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Preparation method of strontium chelated sodium alginate coating on titanium surface

A sodium alginate and chelation technology, which is applied in the field of surface modification of biomedical materials, can solve the problems of graft failure, poor bone integration between graft materials and hosts, and short osteoinductive action time

Active Publication Date: 2016-10-12
TIANJIN UNIV +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, the strontium ions in the organic strontium coatings that have been studied so far are mostly in the form of burst release, and the strontium ions are released in a very short time, which will make the osteoinductive action time of the implant material relatively short , lead to poor bonding between the graft material and the host bone, and finally easily lead to graft failure, so the slow release of strontium ions in the coating plays a crucial role in the success of the graft

Method used

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  • Preparation method of strontium chelated sodium alginate coating on titanium surface
  • Preparation method of strontium chelated sodium alginate coating on titanium surface
  • Preparation method of strontium chelated sodium alginate coating on titanium surface

Examples

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Effect test

Embodiment 1

[0032] Embodiment 1: This example is to prepare the sodium alginate coating of chelating strontium on the surface of titanium sheet, the pH=8 of the Tris-HCl solution that configures dopamine solution to use, the strontium concentration that adopts when soaking is the SrCl of mass fraction 0.1% 2 solution. The specific experimental steps are as follows:

[0033] 1) The titanium sheet is placed in HNO with a mass fraction of 40% 3 , corrode at room temperature for 40min, then take out the titanium piece, rinse it with deionized water and dry it, put it in 5mol / L NaOH solution, keep it in a water bath at 90°C for 5h, and then wash it with absolute ethanol and deionized water successively Ultrasonic cleaning was performed for 10 min, and the titanium sheets obtained in this step were denoted as Ti.

[0034] 2) Dissolve 0.0606g Tris in 50ml of deionized water, add 0.05g DOPA after fully dissolved, and adjust the pH of the solution to 8 with 1mol / L HCl and 1mol / L NaOH, and immers...

Embodiment 2

[0038] Embodiment 2: This example is to prepare the sodium alginate coating of chelating strontium on the surface of titanium sheet, the pH=8 of the Tris-HCl solution that configures dopamine solution to use, the strontium concentration that adopts when soaking is the SrCl of mass fraction 0.3% 2 solution. The specific experimental steps are as follows:

[0039] 5) The titanium sheet is placed in HNO with a mass fraction of 40% 3 , corrode at room temperature for 40min, then take out the titanium piece, rinse it with deionized water and dry it, put it in 5mol / L NaOH solution, keep it in a water bath at 90°C for 5h, and then wash it with absolute ethanol and deionized water successively Ultrasonic cleaning was performed for 10 min, and the titanium sheets obtained in this step were denoted as Ti.

[0040] 6) Dissolve 0.0606g Tris in 50ml of deionized water, add 0.05g DOPA after fully dissolved, and adjust the pH of the solution to 8 with 1mol / L HCl and 1mol / L NaOH, and immers...

Embodiment 3

[0044] Embodiment 3: This example is to prepare the sodium alginate coating of chelating strontium on the surface of titanium sheet, the pH=8 of the Tris-HCl solution that configures dopamine solution to use, the strontium concentration that adopts when soaking is the SrCl of mass fraction 0.5% 2 solution. The specific experimental steps are as follows:

[0045] 1) The titanium sheet is placed in HNO with a mass fraction of 40% 3 , corrode at room temperature for 40min, then take out the titanium piece, rinse it with deionized water and dry it, put it in 5mol / L NaOH solution, keep it in a water bath at 90°C for 5h, and then wash it with absolute ethanol and deionized water successively Ultrasonic cleaning was performed for 10 min, and the titanium sheets obtained in this step were denoted as Ti.

[0046] 2) Dissolve 0.0606g Tris in 50ml of deionized water, add 0.05g DOPA after fully dissolved, and adjust the pH of the solution to 8 with 1mol / L HCl and 1mol / L NaOH, and immers...

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Abstract

The invention relates to a preparation method of a strontium chelated sodium alginate coating on a titanium surface. The preparation method comprises the steps that a trihydroxymethyl aminomethane water solution of dopamine is firstly utilized for treating the titanium surface, sodium alginate is grafted to the surface of the above material by means of an amide reaction of dopamine amidogen and sodium alginate carboxyl, then the obtained material is put into a strontium chloride solution, and chelation of strontium is achieved. A catechol functional group in the dopamine adheres to the titanium surface in a non-covalent manner, and then the coating is constructed on the surface of a substrate. The method is easy to operate, and bonding with a matrix is good. Sodium alginate biocompatibility is good, strontium alginate gel formed after a large quantity of carboxyl existing in molecules and strontium ions react has good chelation performance on the strontium, the strontium chelated sodium alginate coating on the titanium surface is prepared, and long-acting bone inductivity is given to transplant materials by means of slow release and degradation of the strontium. The adopted sodium alginate is good in biocompatibility and has good chelation performance with the strontium, slow release of the strontium is achieved, and quite high promotional value is achieved.

Description

technical field [0001] The invention belongs to the technical field of surface modification of biomedical materials, and mainly relates to the preparation of an organic strontium coating on the surface of titanium to improve the biological performance of titanium materials. Background technique [0002] Titanium and titanium alloys (Ti) are light in weight, high in strength, good in biocompatibility, and have a specific gravity similar to that of human bone. They have attracted great attention as medical bone graft materials in recent years. The organic strontium coating on the titanium surface can not only take advantage of the good biological properties of titanium, but also the strontium on the surface coating will promote bone formation, but an urgent problem to be solved when preparing the coating on the titanium surface is that the titanium surface is too smooth, which increases the Difficulty of preparation. At present, the commonly used coating preparation methods a...

Claims

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Application Information

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IPC IPC(8): C23C22/64C23C22/83A61L27/34A61L27/30A61L27/54
CPCA61L27/306A61L27/34A61L27/54A61L2300/102A61L2300/412A61L2430/02C23C22/64C23C22/83C08L5/04
Inventor 贾莉莉李朝阳杨贤金崔振铎朱胜利吕维加
Owner TIANJIN UNIV
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