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87results about How to "Alleviate hypersensitivity" patented technology

Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders

ActiveUS20170340623A1Reduce interdialytic weight gainMore palatable dietPharmaceutical delivery mechanismPharmaceutical non-active ingredientsIntestinal tract diseasesDisease
The present disclosure is directed to compounds and methods for the treatment of disorders associated with fluid retention or salt overload, such as heart failure (in particular, congestive heart failure), chronic kidney disease, end-stage renal disease, liver disease, and peroxisome proliferator-activated receptor (PPAR) gamma agonist-induced fluid retention. The present disclosure is also directed to compounds and methods for the treatment of hypertension. The present disclosure is also directed to compounds and methods for the treatment of gastrointestinal tract disorders, including the treatment or reduction of pain associated with gastrointestinal tract disorders. The methods generally comprise administering to a mammal in need thereof a pharmaceutically effective amount of a compound, or a pharmaceutical composition comprising such a compound, that is designed to be substantially active in the gastrointestinal (GI) tract to inhibit NHE-mediated antiport of sodium ions and hydrogen ions therein. More particularly, the method comprises administering to a mammal in need thereof a pharmaceutically effective amount of a compound, or a pharmaceutical composition comprising such a compound, that inhibits NHE-3, -2 and / or -8 mediated antiport of sodium and / or hydrogen ions in the GI tract and is designed to be substantially impermeable to the layer of epithelial cells, or more specifically the epithelium of the GI tract. As a result of the compound being substantially impermeable, it is not absorbed and is thus essentially systemically non-bioavailable, so as to limit the exposure of other internal organs (e.g., liver, heart, brain, etc.) thereto. The present disclosure is still further directed to a method wherein a mammal is administered such a compound with a fluid-absorbing polymer, such that the combination acts as described above and further provides the ability to sequester fluid and / or salt present in the GI tract.
Owner:ARDELYX

Alginate dentifrice composition and preparation method thereof

The invention provides an alginate dentifrice composition, belonging to the field of personal care products. The alginate dentifrice composition comprises alginate, a zinc ion source, a fluorine-releasing anti-caries agent provided by a nano-scale fluorine-doped zirconia powder, and a desensitizing material provided by a bioactive glass microsphere loading a catechinic acid substance. A method forpreparing the alginate dentifrice composition includes combining the liquid material and the powder material in the raw materials to prepare a mixture, and then combining a surfactant into the mixture, and mixing in a vacuum environment to obtain the dentifrice composition. The astringency of the dentifrice composition is neutralized, and the dentifrice composition can reduce hypersensitivity ofdentin, induce enamel regeneration and enhance porcelain gloss of the tooth surface, relieve oral mucosa, periodontal tissue and pulp damage, and promote formation of prothrombin to reduce bleeding time of gums. The preparation method can promote the phenomenon of agglomeration of anti-caries agent particles and generate tetragonal phase crystals, reduce system energy consumption, increase glass particle loading capacity and hydroxyapatite mineralization production, and improve resource utilization rate and effective yield.
Owner:嘉兴市爵拓科技有限公司

Astragalus polysaccharide calcium phosphate nano-paclitaxel composite injection, preparation method and application thereof

The invention relates to astragalus polyose calcium phosphate nano taxol complex injection and a preparation method and the application thereof. 100 mL of injection comprises the following components: 0.01 to 1 g of astragalus polyose calcium phosphate nano to particles, 1.0 to 50 mg of taxol, 0 to 5.0 g of osmotic pressure regulator and appropriate amount of water. The pH value of the injection is 6.0 to 7.5. The preparation method comprises the following steps: blending the taxol with absolute ethyl alcohol to form taxol-absolute ethyl alcohol solution; blending the astragalus polyose with ultrapure water to form astragalus polyose solution; performing stirring and ultrasonic processing to the solution, rejecting the supernatant fluid after separation, and after depositing, drying and sterilizing, obtaining astragalus polyose calcium phosphate nano taxol complex granules used for injection, then adding the osmotic pressure regulator into the water for injection, and mixing with the astragalus polyose calcium phosphate nano taxol complex granules; after ultrasonic processing, astragalus polyose calcium phosphate nano taxol complex injection is formed. The complex injection can be used for the treatment or auxiliary treatment of tumor.
Owner:南京凯瑞尔纳米生物技术有限公司
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