The invention discloses a preparation method of a
strontium chloride [89Sr] injection, belongs to the field of injection preparation, and aims to improve the quality of the
strontium chloride [89Sr] injection. The method comprises the following steps: 1, adding 3g of
strontium chloride into a liquid preparation bag made of a
polypropylene material, and then adding 75ml of water for injection to completely dissolve
strontium chloride; 2, adding 100 mci of a
strontium chloride [89Sr] solution in three times on average, adjusting the pH value to 4.0-4.5 by using a 0.1 mol / L
sodium hydroxide solution after the first two times of adding, and continuously adjusting the pH value to 4.0-5.0 by using the 0.1 mol / L
sodium hydroxide solution after the third time of adding of the
strontium chloride [89Sr] solution. And 3, adding water for injection until the total volume of the liquid is 100ml, and uniformly mixing. And step 4, filtering and sub-packaging. And step five, sterilizing. According to the method, the
polypropylene liquid preparation bag is adopted, the strontium chloride solution is added step by step, and accurate
pH regulation and control step by step are combined, so that concentrated release of strong acid is avoided, a
neutralization reaction is performed smoothly, impurities generated by local over-alkali are prevented, aluminum impurities in the injection are reduced, the success rate of
pH regulation is greatly increased, and the success rate of injection preparation is increased.