334results about How to "Preparation method is stable" patented technology

The invention relates to the technical field of a lithium ion secondary battery, in particular to a preparation method of high-rate fast-rapid graphite. The preparation method is characterized by comprising the following steps of (1) smashing and shaping a raw material; (2) mixing; (3) performing graphitization high-temperature processing, in which graphitization high-temperature processing is performed on the mixed material for 24-48 hours at 2,800-3,200 DEG C under protection of inert gas; (4) mixing the materials; (5) performing low-temperature thermal treatment; (6) performing carbonization thermal treatment; and (7) screening the mixed material. compared with the prior art, the preparation method has the advantages that the graphite is high in charge-discharge rate, large in discharge capacity and good in cycle performance, a button cell prepared from the graphite has excellent comprehensive performance and has main following advantages of relatively good large-current charge-discharge performance, good electrochemical performance, good cycle property, relatively high safety, relatively good adaptability to an electrolyte and other additives and stable product characteristic, the charge-discharge rate can reach over 10C, and the preparation method is suitable for industrial production.

The invention discloses a magnetic carbon-based iron oxide compound material and a preparation method of the magnetic carbon-based iron oxide compound material. Particularly, the invention discloses a prepraation method of the magnetic carbon-based iron oxide compound material. The preparation method comprises the following steps of: (a) providing a mixture comprising a carbon-based precursor, elemental iron and a solvent; and (b) carrying out heating reaction on the mixture in the step (a), thus obtaining the carbon-based iron oxide compound material. The method has the advantages that materials are common and are easily available, and the process is simple, safe and effective and the like. The obtained compound material has stable magnetism, and is wide in application.

The invention discloses a preparation method for directly generating a hydroxyapatite-containing biological ceramic membrane on the surface of titanium, and aims to solve the practical problems that the prior art is complex in process, time-consuming, low in electrolyte utilization ratio, poor in membrane forming efficiency and the like. The preparation method adopts a basic method of micro-arc oxidation, and is characterized in that during the preparation of electrolyte, low-solubility calcium dihydrogen phosphate is used for providing phosphate anions and citric acid is used as a complexing agent. Compared with the prior art, although the solubility of the calcium dihydrogen phosphate used in the preparation method is low, the solubility of the calcium dihydrogen phosphate is improved after the calcium dihydrogen phosphate is complexed with the citric acid, calcium ions and phosphate anions are provided at the same time, the utilization ratio of the electrolyte is high, the reaction speed is high, the membrane forming efficiency is high, the preparation method is simple and easy to operate and low in cost, the hydroxyapatite-containing biological ceramic membrane prepared by the preparation method is stable in structure, uniform in distribution and high in effective matter content, and has a wide prospect in the fields of hard tissue implants, tooth planting and the like.

The invention provides a hydrate of an ilaprazole salt and a preparation method thereof. The hydrate is shown by a formula (I), wherein M is Li, Na or K, n is equal to 1, and x is equal to 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4 and 4.5 or M is Ca, Mg or Zn, n is equal to 2 and x is equal to 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4 and 4.5. The invention also provides application of the hydrate of the ilaprazole salt. Compared with ilaprazole and a salt thereof, the hydrate of the ilaprazole salt can be used as a proton pump inhibitor for treating diseases relevant with disorder in gastric acid secretion, has low side effect, and can be developed to form new clinically-acceptable medicaments. Simultaneously, the preparation method is simple and easy, and repeated experiments prove that the hydrate of the ilaprazole salt has a stable process and can be used for industrial production.

The invention discloses a polythiophene / tungsten trioxide nanorod electrochromic material. The polythiophene / tungsten trioxide nanorod electrochromic material has a core-shell structure, tungsten trioxide nanorods are used as a core, polythiophene is used as a shell, the diameter of the tungsten trioxide nanorods is 50-100 nm, the polythiophene has a porous structure, the thickness of the polythiophene is 2-10 nm, the average pore size of the polythiophene is 2-3 nm, and the polythiophene uniformly wraps the tungsten trioxide nanorods. By an electrochemical working station and a three-electrode system, thiophene monomers are polymerized on the surface of FTO conductive glass subjected to thermal treatment by a solvent in an electrochemical polymerization mode, and therefore, the electrochromic material is prepared. The tungsten trioxide nanorods are perpendicular to a substrate, and grow and are distributed uniformly, and the polythiophene has the porous structure and uniformly wraps the peripheries of the nanorods to form the novel core-shell structure. The material has the excellent electrochromic property; the transparent material can be rapidly reversibly converted into the navy-blue material under different voltages; circulation stability is good; and therefore, the polythiophene / tungsten trioxide nanorod electrochromic material can be used as a concealed material and an intelligent color changeable film.

The invention discloses thermoplastic flame-retardant alloy and a preparation method thereof. The alloy consists of the following components in portion by weight: 5 to 94 parts of ABS resin, 3 to 94 parts of polyester or copolyester or mixture of the polyester and the copolyester, 1 to 50 parts of brominated flame retardants, 1 to 10 parts of auxiliary flame retardants, 0.001 to 30 parts of chlorinated polyethylene (CPE), 0.001 to 2 parts of anti-dripping additives, and 0.1 to 6 parts of processing aids. The thermoplastic flame-retardant alloy has better glossiness and scratch resistance, stronger ultraviolet radiation resistance and better mechanical property compared with the conventional flame-retardant ABS, and overcomes the disadvantage of easy yellowing of the flame-retardant ABS on certain occasions with high weather-resistant requirements. In addition, the method for preparing the thermoplastic flame-retardant alloy has continuity, stability and high feasibility.

The invention discloses an alcohol photo-oxidization catalyst, and a preparation method and application thereof. The catalyst is in a titanium dioxide-wrapped gold nanorod hollow shell-core structure. The method comprises the following steps of synthesizing a gold nanorod, wrapping the outer side of the gold nanorod with silicon dioxide, wrapping the silicon dioxide with a layer of unshaped titanium dioxide, wrapping the outermost layer with a layer of silicon dioxide, and performing calcination and sodium hydroxide aqueous solution etching to form the catalyst. The catalyst can be used for oxidizing an alcohol substance into an aldehyde substance in an oxygen atmosphere by virtue of visible light and even near infrared light, for example, the oxidization of benzyl alcohol into benzaldehyde, the amount of benzaldehyde generated under the existence of every gram of catalyst for 16 hours is maximally 685.7 micromole.

The invention discloses microcapsule slow release essence. The microcapsule slow release essence comprises a nanometer core material, essence and a coating material. The porous structure of the nanometer core material is filled with the essence. The nanometer core material filled with the essence is coated with the coating material so that the microcapsule slow release essence is formed. The microcapsule slow release essence comprises, by weight, 5-15 parts of the nanometer core material, 5-15 parts of the essence and 70-90 parts of the coating material. The essence comprises one or more of sweet-scented osmanthus essence, jasmine essence and rose essence. The nanometer core material comprises porous resin or nanometer silica. The coating material comprises drug-grade PEG or monoglyceride. The preparation method of the microcapsule slow release essence comprises preparing a mixture of the nanometer core material and essence, adding the coating material into the mixture, preparing an essence stock solution, carrying out curing treatment and carrying out grinding to obtain powder. The preparation method has simple processes, utilizes eco-friendly raw materials and realizes long fragrance holding time and a wide application range.

The invention provides a traditional Chinese medicine compound preparation for preventing and treating vaginitis and a preparation method thereof. The traditional Chinese medicine compound preparation comprises the following main raw materials in parts by weight: 50-70 parts of biological peptide, 15-28 parts of kuh-seng, 10-20 parts of cortex phellodendri, 10-20 parts of fructus cnidii, 5-10 parts of mint, 3-8 parts of chitosan, 5-30 parts of carbopol 940, 40-60 parts of glycerol, 2-5 parts of sodium hydroxide and 15-30 parts of mint oil. The biological peptide and traditional Chinese medicines are mixed and complementary mutually, can adjust balance, inhibit bacteria, purge fire for removing toxin, sterilize, resist inflammations, clear heat, dry dampness, dispel the wind, and kill parasites. Compared with the available preparation for preventing and treating the vaginitis, the traditional Chinese medicine compound preparation adopts a principle of mainly adjusting the balance, sterilizing and resisting the inflammations, and auxiliarily purging the fire for removing the toxin, clearing the heat, drying the dampness, dispelling the wind and killing the parasites, and is used for improving an acid environment in a vagina, inhibiting and eliminating the growth of the harmful bacteria, detoxifying, eliminating the dampness and diminishing the inflammations, so that the purpose of preventing and treating the vaginitis is achieved; and the preparation method is stable, practicable, controllable and applicable to mass production.

The invention discloses a method for industrially producing graphene based on a detonation process and a device for preparing large-sized graphene. According to the method, a gaseous hydrocarbon is utilized as a carbon source and mixed with a certain proportion of oxygen, which are filled in a sealed detonation special device; an appropriate amount of solid metal or non-metal compounds are added as a catalyst; a mixed gas is preheated to a certain temperature and pressure, and is ignited by ignition of a high-energy ignition device; and condensed carbon and free carbon decomposed by hydrocarbons under high temperature and high pressure self-assemble into graphene, and oxygen components and hydrogen components are combined to form water vapor. Raw materials used by the method are low in cost; prepared graphene has no surface functional group, and is controllable in number of layers and in area, and the yield of the graphene yield is up to 30%-60%; and the method is extremely suitable for industrial scale production and application.

The invention discloses a preparation method and an application of hydrophobization beta-cyclodextrin cation polyelectrolyte. In a water phase, three monomers, namely polymerizable beta-cyclodextrin derivatives, acryloyl oxyethyl trimethyl ammonium chloride and styrene, are subjected to a free radical copolymerization reaction under an oxidation / reduction (potassium peroxodisulfate / sodium hydrogen sulphite) initiating system to obtain the hydrophobization beta-cyclodextrin cation polyelectrolyte product. The hydrophobization beta-cyclodextrin cation polyelectrolyte product is white powder solids and is stable in structure and convenient to store and transport, hydrophilcity is reduced and better solubility is still maintained; the preparation method of the hydrophobization beta-cyclodextrin cation polyelectrolyte product is simple, and low in energy consumption; no other auxiliaries such as a surface active agent is added in an aqueous solution polymerization process, and environmental pollution is less; and the hydrophobization beta-cyclodextrin cation polyelectrolyte product can serve as a novel flocculating agent for decoloration, the specific structure of beta-cyclodextrin (beta-CD) is reserved, toxicity and cost are low, flocculation capacity is strong, decoloration speed is high, an applicable pH range is wider (2-12), and salt tolerance is high.

The present invention discloses a preparation method for positioning ferreous crystal; the preparation of the base glaze is that: potassic feldspar, quartz, kaoline, ocher, steatite, limestone and bone ash are mixed with ferric oxide for grilling; the proportion of the glaze slurry is 1.6-1.7 g / cm3; the preparation method of the crystal core is that: kaoline is mixed with ferric oxide for grilling and calcining and cooling to become grain powder; and then crystal core is pre-buried in the position for the blank body to form the crystal flower; the size Phi of the preburied hole is about 1mm; the quantity and distribution are adjusted according to the actual requirement; the base glaze is put on the ceramic blank body preburied with crystal core evenly; the thickness of the glaze level is controlled on 0.7-1.0mm; the semi finished product of the ceramic glaze is baked to the maximum temperature with oxidation blaze, and then is cooled into the room temperature. The present invention uses the common ceramic raw material and the positioning crystal measure to produce the positioning ferreous crystal glaze, which solves the shortcoming that the size and the distribution for the ferreous crystal flower is hard to be controlled; the method is a stable preparation method with simple process technical, wide baking temperature range, good stability, without needing middle temperature heat preservation; the produce cost is much lower.

The invention provides a method for preparing environment-friendly bimetallic perovskite quantum dots. The method comprises the following steps: mixing AgBr, BiBr3, a reaction solvent octadecene and surfactants oleic acid and oleylamine under the condition of inert gas shielding until the mixture is completely dissolved; heating the mixed solution to a reaction temperature, then injecting a DMF (Dimethyl Formamide) solution dissolved with brominated butyl amine, starting to react so as to produce a perovskite structure in the system, and gradually forming (C4H9NH3)2AgBiBr6 quantum dots along with the reaction; and finally, carrying out a quenching reaction by using acetone, thereby obtaining the final (C4H9NH3)2AgBiBr6 bimetallic perovskite quantum dots. With the adoption of a thermal injection synthesis method in the invention, the optical property of perovskite is regulated by regulating the acidity in a synthetic environment on the premise of not changing the morphology and crystal structure of the perovskite. The synthetic perovskite quantum dots have excellent dispersion property and stability and uniform morphology and have profound significance on constructing photoelectric devices with tunable bandgaps.

The invention relates to the technical field of a lithium ion secondary battery, in particular to a preparation method of high-rate and rapid-charge graphite. The preparation method is characterized by comprising the following steps of (1) smashing and shaping; (2) mixing a modifying agent; (3) performing graphitization high-temperature processing; (4) mixing an adhesive; (5) performing low-temperature thermal treatment; (6) performing carbonization thermal treatment; and (7) screening a mixture. Compared with the prior art, the graphite has the advantages of high charge-discharge rate, large discharge capacity and good cycle performance; and the prepared button cell is excellent in integral performance and mainly has the following advantages that 1, the large-current charge-discharge performance is relatively good; 2, the electrochemical performance is good; 4, the cycle property is good; 5, the safety is relatively good; 6, the adaptability to an electrolyte and other additives is relatively good; and 7, the product property is stable, and the button cell is suitable for industrial production.

The invention relates to a polyketone iodine eyedrops, and relative production, wherein it adds polyketone iodine into osmotic pressure adjuster, stabilizer, and pH adjuster to be dissolved, and using pH adjuster to realize constant volume; pH adjuster at 100 volume units contain 0.1-0.5 units of polyketone iodine, 0.35-0.65 osmotic pressure adjuster mass units, stabilizer at 0.05 mass units; the pH of osmotic pressure adjuster is 6.0-6.8. The invention can treat kinds of ceratitis, with high safety but no side effect.

The invention belongs to the field of food processing and particularly relates to preserved dark plum fruits containing dried tangerine peel and a preparation method of the preserved dark plum fruits. The preserved dark plum fruits containing the dried tangerine peel comprise raw materials in parts by weight as follows: 160-200 parts of preserved dark plum fruits, 15-20 parts of dried tangerine peel powder, 6-10 parts of coix seed powder, 5-8 parts of yam flour and 3-6 parts of mint powder. The preserved dark plum fruits containing the dried tangerine peel taste cool, sour, sweet and delicious, is moderate in softness and stable in quality and has the dietary therapy effects of promoting appetite, tonifying the spleen and the like, and the shelf life can be as long as 12 months or longer.

The invention relates to the technical field of glucose detection, and particularly relates to an enzyme-free glucose sensor, a production method and an application thereof. Magnolia grandiflora leaves are used as a carbon-based catalyst, nickel atoms are well dispersed when the magnolia grandiflora leaves are used as a substrate material, and the catalytic activity of the material is improved. And the prepared Ni@ NSiC nano molecular layer is modified on a pretreated white glassy carbon electrode to obtain a high-activity modified working electrode Ni@ NSiC / GCE, and glucose is detected by adopting a cyclic voltammetry and a chronoamperometry. The method solves a problem that dopamine, ascorbic acid, uric acid and other easily oxidized interfering substances exist when the glucose is detected through a traditional electrooxidation method. Test results show that the material has excellent electrochemical sensing performance on the glucose, has relatively high sensitivity, a good stability and anti-interference capability, and has a wide application prospect in the fields of electro-catalysis and biosensing.

A manufacturing method of a semiconductor device including an LDMOS transistor includes: a process (a) of forming a first conductive well diffusion layer in the semiconductor substrate; a process (b) of sequentially forming a gate insulator film, a gate conductive film, and a photoresist film on a region on the semiconductor substrate corresponding to the well diffusion layer; a process (c) of performing photolithography to remove a part of the photoresist film formed in a predetermined region, and etching the gate conductive film using a remaining part of the photoresist film as a mask so as to form an opening in the predetermined region; a process (d) of doping second conductive impurity ions using a remaining part of the gate conductive film and the remaining part of the photoresist film as a mask so as to form the body layer; and a process (e) of removing the remaining part of the gate conductive film except a part corresponding to the gate electrode formed based on a part that constitutes a lateral surface of the gate conductive film facing the opening.

The invention discloses a preparation method of acanthopanax effervescent tablet, which comprises the following steps of: (1) evenly mixing the acanthopanax extract with the lactose, drying and crashing to fine powder for later use; (2) wrapping the sodium bicarbonate with the polyethyleneglycol 4000 to obtain a mixed solution containing the inclusion; (3) spraying the mixed solution containing the inclusion in a rotation coating pan filled with the powder obtained in the step (1), screening and granulating to obtain the grains; and (4) screening the citric acid and the sodium cyclamate to obtain the grains, mixing with the grains prepared in the step (3) and the boletic acid powder and tabletting to prepare the finished product. In the preparation method, the sodium bicarbonate is wrapped by the polyethyleneglycol 4000 to avoid the direct contact of the sodium bicarbonate with the acid, thereby the stability of the preparation is enhanced, and the sticking problem when tabletting is solved. In addition, in the method of the invention, the lactose and the sodium cyclamate are utilized to replace the cane sugar for filling so that the moisture absorption is reduced. The preparation method has the advantages of simpleness, security, stability and high operability.

The invention discloses a preparation method of a pH-responsive dual-drug-release metal-organic framework-upconversion nano-system. The preparation method comprises the following steps of: adopting apolymer modification method to improve the water solubility of the upconversion nano-crystal with a core-shell structure, and growing a metal-organic framework on the surface of the upconversion luminescent nano-crystal to obtain an upconversion nano-system coated with the metal-organic framework; and attaching Adriamycin hydrochloride containing amino group to the surface of the metal-organic framework, and adsorbing other anticancer drugs into the porous structure of the metal-organic framework to obtain the double-drug-loaded metal-organic framework-up-conversion nano-system. The nano system provided by the invention has good stability, good biocompatibility, simple and reliable preparation method and good repeatability. The nanosystems have tumor diagnostics-Therapeutic integration canbe used as an imaging agent for fluorescence imaging and magnetic resonance imaging, as well as drug delivery and pH-responsive dual drug release, and can be used as a drug carrier.

The invention provides a tungsten trioxide nano bowl electrochromic material and a preparation method thereof, and belongs to the technical field of electrochromic films. The electrochromic material has a hierarchical porous structure, the tungsten trioxide nano bowl electrochromic material takes FTO conductive glass as a substrate, the surface of the substrate sequentially wraps a bottom layer and an outer layer, crystalline tungsten trioxide is used as the bottom layer, and amorphous tungsten trioxide is used as the outer layer, the outer layer is in a porous structure and comprises independent dispersed micro-region crystalline structures, and tungsten trioxide crystal nuclei with the diameter of 2-5 nm are distributed on the outer layer. According to the tungsten trioxide nano bowl electrochromic material and the preparation method thereof, the combination of crystalline and amorphous tungsten trioxide on a nano scale is achieved, the electrochromic performance is greatly improved,complementary advantages are achieved, the specific surface area of the nano bowl electrochromic material is increased, the kinetic process of the electrochromic reaction is obviously enhanced, so that the electrochromic performance is improved.

A method for manufacturing an optical film comprising a transparent substrate and at least one functional layer on or above the transparent substrate, wherein said at least one functional layer to be laminated on the transparent substrate is formed by a layer-forming method comprising the following steps (1) and (2): (1) step of applying a coated layer on the transparent substrate, and (2) step of curing the coated layer by irradiating ionizing radiation in an oxygen environment in which the oxygen concentration is lower than an atmospheric oxygen concentration.

The invention discloses a valsartan amlodipine tablet and a preparation method thereof. The valsartan amlodipine tablet comprises the following substances as raw materials in parts by weight: 80 partsof valsartan, 5 parts of amlodipine besylate (counted by amlodipine), 50-100 parts of microcrystalline cellulose PH102, 8-30 parts of crospovidone XL, 0.1-10 parts of poloxamer 188, 1-5 parts of magnesium stearate, 1- 3 parts of copovidone S630, 1-5 parts of colloidal silicon dioxide and 4-10 parts of a film coating premix (gastric). Through addition of the poloxamer 188 into a medicinal auxiliary material of the valsartan amlodipine tablet, the solubility of the valsartan is improved and the retention time thereof in the gastrointestinal tract is prolonged, so that absorption is improved, and thus the bioavailability of the valsartan amlodipine tablet is improved; through addition of the copovidone S630 into a coating solution, the solubility and the bioavailability of the valsartan canbe also improved, and thus the bioavailability of the valsartan amlodipine tablet is further improved. The preparation method of the valsartan amlodipine tablet is stable, and is suitable for large-scale preparation.

The invention discloses formaldehyde-removal nano-photocatalyst paint and belongs to the technical field of paint. The paint is prepared from raw materials in parts by weight as follows: 55-60 parts of a fluorocarbon emulsion, 13-15 parts of nano-titania, 7-9 parts of modified silicon dioxide, 3-7 parts of modified magnesium hydroxide, 1-2 parts of dodecanol, 4-6 parts of zinc borate, 5-7 parts of diammonium hydrogen phosphate, 1-3 parts of plant essential oil, 0.5-1.5 parts of a preservative, 0.1-0.8 parts of a leveling agent, 0.1-0.5 parts of an ultraviolet absorbent, 2-6 parts of a dispersant, 1-2 parts of a defoaming agent, 1-2 parts of a thickening agent, 5-10 parts of glycol and a proper amount of water. The invention further discloses a preparation method of the formaldehyde-removal nano-photocatalyst paint. The paint is environment-friendly, pollution-free, high in intensity, corrosion-resistant, waterproof, flame-retardant and high-temperature-resistant and has excellent formaldehyde removal capacity.

The invention discloses a seed-dressing agent as well as a preparation method and application thereof. The seed-dressing agent comprises effective ingredients extracted from anemone vitifolia, radix sophorae flavescentis, golden cypress, folium artemisiae argyi, angelica sinensis and thunder god vines. The seed-dressing agent is simple in component, convenient to use, free from pollution and residue on grain and economic crop seeds, and low in toxicity to people and livestock and has the effects of mouse preventing, insecticide, sterilization and crop nourishing; the preparation method is simple, the flow is easy to control, the operation is convenient and easy, the yield of effective ingredients of materials is high, the components of the seed-dressing agent are stable, and the seed-dressing agent is easy to store and use. The invention also provides a using method of the seed-dressing agent. In the method, seeds are mixed with the seed-dressing agent after the agent is diluted, and the application is convenient.

The invention discloses a compound microbial preparation for preventing brown spot of Cassava and a preparing method thereof. The raw materials of the compound microbial preparation comprises fermentation liquor of streptomyces Durham, fermentation liquor of streptomyces Russa, fermentation liquor of mud Bacillus licheniformis, fermentation liquor of Paenibacillus Barcelona, and fermentation liquor of Trichoderma aggression. According to the compound microbial preparation for preventing brown spot of Cassava, cultures can make full use of antibiosis, competition, hyperparasitism, bacteriolysis of interspecific or intraspecific microorganism; and through secondary metabolite, Trichoderma is induced to generate disease resistance, which can produce multiple antibiotics such as durhamycin, antifungal pentaene antibiotics, and antibiotics which can produce antifungal tetraene; russa mycin is used to prohibit pathogenic bacteria in brown spot of Cassava, and improves disease preventing effect of Cassava. The Compound microbial preparation for preventing brown spot of Cassava is environmental friendly and safe to people and livestock, and can not easily generate drug resistance; meanwhile, the preparing method is simple in procedures, low in cost and easy in using.

The invention provide a method for preparing a simulated human body model. The method comprises the following steps that firstly, a head of the simulated human body model is prepared, and then an upper body and limbs of the simulated human body model are prepared; and each preparation step comprises processes of turning mold, mold covering by silica gel, finishing by oil sludge, obtaining glass fiber reinforced plastic female molds, obtaining glass fiber reinforced plastic male molds, discharging silica gel skins, fine repairing and coloring, and implanting hairs later. The simulated human body model is stable in preparation method and good in repeatability, a whole and complete simulated human body model can be made, the appearance of the made model is vivid, and a real person skin texture and skin color are realized; and the preparation method is simple, the operation is easy, the requirement on operators is low, and the method is suitable for large-scale production.

The invention discloses a nuclear acid probe marked with quantum-dots composite sphere and a preparation method and application thereof. Nuclear acid probes with different sequences are marked with quantum-dots composite sphere with different emission spectrum characteristics; the quantum-dots composite sphere comprises a sphere and a quantum-dots composite contained in the sphere, the quantum-dots composite is composed of randomly selected m types of quantum-dots with different emission spectrum characteristics from n types thereof, n and m are both positive whole numbers and m is less than or equal to n; the preparation method of the nuclear acid probe comprises the following steps: preparing numerous probes with different sequences and marking the probes with X; preparing numerous quantum-dots composite sphere with different emission spectrum characteristics and marking the sphere with Y; integrating probes marked with X and quantum-dots composite sphere marked with Y through specificity of X and Y and carrying out coupling on the probes and sphere; applied to multicolor fluorescence in situ hybridization, spectral karyotype analysis and chromosome karyotype analysis, the probeof the invention can improve sensitivity, repetitiveness and specificity of detection, simplify detection device, increase detection speed and prevent false positive result from occurring.

A center of a substrate having peripheral circuit components mounted thereon is hollowed in a size maintaining a distance for establishing a connection with a semiconductor chip through a conductor such that the semiconductor chip is bonded to a heatsink and the peripheral circuit components are arranged near the semiconductor chip so as to surround the semiconductor chip. Upon adhesion of a conductive paste material, for bonding the substrate to the heatsink having the semiconductor chip mounted thereon in a conductive manner, to a bottom face of the substrate, an adhesive tape is stuck to an edge of the substrate so as to prevent outflow of the conductive paste material, respective terminals are connected through conductors, and both the substrate and the heatsink are sealed with a resin.

The invention relates to stabilized pharmaceutical composition comprising pregabalin and a disaccharide or higher polyol as stabilizer and optionally a conventional pharmaceutically acceptable carrier. The stabilized pharmaceutical composition according to the invention is useful in the treatment of a number of diseases such as epilepsy, Alzheimer's disease or Parkinson's disease.