8 results about "Graft failure" patented technology

Systems and methods for identifying risk of kidney graft failure in a subject are provided. An image of a graft biopsy is obtained, the image representing at least a subset of a plurality of morphological classes including a tissue compartment and inflammation class. The image is inputted into a trained model that identifies, as output, for each morphological class in at least the subset, corresponding objects in the image that fall within the morphological class. For each morphological class, corresponding digital features are generated comprising a first subset of individual feature scores obtained using the objects for the morphological class and a second subset of composite feature scores obtained by combining individual feature scores. Digital features for each morphological class are compared to a reference criterion, thus determining risk of kidney graft failure.

Current approaches in small diameter vascular grafts for coronary artery bypass surgeries fail to address physiological variations along the graft that contribute to thrombus formation and ultimately graft failure. An interlayer drug delivery system can sustain delivery of heparin through the graft with a high degree of temporal and spatial control. A heparin-loaded gelatin methacrylate interlayer sits between a biohybrid composed of decellularized bovine pericardium and poly(propylene fumarate) and UV crosslinking is controlled via 3D printed shadow masks. The masks enable control of the resultant gelMA crosslinking and properties by modulating the incident light intensity on the graft. High doses of heparin have detrimental effects on endothelial cell function. When exposed to heparin in a slower, more sustained manner consistent with the masks, endothelial cells behave similarly to untreated cells. Slower release profiles cause significantly more release of tissue factor pathway inhibitor, an anticoagulant, than a faster release profile.

Enhancing the fusion ability of transplant cells tends to arrest their proliferation in the production thereof, whereas promoting the proliferation of transplant cells tends to hinder their fusion at a transplantation site. Under such circumstances, the purpose of the present invention is to enable long-term engraftment of transplant cells regardless of concomitant use of immunosuppressants by endowing transplant cells with fusion ability and allowing the transplant cells to exert the fusion ability at a transplantation site at a desired time point, thereby overcoming the problem of graft failure and immune rejection resulting in loss of cells. The present invention provides a cell containing a cell-cell fusion gene as a foreign gene, wherein the cell-cell fusion gene is allowed to be expressed in the presence of an extracellular factor.

Chronic Lung Allograft Dysfunction (CLAD) is characterized by a progressive and irreversible decline in lung function affecting half of lung transplant recipients within five years and is the major cause of death contributing to a low median post-transplant survival. Disclosed herein is an optimized airway inflammation gene set (AI2) and AI2 score, as well as RSI, RS2, and RS3 subscores, for use in methods of treating or preventing CLAD, methods of treating or preventing graft failure, methods of treating or preventing transplant rejection, methods of treating or preventing small airway fibrosis, methods of treating or preventing antibody mediated rejection (AMR) and methods of reducing mortality associated with graft failure. Also disclosed are methods of detecting or diagnosing CLAD and methods of predicting transplant rejection.

Chronic Lung Allograft Dysfunction (CLAD) is characterized by a progressive and irreversible decline in lung function affecting half of lung transplant recipients within five years and is the major cause of death contributing to a low median post-transplant survival. Disclosed herein is an optimized airway inflammation gene set (AI2) and AI2 score, as well as RS1, RS2, and RS3 subscores, for use in methods of treating or preventing CLAD, methods of treating or preventing graft failure, methods of treating or preventing transplant rejection, methods of treating or preventing small airway fibrosis, methods of treating or preventing antibody mediated rejection (AMR) and methods of reducing mortality associated with graft failure. Also disclosed are methods of method of detecting or diagnosing CLAD and methods of predicting transplant rejection.

The traditional Chinese medicine composition of charred astragalus root, herba lycopi, fried atractylodes, poria, radix cyathulae, radix cyathulae, semen cuscutae, radix puerariae, fried white peony root, albizia flower, and charred licorice can be used for treating gynecological diseases or symptoms such as intrauterine adhesion, thin endometrium, oligomenorrhea, postmenstrual error, dysmenorrhea, endometritis, pelvic inflammatory disease, decreased ovarian reserve, repeated implantation failure, and infertility, or preparing drugs for treating gynecological diseases or symptoms.

The utility model provides a fruit tree grafting union protection device, which relates to the technical field of grafting protection and comprises rubber sleeves, two rubber sleeves are clamped at grafting positions of fruit tree branches, grafting points are positioned in the middles of the rubber sleeves, and binding pieces are arranged in the middles of the rubber sleeves. The binding piece is tied on the surface of the rubber sleeve so that the rubber sleeve can be fixed to the surface of the branch to support the branch, the positions, close to the two end openings, of the surface of the rubber sleeve are bound and fixed to the surface of the branch through restraint straps, and the two end openings of the rubber sleeve and the branch are sealed through sealing cement gum. Wherein an auxiliary component for conveying disinfectant to a grafting wound through capillarity is arranged on the rubber sleeve. The fiber core for wetting the plant antibiotic disinfectant penetrates through the rubber sleeve and is inserted into the gap between the rubber sleeve and the branch, the capillary gap in the fiber core can continuously convey the external plant antibiotic disinfectant into the interior to be evaporated, the internal space is disinfected, and then grafting failure caused by fruit tree branch grafting wound infection is reduced.

The invention discloses a grafting culture method and application of a composition containing a UV photocuring adhesive. The UV light-cured adhesive composition comprises a UV light-cured resin and hydrophilic particles dispersed in the UV light-cured resin, and the hydrophilic particles absorb water and swell. According to the grafting method of the UV glue containing the hydrophilic particles, the continuous and soft endogenous clamping force generated by water absorption swelling of the hydrophilic particles provides a stable microenvironment for the joint part of the rootstock and the scion, formation of calluses and communication of vascular bundles are facilitated, and grafting failures caused by disturbance or water loss are reduced.