15 results about "Oral disorder" patented technology

This invention relates to the field of medical device technology and provides a flexible self-powered oral diagnostic and treatment device and its preparation method. The device includes a flexible conductive porous microneedle, a flexible microfluidic module, a flexible triboelectric nanogenerator, and a flexible transparent dental crown. The flexible conductive porous microneedle is used to extract gingival crevicular fluid, and its surface has multiple rings of needles at different heights. The flexible microfluidic module incorporates a microchannel structure and a detection unit to analyze biomarkers in the gingival crevicular fluid. The flexible triboelectric nanogenerator converts the mechanical energy of oral motion into electrical energy to provide exogenous electrical stimulation and achieve electrically controlled drug release. This device enables real-time monitoring, diagnosis, and treatment of the oral microenvironment, and has advantages such as self-powered operation, good fit, and discreet comfort, making it suitable for closed-loop management of oral diseases such as periodontitis.

This invention belongs to the field of pharmaceutical technology for the treatment and prevention of oral diseases, and particularly relates to a porphyrin and ferrocene derivative, nanoparticles, preparation methods, and applications of synergistic photothermal and acoustic therapy for oral diseases. The porphyrin and ferrocene derivative are formed by organically combining tetraaminophenylporphyrin and diformaldehyde ferrocene through imine dynamic covalent bonds. This invention, through innovative raw material coupling methods and functional integration design, synergistically achieves PTT-SDT dual therapy, providing a new and superior technical solution for precise, efficient, and low-drug-resistance treatment of deep oral bacterial-fungal biofilm infections.

An orally administrable composition for maintaining oral health comprising as active ingredients an antibiotic agent, an anti-inflammatory agent and optionally a remineralizing agent is disclosed. Methods of using the composition for maintaining or improving oral health and for treating oral diseases or conditions by self-administration or by administration by a health care professional are also provided.

This invention relates to the field of intelligent diagnostic technology for oral medical imaging, specifically an intelligent auxiliary diagnostic system for oral diseases integrating multimodal imaging. The system includes: a data receiving module that receives intraoral optical photographs, cone-beam CT, and oral and maxillofacial MRI; an image analysis module that automatically delineates and segments the optical photographs to generate two-dimensional structural maps with tooth position markers, reconstructs a three-dimensional jawbone from CBCT and extracts root canal structures to generate a model containing bone density and root canal parameters, and enhances soft tissue from MRI and identifies inflammatory areas to generate a model showing muscles, blood vessels, nerves, and inflammatory boundaries; a multimodal fusion module that uses spatial registration and feature fusion to construct a unified digital model; and an intelligent diagnostic module that calls a pre-trained model for analysis and reasoning to generate a disease list and quantitative parameters. Through differentiated image processing and multimodal fusion, the system achieves a panoramic presentation of oral structure and lesions, enhancing the comprehensiveness of disease identification. This invention can improve the accuracy and efficiency of intelligent auxiliary diagnosis of oral diseases.

This invention relates to the field of medical device technology, and more particularly to a phototherapy device for dental implants with an automatic drug delivery function. The phototherapy device uses a medication solution and an expansion structure placed between a filter membrane and a base. In the non-treatment state, because the diameter of water molecules in the medication solution is larger than the diameter of drug molecules, and the diameter of drug molecules is larger than the micropore diameter of the filter membrane, this prevents the drug from flowing into the oral cavity through the micro-release holes. When it is necessary to release the drug into the oral cavity in conjunction with phototherapy, the patient holds warm water in their mouth to heat the expansion structure. The expansion structure expands due to heat, squeezing the medication solution. The drug molecules are squeezed by the expansion structure, and as the squeezing pressure increases, the drug molecules are forced out of the micropores of the filter membrane. The drug molecules then flow out through the micro-release holes and into the oral cavity to assist in the treatment of oral diseases using phototherapy.

The application discloses an imaging method of an oral imaging device, comprising the following steps: S1, acquiring an image sequence of not less than one view angle collected by the oral imaging device when imaging the upper jaw and / or the lower jaw; S2, extracting useful video clips of the upper jaw and the lower jaw from the image sequence, and arranging the video clips into at least two video segments corresponding to the upper jaw and the lower jaw respectively; S3, recognizing the shooting direction of the video segments by combining motion detection data with a deep learning model, and unifying the video sequence; S4, dynamically adjusting the frame extraction method of the video segments according to the motion detection data, retaining key motion node images, reconstructing the calibrated video segments into a standard sequence in a unified direction, and outputting the standard sequence, so as to perform oral three-dimensional scene reconstruction and oral disease analysis. The application also provides an oral imaging device. The application reduces the operation burden of a user, significantly reduces the operation amount of a visual algorithm, and improves the reliability of three-dimensional modeling and the accuracy of oral disease identification.

An areca nut product and preparation method thereof, and an areca nut additive agent are provided. The areca nut product is prepared from areca nuts, citric acid, mature vinegar, chitosan, active zinc oxide, monazite calcined distilled water, bovine bone protein peptide, lipase, isomaltooligosaccharide, soybean lecithin, ginseng, atractylodes macrocephala, poria cocos, liquorice, astragalus, notoginseng, tangerine peel, folium eucommiae, citronella grass, and mucor. Experimental tests shows that the areca nut product of the disclosure has a good antiviral effect, and the areca nut product has good preventive and therapeutic effects on oral diseases; compared with ordinary areca nut products, carcinogenic study has shown that carcinogenicity of the areca nut product of the disclosure has significantly reduced.

A nanoparticle composition for oral care includes at least one of a first set of spherical nanoparticles or a second set of coral shaped nanoparticles, and a stabilizing agent. The nanoparticle composition is added to a carrier suitable for application to an oral cavity, including to teeth and surrounding oral tissues. The nanoparticle composition can be a stable, 1-part composition. The nanoparticle composition is configured to control the pH of the microenvironment to which it is applied, thereby preventing and / or treating a variety of oral conditions. The nanoparticle composition can be provided as a concentrated nanoparticle additive addable to a mouthwash, mouth rinse, dentifrice, mouth spray, oral gel, denture cleaning solution, or other carrier suitable for oral application. The oral care composition is not a nasal spray.

FIELD: pharmaceutical industry.SUBSTANCE: use of the composition in the treatment of inflammatory diseases of the oral cavity. The use of a composition in the form of a chewing marmalade, including components in the following ratio, wt.%: stevioside 2.0 to 10.0, gum arabic 2.0 to 20.0, ginger 0.5 to 5.0, Siberian fir extract 1.0 to 10.0, quercetin 0.01 to 0.5, pine extract 0.01 to 0.5, green chlorophyll 0.01 to 0.5, pine chlorophyll 0.01 to 0.5, pine paste 0.01 to 0.5, kelp extract 0.01 to 0.5, citric acid 0.1 to 0.7, flavoring 0.01 to 0.1, preservative 0.1 to 0.5, drinking water - up to 100.0, in the treatment of inflammatory diseases of the oral cavity.EFFECT: above-described composition is effective in the treatment of inflammatory diseases of the oral cavity.2 cl, 6 dwg, 1 tbl, 3 ex

This application discloses the application of Fe / Mn bimetallic enzymes in the preparation of anti-periodontalgia or teeth whitening agents. The Fe / Mn bimetallic enzyme exhibits excellent photothermal properties and peroxidase-like activity; that is, under photothermal synergy, its POD-like activity can be significantly enhanced, generating more ·OH groups. In antibacterial coating experiments against *Porphyromonas gingivalis* and drug-resistant *Staphylococcus aureus*, Fe / Mn BA, through photothermal synergistic chemokinetic therapy, achieved antibacterial rates exceeding 90%. By treating periodontitis through anti-inflammatory and antibacterial action and achieving teeth whitening through pigment degradation, the application of this biatomic nanozyme provides a new research direction for the application of artificial enzymes in oral diseases and is expected to open up broader pathways to address the challenges currently faced by artificial enzyme antibacterial technologies.

The present invention relates to oral care compositions comprising a peptidase or lactonase, preferably a peptidase and a lactonase, the use of said compositions in medicine, the use of said compositions in the treatment of oral diseases, methods of treatment comprising the administration of said compositions to a human subject, methods of preventing or removing oral biofilm comprising contacting an oral biofilm with said compositions, methods for reducing the risk of oral biofilm formation, and kits comprising said compositions.

The present invention relates to an enzymatic oral care composition comprising a DNase, a mutanase, a beta-glucanase, and at least one oral care ingredient. The invention further relates to the use of said composition as a medicament, use of said composition in treatment of oral disease, methods of treatment comprising administering said composition to a human subject, methods of removing biofilm comprising contacting an object with said composition, and kits of parts comprising said composition.

This invention discloses a formulation for pet oral cleaning and softening of dental plaque and tartar, and its preparation method, belonging to the technical field of pet oral cleaning formulations. The formulation comprises the following components: 0.5%-2.0% complex protease, 0.3%-1.2% repair agent, 0.05%-0.2% antibacterial agent, 0.2%-0.8% probiotic active liquid, 0.03%-0.3% metal chelating agent, 0.1%-2% emulsifier, 5%-15% humectant, 0.01%-0.3% breath freshener, 0.1%-0.5% pH adjuster, and the balance purified water. The complex protease is composed of subtilisin, bromelain, and papain. This invention, through the combination of a multi-enzyme synergistic system and active components, achieves effective removal of pet dental plaque and a significant softening and peeling effect on dental tartar. The resulting formulation is compatible with the pet's oral physiological environment, and long-term use can effectively prevent the occurrence of oral diseases.