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Tooth sensitivity prevention composition

A composition and technology of polycarboxyl compounds, applied in the field of oral care, can solve problems such as no hydroxyapatite plugging method found

Active Publication Date: 2016-06-22
HAWLEY & HAZEL CHEMICAL CO (ZHONGSHAN) LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, no plugging method has been found to allow hydroxyapatite to penetrate deep into the dentinal tubules

Method used

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  • Tooth sensitivity prevention composition
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preparation example Construction

[0036] The invention provides a composition capable of entering the inside of the dentine tubule to block the dentine tubule, its preparation method and application.

[0037] Dentin is an important component of teeth. Dentin tubules are arranged and distributed in the dentin, radiating from the pulp end to the enamel-dentin interface. It is generally believed that when the opening of the dentinal tubules is exposed on the surface of the dentin and encounters cold, heat, acid, sweet, mechanical or chemical stimuli, the nerve endings of the dental pulp are excited, resulting in short-term pain, that is, dentin hypersensitivity symptoms. Studies have shown that individuals with dentin sensitivity have a greater number of open dentinal tubules and a larger mean diameter than individuals with dentin insensitivity. Therefore, dentinal hypersensitivity can be alleviated or treated by reducing the permeability of dentin by blocking dentinal tubules.

[0038] An important component o...

Embodiment 1

[0114] Example 1: Preparation of an aqueous mixed solution of nano-hydroxyapatite, citrate and soluble calcium

[0115] 1.1 Raw material

[0116] Raw material 1: Nano-hydroxyapatite (NanoHAP) is a commercial product (purchased from Fluidinova, Portugal), which is about 15% NanoHAP aqueous solution, which contains about 1053ppm soluble calcium, which is derived from incomplete reaction when preparing nano-hydroxyapatite Calcium chloride, a soluble calcium source, has not been removed by means known to those skilled in the art.

[0117] Raw material 2: Nano-hydroxyapatite (NanoHAP) is a commercial product (purchased from Shanghai Zilin Biotechnology Co., Ltd.). It is very small, and the soluble calcium produced by its dissolution in water is basically negligible.

[0118] The morphology and size of the two NanoHAPs are as follows: figure 1 , figure 2 as shown, figure 1 It is a short rod with a length of 20nm-50nm, figure 2 Needle shape of 20nm-50nm.

[0119] Potassium c...

Embodiment 2

[0139] Example 2: Nano-hydroxyapatite plugging and access to dentinal tubules

[0140] 2.1 Preparation method of dentin tubule exposure model

[0141] (A) Preparation method of model A perpendicular to the observation surface of dentinal tubules

[0142] Take bovine teeth, cut a 2mm thick disc 3mm down from the junction of the root and the crown perpendicular to the long axis of the bovine tooth, and use a polishing machine to erase the edge of the disc to obtain a rectangular observation area of ​​2mmx6mm. Then use 600-mesh, 1200-mesh, and 2000-mesh sandpaper to polish the observation area to obtain a flat and smooth observation surface. After polishing, etched with 6wt% citric acid for 5 minutes to expose the dentinal tubules, and then washed 3 times with an ultrasonic cleaner for 15 minutes each time to obtain the model A perpendicular to the observation surface of the dentinal tubules. Observed under SEM, the model A perpendicular to the observation surface of the dentin...

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Abstract

The invention relates to an oral care composition containing hydroxyapatite, a polycarboxylic compound, soluble calcium and an orally acceptable carrier, an aqueous mixed liquid containing hydroxyapatite, the polycarboxylic compound and soluble calcium, and a use of the aqueous mixed liquid in alleviation and prevention of tooth sensitivity. Hydroxyapatite in the oral care composition can plug openings of dentinal tubules, and also can deeply enter dozens-of-micrometers deep positions in the dentinal tubules. The oral care composition is prepared through mixing the aqueous mixed liquid with the orally acceptable carrier. The aqueous mixed liquid is prepared through mixing the polycarboxylic compound hydroxyapatite and soluble calcium in an aqueous solution.

Description

technical field [0001] The invention relates to the field of oral care, in particular to a composition that can be used to block dentin tubules, a preparation method and an application thereof. Background technique [0002] Dentin hypersensitivity is a common and frequently-occurring disease in the Department of Stomatology, and it is also one of the common causes of clinical toothache. The pathogenesis of dentin hypersensitivity is still unclear, but the hydrodynamic theory proposed by Brannstrom et al. Fluid dynamics believes that there is dentinal tubule fluid in dentinal tubules. When various reasons such as gingival recession or tooth erosion lead to excessive opening and exposure of dentinal tubules, various external stimuli (temperature, chemical, mechanical, etc.) It will cause the body fluid in the dentinal tubules to flow excessively inside and outside, and mechanically stimulate the nerve endings of the dental pulp which are very sensitive to pressure, generate i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/24A61K8/365A61K8/88A61K8/55A61K8/81A61K8/44A61Q11/00A61P37/08
CPCA61Q11/00A61K8/19A61K8/24A61K8/365A61P37/08
Inventor 岳红雷李艳晓
Owner HAWLEY & HAZEL CHEMICAL CO (ZHONGSHAN) LTD
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