Preparation method of whitening and antiallergic toothpaste

Abstract

The invention relates to the field of oral care products, and particularly discloses a preparation method of whitening and antiallergic toothpaste which comprises the following raw materials: deionized water, an abrasive, a traditional Chinese medicine extract, sodium phytate, a microcapsule desensitizer, torreya grandis seed oil, sorbitol, cocamidopropyl betaine, xanthan gum and sodium carboxymethyl cellulose. The preparation method comprises the following steps: mixing the xanthan gum, the sodium carboxymethyl cellulose, the sorbitol and the deionized water, stirring and dispersing, then adding the abrasive, the sodium phytate and the cocamidopropyl betaine, stirring and dispersing in vacuum, finally adding the traditional Chinese medicine extract, the microcapsule desensitizer and the torreya grandis seed oil, continuously stirring and dispersing, and vacuumizing, discharging and filling in a vacuum state. The whitening and antiallergic toothpaste is obtained. The whitening anti-allergic toothpaste prepared by the invention is proper in friction value, excellent in tooth stain and dental plaque removal effect, remarkable in tooth whitening effect, capable of solving the problem of dentin hypersensitivity in multiple aspects and remarkable in anti-allergic effect.

Description

Technical Field

[0001] The present application relates to the field of oral care products, and more specifically, to a method for preparing a whitening and anti-allergic toothpaste. Background Art

[0002] With the development of society, people's living standards are gradually improving, material and cultural life is becoming more and more abundant, and people pay more and more attention to teeth. While pursuing a clean mouth, they also hope to protect their mouth and whiten their teeth. A mouthful of white teeth is the pursuit of almost everyone.

[0003] In daily life, items such as cigarettes, tea, coffee, etc. often leave residues on the surface of teeth as they pass through the mouth. Over a long period of time, the teeth will gradually turn yellow or even black, affecting their appearance and having a certain impact on people's normal social activities.

[0004] At the same time, most people have the problem of dentin hypersensitivity, which is manifested in that when the teeth are stimulated by external factors, such as drinking water, eating cold, hot, sour, or sweet food, rubbing or biting hard objects, the teeth will feel obvious soreness and discomfort.

[0005] In order to pursue white teeth, people generally use different teeth whitening methods to whiten their teeth, such as cold light whitening, dental veneers, etc. These teeth whitening methods can help teeth whiten quickly, but at the same time they will have a certain erosion on tooth enamel, which will seriously damage tooth enamel and aggravate the problem of dentin hypersensitivity.

[0006] Brushing teeth is a daily way of life for people to keep their oral cavity clean and protect their teeth. Toothpaste for brushing teeth has become a necessity in daily life. Based on people's demand for teeth whitening and the problem of dentin allergy, the present application provides a method for preparing a whitening and anti-allergic toothpaste. Summary of the invention

[0007] In order to solve people's pursuit of white teeth and the problems of dentin hypersensitivity faced by most people, the present application provides a method for preparing a whitening and anti-allergic toothpaste.

[0008] In the first aspect, the present application provides a whitening and anti-allergic toothpaste, which adopts the following technical solution:

[0009] A whitening and anti-allergic toothpaste, characterized by comprising the following raw materials in parts by weight:

[0010] 10-30 parts of deionized water, 15-25 parts of abrasives, 1-3 parts of Chinese herbal extracts, 0.8-1.2 parts of sodium phytate, 8-12 parts of microcapsule desensitizers, 0.8-1.6 parts of Torreya grandis seed oil, 8-12 parts of sorbitol, 2-3 parts of cocamidopropyl betaine, 0.8-1 parts of xanthan gum, and 0.8-1 parts of sodium carboxymethyl cellulose.

[0011] Preferably, the friction agent is a mixture of hydrated silica and plant fiber particles in a mass ratio of 1:8-12.

[0012] Preferably, the particle size of the hydrated silica is 10-20 μm.

[0013] Preferably, the plant fiber particles are prepared by the following method:

[0014] A1. Crushing: Add bamboo chips, coconut shells and walnut shells into a crusher and crush them respectively, then pass through a 400-500 mesh sieve to obtain bamboo fiber particles, coconut shell fiber particles and walnut shell fiber particles;

[0015] A2, mixing bamboo fiber particles, coconut shell fiber particles, and walnut shell fiber particles in a mass ratio of 10:5-8:3-5 to obtain a plant fiber particle mixture;

[0016] A3. Disinfection and sterilization: sterilize the plant fiber particle mixture in step A1 by high temperature steam for 2-3 hours, and cool it to obtain the desired plant fiber particles.

[0017] Preferably, the Chinese medicine extract is prepared by the following method:

[0018] B1. Mixing mint leaves, tea leaves, scutellaria baicalensis, angelica dahurica and Panax notoginseng to obtain a Chinese medicine mixture;

[0019] B2, crushing the Chinese medicine mixture in step B1, passing through a 60-100 mesh sieve, soaking in distilled water for 3-5 hours, adding ethanol, reflux extraction, filtering while hot, and collecting the filtrate;

[0020] B3, concentrating the filtrate in step B2 under reduced pressure until the ethanol is completely evaporated, and collecting the concentrated solution;

[0021] B4. Distilled water is added to the concentrated solution in step B3 for dilution, the solution is allowed to stand for 4-6 hours, and the supernatant is taken by centrifugation and further concentrated into a paste to obtain the desired Chinese medicine extract.

[0022] Preferably, in step B1, the mass ratio of mint leaves, tea leaves, scutellaria baicalensis, angelica dahurica and Panax notoginseng is 12-16:8-10:2-3:1.5-4.5:1-1.5; in step B2, the mass ratio of the traditional Chinese medicine mixture, distilled water and ethanol is 1:10-15:8-10; and in step B4, the mass ratio of the concentrate and distilled water is 1:4-5.

[0023] Preferably, the microcapsule desensitizer is prepared by the following method:

[0024] C1, mixing the chitosan solution and the citric acid solution to form a mixed solution A;

[0025] C2, adding arginine, calcium silicate and paeonol to the mixed solution A, and dispersing them ultrasonically at a frequency of 20-30 kHz for 0.5-1 h to obtain a mixed solution B;

[0026] C3, adding sodium lauryl sulfate and soybean oil to the mixed solution B, stirring at a rate of 100-200 r / min for 0.5-1 h to obtain a microcapsule suspension;

[0027] C4. After the microcapsule suspension is spray-dried, the desired microcapsule desensitizer is obtained.

[0028] Preferably, in step C1, the mass ratio of chitosan solution to citric acid solution is 5-8:1-2; in step C2, the mass ratio of arginine, calcium silicate, paeonol to mixed solution A is 1:3-5:0.8-1.2:10-14; in step C3, the mass ratio of sodium lauryl sulfate, soybean oil to mixed solution B is 1:30-40:10-14.

[0029] Preferably, the arginine in step C2 is L-arginine; and the spray drying conditions in step C4 are that the inlet air temperature is 130-160°C and the outlet air temperature is 65-85°C.

[0030] In a second aspect, the present application provides a method for preparing a whitening and anti-allergic toothpaste, using the following technical solution:

[0031] A preparation method of a whitening and anti-allergic toothpaste comprises the following steps: mixing xanthan gum, sodium carboxymethyl cellulose, sorbitol and deionized water, stirring and dispersing, then adding an abrasive, sodium phytate and cocamidopropyl betaine and stirring and dispersing them in a vacuum, finally adding a traditional Chinese medicine extract, a microcapsule desensitizer and Torreya grandis seed oil and continuing to stir and disperse them, maintaining bubbling for 3-6 minutes at a vacuum degree of ≥0.1MPa, discharging the materials, and filling the products to obtain the whitening and anti-allergic toothpaste.

[0032] In summary, this application has the following beneficial effects:

[0033] 1. This application adopts a mixture of hydrated silica and plant fiber particles as an abrasive. The plant fiber particles are selected from bamboo fiber particles, coconut shell fiber particles, and walnut shell fiber particles. Different plant fiber particles have different hardnesses. The mixed use of the three provides a more comprehensive cleaning ability and more efficiently removes dental plaque and tooth stains. The mixed use of the three also has better wear balance and can reduce excessive wear on the tooth surface. At the same time, plant fiber particles are derived from natural plants. Compared with traditional chemical synthetic abrasives, they have lower irritation and better biocompatibility, which helps to reduce potential damage to teeth and oral cavity.

[0034] 2. The present application adds Chinese herbal medicine extracts, and the raw materials are mint leaves, tea leaves, scutellaria baicalensis, angelica dahurica, and Panax notoginseng; mint leaves and tea extracts added to toothpaste can significantly improve breath and make the oral cavity more fresh and pleasant; tea leaves are rich in tea polyphenols, which help remove stains and plaque on the surface of teeth; the active ingredients in the extracts of scutellaria baicalensis, angelica dahurica and Panax notoginseng can combine with and decompose stains on the surface of teeth, thereby removing stains. The combination of scutellaria baicalensis, angelica dahurica and Panax notoginseng can enhance the cleaning effect of toothpaste and more effectively remove tooth stains and plaque.

[0035] 3. The present application adds Torreya grandis seed oil to the toothpaste. Torreya grandis seed oil has antioxidant and anti-inflammatory activity, which helps to reduce free radicals and inflammatory reactions in the oral cavity, helps to reduce the formation of dental plaque, and inhibits the production of tooth stains. The nutrients in Torreya grandis seed oil can provide the necessary nourishment for teeth and gums, help to improve the texture and gloss of teeth, and enhance the health of gums. Long-term use of toothpaste containing Torreya grandis seed oil can help reduce problems such as tooth sensitivity and swollen and painful gums.

[0036] 4. This application uses arginine, calcium silicate, and paeonol in a mixed form to make a desensitizer, and uses microcapsule coating technology to make a microcapsule desensitizer. Arginine is a natural amino acid present in saliva. After entering the oral cavity, it can promote the deposition of calcium and phosphorus ions, forming a calcium-rich protective layer, which can block and seal the open dentinal tubules, thereby blocking the generation of dentin sensitivity and pain; calcium silicate can promote the remineralization of teeth, enhance the hardness and acid resistance of teeth, and help prevent caries and dentin sensitivity; arginine seals the dentinal tubules, and calcium silicate promotes remineralization, and the two complement each other and further enhance the desensitization effect; paeonol can reduce the sensitivity of the pulp nerve to dentin hypersensitivity, and play an analgesic and sedative role; arginine, calcium silicate, and paeonol are mixed together, and the mechanism of action complements each other, which can more comprehensively solve the problem of dentin sensitivity, and the three mixed can also prevent caries, remove stains, keep the mouth clean and hygienic, and provide comprehensive oral care.

[0037] The present application further adopts microcapsule coating technology to make microcapsule desensitizer. Microcapsule technology can encapsulate the desensitizer in tiny capsules, thereby protecting it from the influence of the external environment and improving the stability of the desensitizer. Microcapsules can control the release rate and method of the desensitizer, thereby ensuring that the desensitizer can act more effectively on the tooth surface and dentinal tubules when brushing teeth, which helps to more comprehensively seal the dentinal tubules and relieve the symptoms of dentin sensitivity.

[0038] 5 The whitening and anti-allergic toothpaste prepared in this application has an appropriate friction value, excellent effect in removing tooth stains and dental plaque, has a significant effect of whitening teeth, solves the problem of dentin sensitivity in many aspects, and has a significant anti-allergic effect. DETAILED DESCRIPTION

[0039] The present application is further described in detail below with reference to the embodiments.

[0040] The raw materials used in the examples and comparative examples of the present application are as follows:

[0041] Torreya grandis seed oil was purchased from Kangmin Herbal Oil Refinery in Jishui County, Jiangxi Province.

[0042] Embodiment 1-3 provides a whitening and anti-allergic toothpaste and a preparation method thereof.

[0043] Example 1

[0044] Preparation of friction agent:

[0045] A1. Crushing: Add bamboo chips, coconut shells and walnut shells into a crusher and crush them respectively, then pass through a 400-mesh sieve to obtain bamboo fiber particles, coconut shell fiber particles and walnut shell fiber particles;

[0046] A2, mixing bamboo fiber particles, coconut fiber particles, and walnut shell fiber particles in a mass ratio of 10:5:3, and mixing them evenly to obtain a plant fiber particle mixture;

[0047] A3. Disinfection and sterilization: sterilize the plant fiber particle mixture in step A1 by placing it in 100° C. high-temperature steam for 2 hours, and cool it for 5 hours to obtain the desired plant fiber particles;

[0048] A4. Mix hydrated silica and plant fiber particles in a mass ratio of 1:8 to obtain the desired friction agent, wherein the particle size of the hydrated silica is 10 μm.

[0049] Preparation of Chinese herbal medicine extracts:

[0050] B1. Mix mint leaves, tea leaves, scutellaria baicalensis, angelica dahurica and Panax notoginseng in a mass ratio of 12:8:2:1.5:1 to obtain a Chinese medicine mixture;

[0051] B2, crush the Chinese medicine mixture in step B1, pass through a 60-mesh sieve, soak in distilled water for 3 hours, add ethanol, reflux extract twice, each time for 2 hours, filter while hot, collect the filtrate, wherein the mass ratio of the Chinese medicine mixture, distilled water, and ethanol is 1:10:8;

[0052] B3, concentrating the filtrate in step B2 under reduced pressure until the ethanol is completely evaporated, and collecting the concentrated solution;

[0053] B4. Add distilled water to dilute the concentrate in step B3, let it stand for 4 hours, centrifuge at 12000 rpm for 5 minutes, take the supernatant, and further concentrate it to a specific gravity of 1.3 g / cm 3 The desired Chinese medicine extract is obtained by mixing the concentrated solution with distilled water in a mass ratio of 1:4.

[0054] Preparation of microcapsule desensitizer:

[0055] C1, mixing a 3% chitosan solution and a 20% citric acid solution in a mass ratio of 8:1 to form a mixed solution A;

[0056] C2, adding L-arginine, calcium silicate and paeonol to the mixed solution A, and ultrasonically dispersing them at a frequency of 20 kHz for 0.5 h to obtain a mixed solution B, wherein the mass ratio of L-arginine, calcium silicate and paeonol to the mixed solution A is 1:3:0.8:10;

[0057] C3, adding sodium dodecyl sulfate and soybean oil to the mixed solution B, stirring at a rate of 100 r / min for 0.5 h to obtain a microcapsule suspension, wherein the mass ratio of sodium dodecyl sulfate, soybean oil to the mixed solution B is 1:30:10;

[0058] C4. After the microcapsule suspension is spray-dried, the desired microcapsule desensitizer is obtained, wherein the spray-drying conditions are as follows: the inlet air temperature is 130° C. and the outlet air temperature is 65° C.

[0059] A preparation method of a whitening and anti-allergic toothpaste comprises the following steps: 0.8 parts of xanthan gum, 0.8 parts of sodium carboxymethyl cellulose, 8 parts of sorbitol and 10 parts of deionized water are mixed, and the mixture is stirred at a rate of 100 r / min for 1 hour; then 15 parts of abrasives, 0.8 parts of sodium phytate and 2 parts of cocamidopropyl betaine are added, and the mixture is stirred at a rate of 100 r / min for 1 hour under a vacuum state; finally, 1 part of a traditional Chinese medicine extract, 8 parts of a microcapsule desensitizer and 0.8 parts of Torreya grandis seed oil are added, the mixture is stirred at a rate of 100 r / min for 1 hour, and the bubbling is maintained at a vacuum degree of 0.1 MPa for 3 minutes, the material is discharged and the mixture is filled to obtain the whitening and anti-allergic toothpaste.

[0060] Example 2

[0061] Preparation of friction agent:

[0062] A1. Crushing: Add bamboo chips, coconut shells and walnut shells into a crusher and crush them respectively, then pass through a 450-mesh sieve to obtain bamboo fiber particles, coconut shell fiber particles and walnut shell fiber particles;

[0063] A2, mixing bamboo fiber particles, coconut shell fiber particles, and walnut shell fiber particles in a mass ratio of 10:6.5:4, and mixing them evenly to obtain a plant fiber particle mixture;

[0064] A3. Disinfection and sterilization: sterilize the plant fiber particle mixture in step A1 by placing it in 100° C. high-temperature steam for 2.5 hours, and cool it for 6.5 hours to obtain the desired plant fiber particles;

[0065] A4. Mix hydrated silica and plant fiber particles in a mass ratio of 1:10 to obtain the desired friction agent, wherein the particle size of the hydrated silica is 15 μm.

[0066] Preparation of Chinese herbal medicine extracts:

[0067] B1. Mix mint leaves, tea leaves, scutellaria baicalensis, angelica dahurica and Panax notoginseng in a mass ratio of 14:9:2.5:3:1.25 to obtain a Chinese medicine mixture;

[0068] B2, crush the Chinese medicine mixture in step B1, pass through an 80-mesh sieve, soak in distilled water for 4 hours, add ethanol, reflux extract twice, each time for 2.5 hours, filter while hot, collect the filtrate, wherein the mass ratio of Chinese medicine mixture, distilled water, and ethanol is 1:12.5:9;

[0069] B3, concentrating the filtrate in step B2 under reduced pressure until the ethanol is completely evaporated, and collecting the concentrated solution;

[0070] B4. Distilled water was added to the concentrated solution in step B3 for dilution, and the solution was allowed to stand for 5 h. The supernatant was taken after centrifugation at 12000 rpm for 7.5 min and further concentrated to a specific gravity of 1.3 g / cm 3 The desired Chinese medicine extract is obtained by mixing the concentrated solution with distilled water in a mass ratio of 1:4.5.

[0071] Preparation of microcapsule desensitizer:

[0072] C1, mixing a 4% chitosan solution and a 25% citric acid solution in a mass ratio of 6.5:1.5 to form a mixed solution A;

[0073] C2, adding L-arginine, calcium silicate and paeonol to the mixed solution A, and ultrasonically dispersing them at a frequency of 25 kHz for 0.75 h to obtain a mixed solution B, wherein the mass ratio of L-arginine, calcium silicate and paeonol to the mixed solution A is 1:4:1:12;

[0074] C3, adding sodium lauryl sulfate and soybean oil to the mixed solution B, stirring at a rate of 150 r / min for 0.75 h to obtain a microcapsule suspension, wherein the mass ratio of sodium lauryl sulfate, soybean oil to the mixed solution B is 1:35:12;

[0075] C4. After the microcapsule suspension is spray-dried, the desired microcapsule desensitizer is obtained, wherein the spray-drying conditions are as follows: the inlet air temperature is 145°C and the outlet air temperature is 75°C.

[0076] A preparation method of a whitening and anti-allergic toothpaste comprises the following steps: 0.9 parts of xanthan gum, 0.9 parts of sodium carboxymethyl cellulose, 10 parts of sorbitol and 20 parts of deionized water are mixed, and the mixture is stirred at a rate of 150 r / min for 1.5 hours; then 20 parts of abrasives, 1 part of sodium phytate and 2.5 parts of cocamidopropyl betaine are added, and the mixture is stirred at a rate of 150 r / min for 1.5 hours under a vacuum state; finally 2 parts of a Chinese herbal medicine extract, 10 parts of a microcapsule desensitizer and 2.4 parts of Torreya grandis seed oil are added, and the mixture is stirred at a rate of 150 r / min for 1.5 hours; the mixture is bubbling at a vacuum degree of 0.13 MPa for 4.5 minutes; the mixture is discharged and filled to obtain the whitening and anti-allergic toothpaste.

[0077] Example 3

[0078] Preparation of friction agent:

[0079] A1. Crushing: Add bamboo chips, coconut shells and walnut shells into a crusher and crush them respectively, then pass through a 500-mesh sieve to obtain bamboo fiber particles, coconut shell fiber particles and walnut shell fiber particles;

[0080] A2, mixing bamboo fiber particles, coconut shell fiber particles, and walnut shell fiber particles in a mass ratio of 10:8:5, and mixing them evenly to obtain a plant fiber particle mixture;

[0081] A3. Disinfection and sterilization: sterilize the plant fiber particle mixture in step A1 by placing it in 100° C. high-temperature steam for 3 hours, and cool it for 8 hours to obtain the desired plant fiber particles;

[0082] A4. Mix hydrated silica and plant fiber particles in a mass ratio of 1:12 to obtain the desired friction agent, wherein the particle size of the hydrated silica is 20 μm.

[0083] Preparation of Chinese herbal medicine extracts:

[0084] B1. Mix mint leaves, tea leaves, scutellaria baicalensis, angelica dahurica and Panax notoginseng in a mass ratio of 16:10:3:4.5:1.5 to obtain a Chinese medicine mixture;

[0085] B2, crush the Chinese medicine mixture in step B1, pass through a 100-mesh sieve, soak in distilled water for 5 hours, add ethanol, reflux extract twice, each time for 3 hours, filter while hot, collect the filtrate, wherein the mass ratio of the Chinese medicine mixture, distilled water, and ethanol is 1:15:10;

[0086] B3, concentrating the filtrate in step B2 under reduced pressure until the ethanol is completely evaporated, and collecting the concentrated solution;

[0087] B4. Add distilled water to dilute the concentrate in step B3, let it stand for 6 hours, centrifuge at 12000 rpm for 10 minutes, take the supernatant, and further concentrate to a specific gravity of 1.3 g / cm 3 The desired Chinese medicine extract is obtained by mixing the concentrated solution with distilled water in a mass ratio of 1:5.

[0088] Preparation of microcapsule desensitizer:

[0089] C1, mixing a 5% chitosan solution and a 30% citric acid solution in a mass ratio of 8:2 to form a mixed solution A;

[0090] C2, adding L-arginine, calcium silicate and paeonol to the mixed solution A, and ultrasonically dispersing them at a frequency of 30 kHz for 1 hour to obtain a mixed solution B, wherein the mass ratio of L-arginine, calcium silicate and paeonol to the mixed solution A is 1:5:1.2:14;

[0091] C3, adding sodium dodecyl sulfate and soybean oil to the mixed solution B, stirring at a rate of 200 r / min for 1 h to obtain a microcapsule suspension, wherein the mass ratio of sodium dodecyl sulfate, soybean oil to the mixed solution B is 1:40:14;

[0092] C4. After the microcapsule suspension is spray-dried, the desired microcapsule desensitizer is obtained, wherein the spray-drying conditions are as follows: the inlet air temperature is 160°C and the outlet air temperature is 85°C.

[0093] A preparation method of a whitening and anti-allergic toothpaste comprises the following steps: mixing 1 part of xanthan gum, 1 part of sodium carboxymethyl cellulose, 12 parts of sorbitol and 30 parts of deionized water, stirring at a speed of 200 r / min for 2 hours, then adding 25 parts of abrasives, 1.2 parts of sodium phytate and 3 parts of cocamidopropyl betaine, stirring at a speed of 200 r / min for 2 hours under vacuum, finally adding 3 parts of Chinese herbal extracts, 12 parts of microcapsule desensitizers and 1.6 parts of Torreya grandis seed oil, continuing to stir at a speed of 200 r / min for 2 hours, maintaining bubbling at a vacuum degree of 0.15 MPa for 6 minutes, discharging and filling to obtain the whitening and anti-allergic toothpaste.

[0094] In order to verify the comprehensive performance of the whitening and anti-allergic toothpaste prepared in Examples 1-3 of the present application, the applicant set up comparative examples 1-12, which are as follows:

[0095] Comparative Example 1

[0096] Comparative Example 1 is the same as Example 1, except that the friction agent is only hydrated silica, as follows:

[0097] A preparation method of a whitening and anti-allergic toothpaste comprises the following steps: 0.8 parts of xanthan gum, 0.8 parts of sodium carboxymethyl cellulose, 8 parts of sorbitol and 10 parts of deionized water are mixed, and the mixture is stirred at a rate of 100 r / min for 1 hour; then 15 parts of hydrated silica with a particle size of 10 μm, 0.8 parts of sodium phytate and 2 parts of cocamidopropyl betaine are added, and the mixture is stirred at a rate of 100 r / min for 1 hour under a vacuum state; finally 1 part of a traditional Chinese medicine extract, 8 parts of a microcapsule desensitizer and 0.8 parts of Torreya grandis seed oil are added, the mixture is stirred at a rate of 100 r / min for 1 hour, and the bubbling is maintained at a vacuum degree of 0.1 MPa for 3 minutes, the material is discharged and the mixture is filled to obtain the whitening and anti-allergic toothpaste.

[0098] Comparative Example 2

[0099] Comparative Example 2 is the same as Example 1, except that the friction agent is made of bamboo chips and hydrated silica only, as follows:

[0100] Preparation of friction agent:

[0101] A1. Crushing: adding bamboo chips into a crusher and crushing them, and then passing through a 400-mesh sieve to obtain bamboo fiber particles 1;

[0102] A2. Disinfection and sterilization: sterilize the bamboo fiber particles 1 in step A1 in 100°C high temperature steam for 2 hours, and cool for 5 hours to obtain the required bamboo fiber particles 2;

[0103] A3. Mix hydrated silica and bamboo fiber particles 2 in a mass ratio of 1:8 to obtain the desired friction agent, wherein the particle size of the hydrated silica is 10 μm.

[0104] Comparative Example 3

[0105] Comparative Example 3 is the same as Example 1, except that the friction agent is made only from coconut shell and hydrated silica, as follows:

[0106] Preparation of friction agent:

[0107] A1. Crushing: adding coconut shells into a crusher, crushing and then passing through a 400-mesh sieve to obtain coconut shell fiber particles 1;

[0108] A2, disinfection and sterilization: sterilize the coconut shell fiber particles 1 in step A1 in 100°C high temperature steam for 2 hours, and cool for 5 hours to obtain the required coconut shell fiber particles 2;

[0109] A3. Mix hydrated silica and coconut shell fiber particles 2 in a mass ratio of 1:8 to obtain the desired friction agent, wherein the particle size of the hydrated silica is 10 μm.

[0110] Comparative Example 4

[0111] Comparative Example 4 is the same as Example 1, except that the friction agent is made only from walnut shells and hydrated silica, as follows:

[0112] Preparation of friction agent:

[0113] A1. Grinding: adding walnut shells into a grinder, grinding them and passing through a 400-mesh sieve to obtain walnut shell fiber particles 1;

[0114] A2. Sterilization: sterilize the walnut shell fiber particles 1 in step A1 by placing them in 100° C. high-temperature steam for 2 hours, and cool them for 5 hours to obtain the desired walnut shell fiber particles 2;

[0115] A3. Mix hydrated silica and walnut shell fiber particles 2 in a mass ratio of 1:8 to obtain the desired friction agent, wherein the particle size of the hydrated silica is 10 μm.

[0116] Comparative Example 5

[0117] Comparative Example 5 is the same as Example 1, except that the Chinese medicine extract is prepared from mint leaves, tea leaves, and Scutellaria baicalensis, as follows:

[0118] Preparation of Chinese herbal medicine extracts:

[0119] B1. Mix mint leaves, tea leaves, and scutellaria baicalensis in a mass ratio of 12:8:2:1.5:1 to obtain a Chinese medicine mixture;

[0120] B2, crush the Chinese medicine mixture in step B1, pass through a 60-mesh sieve, soak in distilled water for 3 hours, add ethanol, reflux extract twice, each time for 2 hours, filter while hot, collect the filtrate, wherein the mass ratio of the Chinese medicine mixture, distilled water, and ethanol is 1:10:8;

[0121] B3, concentrating the filtrate in step B2 under reduced pressure until the ethanol is completely evaporated, and collecting the concentrated solution;

[0122] B4. Add distilled water to dilute the concentrate in step B3, let it stand for 4 hours, centrifuge at 12000 rpm for 5 minutes, take the supernatant, and further concentrate it to a specific gravity of 1.3 g / cm 3 The desired Chinese medicine extract is obtained by mixing the concentrated solution with distilled water in a mass ratio of 1:4.

[0123] Comparative Example 6

[0124] Comparative Example 6 is the same as Example 1, except that the Chinese medicine extract is prepared from only mint leaves, tea leaves, and Angelica dahurica, as follows:

[0125] Preparation of Chinese herbal medicine extracts:

[0126] B1. Mix mint leaves, tea leaves and angelica dahurica in a mass ratio of 12:8:2:1.5:1 to obtain a Chinese medicine mixture;

[0127] B2, crush the Chinese medicine mixture in step B1, pass through a 60-mesh sieve, soak in distilled water for 3 hours, add ethanol, reflux extract twice, each time for 2 hours, filter while hot, collect the filtrate, wherein the mass ratio of the Chinese medicine mixture, distilled water, and ethanol is 1:10:8;

[0128] B3, concentrating the filtrate in step B2 under reduced pressure until the ethanol is completely evaporated, and collecting the concentrated solution;

[0129] B4. Add distilled water to dilute the concentrate in step B3, let it stand for 4 hours, centrifuge at 12000 rpm for 5 minutes, take the supernatant, and further concentrate it to a specific gravity of 1.3 g / cm 3 The desired Chinese medicine extract is obtained by mixing the concentrated solution with distilled water in a mass ratio of 1:4.

[0130] Comparative Example 7

[0131] Comparative Example 7 is the same as Example 1, except that the Chinese medicine extract is prepared from only mint leaves, tea leaves, and Panax notoginseng, as follows:

[0132] Preparation of Chinese herbal medicine extracts:

[0133] B1. Mix mint leaves, tea leaves and Panax notoginseng in a mass ratio of 12:8:2:1.5:1 to obtain a Chinese medicine mixture;

[0134] B2, crush the Chinese medicine mixture in step B1, pass through a 60-mesh sieve, soak in distilled water for 3 hours, add ethanol, reflux extract twice, each time for 2 hours, filter while hot, collect the filtrate, wherein the mass ratio of the Chinese medicine mixture, distilled water, and ethanol is 1:10:8;

[0135] B3, concentrating the filtrate in step B2 under reduced pressure until the ethanol is completely evaporated, and collecting the concentrated solution;

[0136] B4. Add distilled water to dilute the concentrate in step B3, let it stand for 4 hours, centrifuge at 12000 rpm for 5 minutes, take the supernatant, and further concentrate it to a specific gravity of 1.3 g / cm 3 The desired Chinese medicine extract is obtained by mixing the concentrated solution with distilled water in a mass ratio of 1:4.

[0137] Comparative Example 8

[0138] Comparative Example 8 is the same as Example 1, except that Torreya grandis seed oil is replaced with glycerol, as follows:

[0139] A preparation method of a whitening and anti-allergic toothpaste comprises the following steps: 0.8 parts of xanthan gum, 0.8 parts of sodium carboxymethyl cellulose, 8 parts of sorbitol and 10 parts of deionized water are mixed, and the mixture is stirred at a rate of 100 r / min for 1 hour; then 15 parts of abrasives, 0.8 parts of sodium phytate and 2 parts of cocamidopropyl betaine are added, and the mixture is stirred at a rate of 100 r / min for 1 hour under a vacuum state; finally, 1 part of a Chinese herbal medicine extract, 8 parts of a microcapsule desensitizer and 0.8 parts of glycerol are added, the mixture is stirred at a rate of 100 r / min for 1 hour, and the bubbling is maintained at a vacuum degree of 0.1 MPa for 3 minutes, the material is discharged and the mixture is filled to obtain the whitening and anti-allergic toothpaste.

[0140] Comparative Example 9

[0141] Comparative Example 9 is the same as Example 1, except that the microcapsule desensitizer is replaced with a desensitizer, as follows:

[0142] Preparation of the desensitizing agent: L-arginine, calcium silicate and paeonol are mixed in a mass ratio of 1:3:0.8 to obtain the desensitizing agent.

[0143] Comparative Example 10

[0144] Comparative Example 10 is the same as Example 1, except that paeonol is not added during the preparation of the microcapsule desensitizer, as follows:

[0145] Preparation of microcapsule desensitizer:

[0146] C1, mixing a 3% chitosan solution and a 20% citric acid solution in a mass ratio of 8:1 to form a mixed solution A;

[0147] C2, adding L-arginine and calcium silicate to the mixed solution A, and ultrasonically dispersing them at a frequency of 20 kHz for 0.5 h to obtain a mixed solution B, wherein the mass ratio of L-arginine, calcium silicate to the mixed solution A is 1:3:10;

[0148] C3, adding sodium dodecyl sulfate and soybean oil to the mixed solution B, stirring at a rate of 100 r / min for 0.5 h to obtain a microcapsule suspension, wherein the mass ratio of sodium dodecyl sulfate, soybean oil to the mixed solution B is 1:30:10;

[0149] C4. After the microcapsule suspension is spray-dried, the desired microcapsule desensitizer is obtained, wherein the spray-drying conditions are as follows: the inlet air temperature is 130° C. and the outlet air temperature is 65° C.

[0150] Comparative Example 11

[0151] Comparative Example 11 is the same as Example 1, except that L-arginine is not added during the preparation of the microcapsule desensitizer, as follows:

[0152] Preparation of microcapsule desensitizer:

[0153] C1, mixing a 3% chitosan solution and a 20% citric acid solution in a mass ratio of 8:1 to form a mixed solution A;

[0154] C2, adding calcium silicate and paeonol to the mixed solution A, and ultrasonically dispersing them at a frequency of 20 kHz for 0.5 h to obtain a mixed solution B, wherein the mass ratio of calcium silicate to paeonol to the mixed solution A is 3:0.8:10;

[0155] C3, adding sodium dodecyl sulfate and soybean oil to the mixed solution B, stirring at a rate of 100 r / min for 0.5 h to obtain a microcapsule suspension, wherein the mass ratio of sodium dodecyl sulfate, soybean oil to the mixed solution B is 1:30:10;

[0156] C4. After the microcapsule suspension is spray-dried, the desired microcapsule desensitizer is obtained, wherein the spray-drying conditions are as follows: the inlet air temperature is 130° C. and the outlet air temperature is 65° C.

[0157] Comparative Example 12

[0158] Comparative Example 12 is the same as Example 1, except that calcium silicate is not added during the preparation of the microcapsule desensitizing agent, as follows:

[0159] Preparation of microcapsule desensitizer:

[0160] C1, mixing a 3% chitosan solution and a 20% citric acid solution in a mass ratio of 8:1 to form a mixed solution A;

[0161] C2, adding L-arginine and paeonol to the mixed solution A, and ultrasonically dispersing them at a frequency of 20 kHz for 0.5 h to obtain a mixed solution B, wherein the mass ratio of L-arginine, paeonol to the mixed solution A is 1:0.8:10;

[0162] C3, adding sodium dodecyl sulfate and soybean oil to the mixed solution B, stirring at a rate of 100 r / min for 0.5 h to obtain a microcapsule suspension, wherein the mass ratio of sodium dodecyl sulfate, soybean oil to the mixed solution B is 1:30:10;

[0163] C4. After the microcapsule suspension is spray-dried, the desired microcapsule desensitizer is obtained, wherein the spray-drying conditions are as follows: the inlet air temperature is 130° C. and the outlet air temperature is 65° C.

[0164] Performance Testing

[0165] The comprehensive performance of the whitening and anti-allergic toothpastes prepared in Examples 1-3 of the present application and Comparative Examples 1-12 were tested respectively.

[0166] 1. Friction

[0167] The friction value Ra of the toothpastes prepared in Examples 1-3 and Comparative Examples 1-12 was tested according to the "Toothpaste Friction Value Test Method (GB / T 35832-2018)".

[0168] 2. Color stain removal experiment

[0169] Experiment on removing exogenous black tea stains

[0170] The whiteness value of the eggs before dyeing was measured with a whiteness meter, and 45 eggs with a whiteness value difference within the range of 1.5 were selected, and 3 eggs were grouped, and soaked in a 2% mass concentration of black tea aqueous solution, heated and boiled in a constant temperature water bath at 100°C for 3 hours, and dried to measure the whiteness value L1 of each egg after dyeing with black tea water, and a toothbrush was wetted with water, and each group of eggs was respectively dipped in 0.3g of toothpaste prepared in Examples 1-3 and Comparative Examples 1-12, and brushed on the top of the dyed eggshell for 3 minutes, keeping the brushing speed and strength consistent, and measuring the whiteness value L2 after brushing. The ability P value of removing exogenous black tea stains was calculated according to the formula: P = (L2-L1) / L1*100%.

[0171] Experiment on removing exogenous chlorophyll stains

[0172] The whiteness value of the egg before dyeing was measured by a whiteness meter, and 45 eggs with a whiteness value difference within the range of 1.5 were selected, and 3 eggs were grouped, and immersed in a chlorophyll aqueous solution with a mass concentration of 1%, heated and boiled in a constant temperature water bath at 100°C for 3 hours, dried, and the whiteness value of each egg after chlorophyll dyeing was measured, recorded as L1, and a toothbrush was wetted with water, and each group of eggs was respectively dipped in 0.3g of toothpaste prepared in Examples 1-3 and Comparative Examples 1-12, and brushed on the top of the dyed eggshell for 3min, keeping the brushing speed and strength consistent, and measuring the whiteness value after brushing, recorded as L2. The ability P value of whitening tooth powder to remove exogenous chlorophyll stains from eggs was calculated according to the formula: P = (L2-L1) / L1*100%.

[0173] 3. Plaque removal effectiveness

[0174] 150 subjects were randomly divided into 15 groups, 10 subjects in each group. The subjects sucked on the other side of the back of the tongue to collect bacteria, and then the collected samples were cultured with blood agar medium under anaerobic conditions at 37°C. After 72 hours, the average bacterial colony forming unit was calculated and recorded as CFU1. Each group of subjects used the toothpaste of Examples 1-3 and Comparative Examples 1-12 respectively, brushed their teeth once in the morning and evening with a horizontal vibration method every day, and used 2 grams of toothpaste each time for 3 months. After 3 months, the subjects sucked on the other side of the back of the tongue to collect bacteria, and then the collected samples were cultured with blood agar medium under anaerobic conditions at 37°C. After 72 hours, the average bacterial colony forming unit was calculated and recorded as CFU2. The CFU reduction rate was calculated as [(CFU1-CFU2) / CFU1]×100%. The results are shown in Table 1.

[0175] Table 1

[0176]

[0177] From the data shown in Table 1 above, it can be seen that the whitening and anti-allergic toothpastes prepared in Examples 1-3 have appropriate friction values, significant stain removal capabilities, and significant plaque removal effects.

[0178] Compared with Comparative Examples 1-4, Example 1 is based on Example 1, and the abrasive agent only uses hydrated silica; Comparative Example 2 is based on Example 1, and the plant fiber particles in the abrasive agent only use bamboo fiber particles; Comparative Example 3 is based on Example 1, and the plant fiber particles in the abrasive agent only use coconut shell fiber particles; Comparative Example 4 is based on Example 1, and the plant fiber particles in the abrasive agent only use walnut shell fiber particles. The stain removal ability and dental plaque removal efficiency of Comparative Examples 1-4 are worse than those of Example 1, indicating that the plant fiber particles and hydrated silica are added as abrasives in toothpaste. The plant fiber particles have different hardness and different particle sizes. The mixed use of the three provides a more comprehensive cleaning ability and more efficient removal of dental plaque and tooth stains. The mixed use of the three also has better wear balance, which can reduce excessive wear on the tooth surface.

[0179] Compared with Example 1 and Comparative Examples 5-7, Comparative Example 5 is based on Example 1, and raw materials Angelica dahurica and Panax notoginseng are deleted from the preparation of the Chinese medicine extract. Comparative Example 6 is based on Example 1, and raw materials Scutellaria baicalensis and Panax notoginseng are deleted from the preparation of the Chinese medicine extract. Comparative Example 7 is based on Example 1, and raw materials Scutellaria baicalensis and Angelica dahurica are deleted from the preparation of the Chinese medicine extract. The removal ability of Comparative Examples 5-7 for black tea, chlorophyll stains, and dental plaque is worse than that of Example 1, indicating that the active ingredients in the extracts of Scutellaria baicalensis, Angelica dahurica and Panax notoginseng can combine with and decompose the stains on the tooth surface, thereby playing a role in removing stains. The combination of the three can enhance the cleaning effect of toothpaste and more effectively remove tooth stains and dental plaque. The lack of one of them will reduce the ability to remove tooth stains and dental plaque.

[0180] 4. Periodontal sensitivity

[0181] 150 volunteers with dentin hypersensitivity were recruited as research subjects, 10 people in each group, and the toothpaste of the embodiment and the comparative example was used for 6 weeks. The differences in the age, severity and other data of the two groups of volunteers selected for this study were statistically analyzed without statistical differences (P>0.05), and were comparable. During the trial, the volunteer patients did not use other toothpastes, mouthwashes, desensitization drugs, and did not undergo treatments that affect tooth sensitivity such as cleaning, scaling, and vital tooth filling. Before and after the trial, the volunteers removed dental calculus, soft plaque and plaque and cleaned the tooth surface with a cotton ball of physiological saline, dried the tooth surface with soft compressed air, and applied the tooth surface with a cotton swab to keep it for 2 minutes. Each case was evaluated in two stages. Evaluation method: Use the air gun of the dental comprehensive treatment chair to spray 1s at a distance of 1cm from the sensitive teeth, the blowing temperature is 18-21℃ in the air gun, and the air pressure is 60kPa. Repeat 2 times. If the degree is inconsistent in the 2 times, take the heavier degree. The sensitivity was evaluated by Schiff cold air sensitivity index, and the scores were as follows: 0 = the teeth and the subjects did not respond to air stimulation; 1 = the teeth and the subjects responded to air stimulation, but did not request to stop the stimulation; 2 = the teeth and the subjects responded to air stimulation, and requested to stop the stimulation or remove the stimulation; 3 = the teeth and the subjects responded to air stimulation, the stimulation caused pain, and requested to stop. Statistics of Schiff cold air sensitivity index: marked effect: the difference between the degree before and after treatment is ≥2; effective: the difference is 1; ineffective: the difference is 0; worsening: the difference is a negative number. Calculation method of effective rate: effective rate (%) = (number of teeth with marked effect + number of effective teeth) / total number of teeth × 100%. The results are shown in Table 2.

[0182] Table 2

[0183] Effectiveness (%) Example 1 95.4 Example 2 97.2 Example 3 96.8 Comparative Example 1 90.2 Comparative Example 2 89.1 Comparative Example 3 88.4 Comparative Example 4 87.2 Comparative Example 5 84.5 Comparative Example 6 83.4 Comparative Example 7 86.8 Comparative Example 8 68.3 Comparative Example 9 62.1 Comparative Example 10 51.2 Comparative Example 11 48.9 Comparative Example 12 49.6

[0184] It can be seen from the data shown in Table 2 above that the whitening and anti-allergic toothpastes prepared in Examples 1-3 have significant therapeutic effects on dentin hypersensitivity.

[0185] Compared with Example 1 and Comparative Example 8, Comparative Example 8 is based on Example 1 without adding Torreya grandis seed oil. The therapeutic effect of the toothpaste prepared in Comparative Example 8 on dentin hypersensitivity is worse than that in Comparative Example 1, which shows that the nutrients in Torreya grandis seed oil can provide the required nourishment for teeth and gums, help improve the texture and gloss of teeth, and enhance the health of gums. Long-term use of toothpaste containing Torreya grandis seed oil can help reduce problems such as tooth sensitivity and swollen and painful gums.

[0186] Compared with Example 1 and Comparative Example 9, Comparative Example 9 is based on Example 1, but does not adopt the microcapsule coating technology in the preparation of the desensitizer, and directly adds the desensitizer to the toothpaste. The toothpaste prepared in Comparative Example 9 has a worse therapeutic effect on dentin hypersensitivity than that in Comparative Example 1, which shows that the microcapsule technology can encapsulate the desensitizer in tiny capsules, improve the stability of the desensitizer, control the release rate and method of the desensitizer, and ensure that the desensitizer can act more effectively on the tooth surface and dentinal tubules when brushing teeth, which helps to more comprehensively seal the dentinal tubules and relieve the symptoms of dentin sensitivity.

[0187] Compared with Comparative Examples 10-12, Example 10 is based on Example 1, but paeonol is not added during the preparation of the microcapsule desensitizer, Comparative Example 11 is based on Example 1, but arginine is not added during the preparation of the microcapsule desensitizer, and Comparative Example 12 is based on Example 1, but calcium silicate is not added during the preparation of the microcapsule desensitizer. The toothpaste prepared by Comparative Examples 10-12 has a worse therapeutic effect on dentin hypersensitivity than Comparative Example 1, indicating that arginine blocks dentinal tubules and calcium silicate promotes remineralization, and the two complement each other to further enhance the desensitization effect; paeonol can reduce the sensitivity of dental pulp nerves to dentin hypersensitivity, and play an analgesic and sedative role; arginine, calcium silicate and paeonol are mixed together, and the action mechanisms complement each other, which can more comprehensively solve the problem of dentin sensitivity.

[0188] This specific embodiment is merely an explanation of the present application and is not a limitation of the present application. After reading this specification, those skilled in the art may make modifications to the present embodiment without any creative contribution as needed, but such modifications are protected by the patent law as long as they are within the scope of the claims of the present application.

Claims

1. A whitening and anti-allergic toothpaste, characterized in that: The invention comprises the following raw materials in parts by weight: 10-30 parts of deionized water, 15-25 parts of abrasives, 1-3 parts of Chinese herbal extracts, 0.8-1.2 parts of sodium phytate, 8-12 parts of microcapsule desensitizers, 0.8-1.6 parts of Torreya grandis seed oil, 8-12 parts of sorbitol, 2-3 parts of cocamidopropyl betaine, 0.8-1 parts of xanthan gum and 0.8-1 parts of sodium carboxymethyl cellulose.

2. The whitening and anti-allergic toothpaste according to claim 1, characterized in that: The friction agent is a mixture of hydrated silica and plant fiber particles in a mass ratio of 1:8-12.

3. The whitening and anti-allergic toothpaste according to claim 2, characterized in that: The particle size of the hydrated silica is 10-20 μm.

4. The whitening and anti-allergic toothpaste according to claim 2, characterized in that: The plant fiber particles are prepared by the following method: A1. Crushing: Add bamboo chips, coconut shells and walnut shells into a crusher and crush them respectively, then pass through a 400-500 mesh sieve to obtain bamboo fiber particles, coconut shell fiber particles and walnut shell fiber particles; A2, mixing bamboo fiber particles, coconut shell fiber particles, and walnut shell fiber particles in a mass ratio of 10:5-8:3-5 to obtain a plant fiber particle mixture; A3. Disinfection and sterilization: sterilize the plant fiber particle mixture in step A1 by high temperature steam for 2-3 hours, and cool it to obtain the desired plant fiber particles.

5. The whitening and anti-allergic toothpaste according to claim 1, characterized in that: The Chinese medicine extract is prepared by the following method: B1. Mixing mint leaves, tea leaves, scutellaria baicalensis, angelica dahurica and Panax notoginseng to obtain a Chinese medicine mixture; B2, crushing the Chinese medicine mixture in step B1, passing through a 60-100 mesh sieve, soaking in distilled water for 3-5 hours, adding ethanol, reflux extraction, filtering while hot, and collecting the filtrate; B3, concentrating the filtrate in step B2 under reduced pressure until the ethanol is completely evaporated, and collecting the concentrated solution; B4. Distilled water is added to the concentrated solution in step B3 for dilution, the solution is allowed to stand for 4-6 hours, and the supernatant is taken by centrifugation and further concentrated into a paste to obtain the desired Chinese medicine extract.

6. The whitening and anti-allergic toothpaste according to claim 5, characterized in that: In step B1, the mass ratio of mint leaves, tea leaves, scutellaria baicalensis, angelica dahurica and Panax notoginseng is 12-16:8-10:2-3:1.5-4.5:1-1.5; in step B2, the mass ratio of the Chinese medicine mixture, distilled water and ethanol is 1:10-15:8-10; and in step B4, the mass ratio of the concentrate and distilled water is 1:4-5.

7. The whitening and anti-allergic toothpaste according to claim 1, characterized in that: The microcapsule desensitizer is prepared by the following method: C1, mixing the chitosan solution and the citric acid solution to form a mixed solution A; C2, adding arginine, calcium silicate and paeonol to the mixed solution A, and dispersing them ultrasonically at a frequency of 20-30 kHz for 0.5-1 h to obtain a mixed solution B; C3, adding sodium lauryl sulfate and soybean oil to the mixed solution B, stirring at a rate of 100-200 r / min for 0.5-1 h to obtain a microcapsule suspension; C4. After the microcapsule suspension is spray-dried, the desired microcapsule desensitizer is obtained.

8. The whitening and anti-allergic toothpaste according to claim 7, characterized in that: In step C1, the mass ratio of chitosan solution to citric acid solution is 5-8:1-2; in step C2, the mass ratio of arginine, calcium silicate, paeonol to mixed solution A is 1:3-5:0.8-1.2:10-14; in step C3, the mass ratio of sodium lauryl sulfate, soybean oil to mixed solution B is 1:30-40:10-14.

9. The whitening and anti-allergic toothpaste according to claim 6, characterized in that: The arginine in step C2 is L-arginine; the spray drying conditions in step C4 are that the inlet air temperature is 130-160°C and the outlet air temperature is 65-85°C.

10. A method for preparing the whitening and anti-allergic toothpaste according to any one of claims 1 to 9, characterized in that: The method comprises the following steps: mixing xanthan gum, sodium carboxymethyl cellulose, sorbitol and deionized water, stirring and dispersing, then adding abrasive, sodium phytate and cocamidopropyl betaine and stirring and dispersing them in vacuum, finally adding Chinese medicine extract, microcapsule desensitizer and Torreya grandis seed oil and continuing to stir and disperse them, maintaining bubbling for 3-6 minutes at a vacuum degree of ≥0.1MPa, discharging and filling to obtain whitening and anti-allergic toothpaste.

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