The invention belongs to the scientific and technical field of 
oral medicine and 
oral health, and particularly relates to an 
oral health-care agent capable of clearing away heat and toxic materials, and a preparation method thereof. The 
oral health-care agent contains a food-grade heat-clearing and detoxicating prescription, an anti-ulcer agent, a caries-prevention agent, a 
cell adhesion 
moisturizer, a natural antibacterial and anti-inflammatory agent and an oral health-care agent, preferably, the preparation further contains a 
preservative, more preferably, the preparation further contains apreparation-acceptable safety carrier or excipients; and all the ingredients are scientifically prepared and optimized to obtain a group of safety and multi-effect compositions which not only can clear away heat and toxic materials and is antibacterial and anti-inflammatory, but also can prevent tooth and 
periodontium and other oral diseases, and then a convenient and practical oral health-care agent is prepared by adopting a mild technological method. The oral health-care agent capable of clearing away heat and toxic materials not only has 
medicine efficacy, but also has the safety of health-care food, and is convenient to use, good in 
efficacy and fast in effect.