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Strontium-doped calcium phosphate ceramic particles for repairing defective alveolar bone, and preparation method of strontium-doped calcium phosphate ceramic particles

A technology of strontium calcium phosphate and ceramic particles, which is applied in the field of strontium-doped calcium phosphate ceramic particles for alveolar bone defect repair and its preparation, can solve the problems of irregular shape, poor bone repair ability, and poor uniformity of calcium phosphate ceramics. Achieve the effect of facilitating migration and growth, convenient implantation and simple method

Active Publication Date: 2019-10-08
SICHUAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem solved by the present invention is: to provide a preparation method of strontium-doped calcium phosphate ceramic particles for alveolar bone defect repair, to solve the problem of irregular appearance, poor uniformity, low porosity and bone loss of calcium phosphate ceramics in the prior art. Problems with poor repair ability

Method used

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  • Strontium-doped calcium phosphate ceramic particles for repairing defective alveolar bone, and preparation method of strontium-doped calcium phosphate ceramic particles
  • Strontium-doped calcium phosphate ceramic particles for repairing defective alveolar bone, and preparation method of strontium-doped calcium phosphate ceramic particles
  • Strontium-doped calcium phosphate ceramic particles for repairing defective alveolar bone, and preparation method of strontium-doped calcium phosphate ceramic particles

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Embodiment 1

[0043] as attached figure 1 As shown, this embodiment discloses the dropping device adopted by the present invention. The dripping device includes a constant flow injection pump provided with a syringe, an electrostatic generator provided with a metal wire, and a collection container. The needle of the syringe is a metal needle. The ends of the metal wires are connected with electrode clips. The electrode clamp clamps the metal needle and is used for conducting the static electricity generated by the static generator to the metal needle through the metal wire.

[0044] When in use, the syringe containing the foaming slurry is pushed out from the syringe under the action of a constant-flow injection pump, and the foaming slurry enters the metal needle and drips under the action of static electricity on the metal needle. into the strontium salt solution in the collection container to form composite hydrogel microspheres. By controlling the magnitude of the electrostatic volt...

Embodiment 2

[0048] The preparation process of strontium-doped calcium phosphate ceramic particles in the present embodiment is as follows:

[0049] (1) 10g of biphasic calcium phosphate powder, 25mL of 6% sodium alginate aqueous solution, 2mL of 6% methylcellulose solution and 30mL of deionized water were uniformly mixed to obtain calcium phosphate mixed slurry . The biphasic calcium phosphate powder is composed of hydroxyapatite and calcium phosphate, and its Ca / P molar ratio is 1.53.

[0050] (2) Add the obtained calcium phosphate mixed slurry to 5 ml of hydrogen peroxide with a mass concentration of 27%, heat and stir until the slurry forms uniformly sized and abundant bubbles, and obtains a foamed slurry.

[0051] (3) The resulting foaming slurry is added dropwise to the strontium chloride solution with a mass concentration of 5% by the dripping device of Example 1, and the electrostatic voltage is adjusted to be 5kV to form 1000 μm composite hydrogel microspheres. It is soaked in a...

Embodiment 3

[0056] The preparation process of strontium-doped calcium phosphate ceramic particles in the present embodiment is as follows:

[0057] (1) 10g of hydroxyapatite powder, 25mL of 6% sodium alginate aqueous solution, 2mL of 6% methylcellulose solution and 30mL of deionized water were uniformly mixed to obtain calcium phosphate mixed slurry . The Ca / P molar ratio of this hydroxyapatite powder was 1.67.

[0058] (2) Add the obtained calcium phosphate mixed slurry to 5 ml of hydrogen peroxide with a mass concentration of 30%, heat and stir until the slurry forms uniformly sized and abundant bubbles to obtain a foamed slurry.

[0059] (3) The resulting foaming slurry is added dropwise to the strontium chloride solution with a mass concentration of 5% by the dripping device of Example 1, and the electrostatic voltage is adjusted to be 15kV to form a 500 μm composite hydrogel microsphere. It is soaked in a strontium salt solution until it is completely solidified, and then washed an...

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Abstract

The invention discloses strontium-doped calcium phosphate ceramic particles for repairing defective alveolar bone, and a preparation method of the strontium-doped calcium phosphate ceramic particles,and solves the problems that calcium phosphate ceramics in the prior art are irregular in morphology, poor in uniformity, low in porosity and poor in bone repair capability. The preparation method comprises the following steps: uniformly mixing calcium phosphate powder, a sodium alginate solution, a binder solution and water to obtain a calcium phosphate mixed slurry; adding a foaming agent solution into the calcium phosphate mixed slurry, and carrying out heating and stirring to obtain foamed slurry; dropwise adding the foamed slurry into a soluble strontium salt solution to form composite hydrogel microspheres, and continuing soaking until the composite hydrogel microspheres are completely cured, and then carrying out washing and drying to obtain composite microspheres; and sintering thecomposite microspheres at a high temperature to obtain the strontium-doped calcium phosphate ceramic particles. According to the invention, strontium ions are uniformly distributed, so that improvement of biological activity and bone induction capability of the calcium phosphate ceramic particles is facilitated, and requirements for regeneration repair of defective alveolar bone are met. The strontium-doped calcium phosphate ceramic particles are regular in morphology and controllable in size.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to strontium-doped calcium phosphate ceramic particles for alveolar bone defect repair and a preparation method thereof. Background technique [0002] Insufficient alveolar bone mass, especially alveolar bone defect caused by trauma, periodontal disease, alveolar bone cyst, etc., is a common clinical disease. Local damage to the alveolar bone greatly increases the risk of dental implant restoration, reduces the success rate of surgery, and becomes the main obstacle to dental implant restoration. According to statistics, about 40%-60% of patients with dental implants have insufficient alveolar bone mass and need to undergo different degrees of bone augmentation surgery. The current clinical repair methods for alveolar bone defects mainly use autologous bone and allogeneic bone grafting. However, the source of autologous bone transplantation is limited, caus...

Claims

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Application Information

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IPC IPC(8): C04B38/10C04B38/02C04B35/447C04B35/622C04B35/624C04B35/636A61L27/12A61L27/10A61L27/56A61L27/50
CPCA61L27/10A61L27/12A61L27/50A61L27/56A61L2430/12C04B35/447C04B35/622C04B35/624C04B35/636C04B35/6365C04B38/009C04B2235/444C04B2235/786C04B38/02C04B38/0074C04B38/10
Inventor 李向锋肖玉梅汪瑜懿陈雪宁周长春张兴栋
Owner SICHUAN UNIV
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