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Method for preparing strontium ranelate

A technology of strontium ranelate and ethyl thiophenecarboxylate, which is applied in the field of strontium ranelate preparation, can solve problems such as low yield of diethyl acetonedicarboxylate, impact on product purity and quality, and difficulty in controlling product quality. Achieve the effects of reducing production costs, smooth response, and easy control of product quality

Active Publication Date: 2012-01-18
SHANDONG BOYUAN PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology solves issues with current methods for producing pure strontum ranelates due to its excessively complicated manufacturing processes requiring expensive chemicals or multiple steps involving different materials such as hydrolysis/esterification, extraction from bacteria cells, crystallization, etc., which can be difficult to achieve consistently within specifications. By utilising lower-cost raw material without any unwanted substances like chlorine gas, this new method improves both purity (less monochlorobutyltoluene) and stability over long periods of storage. Additionally, while generating ethanols during synthetic procedures, reducing costs through wastewater processing reduces environmental impact. Overall, this innovative approach provides technical benefits to making better products containing more effective ingredients.

Problems solved by technology

This patented technical problem addressed by this patents relates to improving the efficiency or production rates of producing strontia (stramenorite). Current methods have limitations such as low yields due to difficulties in controlling process variables like pH levels during reaction steps, difficulty in obtaining desired products from crude mixtures containing impurities, complex operations involved, poor overall performance, and increased costs associated with each step.

Method used

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Embodiment Construction

[0012] The various raw material and output ratios used in the method for preparing strontium ranelate described in the present invention can be calculated by analogy according to the examples of the present invention. The strontium ranelate obtained by the preparation method of the present invention is a heptahydrate, and its structural formula is:

[0013]

[0014] The preparation method of strontium ranelate of the present invention is made by following steps:

[0015] ①Preparation of diethyl acetonedicarboxylate (intermediate I): Put 75kg of chlorosulfonic acid into the reactor at room temperature, take 25kg of anhydrous citric acid, and put it into the reactor three times within 1 hour. 10kg, add 7.5kg at intervals of 30 minutes, react at room temperature for 5 hours, control the temperature below 30°C and add 60kg of ethanol dropwise to the reactor, after the addition, raise the temperature to 30-35°C for 2 hours, then cool down to 24- 27°C, preferably 25°C, import th...

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PUM

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Abstract

The invention discloses a method for preparing strontium ranelate, which comprises the following steps of: 1, preparing diethyl acetonedicarboxylate, namely adding chlorosulfonic acid into a reaction kettle, adding anhydrous citric acid into the reaction kettle, dripping ethanol into the reaction kettle, adding magnesium sulfate into an organic layer for drying, and filtering to obtain the diethyl acetonedicarboxylate; 2, preparing 5-amino-4-cyano-2-(ethoxycarbonyl)-3-thiopheneacetic acid ethyl ester, namely adding the diethyl acetonedicarboxylate, propane dinitrile and water into the reaction kettle, centrifuging and drying; 3, preparing ethyl 5-amino-4-cyano-3-(2-ethoxy-2-oxoethyl)thiophene-2-carboxylate; and 4, preparing the strontium ranelate which has the purity of over 99.8 percent,the content of a single impurity of less than 0.1 percent and the yield of 70 percent. The strontium ranelate prepared by the method has high product purity, a few single impurity and low manufacturing cost.

Description

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Claims

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Application Information

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Owner SHANDONG BOYUAN PHARM CO LTD
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