40results about How to "Trigger immune response" patented technology

The present invention relates to immunotherapeutic peptides and their use in immunotherapy, in particular the immunotherapy of cancer. The present invention discloses tumor-associated T-helper cell peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions which stimulate anti-tumor immune responses. In particular, the composition of the peptides of the present invention can be used in vaccine compositions for eliciting anti-tumor immune responses against gastric cancers (GC).

The invention discloses a poultry antivirus composition, freeze-dried powder, a preparation method and applications of the composition, and belongs to the technical field of feed additive for poultry and livestock. The poultry antivirus composition is mainly composed of the following components in parts by weight: 90 to 100 parts of poultry antivirus yolk antibody, 1 to 2 parts of poultry antivirus transfer factor, and 1 to 2 parts of alpha-interferon, and preferably also comprises the following components in parts by weight: 5 to 10 parts of astragalus polysaccharide, 5 to 10 parts of angelica polysaccharide, 10 to 20 parts of wolfberry polysaccharide, and 10 to 30 parts of licorice polysaccharide. The poultry antivirus yolk antibody, poultry antivirus transfer factor, alpha-interferon, and traditional Chinese herbal extracts (astragalus polysaccharide, angelica polysaccharide, wolfberry polysaccharide, and licorice polysaccharide) are compounded to prepare the composition, which can effectively improve the immunity and disease preventing performance of poultry organism and has a good preventing and treating effect on poultry viral diseases. The composition can be made into freeze-dried powder, which can be preserved at a normal temperature for a long time and has the advantages of high antibody titer and good bio-activity.

The present invention relates to antigens and methods for the suppression of a hypersensitivity immune response via bystander suppression with an antigen unrelated to the allergen triggering a hypersensitivity immune response such as an allergic response in an individual. Treatment regiments covering the administering the unrelated antigen to the oral cavity (e.g. sublingual mucosa) combined with the administration of the unrelated antigen to either the respiratory tract, gastro-intestinal tract or skin in a simultaneous, contemporaneous, separate or sequential manner is provided.

The invention provides a preparation method and application of a bacillus cereus monoclonal antibody. The preparation method comprises the following steps of: 1, preparing bacterial antigen through fixation of bacillus cereus by incubation treatment of paraform; 2, injecting the bacterial antigen so as to avoid emulsification; 3, performing short spacing impulse injection so as to quickly promote immunization; 4, planting solid tumors so as to rejuvenate tumor cells; 5, performing chemical induction and fusion; 6, performing semifluid selection so as to obtain monoclonal hybridoma; 7, performing cooperation of negative screening and positive screening so as to obtain a specific antibody; and 8, using a polyclonal antibody as a capture antibody and using a monoclonal antibody as a detection antibody to establish dual-antibody sandwich ELISA.

The invention discloses a veterinary antivirus composition, freeze-dried powder, a preparation method and applications of the composition, and belongs to the technical field of veterinary feed additive. The veterinary antivirus composition is mainly composed of the following components in parts by weight: 85 to 100 parts of veterinary antivirus yolk antibody, 1 to 5 parts of veterinary antivirus transfer factor, and 1 to 5 parts of alpha-interferon; and preferably also comprises the following components in parts by weight: 5 to 10 parts of astragalus polysaccharide, 5 to 10 parts of angelica polysaccharide, 10 to 20 parts of wolfberry polysaccharide, and 10 to 30 parts of licorice polysaccharide. The veterinary antivirus yolk antibody, veterinary antivirus transfer factor, alpha-interferon, astragalus polysaccharide, angelica polysaccharide, wolfberry polysaccharide, and licorice polysaccharide are co-used, and thus the composition has the advantages of strong pertinency, high antibody titer, and good bio-activity, is capable of improving the organism immunity and disease preventing ability, and effectively prevents the animal viral diseases.

The hepatitis treating medicine is prepared with Japanese St. Johnswort, Cordate houttuynia, paraglaucous bauhinia, lily and other medicinal materials, which cooperate mutually to kill all the hepatitis viruses, regenerate blood and eliminate toxic matter from body. It has obvious curative effect, high curative rate and reliable performance. The present invention is suitable for being prepared into different forms, such as medicine powder, bolus, effervescent preparation, etc.

The invention discloses a CCL1-containing fusion protein, a preparation method and application, the fusion protein sequentially comprises an IgE signal peptide, CCL1, a linker and an antigen from an N terminal to a C terminal, or the IgE signal peptide, CCL1, the linker, the antigen and a T2 fragment, and the amino acid sequence of the T2 fragment is shown as SEQ ID NO: 4. According to the invention, different antigen proteins are transferred and crossly presented to the surface of the DC cell by utilizing the chemotactic binding capacity of CCL1 and surface receptors of immune cells such as the DC cell, so that the efficiency of phagocytosis, processing and presentation of various antigen proteins by the DC cell is improved, and the effect of preventing and treating related diseases is improved. Experiments prove that the T2 sequence disclosed by the invention has a very strong immune enhancement effect, and can further excite body fluid and cellular immune response in the process of promoting antigen presentation, so that the effect of inhibiting growth of related tumors is finally achieved.

The present invention provides attenuated live cultures of the pathogenic protozoan parasite, Neospora, and live vaccines against neosporosis prepared therefrom which are useful in the prevention of clinical disease and abortion in mammals.

The invention discloses a pharmaceutical composition for preventing duck viral diseases, freeze-dried powder, a preparation method, and applications of the composition, and belongs to the technical field of poultry feed additive. The pharmaceutical composition is mainly composed of the following components in parts by weight: 85 to 95 parts of duck viral disease preventing yolk antibody, 1 to 5 parts of duck viral disease preventing transfer factor, and 1 to 5 parts of alpha-interferon, and preferably comprises the following components in parts by weight: 5 to 10 parts of astragalus polysaccharide, 5 to 10 parts of angelica polysaccharide, 10 to 20 parts of wolfberry polysaccharide, and 10 to 30 parts of licorice polysaccharide. The duck viral disease preventing yolk antibody, duck viral disease preventing transfer factor, alpha-interferon, and traditional Chinese medicine extract (astragalus polysaccharide, angelica polysaccharide, wolfberry polysaccharide, and licorice polysaccharide) are compounded to prepare the pharmaceutical composition, which can prominently improve the organism immunity and disease preventing ability and effectively prevent the duck viral diseases. The pharmaceutical composition can be made into freeze-dried powder, which can be preserved at a normal temperature for a long time and has the advantages of high antibody titer and good bio-activity.