatite powder, 10g of gelatin microspheres (300-400μm in particle size) and 10g of dextrin in a high-speed mixer to make a solid phase; 5g of glycerin, 10g of tung oil and 25mL of Ionized water is mixed evenly, and then added dropwise to the solid phase to make a mud mass.

[0043] Practicing mud and stale: use a mud refining machine to refine the mud balls for 5 times, and then seal and stale for 24 hours to obtain plastic mud balls.

[0044] Extrusion molding: put the stale mud into the mold (the width of the discharge groove is 0.5mm, and the center distance of the discharge groove is 0.8mm) for extrusion molding. The extrusion die in the mold is a square hole. Extrusion The speed is 8mm / min.

[0045] Drying: Dry in an oven at 120°C for 12 hours.

[0046] Sintering: The dried green body is fired in an air atmosphere furnace at 1300°C for 3 hours to obtain a three-dimensionally connected honeycomb porous calcium phosphate...

Embodiment 3

[0049]Preparation of mud mass: Mix 100g of α-phase tricalcium phosphate powder, 20g of polyethylene microspheres (400-500μm) and 10g of carboxymethyl cellulose in a high-speed mixer to make a solid phase; mix 7.5g of oxalic acid, 15g of castor oil Mix well with 28mL of deionized water, then add dropwise to the solid phase to make a mud ball.

[0050] Practicing mud and stale: use a mud training machine to refine the mud ball once, and then seal and stale for 72 hours to obtain plastic mud balls.

[0051] Extrusion molding: Put the dried mud into the mold (the diameter of the outlet chute is 0.5mm, and the center distance of the outlet chute is 0.8mm) for extrusion molding. The extrusion die in the mold is a square hole, and the extrusion speed It is 12mm / min.

[0052] Drying: Dry in an oven at 60°C for 48h.

[0053] Sintering: The dried green body is fired in an air atmosphere furnace at 1300°C for 1 hour to obtain a three-dimensionally connected honeycomb porous calcium pho...

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Abstract

The invention discloses a three-dimensional connected honeycomb porous calcium phosphate ceramic artificial bone material. A plurality of longitudinal straight-through holes are distributed in the calcium phosphate ceramic artificial bone material in a honeycomb manner; and a plurality of transverse through holes are distributed in the hole walls of the straight-through holes to connect the adjacent straight-through holes. The invention also discloses a preparation method of the three-dimensional connected honeycomb porous calcium phosphate ceramic artificial bone material. The three-dimensional connected honeycomb porous calcium phosphate ceramic artificial bone material is prepared once through an extrusion molding technology and a pore forming agent adding technology. The straight-through holes are helpful for growing newborn bone tissues and forming blood vessels, and the three-dimensional connected holes are helpful for connecting cells into pieces and facilitate transportation of nutrient substances and discharging of metabolites. The preparation method is simple and can realize continuous production; and the prepared porous calcium phosphate ceramic has the advantages of high porosity, high connectivity and good mechanical performances.

Description

technical field [0001] The invention relates to the field of medical materials for bone defect repair, in particular to a three-dimensionally connected cellular porous calcium phosphate ceramic artificial bone material and a preparation method thereof. Background technique [0002] Bone defects often need to be repaired by implanting artificial bone, and porous calcium phosphate ceramics are an ideal artificial bone material. In recent years, the preparation and properties of porous calcium phosphate ceramics have become an important research direction. Porous calcium phosphate ceramics refer to calcium phosphate ceramics with a large number of pores distributed in a continuous solid matrix, in which the main parameters affecting the pore structure include pore size, porosity, and communication paths. It is generally believed that the pore size distribution of 100-500 μm is suitable for the needs of bone tissue ingrowth, and the pore size in this range can provide a suitabl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C04B38/06C04B35/447C04B35/622A61L27/12A61L27/56
CPCC04B38/067A61L27/12A61L27/56A61L2430/02A61L2430/40C04B35/447C04B35/622C04B38/0009C04B38/06C04B2235/6021C04B2235/96C04B38/0074C04B38/0054
Inventor 叶建东冯胜雷刘高梅刘艳春
Owner SOUTH CHINA UNIV OF TECH
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