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Ion doping and protein dipping double modified porous calcium phosphate ceramic and preparation method thereof

A technology of porous calcium phosphate and ion doping, which is applied in the field of ion doping and protein impregnation double-modified porous calcium phosphate ceramics and its preparation, which can solve the problems affecting clinical application, weak binding force, poor mechanical properties, etc., and achieve good Effects of promoting vascularization, promoting adhesion, and improving compressive strength

Active Publication Date: 2019-04-26
SOUTH CHINA UNIV OF TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In the prior art, calcium phosphate / silk fibroin composite scaffolds are also disclosed (Chinese patent CN 105363074 A). The composite scaffolds are prepared by directly mixing silk fibroin and calcium phosphate powder and then freeze-dried. However, these composite scaffolds cannot After high-temperature sintering, the internal bonding force of the material is weak, resulting in poor mechanical properties, which affects its clinical application in the field of bone injury repair medical materials

Method used

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  • Ion doping and protein dipping double modified porous calcium phosphate ceramic and preparation method thereof
  • Ion doping and protein dipping double modified porous calcium phosphate ceramic and preparation method thereof
  • Ion doping and protein dipping double modified porous calcium phosphate ceramic and preparation method thereof

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preparation example Construction

[0043] The preparation method of the silk fibroin solution involved in the present invention is the method disclosed in Chinese patent CN 102516777 A.

[0044] The preparation of calcium phosphate powder involved in the present invention, wherein the preparation of β-tricalcium phosphate powder refers to the literature Y. Pan, J.L. Huang, C.Y. Shao. Preparation of β-TCP with high thermal stability by solid reaction route. J. Mater. Sci. 2003;38;1049-1056. References for the preparation of hydroxyapatite powder Jiming Zhou, Zhang X., Chen J. High temperature characteristics of synthetic hydroxyapatite. Journal of Materials Science: Materials in Medicine. 1993;4;83- 85. The preparation of α-tricalcium phosphate powder refers to the literature Duncan Jo, MacDonald, James F, et al. The role of the chemical composition of monetite on the synthesis and properties of α-tricalcium phosphate. Materials science and engineering: C. 2014; 34;123-129.

[0045] The preparation methods of t...

Embodiment 1

[0047] In this example, β-tricalcium phosphate powder doped with 1 mol.% zinc ions and hydroxyapatite powder doped with 1 mol.% were used as raw materials to prepare the ion-doped and protein-impregnated double modified porous Calcium phosphate ceramics, the specific process includes:

[0048] (1) Prepare a silk fibroin solution with a concentration of 6 wt.%.

[0049] (2) Synthesize β-tricalcium phosphate powder doped with 1 mol.% zinc ions and hydroxyapatite powder doped with 1 mol.% zinc ions to form a mixed powder; among them, doped with 1 mol.% The mass ratio of β-tricalcium phosphate powder with zinc ions to hydroxyapatite powder doped with 1 mol.% zinc ions is 83:17;

[0050] (3) The zinc ion-doped calcium phosphate powder obtained in step (2) was prepared into a porous calcium phosphate ceramic body by extrusion molding; the temperature was raised to 1200°C at a rate of 2°C / min, and kept for 2 h. Carry out high-temperature sintering to obtain ion-doped porous calcium...

Embodiment 2

[0067] In this example, β-tricalcium phosphate powder doped with 0.5 mol.% zinc ions was used as raw material to prepare the ion-doped and protein-impregnated double modified porous calcium phosphate ceramics. The specific process includes:

[0068] (1) Prepare a silk fibroin solution with a concentration of 7 wt.%;

[0069] (2) Synthesis of β-tricalcium phosphate powder doped with 0.5 mol.% zinc ions;

[0070] (3) The zinc ion-doped calcium phosphate powder obtained in step (2) was prepared into a porous calcium phosphate ceramic body by a pore-forming agent method, and the temperature was raised to 1100°C at a rate of 5°C / min, and kept for 3 h. Carry out high-temperature sintering to obtain ion-doped porous calcium phosphate ceramics;

[0071] (4) Immerse the zinc ion-doped porous calcium phosphate ceramic obtained in step (3) in the silk fibroin solution prepared in step (1), the immersion time is 3 min, and the osmotic negative pressure is 0.1 MPa;

[0072] (5) Step (4) ...

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Abstract

The invention belongs to the field of a medical material for bone injury repair and discloses ion doping and protein dipping double modified porous calcium phosphate ceramic and a preparation method thereof. The preparation method comprises the following steps: preparing calcium phosphate powder doped with osteogenesis promoting ions, preparing ion-doped porous calcium phosphate ceramic by a pore-forming mode, dipping the ion-doped porous calcium phosphate ceramic into a silk fibroin solution, and repeatedly dipping and drying to obtain the ion doping and protein dipping double modified porouscalcium phosphate ceramic capable of promoting osteogenesis and promoting vascularization. The porous calcium phosphate ceramic is dipped with multiple layers of protein, so that the mechanical property of the porous calcium phosphate ceramic is improved. By the ion doping and protein dipping double modification mode, mechanical and biological properties of the porous calcium phosphate ceramic are improved and certain significance in expanding the clinical application of the porous calcium phosphate ceramic is achieved.

Description

technical field [0001] The invention belongs to the field of medical materials for repairing bone damage, and in particular relates to a double-modified porous calcium phosphate ceramic of ion doping and protein impregnation and a preparation method thereof. Background technique [0002] The artificially synthesized porous calcium phosphate ceramic not only exhibits excellent biocompatibility but also has good biological activity due to its similar composition to the inorganic matter in natural bone. At the same time, it can biochemically react with the natural bone in the body. These advantages make calcium phosphate ceramics a research hotspot in the field of medical materials for bone repair. Although porous calcium phosphate ceramics have shown many advantages in the repair of bone injuries, they still have shortcomings such as insufficient biological properties such as osteogenesis and angiogenesis and poor mechanical properties, which affect their clinical effects. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C04B35/447C04B35/622C04B38/00C04B41/83A61L27/10A61L27/12A61L27/34A61L27/56A61L27/50
CPCA61L27/10A61L27/12A61L27/34A61L27/50A61L27/56C04B35/447C04B35/622C04B38/00C04B41/4807C04B41/83A61L2430/02A61L2300/412A61L2300/252C04B2235/3213C04B2235/3212C04B2235/3284C04B2235/3262C04B2235/6567C04B2235/6562C08L89/00C04B41/4535C04B41/52
Inventor 叶建东马宁
Owner SOUTH CHINA UNIV OF TECH
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