101 results about "Strontium ranelate" patented technology

Compounds and pharmaceutical compositions for use in the treatment and / or prophylaxis of cartilage and / or bone conditions and for methods of treating such condition. The compounds are salts of strontium that have a water-solubility of from about 1 g / l to about 100 g / l at room temperature, especially amino acid salts of strontium or dicarboxylic acid salts of strontium. Examples of novel water-soluble strontium salts are e.g. strontium glutamate and strontium alpha-ketoglutarate. The present invention also relates to an improved method for preparing the strontium salt of glutamic acid.

Disclosed are therapeutic oral compositions useful in the treatment of a variety of oral disorders, in which the composition can provide blockage of dentinal tubes, while at the same time provide antibacterial and anti-caries efficacy. The compositions include arginine in free or salt form, a mucoadhesive polymer, and at least one component selected from pyrophosphates, zinc salts, potassium salts, strontium salts, and mixtures thereof.

The process for the industrial The synthesis of strontium ranelate of formula (I):and its hydrates.

The invention relates to a method for preparing strontium ranelate heptahydrate. The product prepared by the method has a water content of 19.0-20.4%, and related substances are less than 0.5%. The strontium ranelate heptahydrate prepared by the method is stable at room temperature, the difference in water content between batches is small, and its water content, content and related substances remain unchanged when stored in a natural environment for a long time. It is characterized in that: 1. 2-[N, N-bis(carboxymethyl)amino]-3-cyano-4-carboxymethylthiophene-5-carboxylic acid tetraester (b) in an appropriate amount of sodium hydroxide hydroalcohol Reflux the solution for 5 to 6 hours, and keep the pH value above 10 during the hydrolysis process; ② Then add 20-60% ethanol, and then directly add 2-2.5 times the molar amount of strontium chloride aqueous solution, precipitate crystals, filter, and dry; ③ Add water Reflux, remove a small amount of salt wrapped in the crude product, heat filter, and collect the product. The invention also discloses a pharmaceutical composition containing strontium ranelate heptahydrate, which is used for treating postmenopausal women's osteoporosis.

The present invention relates to the double antiallergic toothpaste containing potassium salt and strontium salt. In the toothpaste component, it contains humectant, friction agent, binding agent, surfactant, sweetener, spices, preservative, water; it is characterized in that : The toothpaste component contains the whole toothpaste component by weight percentage and is divided into 0.1%~10% strontium salt and 0.1%~5% potassium salt. Tests have shown that the synergistic antiallergic effect of salt and strontium salt is better than that of single potassium salt or strontium salt. Toothpaste containing a single strontium salt or potassium salt cannot achieve the desired effect after three months of use, while toothpaste containing potassium salt and strontium salt can indeed reduce and prevent patients' sensitivity.