The invention discloses multiple-effect toothpaste capable of removing stains and conducting maintenance. The toothpaste comprises 3-8 parts of a stain-removing agent, 2-6 parts of an enzyme preparation, 3-9 parts of sodium carboxymethylcellulose, 2-6 parts of green tea extract, 5-10 parts of glycerin, 2-7 parts of xanthan gum, 1-7 parts of stevioside, 2-5 parts of mint oil, 6-15 parts of water, 1-3 parts of strontium chloride, 1-4 parts of paeonol, 2-5 parts of thymol crystals, 4-9 parts of asarum, 2-6 parts of herba schizonepetae, 1-4 parts of immune globulin, 3-8 parts of Chinese barberry root extract, 2-6 parts of betel nut extract, 1-6 parts of herba patriniae, 4-10 parts of halite, 3-7 parts of Japanese pagodatree twig extract, 2-5 parts of radix ophiopogonis, 2-6 parts of fructus piperis longi, 4-9 parts of lasiosphaera seu calvatia, 1-6 parts of fructus arctii, 2-5 parts of nidus vespae and 1-5 parts of honey. The toothpaste has good tooth stain removal efficacy and can maintain gingiva and prevent redness and swelling of the gingiva.