Strontium ranelate dry suspension

A dry suspension, strontium ranelate technology, applied in the direction of organic active ingredients, bone diseases, medical preparations containing active ingredients, etc., can solve the problems that are not suitable for elderly patients

Inactive Publication Date: 2008-06-25
BEIJING D VENTUREPHARM TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It can be taken without boiling water, but it is...

Method used

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  • Strontium ranelate dry suspension
  • Strontium ranelate dry suspension
  • Strontium ranelate dry suspension

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Prescription composition:

[0020] Strontium ranelate 2000g

[0021] Mannitol 2810g

[0022] Aspartame 10g

[0023] Orange flavor 5g

[0024] lemon yellow 15g

[0025] 15% starch slurry appropriate amount

[0026] Sodium carboxymethyl starch 150g

[0027] Xanthan gum 10g

[0028]

[0029] Make 1000 bags of granules

[0030] Preparation process: Weigh the raw and auxiliary materials of the prescription amount, pass through a 100-mesh sieve, and make starch into 15% starch slurry for later use; mix strontium ranelate and mannitol evenly to obtain mixture I; then mix mixture I with xanthan gum, Sodium carboxymethyl starch is uniformly mixed according to the equal amount incremental method, and an appropriate amount of 15% starch slurry is added to granulate, dried at 50°C, granulated, and classified to obtain granule I, and granule I is mixed with tartrazine, aspartame, and orange essence The mixture II is uniformly obtained, and ...

Embodiment 2

[0046] Strontium ranelate 2000g

[0047] Lactose 1950g

[0048] Sucralose 15g

[0049] Green Apple Flavor 5g

[0050] Fruit green 10g

[0051] Sodium Alginate 20

[0052] 20% maltodextrin pulp appropriate amount

[0053]

[0054] Make 1000 bags of granules

[0055] Preparation process: Weigh the raw and auxiliary materials of the prescription amount, pass through a 100-mesh sieve, and make 20% maltodextrin slurry from maltodextrin for later use; firstly mix strontium ranelate and mannitol evenly to obtain mixture I; then mix mixture I with Sodium alginate is uniformly mixed according to the equal amount incremental method, and an appropriate amount of 20% maltodextrin pulp is added to granulate, dried at 50°C, granulated, and graded to obtain granule I, and granule I is mixed with fruit green, sucralose, and green apple essence The mixture II is uniformly obtained, and the mixture II is divided to obtain a dry suspension.

[0056]...

Embodiment 3

[0070] Prescription composition:

[0071] Strontium ranelate 2000g

[0072] Xylitol 2810g

[0073] Aspartame 10g

[0074] Orange flavor 5g

[0075] lemon yellow 15g

[0076] 15% starch slurry appropriate amount

[0077] Sodium carboxymethyl starch 150g

[0078] Xanthan gum 10g

[0079]

[0080] Make 1000 bags of granules

[0081] Preparation process: Weigh the raw and auxiliary materials of the prescription amount, pass through a 100-mesh sieve, and make starch into 15% starch slurry for later use; mix strontium ranelate and xylitol to obtain mixture I; then mix mixture I and xanthan gum , Sodium carboxymethyl starch is mixed uniformly by equal amount incremental addition method, and an appropriate amount of 15% starch slurry is added to granulate, dried at 50°C, granulated, and graded to obtain granule I, and granule I is mixed with tartrazine, aspartame, and orange essence Mix evenly to obtain the mixture II, and divide the mixture I...

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Abstract

The invention discloses a dry suspension containing strontium ranelate. The dry suspension contains the following components by weight ratio: 50-90 per cent of lactose, or xylitol, or mannite or 50-90 per cent of the combination of lactose, xylitol, mannite; 10-49 per cent of strontium ranelate; 0.1-10 per cent of correctives; 0.1-10 per cent of colorant; and 1-20 per cent of adhesive. With good stability, the dry suspension containing strontium ranelate disclosed in the invention is used for curing and preventing the menopausal osteoporosis.

Description

technical field [0001] The invention relates to a dry suspension, in particular to an oral dry suspension containing strontium ranelate. Background technique [0002] Strontium ranelate, the chemical name is 3-thiopheneacetic acid-5-[di(carboxymethyl)amino]-2-carboxy-4-cyano, strontium salt (1:2). The structural formula is as follows: [0003] [0004] Molecular formula: C12H6N208SSr2 Molecular weight: 513.49 [0005] The strontium ranelate involved in the present invention is developed by Servier of France, approved in the European Union in September 2004, and listed in Ireland and the United Kingdom. The trade name is Protelos, and the dosage form is granules. Prevention of osteoporosis in postmenopausal women. [0006] Osteoporosis is a systemic skeletal disease characterized by low bone mass and microarchitectural deterioration of bone tissue, accompanied by symptoms such as increased bone fragility, susceptibility to fractures, and pain. [0007] Strontium ranela...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K31/381A61P19/10
Inventor 陈芳
Owner BEIJING D VENTUREPHARM TECH DEV
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