33 results about "Graft failure" patented technology

An inhibitor of a glutaminyl peptide cyclotransferase, and use thereof for the treatment and/or prevention of a disease or disorder selected from the group consisting of inflammatory diseases selected from

• • a. neurodegenerative diseases, e.g. mild cognitive impairment (MCI), Alzheimer's disease, neurodegeneration in Down Syndrome, Familial British Dementia, Familial Danish Dementia, multiple sclerosis,
  • b. chronic and acute inflammations, e.g. rheumatoid arthritis, atherosclerosis, restenosis, pancreatitis,
  • c. fibrosis, e.g. lung fibrosis, liver fibrosis, renal fibrosis,
  • d. cancer, e.g. cancer/hemangioendothelioma proliferation, gastric carcinomas,
  • e. metabolic diseases, e.g. hypertension,
  • f. and other inflammatory diseases, e.g. neuropathic pain, graft rejection/graft failure/graft vasculopathy, HIV infections/AIDS, gestosis, tuberous sclerosis.

Additionally disclosed are a respective diagnostic method, assay and kit.

The present invention provides methods and compositions for treating graft failure resulting from neointimal hyperplasia. These methods and compositions feature the use of platelet derived growth factor receptor (PDGFR) inhibitor compounds, such as N-phenyl-2-pyrimidine compounds (e.g., imatinib mesylate) to inhibit the biological activity of the PDGFR.

The present invention provides a method of preventing or reducing restenosis, neointima formation, graft failure, atherosclerosis, angiogenesis and/or solid tumour growth in a subject The method comprises administering to the subject a prophylactically effective dose of a nucleic acid which decreases the level of c-Jun mRNA, c-Jun mRNA translation or nuclear accumulation or activity of c-Jun. It is preferred that the nucleic acid is a DNAzyme that targets c-Jun mRNA.

The invention discloses a medical implant for improving cell osteogenesis performance and a preparation method thereof. The polished and cleaned medical metal is subjected to laser processing so as toobtain a surface structure with super-hydrophilic performance, and a statin drug coating is prepared on the super-hydrophilic surface, so that the drug loading is more uniform and sufficient. The medical implant with the drug coating has the function of enhancing the osteogenesis performance of human cells, is beneficial to rapid and tight combination with human tissues after being implanted intoa human body, is beneficial to smooth implementation of a transplantation operation, and effectively avoids secondary injury caused by transplantation failure.

The present invention provides methods and compositions for treating graft failure resulting from neointimal hyperplasia. These methods and compositions feature the use of platelet derived growth factor receptor (PDGFR) inhibitor compounds, such as N-phenyl-2-pyrimidine compounds (e.g., imatinib mesylate), or mTOR inhibitors (e.g., rapamycin).

The invention relates to grafting methods, in particular to a grafting method for vine plants. The grafting method comprise the steps that 1, a connecting hose which makes wood penetrate through one end of a ball extends into a ball body; 2, the connecting hose which makes a scion penetrate through the other end of the ball extends into the ball body; 3, docking and positioning of the wood and scion are completed; 4, agar is applied to the connecting place of the wood and the ball body, then the connecting hose is wrapped outside, agar is applied to the connecting place of the scion and the ball body, and the connecting hose is wrapped outside; 5, nutrient solution and growth hormone are injected into the ball body; 6, air or air mixture lighter than the air is injected into the ball body, and then a sealed ball is inflated to seal the ball body. The method for improving the success rate of grafting vine plants is provided in order to solve the problem of grafting failure caused by the soft texture of vine plants.

A vascular bypass graft having a primary member and a secondary member is disclosed. The secondary member extends from a distal second end of the primary member and has a common fluid pathway there between. The secondary member may have a flared or diffused proximal first end that facilitates low pressure fluid return and may be integrally formed with the primary member. An adjustable or fixed stenosis is provided in the secondary member which allows the fluid flow through the vascular bypass graft to be modified. The stenosis may be adjusted either manually or by way of a controller. The primary member is surgically connected to a patient's vascular system to provide an alternate route for blood flow around a vascular occlusion. The secondary member is surgically connected to another point in the vascular system to allow continuous circulation of blood through the graft thereby preventing clotting and graft failure.

The invention discloses a multi-species top grafting method for pumpkins, and relates to the field of pumpkin grafting. The method specifically comprises the following steps of step 1, species selection, wherein a rootstock pumpkin and a scion pumpkin are selected; step 2, preparation before seeding; step 3, seeding; step 4, grafting, wherein when 12-15 main pumpkin leaves grow, topping is performed, and a sufficient amount of fertilizers and water are applied, when the third main leaf of a branch is expands, grafting is performed by adopting a cleft grafting method, hydrogen-rich water with amass fraction of 270-320 ppm is sprayed 4-5 times a day, and grafting plastic or grafting clips are removed after survival; step 5, maintenance in a viewing period. The multi-species top grafting method for the pumpkins has the advantages that the design is reasonable, by using the hydrogen-rich water for grafting of ornamental pumpkins with the assistance of the steps such as the species selection and seeding, the problems of high multi-species grafting failure rate, difficult fruiting, difficult wound healing and weaker growth of the ornamental pumpkins can be solved, the pumpkins with great ornamental value can be obtained, and the application prospect is broad.

Disclosed are methods for treating a vascular graft that include introducing an effective amount of at least one nucleic acid encoding at least one agent that increases activated protein C (APC), expressing the agent in the cells; and increasing the APC sufficient to treat the blood vessel. Also provided are vascular grafts engineered to resist early and/or late graft failure.

The present invention provides a method for detecting transplantation failure of a transplanted organ or cells which comprises detecting a donor-positive but recipient-negative DNA marker in the recipient's plasma using pyrophosphorolysis activated polymerization. Because of the high sensitivity, specificity and selectivity of pyrophosphorolysis activated polymerization, transplantation failure can be detected at early stages and treatment can be initiate earlier.

The invention provides a medicine for treating low blocking antibodies. The traditional Chinese medicine composition is prepared from 15-30 parts of radix astragali, 9-15 parts of rhizoma atractylodis macrocephalae, 6-9 parts of dried orange peel, 12-24 parts of radix ginseng, 6-9 parts of radix bupleuri, 6 parts of rhizoma cimicifugae, 6 parts of radix glycyrrhizae, 10-12 parts of radix angelicae sinensis, 12-15 parts of parched white peony roots, 12-15 parts of radix rehmanniae preparata, 3-6 parts of fructus amomi and 9-12 parts of rhizoma chuanxiong. All the medicines are combined for use and can provide sufficient healthy qi and full qi and blood to obtain yang blocking antibodies. The traditional Chinese medicine composition is simple to use, convenient, safe, harmless to the human body, high in cure rate, short in treatment course and low in treatment cost. The traditional Chinese medicine composition has the benefits that the traditional Chinese medicine composition is used for patients with low blocking antibodies due to inevitable abortion, recurrent spontaneous abortion, transplantation failure history or repeated transplantation failure.

The present invention relates to a nucleus covered or coated with a film including one or more PHA. The invention also relates to a PHA, characterized in that it is of the type PHB-V, a film and a composition including the PHA. The invention further relates to a film or a composition including a PHA and zosteric acid or a bioactive molecule. The invention moreover relates to a surface, preferably a nucleus, covered with the film of PHA, a method for production thereof, and methods for grafting a pearl oyster and producing a pearl using this nucleus. Finally, the present invention relates to a method for reducing graft failure and/or for improving the quality of the pearl using the nucleus according to the invention.

The invention provides an aeroponic culture breeding method for grafting tomatoes on potatoes and potato and tomato seedlings bred by the aeroponic culture breeding method, and particularly relates to the technical field of soilless culture. According to the aeroponic culture breeding method for grafting the tomatoes on the potatoes, the problems of grafting failure and low survival rate after grafting due to incoordination of a reservoir source relationship of the potatoes and the tomatoes can be effectively solved, the potato and tomato seedlings with the tomatoes growing on the upper portion and the potatoes (potato breeder's seeds) growing on the lower portion can be cultivated through the method, and the survival rate is high. Moreover, the potato and tomato seedlings are cultivated by adopting the aeroponic cultivation method, and soilless and matrix-free cultivation is realized, so that the absorption and utilization rate of the seedlings on a nutrient solution is high, and the economic benefit is relatively high. In addition, the potato and tomato seedlings bred through the method are high in disease resistance and good in pest control effect. The miniature potatoes and the tomatoes produced by the potato and tomato seedlings are good in quality, the tomatoes are good in taste and flavor, and economic benefits are high.

The present invention relates to methods for assessing graft failure risk. Many predictive models of graft survival based on large panels of data collected exist but a limitation of these models is that they do not take into account the onset of adverse events over time, which modify graft outcome. The inventors developed a conditional and adjustable score, taking into account onset of emerging risks over time such as development of dnDSA, for prediction of graft failure (AdGFS) up to 10 years post-transplantation in 664 kidney transplant patients. AdGFS was externally validated and calibrated in 896 kidney transplant patients. In particular, the present invention relates to a method of assessing graft failure risk in a subject by measuring several factors: serum creatinine concentration, de novo donor-specific anti-HLA antibodies, pretransplant non donor-specific anti-HLA antibodies, acute rejection, age, proteinuria longitudinal serum creatinine cluster.

The invention discloses a management method used after peach tree grafting. The management method used after peach tree grafting includes the steps of film uncovering, piled soil inspection, rootstockbud stripping, fertilization, drainage and irrigation, and prevention of diseases, pests and weeds. Compared with the prior art, the method reduces branches competing for nutrients, tree vigor aftergrafting restores robustness, grafting wounds quickly heal, the manpower and material cost for secondary grafting caused by grafting failures is reduced, the phenomenon that annual shoots are likely to be dry at extreme low temperature in winter is avoided, scions are prevented from being broken by strong winds, and the preservation rate and next-year yield of peach trees after grafting are improved.