Preparation method of sodium alginate coating with strontium chelated on titanium surface

A sodium alginate and chelation technology, which is applied in the field of surface modification of biomedical materials, can solve the problems of graft failure, short osteoinductive action time, and poor osseointegration between graft materials and hosts

Active Publication Date: 2018-12-04
TIANJIN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, the strontium ions in the organic strontium coatings that have been studied so far are mostly in the form of burst release, and the strontium ions are released in a very short time, which will make the osteoinductive action time of the implant material relatively short , lead to poor bonding between the graft material and the host bone, and finally easily lead to graft failure, so the slow release of strontium ions in the coating plays a crucial role in the success of the graft

Method used

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  • Preparation method of sodium alginate coating with strontium chelated on titanium surface
  • Preparation method of sodium alginate coating with strontium chelated on titanium surface
  • Preparation method of sodium alginate coating with strontium chelated on titanium surface

Examples

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Embodiment 1

[0032] Example 1: This example is to prepare a strontium-chelated sodium alginate coating on the surface of a titanium sheet. The pH of the Tris-HCl solution used for the dopamine solution is 8 and the strontium concentration used during soaking is SrCl with a mass fraction of 0.1% 2 Solution. The specific experimental steps are as follows:

[0033] 1) The titanium sheet is placed in HNO with a mass fraction of 40% 3 Corrosion at room temperature for 40 minutes, then take out the titanium sheet, rinse with deionized water and blow dry, put it in a 5mol / L NaOH solution, heat it in a water bath at 90℃ for 5h, and then use absolute ethanol and deionized water in sequence After ultrasonic cleaning for 10 minutes, the titanium sheet obtained in this step is marked as Ti.

[0034] 2) Dissolve 0.0606g Tris in 50ml deionized water, add 0.05g DOPA after it is fully dissolved, and adjust the pH of the solution to 8 with 1mol / L HCl and 1mol / L NaOH, and immerse the above-mentioned acid-base tr...

Embodiment 2

[0038] Example 2: This example is to prepare a strontium-chelated sodium alginate coating on the surface of a titanium sheet. The pH of the Tris-HCl solution used for the dopamine solution is 8 and the strontium concentration used during immersion is 0.3% by mass SrCl 2 Solution. The specific experimental steps are as follows:

[0039] 5) The titanium sheet is placed in HNO with a mass fraction of 40% 3 Corrosion at room temperature for 40 minutes, then take out the titanium sheet, rinse with deionized water and blow dry, put it in a 5mol / L NaOH solution, heat it in a water bath at 90℃ for 5h, and then use absolute ethanol and deionized water in sequence After ultrasonic cleaning for 10 minutes, the titanium sheet obtained in this step is marked as Ti.

[0040] 6) Dissolve 0.0606g Tris in 50ml deionized water, add 0.05g DOPA after it is fully dissolved, and adjust the pH of the solution to 8 with 1mol / L HCl and 1mol / L NaOH, and immerse the above-mentioned acid-base treated titanium...

Embodiment 3

[0044] Example 3: This example is to prepare a strontium-chelated sodium alginate coating on the surface of a titanium sheet. The pH of the Tris-HCl solution used for the dopamine solution is 8 and the strontium concentration used during immersion is 0.5% by mass SrCl 2 Solution. The specific experimental steps are as follows:

[0045] 1) The titanium sheet is placed in HNO with a mass fraction of 40% 3 Corrosion at room temperature for 40 minutes, then take out the titanium sheet, rinse with deionized water and blow dry, put it in a 5mol / L NaOH solution, heat it in a water bath at 90℃ for 5h, and then use absolute ethanol and deionized water in sequence After ultrasonic cleaning for 10 minutes, the titanium sheet obtained in this step is marked as Ti.

[0046] 2) Dissolve 0.0606g Tris in 50ml deionized water, add 0.05g DOPA after it is fully dissolved, and adjust the pH of the solution to 8 with 1mol / L HCl and 1mol / L NaOH, and immerse the acid-base treated titanium sheet in The s...

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Abstract

The invention relates to a preparation method of a strontium chelated sodium alginate coating on a titanium surface. The preparation method comprises the steps that a trihydroxymethyl aminomethane water solution of dopamine is firstly utilized for treating the titanium surface, sodium alginate is grafted to the surface of the above material by means of an amide reaction of dopamine amidogen and sodium alginate carboxyl, then the obtained material is put into a strontium chloride solution, and chelation of strontium is achieved. A catechol functional group in the dopamine adheres to the titanium surface in a non-covalent manner, and then the coating is constructed on the surface of a substrate. The method is easy to operate, and bonding with a matrix is good. Sodium alginate biocompatibility is good, strontium alginate gel formed after a large quantity of carboxyl existing in molecules and strontium ions react has good chelation performance on the strontium, the strontium chelated sodium alginate coating on the titanium surface is prepared, and long-acting bone inductivity is given to transplant materials by means of slow release and degradation of the strontium. The adopted sodium alginate is good in biocompatibility and has good chelation performance with the strontium, slow release of the strontium is achieved, and quite high promotional value is achieved.

Description

Technical field [0001] The invention belongs to the technical field of surface modification of biomedical materials, and mainly relates to the preparation of an organic strontium coating on the surface of titanium to improve the biological performance of the titanium material. Background technique [0002] Titanium and titanium alloy (Ti) have light weight, high strength, good biocompatibility, and a specific gravity similar to human bone. In recent years, they have attracted great attention as medical bone graft materials. The preparation of organic strontium coating on the surface of titanium can not only utilize the good biological properties of titanium, but also the strontium of the surface coating will promote bone formation. However, an urgent problem to be solved in the preparation of coatings on the surface of titanium is that the surface of titanium is too smooth and the coating is added. Difficulty of preparation. At present, the commonly used coating preparation meth...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C23C22/64C23C22/83A61L27/34A61L27/30A61L27/54
CPCA61L27/306A61L27/34A61L27/54A61L2300/102A61L2300/412A61L2430/02C23C22/64C23C22/83C08L5/04
Inventor 贾莉莉李朝阳杨贤金崔振铎朱胜利吕维加
Owner TIANJIN UNIV
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