Method for preparing strontium ranelate
A technology of strontium ranelate and ethyl thiophenecarboxylate, which is applied in the field of strontium ranelate preparation, can solve problems such as low yield of diethyl acetonedicarboxylate, impact on product purity and quality, and difficulty in controlling product quality. Achieve the effects of reducing production costs, smooth response, and easy control of product quality
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[0012] The various raw material and output ratios used in the method for preparing strontium ranelate described in the present invention can be calculated by analogy according to the examples of the present invention. The strontium ranelate obtained by the preparation method of the present invention is a heptahydrate, and its structural formula is:
[0013]
[0014] The preparation method of strontium ranelate of the present invention is made by following steps:
[0015] ①Preparation of diethyl acetonedicarboxylate (intermediate I): Put 75kg of chlorosulfonic acid into the reactor at room temperature, take 25kg of anhydrous citric acid, and put it into the reactor three times within 1 hour. 10kg, add 7.5kg at intervals of 30 minutes, react at room temperature for 5 hours, control the temperature below 30°C and add 60kg of ethanol dropwise to the reactor, after the addition, raise the temperature to 30-35°C for 2 hours, then cool down to 24- 27°C, preferably 25°C, import th...
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