130 results about "Oral disorder" patented technology

The present invention encompasses topical oral care compositions comprising the combination of an anti-bacterial agent with an anti-inflammatory agent in an orally acceptable carrier for effective treatment and prevention of bacteria-mediated diseases and conditions in the oral cavity and for modulating host reaction to bacterial pathogens present in the oral cavity and to the toxins, endotoxins, inflammatory cytokines and mediators released by or prompted by these pathogens. The present invention also encompasses methods of use of these compositions comprising topical application to the oral cavity. The benefits of the present compositions and methods extend beyond treating and preventing oral bacterial infections in the oral cavity to promoting whole body or systemic health.

A method and apparatus for the concurrent treatment of multiple oral diseases and defects while promoting general oral hygiene utilizing direct current electricity. Electrodes are used to deliver a direct current to the gingival tissues of a mouth in order to achieve a number of therapeutic, prophylactic, and regenerative benefits. These benefits include killing oral microbes, increasing oral vasodilation, improving oral blood circulation, reversing oral bone resorption, promoting oral osteogenesis, treating gum recession, and fostering gingival regeneration. Other benefits include the treatment of gingivitis, perdiodontitis, and oral malodor while also promoting general oral hygiene.

A method and apparatus for the concurrent treatment of multiple oral diseases and defects while promoting general oral hygiene utilizing direct current electricity. Electrodes are used to deliver a direct current to the gingival tissues of a mouth in order to achieve a number of therapeutic, prophylactic, and regenerative benefits. These benefits include killing oral microbes, increasing oral vasodilation, reducing oral biofilm, improving oral blood circulation, reversing oral bone resorption, promoting oral osteogenesis, treating gum recession, and fostering gingival regeneration. Other benefits include the treatment of gingivitis, periodontitis, and oral malodor, and other systemic diseases correlated with oral pathogens.

Disclosed are therapeutic oral compositions useful in the treatment of a variety of oral disorders, in which the composition can provide blockage of dentinal tubes, while at the same time provide antibacterial and anti-caries efficacy. The compositions include arginine in free or salt form, a mucoadhesive polymer, and at least one component selected from pyrophosphates, zinc salts, potassium salts, strontium salts, and mixtures thereof.

Disclosed are therapeutic oral compositions useful in the treatment of a variety of oral disorders, in which the composition can provide blockage of dentinal tubes, while at the same time provide antibacterial and anti-caries efficacy. The compositions include arginine in free or salt form, a mucoadhesive polymer, and at least one component selected from pyrophosphates, zinc salts, potassium salts, strontium salts, and mixtures thereof.

Nanoemulsified topical formulation comprising curcumin, tetrahydroxycurcumin (BDMC) and curcuminoid either alone or in combinations in an amount of 0.001% to 50% together with one or more pharmaceutically, nutraceutically or dietically acceptable excipient(s) or inactive ingredients, useful for the treatment of inflammation, various skin and oral disorders, mucosal disorders and other diseases associated or related thereof.

The invention relates to a traditional Chinese medicine composition playing roles of stopping bleeding, diminishing inflammations and preventing bacteria and a toothpaste containing the traditional Chinese medicine composition. The traditional Chinese medicine composition comprises the following components: a cordyceps militaris extract, a pseudo-ginseng extract, a scutellaria baicalensis extract and tea polyphenol. The composition provided by the invention plays roles in stopping bleeding, diminishing inflammations and preventing bacteria, and can be applied to the toothpaste to prevent oral diseases.

The invention provides a lamioplomis rotata medical toothpaste which is prepared with lamioplomis rotate extract as main medical active material and commonly used auxiliary material through common technique. The medical toothpaste of the invention has the functions of easing pain, stopping bleeding, diminishing inflammation and preventing bacteria and can effectively cure oral diseases such as ngival hemorrhage, ngivitis, periodontitis, gingival atrophy and oral ulcer; meanwhile, the invention can clean the teeth and the mouth, nurse the mouth and keep the foul breath fresh.

The present invention relates to oral care compositions suitable for preventing or treating diseases or conditions of the oral cavity in warm-blooded animals including humans, comprising an oral care effective amount of at least one tropolone compound in combination with at least one essential oil, and a pharmaceutically acceptable oral carrier. This invention further relates to a method for preventing or treating diseases or conditions of the oral cavity in warm-blooded animals including humans, by applying an oral care effective amount of the oral care composition to the oral cavity.

The invention provides a method and a system for performing full-automatic segmentation on multiple tissues of an oral cavity CBCT image. According to the obtained original oral cavity three-dimensional CBCT data, a deep learning method is utilized to label the data, a deep learning method is utilized again to segment a new image, the image processing process is simple, excessive manual labeling and intervention are not needed, the difficulty of existing medical data annotation is overcome, and meanwhile human differences in the image annotation process are reduced. In the network training process, the adversarial network is generated for the training data, the training data volume is increased, and the universality of the network can be effectively improved. The establishment of the method greatly promotes the segmentation of a medical image technology, and provides an effective technical support for the automatic diagnosis and prognosis of oral diseases.

The invention relates to Chinese herbal medicine toothpaste containing pseudo-ginseng saponin and a honeysuckle extract. The Chinese herbal medicine toothpaste is prepared by finely processing 0.001-0.5% of pseudo-ginseng saponin, 0.0005-0.2% of the honeysuckle extract and a toothpaste matrix raw material. Sources of the pseudo-ginseng saponin and the honeysuckle extract which are contained in the Chinese herbal medicine toothpaste are rich, low in cost, easy to obtain, safe and non-poisonous and don't harm human health. The pseudo-ginseng saponin and the honeysuckle extract are compounded; compared with a conventional Chinese herbal medicine toothpaste, the Chinese herbal medicine toothpaste containing pseudo-ginseng saponin has more remarkable antibacterial, inflammation diminishing, heat clearing and resolutive effects, and has good prevention and treatment effects for various common oral diseases such as redness and swelling of the gum, gingivitis, throat dryness and the like.

The invention relates to a preparation method of egg yolk immunoglobulin for preventing and curing mouth diseases, and a safe toothpaste with the egg yolk immunoglobulin as main material. When preparing the IgY, according to a main pathogen causing the decayed tooth, periodontal disease and halitosis, types of main pathogenic bacteria are cultured in a conventional method. A complex antigen is made with the cultured strains and injected to laying poultries (including hens, ducks, and turkeys and so on). And then needed IgY is made by the yolks of immune eggs laid by the poultries. When making the toothpaste with the IgY, the toothpaste comprises 0.01-10.0% egg yolk immunoglobulin, vesicant and other components. The IgY activity is maintained and the effect is strengthened by adopting gentle vesicant, film microcapsule, sandwich type or interlayer type toothpaste tube and oral mucosa adsorbent. The prepared toothpaste without harmful chemicals has great effect on preventing and curing decayed tooth, periodontal disease and halitosis, and can be swallowed.

The invention provides an oral caring joint product, in particular to a combined use method of two toothpastes and an application thereof. The combination product consists of a toothpaste A and a toothpaste B, which consists of a traditional Chinese medicine composition or an active ingredient of the traditional Chinese medicine composition, a friction agent, a wetting agent, a binder, a foaming agent, a sweetener, a fragrance, and deionized water; the toothpaste B is composed of sorbitol, hydrated silica, purified water, fructo-oligosaccharide, polyethylene glycol, titanium dioxide, sodium lauryl sulfate, a flavor, a bacteriostatic agent, xanthan gum, hydroxymethyl cellulose, and sodium pyrophosphate. The invention provides the toothpaste for preventing or treating oral diseases, teeth brushing is carried out in the morning by using the toothpaste A, and the teeth brushing is carried out by using the toothpaste B before going to bed. The oral diseases are periodontitis, gingivitis, oral ulcers, and oral mucositis.

The invention discloses a gluconic acid chlorhexidine composite gargle and a preparation method thereof. The gluconic acid chlorhexidine composite gargle is prepared from the following raw materials in parts by weight: 5.5-6 parts of polysorbate 80, 0.8-1.2 parts of metronidazole raw powder, 220-225 parts of ethyl alcohol, 310-315 parts of glycerinum, 275-300 parts of polyethylene glycol 400, 115-125 parts of gluconic acid chlorhexidine, 42.225-72.728 parts of auxiliary materials and a proper amount of purified water. The raw materials supplement one another and work together to play roles, and are capable of preventing and treating oral diseases in an assist manner and improving the oral nursing effect. According to the gluconic acid chlorhexidine composite gargle disclosed by the invention, the stability of the product is improved by adjusting the amount of auxiliary materials, the charging mode or even the charging order in the preparation process; the harmful substance parachloroaniline in the preparation process is greatly reduced; and the quality problems such as opacities and crystal separation easily generated by an existing gluconic acid chlorhexidine composite gargle in the preparation process are effectively solved.

A medicinal composition for preventing and treating the diseases of oral cavity and throat, especially the chronic pharyngolaryngitis is prepared from 8 Chinese-medicinal materials including menthol, cucalyptus oil, anise oil, honeysuckle flower, etc. A food containing said medicinal composition is also disclosed.

The invention discloses an MMP-8 responsive intelligent periodontal drug controlled release hydrogel material and application thereof. A polypeptide CGPQG-IWGQC which can be specifically recognized and cut off by MMP-8 serves as a cross-linking agent, and four-arm polyethylene glycol acrylate is cross-linked to form hydrogel so as to serve as a drug controlled release carrier. According to the hydrogel, the polypeptide serving as the cross-linking agent is specifically cut off by the MMP-8 in presence of the MMP-8, the hydrogel is degraded, and drug release is realized. The designed and synthesized material is simple in preparation process, easily controllable in conditions, stable in material performance and excellent in drug controlled release effect. The material prepared by the invention can serve as the drug controlled release carrier and is widely applied to intelligent drug release of oral diseases such as periodontitis, peri-implantitis and the like. On the one hand, accurate and controlled release of the drug is realized; on the other hand, a novel solution idea or method is provided for drug tolerance encountering in clinical medicine.

An expendable auxiliary tool for the oral therapy in order to provide a sufficient therapeutic space in oral cavity is composed of a local tooth sleeve, a supporting rod, a buccal plate and a position fixing ring for fixing and protecting tongue and fixing a saliva sucking tube.

The invention provides medicinal tea for clearing away ozostomia, bitter taste and xerostomia. The formula comprises the following components: 6 parts of eupatorium fortunei, 3 parts of peucedanum praeruptorum dunn, 2 parts of trichosanthes kirilowii maxim, 1 part of loquat leaves, 3 parts of polygala tenuifolia willd, 1 part of almond, 2 parts of stemona sessilifolia, 4 parts of perillaseed, 2 parts of lonicera japonica, 1 part of stevia rebaudiana, 3 parts of dandelion, 2 parts of corydalis bungeana turcz, 3 parts of radix isatidis, 1 part of folium isatidis, 1 part of ephedra sinica stapf, 2 parts of cassia twig, 3 parts of semen cassiae, 3 parts of semen pruni, 2 parts of polygonatum odoratum and 3 parts of hippophae rhamnoides. The medicinal tea for clearing away ozostomia, the bitter taste and the xerostomia has good treating effects on diseases of the oral cavity, the digestion system and the respiratory system, capable causing ozostomia; and the medicinal tea has good curative effects on the ozostomia and oral cavity diseases and also has the effects of conditioning blood lipid, softening blood vessels, recovering blood vessel elasticity, improving blood circulation and enhancing blood supplying and oxygen supplying capabilities and recovering all functions of bodies.

The invention discloses a method for guiding and segmenting teeth by utilizing morphological data. The method comprises the following steps: S1, acquiring three-dimensional volume data of a patient and three-dimensional surface data of the teeth; S2, carrying out volume rendering; S3, extracting a gingival edge line; S4, performing model registration on the data; S5, carrying out voxel segmentation of tooth attributes; S6, carrying out data verification, and deleting the part which does not belong to the tooth attribute; S7, performing three-dimensional reconstruction; and S8, segmenting the data of the teeth according to the tooth positions. According to the invention, automatic segmentation can be carried out on teeth in an image; operation is simple, and each tooth can be segmented; andautomatic recognition of the teeth, periodontal tissues and other tissues is achieved, the clinical requirements of oral medicine are better met, development of the oral medicine is promoted, automatic diagnosis of oral diseases is achieved through the digitization technology, and a technical foundation is laid for development of automatic orthodontic tooth arrangement, automatic diagnosis of periodontal recovery and the like special for orthodontics.

The invention provides a biological polysaccharide capable of preventing and treating oral diseases and application thereof. Specifically, the invention provides application of beta-glucan to preparation of a preparation or a composition, and the preparation or the composition is used for preventing and / or treating the oral diseases. The beta-glucan has the effects of obviously relieving and improving the oral diseases and controlling the occurrence and development of the oral diseases, and can be used for preparing oral cleaning products.

The invention discloses a Chinese herbal medicine toothpaste and a preparation method thereof. The toothpaste is prepared from 0.1%-10% of panax notoginseng, milkvetch root and rhizoma drynariae Chinese herbal medicine extract, 0.1%-1% of propolis, 0.1%-20% of nano-hydroxyapatite, 10%-70% of humectant, 0.1%-2% of thickener, 1.0%-2.5% of foaming agent, 10%-50% of friction agent, 0.5%-2% of essence, 0.1%-2% of stabilizer and 5%-45% of water. The Chinese herbal medicine toothpaste has the effects of resisting bacteria, diminishing inflammation, repairing and the like, significant curative effects on common oral problems such as decayed teeth, gingivitis, ozostomia, dentin sensitivity and immunity improvement are achieved, and the effects on gingival bleeding, gingival tumefaction, prevention of oral diseases and the like are significant.

The invention discloses desensitization paste. The desensitization paste is prepared from the following components in parts by weight of 0.3-0.5 part of gallnut extract, 0.05-0.3 part of chlorhexidineacetate, 5-10 parts of honeycomb extract liquor, 50-60 parts of calcium powder, 5-15 parts of strontium chloride, 5-15 parts of potassium nitrate, 10-15 parts of sodium fluoride and 30-56 parts of pharmaceutically acceptable auxiliary materials. The gallnut traditional Chinese medicine active extract is added into the desensitization paste provided by the invention, so that the desensitization paste has a convergence effect and a protein precipitation effect, can block and seal dentinal tubules, and can be used for desensitizing fundamentally. Besides, the combined application of the gallnuttraditional Chinese medicine active ingredients, chlorhexidine acetate and the honeycomb extract liquor has a remarkable synergistic effect, can greatly improve the desensitization and sterilization effects of teeth of the product, particularly has a remarkable inhibition effect on streptococcus mutans forming decayed teeth, and plays a role in preventing and treating various oral diseases.

The invention provides a traditional Chinese medicine composition for treating and / or preventing oral diseases. The traditional Chinese medicine composition is prepared from pseudo-ginseng powder, radix salviae milliorrhizae extract and wild chrysanthemum extract. The invention further provides toothpaste capable of treating and / or preventing gingivitis. The toothpaste contains the traditional Chinese medicine composition and auxiliary materials. The ointment is moderate in thickness, rich and fine in foam and high in solubility; due to the fact that natural plant extract is added, the toothpaste is mild, high in safety performance, remarkable in effect and capable of reducing the number of oral cavity germs and regulating the environment of the oil environment.

The invention discloses health chewing gums. The health chewing gums are prepared from the following components in parts by weight: 25-40 parts of tartary buckwheat extract, 0.1-0.3 part of lysozyme, 15-25 parts of poria cocos, 15-25 parts of momordica grosvenori, 15-25 parts of sea buckthorn fruit powder, 10-20 parts of dandelions, 5-10 parts of stevia leaves, 15-30 parts of xylitol, 0.2-1 part of citric acid, 0.2-0.4 part of sodium sulfite, 2.5-3 parts of menthol, 20-35 parts of a gum base, 2-4 parts of a softening agent and 0.1-0.15 part of edible pigment. A preparation method comprises the following steps: (1) treating the poria cocos, the momordica grosvenori, the sea buckthorn fruit powder, the dandelions and the stevia leaves; (2) adding water into the tartary buckwheat extract, the citric acid, the sodium sulfite and the lysozyme and dissolving; (3) melting glue; (4) adding residual substances in the steps (1) and (2), and residual substances in a formula into the melted glue at a temperature lower than 80 DEG C, and mixing; and (5) extruding and storing. The preparation method disclosed by the invention is simple; and the prepared chewing gums have a good taste, and can also be used for processing teeth and treating oral diseases.

The invention aims to provide a traditional Chinese medicine composition for preventing or treating oral diseases. The traditional Chinese medicine composition comprises fructus forsythiae, flos lonicerae, roasted semen armeniacae amarum, gypsum fibrosum, radix isatidis, herba houttuyniae, herba pogostemonis, radix et rhizoma rhodiolae, menthol and radix glycyrrhizae. The traditional Chinese medicine composition has the advantage that the common oral diseases such as periodontitis, gingivitis, oral ulcer and oral mucositis can be treated by the aid of the traditional Chinese medicine composition.

Disclosed are therapeutic oral compositions useful in the treatment of a variety of oral disorders, in which the composition can provide blockage of dentinal tubes, while at the same time provide antibacterial and anti-caries efficacy. The compositions include arginine in free or salt form, a mucoadhesive polymer, and at least one component selected from pyrophosphates, zinc salts, potassium salts, strontium salts, and mixtures thereof.

The invention discloses antimicrobial total triterpenoid saponin of pubescent holly root and application of the antimicrobial total triterpenoid saponin in preparation of medicines for treating oral diseases. The total triterpenoid saponin of the pubescent holly root is prepared from rootstocks or leaves of pubescent holly root as raw materials and contains 20-50 percent by weight of pubescent holly root. The total triterpenoid saponin of pubescent holly root is simple in preparation process; and the prepared total triterpenoid saponin of pubescent holly root is good in antibacterial effect and can be subjected to further study as a main component of medicines for treating oral diseases.

The present invention relates to the field of recombinant protein production in a host cell. More specifically the invention relates to the field of oral protein delivery. Specifically, the inventionprovides oral pharmaceutical formulations comprising the culture medium of a recombinant host secreting a recombinant protein. The resulting oral pharmaceutical formulations are useful for the treatment of gastro-intestinal and / or buccal disorders. Additionally the oral pharmaceutical formulations are useful for prophylactic and vaccine purposes.

The present invention provides autologous oral grafts that may be used, for example, to treat oral cavity disease characterized by inflamed or damaged oral mucosa tissue, or to treat oral caries characterized by damaged enamel, dentin, or cementum. In certain embodiments, the autologous oral grafts comprise a biocompatible matrix and cultured oral cells (e.g., keratinocytes) from the patient to be treated. In certain embodiments, the cultured oral cells comprise an expression vector comprising a nucleic acid sequence encoding a therapeutic polypeptide configured to at least partially reduce the patient's oral mucosa tissue inflammation or damage. In particular embodiments, the oral disease is characterized by infiltration of the oral mucosa with activated, maturing dendritic cells.