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96 results about "Oral disorder" patented technology

Oral health management system based on big data

The invention relates to the technical field of oral health management, and discloses an oral health management system based on big data, which comprises a data acquisition module, a data processing module and a data processing module, the intelligent diagnosis module is used for identifying oral health problems and diagnosing oral diseases through deep learning and an artificial intelligence algorithm, the health management suggestion module is used for predicting the future oral health trend of a user based on historical health data according to an intelligent diagnosis result, and the intelligent prediction module is used for predicting the future oral health trend of the user based on the historical health data. And the remote diagnosis and treatment module is used for providing auxiliary services for remote dental diagnosis and treatment. Through a data acquisition module, a data fusion module and an intelligent diagnosis module, oral cavity data and medical image data of a user are integrated, so that formulation of a personalized health management scheme is achieved, personalized oral cavity nursing schemes, diet guidance and living habit adjustment suggestions are provided for each user, and the user experience is improved. Therefore, the accuracy and effect of oral health management are improved.
Owner:HOSPITAL OF STOMATOLOGY XIAN JIAOTONG UNIVERSITY

Oral risk assessment method and system based on image recognition and medium

The invention discloses an oral risk assessment method and system based on image recognition and a medium, and relates to the technical field of image recognition, and the method comprises the steps: carrying out the block segmentation of a user oral image, activating a lesion recognizer to recognize the features of an image block, carrying out the matching of an oral disease, and obtaining a corresponding flora type set; imaging the target flora by using a fluorescence microscope, and extracting fluorescence characteristics; and generating an oral risk decision of the target user in combination with the identified disease information and the fluorescence characteristics. Therefore, the technical effects of multi-dimensional image comprehensive analysis and evaluation accuracy and efficiency improvement are achieved.
Owner:THE SIXTH MEDICAL CENT OF THE CHINESE PEOPLES LIBERATION ARMY GENERAL HOSPITAL

Oral disease auxiliary detection method, device, equipment and medium

The invention relates to the technical field of artificial intelligence, and provides an oral disease auxiliary detection method, device, equipment and medium, oral disease data is comprehensively collected according to a configuration data collection strategy, and multi-modal fusion is performed on the oral disease data to realize effective integration of heterogeneous data in the field of oral medical treatment; according to the method, a BioBERT + BiLSTM + CRF model is used for entity recognition, a BioBERT + Text-CNN model is used for relation extraction, oral medical entities and relations thereof are accurately recognized and extracted, and therefore construction of a comprehensive and fine oral disease knowledge graph is assisted; according to the technical scheme, the knowledge graph is subjected to vector indexing, the big language model based on RAG pre-training is accessed, high-interactivity knowledge query and retrieval can be performed, decision support is provided for oral clinicians and researchers, the graph can be expanded and dynamically updated, and the timeliness of knowledge can be kept, so that the question and answer result is more accurate and reliable.
Owner:ZHEJIANG UNIV

Auxiliary inquiry system for oral treatment

The invention relates to the technical field of inquiry systems, in particular to an auxiliary inquiry system for oral treatment. Comprising an oral disease knowledge graph construction and inquiry knowledge base establishment module, a patient information acquisition and preprocessing module, an AI guide type inquiry module, a symptom correlation analysis and disease preliminary auxiliary prediction module, an auxiliary inquiry report generation module and a doctor feedback interaction and model iteration optimization module. According to the method, the problems of inaccurate patient description and key symptom omission in traditional inquiry are solved by constructing the oral disease knowledge graph, designing a multi-modal information acquisition and preprocessing process, generating an AI guide type inquiry process, combining the knowledge graph and machine learning to realize preliminary auxiliary disease prediction, and establishing a strict data security mechanism; the integrity and accuracy of symptom information collection are ensured through multi-modal information collection and dynamic guide inquiry.
Owner:PEKING UNIV SCHOOL OF STOMATOLOGY +1

Oral cavity knowledge graph construction method and device, equipment and storage medium

The invention relates to the technical field of image data processing, in particular to an oral cavity knowledge graph construction method and device, equipment and a storage medium. Preprocessing the oral CT original sectional image data based on a preset adaptive threshold method and a preset rigid registration algorithm to obtain standard image data; performing feature extraction on the standard image data based on a preset deep learning model and a preset principal component analysis method to obtain a structured feature vector; constructing the structured feature vector, the structured data and the unstructured data according to a preset entity linking method, a preset inference rule and a preset graph neural network model to obtain an optimized knowledge graph; an optimized knowledge graph is constructed through CT image preprocessing, deep learning feature extraction and multi-source data fusion, an image-to-structured knowledge conversion link is realized, and a comprehensive, reliable and convenient knowledge data support is provided for precise diagnosis and treatment of oral diseases.
Owner:JIHUA LAB

Oral Disease Auxiliary Detection Method, Device, Equipment and Medium

The present invention relates to the field of artificial intelligence technology, and provides an oral disease auxiliary detection method, device, equipment and medium. It comprehensively collects oral disease data according to the configured data acquisition strategy, and performs multi-modal fusion on the oral disease data to achieve the effective integration of heterogeneous data in the field of oral medicine. It uses the BioBERT+BiLSTM+CRF model for entity recognition and the BioBERT+Text-CNN model for relation extraction to accurately identify and extract oral medical entities and their relationships, thereby assisting in constructing a comprehensive and detailed oral disease knowledge graph. It performs vector indexing on the knowledge graph and connects to a large language model pre-trained based on RAG, enabling highly interactive knowledge query and retrieval, providing decision support for oral clinicians and researchers. Moreover, since the graph is extensible and can be dynamically updated, it can also maintain the timeliness of knowledge, making the Q&A results more accurate and reliable.
Owner:ZHEJIANG UNIV

Laser probe fixing device for oral disease treatment

The utility model relates to the technical field of laser probe fixing, and discloses a laser probe fixing device for oral disease treatment, which comprises a fixing seat, the surface of the fixing seat is rotatably connected with a telescopic main rod through a damping rotating shaft, and a telescopic auxiliary rod is inserted into the telescopic main rod. First threaded holes are formed in the surface of the telescopic main rod and the surface of the telescopic auxiliary rod correspondingly, and first fixing bolts are in threaded connection with the interiors of the first threaded holes. According to the laser probe fixing device for oral disease treatment, through cooperative arrangement of a first damping bearing, a first damping rotating block, a first adjusting rod, a second damping bearing, a second damping rotating block and a second adjusting rod, the direction of a laser probe can be adjusted through the first damping bearing and the second damping bearing during use; and the angle of the laser probe is adjusted through the first damping rotating block and the second damping rotating block, so that the effect of adjusting the direction and the angle of the laser probe is achieved.
Owner:HOSPITAL OF STOMATOLOGY SUN YAT SEN UNIV

oral scanner (laval scan)

ActiveCN309718204SDentistryOral disorder
1. The name of the design product: oral cavity scanner (Lei Kou scan). 2. The use of the design product: device for treating oral diseases. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective view.
Owner:WUHAN JINHUI MEDICAL EQUIPMENT CO LTD

Sensing electrode for diagnosing oral diseases as well as preparation method and application of sensing electrode

The invention belongs to the field of detection and analysis, and particularly relates to a sensing electrode for diagnosing oral diseases, which comprises an electrode layer and a signal conversion layer positioned on one side of the electrode layer, a biological recognition probe is fixed on the surface and / or inside the side, far away from the electrode layer, of the signal conversion layer, and the side, far away from the electrode layer, of the signal conversion layer is further connected with a surfactant. The invention further relates to a preparation method and application of the sensing electrode. The sensing electrode is high in accuracy and reliability of detecting index components in a sample, good in repeatability and high in sensitivity.
Owner:PEKING UNIV SCHOOL OF STOMATOLOGY

Oral disease detection method based on artificial intelligence large model

The invention discloses an oral disease detection method based on an artificial intelligence large model, and relates to the technical field of oral detection, and the method comprises the following steps: achieving oral image enhancement through adaptive reflection suppression and non-uniform illumination correction; pathological and environmental features are extracted by using a double-flow network, and orthogonal constraint is applied to enforce feature independence; a gradient inversion layer is introduced into the multi-scale environment discriminator, and feature separation is realized through confrontation loss; the pathological features and the environmental suppression features are fused, and a lesion area is enhanced in combination with cross-scale attention weight; and generating a disease probability and lesion segmentation mask through classification and positioning double branches. Through a feature space decoupling mechanism, pathological features and environmental interference features are orthogonally separated in a potential space, and errors caused by light reflection, saliva shielding or instrument interference can be prevented; the two-channel adversarial training forces the network learning environment to be unchanged pathological representation, so that the model keeps stable recognition performance in a real clinical scene.
Owner:长沙市口腔医院

Antibacterial electric toothbrush based on pulsed ultrasonic piezoelectric response principle, and antibacterial method

Disclosed in the present invention are an antibacterial electric toothbrush based on a pulsed ultrasonic piezoelectric response principle, and an antibacterial method. The electric toothbrush in the present invention comprises a toothbrush head and a driving mechanism for driving the toothbrush head to vibrate, wherein the driving mechanism is configured to generate low-intensity pulsed ultrasonic waves, and the toothbrush head is provided with piezoelectric bristles and enhances the electric responsiveness of the piezoelectric bristles by means of ultrasonic vibration, such that a good antibacterial effect is achieved. The provided electric toothbrush can not only effectively inhibit the growth of bacteria on a standing toothbrush head, but also has improved antibacterial activity during a tooth-brushing operation process, such that dental plaque can be effectively inhibited, and oral diseases, such as periodontitis, can be effectively prevented.
Owner:PEKING UNIV SCHOOL OF STOMATOLOGY +1

Oral health monitoring method and device based on big data

The invention relates to the technical field of oral cavity monitoring, and particularly discloses an oral cavity health monitoring method and device based on big data, and the method comprises the steps: obtaining oral cavity health data of a user and feature data of different frequency components; based on the feature data, utilizing transfer learning of a generative adversarial network to generate a simulated oral cavity lesion image; based on the generated analog image and the oral health data, health states are classified through an adaptive density clustering algorithm, and personalized health labels are obtained; in combination with a reinforcement learning algorithm, adjusting a personalized treatment scheme according to the personalized health label, and optimizing an oral health management plan of the patient; through the adaptive time-frequency decomposition algorithm, accurate frequency characteristics can be extracted from the oral health signals, and potential oral health problems can be predicted in advance. And in combination with the simulated oral disease image generated by the generative adversarial network, the training data set is enhanced, the accuracy of the oral disease prediction model is improved, and the diagnosis efficiency is remarkably improved.
Owner:NANJING PUKOU HOSPITAL

Oral disease diagnosis and treatment question and answer method, device, equipment, medium and product

The invention provides an oral disease diagnosis and treatment question-answering method, device, equipment, medium and product, and relates to the technical field of diagnosis and treatment question-answering, the method comprises the following steps: obtaining an oral disease question input by a user, and determining a query sub-graph based on the oral disease question; querying sub-graph characterization structured oral disease problems; matching the query sub-graph with the oral medical knowledge graph, and determining a complete sub-graph corresponding to the query sub-graph according to a matching result; the oral medical knowledge graph is constructed based on multi-source heterogeneous diagnosis and treatment text data in the field of oral diseases; inputting the complete sub-graph and the oral disease question into a diagnosis and treatment big language model to obtain an oral disease diagnosis and treatment answer corresponding to the oral disease question output by the diagnosis and treatment big language model; the diagnosis and treatment big language model is obtained by training a general big language model based on oral disease diagnosis and treatment sample data. According to the technical scheme, professional nouns and complex relations in the field of oral diseases can be accurately represented, and the accuracy and interpretability of diagnosis and treatment answers are improved.
Owner:PEKING UNIV SCHOOL OF STOMATOLOGY +1

Magnetic suspension type telescopic motor structure of electric toothbrush handle

The utility model discloses a magnetic suspension type telescopic motor structure of an electric toothbrush handle, which relates to the technical field of electric toothbrushes, and comprises a shell and a hair planting round head, one end of the shell is fixedly connected with the hair planting round head, a support is fixedly connected inside the shell, one end of the support is fixedly connected with an electromagnetic generator assembly, and the electromagnetic generator assembly is fixedly connected with the shell. One side of the support is provided with a transmission shaft connected with the electromagnetic generator assembly, the other end of the transmission shaft is fixedly sleeved with a waterproof shaft sleeve, one side of the waterproof shaft sleeve is provided with a shaft cap, one end of the transmission shaft is located in the shaft cap, and the outer side wall of the shaft cap is fixedly connected with an inner shaft through a spring. Through magnetic energy driving and low-friction design, efficient swinging of the brush head is ensured, the cleaning effect is improved, meanwhile, energy loss and part abrasion are reduced, the service life is prolonged, and oral diseases are effectively prevented.
Owner:ABEIKANG TECH (DONGGUAN) CO LTD

Method and system for diagnosing oral diseases in companion animals

The present invention provides a method and system for diagnosing oral diseases in companion animals, the method being performed by a health management server and including the steps of: generating health standard data by matching basic condition information and basic result data; receiving condition measurement information of a test subject from a user terminal; and generating health result data by comparing and analyzing the condition measurement information based on the health standard data, wherein the generating health standard data can include the steps of preprocessing images included in basic radiography information included in the basic condition information; extracting analyzable analysis images from the preprocessed images; extracting region-specific analysis images for a plurality of disease analyses from the analysis images and diagnosing the presence or absence of oral diseases for the region-specific analysis images to generate basic diagnosis data; determining disease progression stages for the region-specific analysis images based on the basic diagnosis data to generate basic assessment data; and generating basic result data including the basic diagnosis data and the basic assessment data corresponding to the basic diagnosis data.
Owner:エイアイフォーペット カンパニー リミテッド

Oral flexible self-powered diagnosis and treatment device and preparation method thereof

PendingCN122350771AGingival Crevicular FluidsNanogenerator
This invention relates to the field of medical device technology and provides a flexible self-powered oral diagnostic and treatment device and its preparation method. The device includes a flexible conductive porous microneedle, a flexible microfluidic module, a flexible triboelectric nanogenerator, and a flexible transparent dental crown. The flexible conductive porous microneedle is used to extract gingival crevicular fluid, and its surface has multiple rings of needles at different heights. The flexible microfluidic module incorporates a microchannel structure and a detection unit to analyze biomarkers in the gingival crevicular fluid. The flexible triboelectric nanogenerator converts the mechanical energy of oral motion into electrical energy to provide exogenous electrical stimulation and achieve electrically controlled drug release. This device enables real-time monitoring, diagnosis, and treatment of the oral microenvironment, and has advantages such as self-powered operation, good fit, and discreet comfort, making it suitable for closed-loop management of oral diseases such as periodontitis.
Owner:JILIN UNIVERSITY

Porphyrin and ferrocene derivatives, nanoparticles, their preparation methods, and applications for the synergistic photothermal and sonodynamic treatment of oral diseases.

PendingCN122080090ABreaking through the limitations of insufficient penetration depthavoid damagePowder deliveryAntibacterial agentsPorphyrinPharmaceutical Substances
This invention belongs to the field of pharmaceutical technology for the treatment and prevention of oral diseases, and particularly relates to a porphyrin and ferrocene derivative, nanoparticles, preparation methods, and applications of synergistic photothermal and acoustic therapy for oral diseases. The porphyrin and ferrocene derivative are formed by organically combining tetraaminophenylporphyrin and diformaldehyde ferrocene through imine dynamic covalent bonds. This invention, through innovative raw material coupling methods and functional integration design, synergistically achieves PTT-SDT dual therapy, providing a new and superior technical solution for precise, efficient, and low-drug-resistance treatment of deep oral bacterial-fungal biofilm infections.
Owner:STOMATOLOGICAL HOSPITAL AFFILIATED TO WENZHOU MEDICAL UNIV

Oral disease diagnosis method based on multi-path feature extraction and frequency enhancement

The invention provides an oral disease diagnosis method based on multi-path feature extraction and frequency enhancement, and relates to the technical field of oral medical treatment, and the method employs a space channel to cooperate with attention enhancement feature extraction, improves the representation of a network on image features, employs a full-dimensional dynamic convolution kernel, employs a three-branch parallel structure to combine with a frequency enhancement technology, and achieves the diagnosis of oral diseases. The collaborative modeling of global and local features of the network is improved, the perceptual ability of edge information is enhanced, difficult sample learning is enhanced through an adaptive threshold focus loss function, the problem of sample imbalance is improved, rare disease focuses with limited sample sizes and low-resolution images are more sensitive, and the detection result is more accurate.
Owner:CHONGQING UNIV OF POSTS & TELECOMM

Novel short-chain peptide and derivative thereof

There is provided a compound of formula I, X-Y (I) wherein: Y comprises a peptide fragment of formula IV, [Ala] m-[Lys-V] n-Lys-V (IV) wherein m represents 0 or 1, n represents the integer 0, 1, 2, 3 or 4, and each V independently represents a sequence of 2 to 4 amino acids wherein the amino acids are selected from one or more of the group consisting of Lys, Pro, Hyp, diHyp, Thr, pThr, DOPA, Tyr and Ser; and X represents at least one optional substituent selected from the group consisting of: (i) a lipid selected from the group consisting of vitamin A, vitamin E, cholesterol and fatty acids comprising one or more carboxylic acid groups, 1 to 50 carbons and / or one or more cyclic rings, said lipids being linear or branched, saturated or unsaturated with between 1 and 10 carbon-carbon double bonds and / or substituted with between 1 and 10-OH groups, or a derivative of any of these lipids; and / or (ii) a non-steroidal anti-inflammatory agent, which compounds may be used in medicine, including as pharmaceutical excipients, adhesives and film-forming materials, and / or may be used in the treatment of conditions characterized by inflammation, including wounds, burns and mucosal disorders such as skin diseases, oral diseases, gynecological diseases and IBD.
Owner:ENLITISA (SHANGHAI) PHARM CO LTD

Oral disease diagnosis platform assisted by 3D modeling

The invention relates to the technical field related to oral treatment and diagnosis, and discloses a 3D modeling assisted oral disease diagnosis platform which comprises a three-dimensional scanning device, a multi-source data fusion module and a biomechanical simulation engine. According to the invention, an oral cavity digital model is constructed through three-dimensional scanning and real-time modeling, and multi-modal data analysis and a deep learning algorithm are integrated, so that automatic identification and quantitative evaluation of a focus are realized; through cooperation of a three-dimensional scanning device, a multi-source data fusion module, a biomechanical simulation engine, an AI focus diagnosis module and a visualization terminal, the problems of insufficient three-dimensional visualization, low early-stage lesion recognition rate, low diagnosis efficiency and poor result consistency of oral disease diagnosis can be effectively solved; therefore, efficient and accurate oral disease diagnosis and judgment and subsequent continuous treatment are achieved, real-time three-dimensional modeling and multi-scale lesion analysis are integrated on the same platform for the first time, and diagnosis accuracy is improved through geometric + gray bimodal data.
Owner:HANGZHOU STOMATOLOGICAL HOSPITAL CO LTD

Composition for supplementing oral hygiene

PendingCN122459002AAntibiotic AgentsOral health
An orally administrable composition for maintaining oral health comprising as active ingredients an antibiotic agent, an anti-inflammatory agent and optionally a remineralizing agent is disclosed. Methods of using the composition for maintaining or improving oral health and for treating oral diseases or conditions by self-administration or by administration by a health care professional are also provided.
Owner:U CO

Self-assembling polypeptide TKH and application thereof

The application discloses a kind of self-assembled polypeptide TKH and its application, belong to the field of biological medicine technology.The amino acid sequence of polypeptide TKH is as follows:TKRQQVVGLLWHLLHHLLHGKGTKRQQVVGLLWH LLHHLLH.The composition of the application includes self-assembled polypeptide TKH, polypeptide derivative or polypeptide pharmaceutically acceptable salt, ester, and pharmaceutically acceptable adjuvant.The application further discloses the application of self-assembled polypeptide TKH, polypeptide derivative or its pharmaceutically acceptable salt or ester in preparing oral care composition for dental hard tissue remineralization, and in preparing medical material for treating or preventing oral diseases.The self-assembled polypeptide TKH of the application shows significantly enhanced self-assembly ability, liquid phase separation behavior and hydroxyapatite adsorption characteristics, not only has more excellent remineralization performance, but also can simultaneously inhibit streptococcus mutans biofilm formation and acid production activity.
Owner:SICHUAN UNIV

Oral cavity scanner control method, oral cavity scanner and storage medium

The invention relates to the technical field of medical instruments for oral cavities, in particular to a control method of an oral cavity scanner, the oral cavity scanner and a storage medium, and can be applied to examination of oral cavity diseases and oral cavity treatment. The oral cavity scanner comprises a grasping part for an operator to grasp and an extension part which is detachably installed on the grasping part and used for entering the oral cavity of a subject, the extension part comprises a reflecting mirror, and the grasping part comprises a light projector used for projecting light to the side of the reflecting mirror and a camera used for obtaining an image of the side of the reflecting mirror. The control method comprises the steps that the light projector projects structured light with a first projection area, a first image is obtained through the camera, and all the reflectors fall into the first projection area; determining the position and size information of the reflector based on the first image; based on the position and size information, the light projector projects planar light at a second projection area, and a second image is acquired using the camera, where the second projection area falls entirely within the mirror.
Owner:NANTONG UNIV +1

Semiconductor Laser Therapeutic Apparatus (CHEESE+)

ActiveCN309418287SMedicineOral disorder
1. Name of the Design Product: Semiconductor Laser Therapeutic Apparatus (CHEESE+). 2. Use of the Design Product: Treating oral diseases with semiconductor laser. 3. Design Key Points of the Design Product: Lies in the shape. 4. Picture or Photograph that Best Indicates the Design Key Points: Perspective view.
Owner:武汉翊晟科技有限公司

Portable waterproof sweeping, vibrating and sterilizing electric toothbrush and waterproof shaver two-in-one device

The invention belongs to the technical field of buildings, and particularly relates to a portable waterproof sweeping, vibrating and sterilizing electric toothbrush and waterproof shaver two-in-one device which comprises a brush handle and a storage box and is characterized in that a knife handle is arranged at the bottom of the brush handle, and head mechanisms are arranged at the top of the brush handle and the bottom of the knife handle; the head mechanism comprises an electric toothbrush cleaning head and a floating tool bit. According to the invention, a user only needs to carry one product, the requirements of oral cavity cleaning and face shaving can be met at the same time, frequent switching among different tools is not needed, and convenience and rapidness are achieved. Through the advanced multifunctional cleaning technology and the intelligent design, the oral cavity and the face can be cleaned and nursed more effectively, oral diseases and skin problems are prevented, and the life quality of a user is improved. Due to the compact design and the waterproof performance, the product can be normally used in different environments and is convenient to carry, and the nursing requirements of a user in different scenes are met. The product service life is prolonged.
Owner:JIANG XI BA QI ZHI NENG KE JI YOU XIAN GONG SI

Medical ice-cream stick for oral cryotherapy

The utility model relates to the technical field of medical instruments, and discloses a medical ice-cream stick for oral cavity cryotherapy, which comprises an oral cavity treatment sterile liquid medicine frozen ice block and a bearing bracket, and the oral cavity treatment sterile liquid medicine frozen ice block is fixed on the bearing bracket after being frozen; the bearing bracket comprises an ice block core rod and a handle; the ice block core rod is a hollow thin-wall cylinder, and a plurality of through holes are formed in the thin wall of the ice block core rod; the ice block core rod of the bearing support and the handle are integrally formed in an injection molding mode through medical plastics. The structural design of the bearing support and the sterile frozen ice block is improved, so that the sterile frozen ice block can meet the sterile requirement, the melting time of the whole ice block is greatly prolonged, the use standard of clinical medical instruments can be met, wound liquid medicine infiltration and freezing therapy can be implemented, and the sterile frozen ice block is used for treating various oral diseases of patients. And the use experience of the patient is improved.
Owner:GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE

Toothbrush detection device and method

According to the toothbrush detection device and method, a mechanical arm and a carrier platform are used for controlling a to-be-detected toothbrush to execute the tooth brushing process, an image collecting device is used for collecting images in the tooth brushing process, and a processor detects the cleaning force effect of the to-be-detected toothbrush according to image detection to obtain a detection result. The cleaning capacity of the toothbrush to be detected is quantified according to the detection result, and the cleaning effect aiming at the tooth target part is introduced, so that the detection result can reflect the capacity of the toothbrush to be detected for preventing or relieving specific oral diseases. Besides, in the implementation mode of the specification, the whole detection process is standardized, long-term observation and test on a large number of subjects are not needed, the detection efficiency is improved, and the detection cost is reduced.
Owner:BEIJING XIAOMI MOBILE SOFTWARE CO LTD

A traditional Chinese medicine composition for treating oral diseases and its preparation method

ActiveCN118453681BDigestive systemLichen medical ingredientsOral ulcersClerodendrum trichotomum
This invention relates to a traditional Chinese medicine composition for treating oral diseases and its preparation method, belonging to the field of traditional Chinese medicine technology. The traditional Chinese medicine composition for treating oral diseases is composed of *Clerodendrum trichotomum* and *Radix Araliae*. This invention discovers that the combined use of *Clerodendrum trichotomum* and *Radix Araliae*, with their synergistic effect, significantly improves the therapeutic effect of the resulting composition on oral diseases such as oral ulcers. This not only broadens the application range of *Clerodendrum trichotomum* and *Radix Araliae*, but also provides a new approach to the treatment of oral diseases.
Owner:STOMATOLOGICAL HOSPITAL TIANJIN MEDICAL UNIV

Oxidation-responsive hydrogel carrying Chinese wolfberry glycopeptide as well as preparation method and application of oxidation-responsive hydrogel

The invention discloses oxidation responsive hydrogel carrying Chinese wolfberry glycopeptide as well as a preparation method and application of the oxidation responsive hydrogel, and belongs to the technical field of biological medicines. The oxidation responsive hydrogel comprises in-situ hydrogel and oxidation responsive microspheres embedded in the in-situ hydrogel, wherein the in-situ hydrogel is formed by crosslinking a hydrogel bracket component A and a component B; the oxidation responsive microsphere comprises a gelatin network formed by crosslinking gelatin and an oxidation responsive cross-linking agent, and wolfberry glycopeptide wrapped by the gelatin network. The invention further discloses a preparation method of the oxidation responsive hydrogel carrying the lycium barbarum glycopeptide and application of the oxidation responsive hydrogel in preparation of drugs for preventing or / and treating oral diseases, the oxidation hydrogel can be slowly released in a high-active oxygen pathological environment, the drug retention time is prolonged, and the treatment effect is improved.
Owner:SICHUAN ACADEMY OF MEDICAL SCI SICHUAN PROVINCIAL PEOPLES HOSPITAL