324 results about "Toad skin" patented technology

The invention relates to a preparation method of a leaf vegetable insecticide. The preparation method comprises the following steps: adding 10-15kg of flos daturae, 8-10kg of aconite, 6-8kg of felwort, 8-12kg of coptis chinensis, 15-20kg of croton, 10-15kg of radix stemonae, 15-20kg of lithospermum and 14-18kg of thunder god vine into 200-300kg of water; boiling by high fire and decocting by soft fire till about 150-200kg of liquid medicine is left; filtering the liquid medicine; grinding 4-5kg of toad skins to fine powder and adding the fine powder to the liquid medicine to be mixed; after cooling to room temperature, adding 0.8-1kg of acetamiprid and 0.8-1kg of fipronil to stir and mix. The preparation method of the leaf vegetable insecticide provided by the invention takes the decoction decocted by traditional Chinese medicines as a main material and acetamiprid and fipronil as auxiliary materials, so that insects are efficiently killed and prevented with the kill ratio over 95%; the vast majority of the insecticide is traditional Chinese medicines, so that the insecticide is green and environment-friendly and free from pollution to the environment and crops.

A cinobufotalin freeze dried injection and preparation process thereof are disclosed. It is prepared by cinobufotalin effective part and pharmaceutical adjuvant extracted from dry toad skin. The effective part of cinobufotalin is obtained by alcohol extraction, centrifugation and macropore polymeric adsorbent separation and purification. Wherein, the main effective component indole total alkaloid content is over than 30%. The content assay result and pharmaceutical examination result indicates that the cinobufotalin freeze dried injection has a higher content of effective part and stronger pharmaceutical function.

The invention provides a detection and identification method of two composition components in a toad skin extract. The method comprises the following steps: preparing dry toad skin as a raw material into a middle extract by water extraction and alcohol precipitation methods, and carrying out gel chromatographic separation and ODS purification, so as to obtain a composition formed by one or N polypeptides. A correction curve is prepared by adopting an HPLC-gel chromatography method and combining with a known standard product. The molecular weight distribution range of the composition components is 1000-10000Da. The invention also relates to a fat-soluble composition in the toad skin. The fat-soluble composition is the composition composed by one or N fat-soluble components obtained by taking the dry toad skin as the raw material and adopting a solvent or chromatography method after preparing the middle extract by the water extraction and alcohol precipitation methods. According to the high performance liquid chromatography, octadecylsilane chemically bonded silica is taken as a filler, acetonitrile-water is taken as a mobile phase to carry out gradient elution, and the compound represented by 33 chromatographic peaks in the fat-soluble composition of the toad skin is identified by the combined mass spectrum (HPLC-MS) by deducing fragment information in the mass spectrum and comparing with the known standard substance.

The invention provides a medicinal composition of Cinobufacini, which is prepared into the forms of drop pill, or dispersible tablet, or soft capsule, or effervescent tablet, or orally disintegrating tablet, or mini-pill, or suppository. The invention also discloses their preparing process. The composition comprises dried toad skin extract and Job's-tears seed oily extract by the weight ratio of 1:0.05-30.

The invention relates to a Chinese medicine for treating cancer which is prepared from the following raw materials, scorpion, house lizard, dysosmapleiantha woods, creeping euphorbia, hairy deerhorn, black-tail snake, long-nosed pit viper, toad skin, centipede, batryticated silkworm, leeches, earthworm, seaweed, wood louse, pangolin scales, safflower, notoginseng, dry human placenta, decapetalous daesalpinia and gadfly.

The present invention provides preparation process of toad skin total alkaloid. The toad skin total alkaloid contains indole total alkaloid 50-95 wt%, cinobufagin and lipo bufogenin 0.02-0.08 wt%, and toad thetine 20-50 wt%. The present invention provides also the method of measuring toad thetine content, and the injection, powder for injection, dripping pill, capsule, oral liquid, etc with the oad skin total alkaloid as effective component and their preparation process.

The invention belongs to the field of traditional Chinese medicines and relates to a traditional Chinese medicine composition cooperatively used in radiotherapy. The traditional Chinese medicine composition cooperatively used in the radiotherapy is prepared from the following raw materials in parts by weight: 8-20 parts of angelica sinensis, 5-15 parts of the rhizome of chuanxiong, 5-15 parts of radix paeoniae alba, 3-10 parts of pinellia ternate, 10-25 parts of codonopsis pilosula, 5-15 parts of rhizoma polygonati, 10-20 parts of the root of bidentate achyranthes, 3-10 parts of dogwood, 10-20 parts of peach kernel, 5-15 parts of pseudo-ginseng, 8-20 parts of mushroom, 5-12 parts of rehmannia glutinosa, 10-20 parts of the root of kudzu vine, 3-10 parts of dried tangerine or orange peel, 5-15 parts of membrane of chicken gizzard, 3-10 parts of dandelion, 3-10 parts of glossy privet fruit, 5-12 parts of epimedium, 10-15 parts of the fruit of Chinese wolfberry, 10-20 parts of toad skin, 3-10 parts of rhizoma anemarrhenae, 5-15 parts of oldenlandia diffusa, 5-15 parts of burdock, 5-25 parts of astragalus membranaceus, and 10-20 parts of liquorice. The traditional Chinese medicine composition cooperatively used in the radiotherapy, which is disclosed by the invention, has the advantages that the toxic and side effects of the radiotherapy can be reduced, the sensitivity of cancer cells can be reinforced, and the like.

The invention relates to an insect repellent agent for Brassica chinensis var chinensis. The insect repellent agent is characterized by mainly comprising the following components by weight: 10-15kg of datura flowers, 8-10kg of Radix Aconiti Kusnezoffii, 6-8kg of Radix Gentianae, 8-12kg of coptis chinensis, 12-15kg of stellera chamaejasme, 15-20kg of croton, 10-15kg of Radix Stemonae, 15-20kg of lithospermum, 14-18kg of tripterygium wilfordii, 4-5kg of toad skin, 0.8-1kg of acetamiprid, and 0.8-1kg of fipronil. The insect repellent agent for Brassica chinensis var chinensis provided by the invention takes the decoction decocted by traditional Chinese medicines as the main component, and adopts acetamiprid and fipronil as auxiliary materials, can kill and prevent insects efficiently, and has a killing rate up to over 96%. Also, the insect repellent agent mostly contains Chinese medicinal ingredients, is green and environment friendly, and has no pollution to the environment and crops. The formula of the insect repellent provided by the invention specifically selects a variety of traditional Chinese medicines, which can be combined to reach high insecticidal efficiency. And trace acetamiprid and fipronil are supplemented to consolidate the insecticidal and pest control effects. Thus, the insect repellent agent has a very ideal effect in prevention and treatment of Brassica chinensis var chinensis insects.

The present invention discloses a Chinese medicine for curing advanced cancers and chronic hbv hepatitis and a preparation method. The present invention is proportionally manufactured by a medicinal active component made of dry toad skin and a medicine-acceptable carrier; the medicine carrier contains sodium carboxymethylcellulose and starch. Compared with the prior dosage, the present invention with advanced process and high medicine content strengthens the curing effect, reduces the toxic side effect of the medicine and ensures safer and more convenient medicine taking for patients.

The invention discloses a Chinese toad bufotoxin extract and a preparation method thereof. The extract contains the main effective components of cinobufagin with the content more than 0.15 percent and resibufogenin with the content more than 0.10 percent. The extract is made from dry toad skin and is prepared by the technologies of poaching, column chromatographic separation, eluting, condensing, drying, etc. The invention effectively removes useless substances (impurity) in the extract, is enriched in effective component and achieves the goals of improving the curative effect and reducing the toxic and side effects.

The invention discloses a medicine for treating tumors and a preparation method thereof. The medicine is prepared from a turtle shell, curcuma zedoary, dried toad skin, rabdosia rubescens, lily, coix seeds, rhizoma polygonati, ligusticum wallichii, subprostrate sophora, salviae miltiorrhizae, ground beeltle, radix curcumae, uniflower swisscentaury root, clematis chinensis, solanum lyratum, nightshade, oldenlandia diffusa, sculellaria barbata, notoginseng powder and auxiliary materials. The medicine disclosed by the invention has the effects of resolving hard lumps, and detoxicating and activating blood (nourishing yin, promoting blood circulation, removing stasis, and disintegrating masses), and is suitable for subcutaneous nodule, phlegm-damp oozing in the body, abdominal mass in the body, and various cancers, malignant and benign tumors in western medicine diagnosis; and the prepared medicine is significant in curative effect, and small in toxic and side effects.

The invention provides a method for collecting selenium enriched toad skins. A toad culture stage comprises the following steps: adding the fodder with the high selenium content 5 to 7 days after the tadpole period, and culturing phycophyta with the high selenium content in the tadpole pond; feeding the bait with the high selenium content and matched fodder in the child toad period; and applying selenium enriched fertilizer to the terrestrial soil of the adult toad pond according to the dosage of 0.4 to 0.6 kg/hm, planting farm crops or vegetables, and feeding artificially cultured bait. A toad skin collecting stage comprises the following steps: adding selenium enriched yeast into the water of an ecdysis pond so as to prevent the selenium contained by the toad from losing; drying the toad skin to the water content less than or equal to 5 percent; and packaging the toad skin into bags after the disinfection through ultraviolet rays so as to obtain the selenium enriched toad skin. The method adds the selenium enriched bait and provides a selenium enriched growing environment in the toad culture process from the child toad to the adult toad, thereby making the toad enriching selenium, and ensuring no loss of selenium in the ecdysis process. Therefore, the toad skin has the high selenium content. The method remarkably improves the medical and functional value of the toad skin.

The invention discloses a traditional Chinese medicine preparation for treating the tumor of the digestive system, comprising ginseng, Brassica alba boiss, atractylodes, rhizoma atractylodis, frondosa, barbata, Tefnon liyard, toad skin, astragalus, galli stomachichum corium, red sage roots, pleione rhizome, tuckahoe, dried orange peel, curcuma, pinellia, hemlock parsley, Rhizoma Zedoariae, mistletoe and trachea. The traditional Chinese preparation has a well-chosen medicinal herb composition, has the efficacy of regulating the flow of qi, invigorating blood circulation, clearing away heat and toxicity, softening hard lumps, dispelling stagnation, reducing phlegm, removing dampness, eliminating stasis to resolve swelling, replenishing qi to invigorate the spleen, benefiting qi, nourishing blood, restoring the stomach, controlling nausea and vomiting, and the like, can obviously improve the living quality of tumor patients and prolong the life time. The medicament also has the advantages of little side effect, low price, convenient use, and the like, thereby being valuable to clinical popularization and application.

A traditional Chinese medicine for treating a tumor comprises the raw material medicines in grams by weight portion as follows: 10 to 100 g of concentrated juice of prunella vulgaris, 20 to 50 g of sinomenium acutum root, 10 to 60 g of valeriana jatamansi jones, 50 to 200 g of spreading hedyotis herb, 20 to 60 g of vinegar-prepared carapax trionycis, 15 to 30 g of pleione bulbocodioides, 15 to 50g of white paeony root, 6 g of licorice, 10 to 50 g of vinegar-prepared toad skin, 10 to 60 g of wall gecko, 10 to 50 g of leech, 10 to 60 g of vinegar-prepared ground beeltle, 6 to 15 g of prepared centipede,0.3 to 0.6 g of prepared nux vomica, and 5 to 20 g of pseudo-ginsheng. The traditional Chinese medicine for treating a tumor can inhibit and kill tumor cells, relieves the pain of patients with tumors, and can prolong the life time of the patients effectively.

The invention relates to a recovery paste for treating the pain of viscera and physiques. The recovery paste is prepared from the following raw material medicines: toad skins, ground beetles, bamboo leaf seseli roots, prepared semen strychni, Japanese ginseng rhizome, pendulous monkshood roots, Chinese clematis roots, herba siegesbeckiae, glaucousback threewingnut root-barks, prepared kusnezoff monkshood roots, prepared common monkshood mother roots, girald daphne barks, daturas, Chinese azalea fruits, licorice roots, stephania, rhizoma arisaematis, haws, gastrodia rhizome, Chinese prickly ash, pinellia ternata, curcuma zedoaria, curcuma aromatica, olibanum, myrrh, dragon blood, borneol, crabs, peach blossoms, hibiscus flowers, henry clematis roots of leaves, Chinese angelica, dog bones, cornu caprae hircus and buffalo horns. The recovery paste is suitable for treating acute and chronic gastroenteritis, ulcer of duodenal bulbs, diarrhoea, abdominal distension, upset stomach, menoxenia, dysmenorrhea, hyperplasia of mammary glands, sterility after long marriage due to salpingemphraxis, injuries from falls, fracture of a broken bone, sudden sprain in the lumbar region, psoatic strain, pain of chest, back and ribs, relapse of old trauma, swelling, pain and numbness of bone joints of hands and feet, rheumatoid arthritis, cervical and lumbar vertebrae disc herniation, hyperosteogeny, pain of sciatic nerve, lung cancers at early stage, middle stage and late stage, breast cancers, liver cancers, intestine and stomach cancers, blood vessel tumours and cervical carcinoma, and the cure rate is high.

The invention discloses an anti-tumor immunity-enhancing traditional Chinese medicine preparation which comprises the following components by weight parts: 10-30 parts of ginseng, 2-7 parts of thunder god vine, 10-30 parts of lanceolata, 10-30 parts of astragalus, 10-30 parts of angelica, 10-30 parts of glaucescent fissistigma root, 10-30 parts of grey polypore, 10-30 parts of fleece-flower roots, 10-30 parts of spatholobus stems, 10-30 parts of dandelion, 10-20 parts of toad skin, 10-20 parts of gecko, 10-30 parts of safflower, 10-30 parts of medlar, 10-30 parts of cinnamon, 10-20 parts of hydnoid mushrooms, 10-30 parts of atractylodes and 10-30 parts of gamboges. The traditional Chinese medicine preparation by the scientific compatibility of medicines can tonify the kidney, einforce deficiency, activate and nourish blood, improve the autoimmunity of human bodies, promote blood circulation by removing blood stasis and dissolving lumps and effectively inhibit tumor growth.

The invention relates to a Chinese medicine preparation for treating malignant lymphoma, which is an anticancer drug and has distinctive effects. The Chinese medicine preparation is prepared by the following Chinese medicine raw materials in parts by weight: 20-30 parts of ginseng, 1-2 parts of gamboge, 4-6 parts of toad skin, 10-20 parts of curcuma zedoary, 20-30 parts of prunella vulgaris, 10-20 parts of lithospermum, 10-20 parts of coix seeds and 20-30 parts of barbed skullcap herb. A preparation method of the Chinese medicine preparation comprises the following steps of: grinding 20-30 parts of ginseng, 1-2 parts of gamboge and 4-6 parts of toad skin into Chinese medicine powder, mixing the Chinese medicine powder with extracted concentrates of the five Chinese medicine raw materials of 10-20 parts of curcuma zedoary, 20-30 parts of prunella vulgaris, 10-20 parts of lithospermum, 10-20 parts of coix seeds and 20-30 parts of barbed skullcap in liquid phase to prepare pills. The pills have functions of strengthening and consolidating the body resistance, eliminating pathogenic factors, clearing heat and toxic materials, resolving hard lumps, promoting blood circulation and removing blood stasis, and improving human immunity, have the vigor to kill cancer cells and no obvious toxic effects for normal cells, and are used for treating malignant lymphoma.

The invention discloses a medicine for treating ascites due to liver cancer. The medicine comprises the following components in parts by weight: 15-19 parts of radix bupleuri, 15-19 parts of bighead atractylodes rhizome, 20-24 parts of white peony root, 15-19 parts of dried tangerine peel, 10-14 parts of chrysanthemum morifolium, 10-14 parts of Chinese angelica, 15-19 parts of salviae miltiorrhizae, 20-24 pats of fiveleaf akebia fruit, 5-9 parts of safflower, 15-19 parts of poria, 20-24 parts of sculellaria barbata, 20-24 parts of rhizoma sparganic, 30-34 parts of polygonum cuspidatum, 10-14 parts of moutan bark, 20-24 parts of dandelion, 20-24 parts of solanum nigrum, 20-24 parts of oriental wormwood, 20-24 parts of curcuma zedoary, 20-24 parts of aspongopus, 20-24 parts of indian iphigenia bulb, 10-14 parts of spina gleditsiae, 20-24 parts of manyleaf paris rhizome, 10-14 parts of fructus aurantii, 15-19 parts of artemisia anomala, 20-24 parts of raw oyster, 20-24 parts of turtle shell, 10-14 parts of costustoot, 15-19 parts of codonopsis pilosula, 30-34 parts of selfheal, 15-19 parts of salvia chinensis, 15-19 parts of verbena, 5-9 parts of rhizoma alismatis, 5-9 parts of polyporus umbellatus, 10-14 parts of plantain seed, 10-14 parts of frankincense, 10-14 parts of myrrh, 10-14 parts of corydalis tuber, 10-14 parts of radix curcumae, 10-14 parts of toad skin, 5-9 parts of greater celandine herb, 5-9 parts of szechwan Chinaberry fruit, 10-14 parts of sappanwood, 3-7 parts of radix phytolaccae, 10-14 parts of paniculate swallowwort root, and 3-7 parts of semen pharbitidis. The effective rate of the medicine in treating ascites due to liver cancer can be 73 percent.

The invention discloses a pharmaceutical composition for treating leukemia or aplastic anemia, and the pharmaceutical composition comprises American ginseng, Chinese caterpillar fungus, dragon's blood, pangolin scales, musk, bezoar, pearl, Hawksbill Carapace, palourde powder, prepared nux vomica, toad venom, toad skin and the like. The pharmaceutical composition is mainly used for treating various types of acute and chronic leukemia, aplastic anemia and thrombocytopenia. The pharmaceutical composition has the effects of clearing heat-toxin, promoting blood circulation, removing blood stasis, stopping bleeding, promoting production of blood and activating hematopoietic function. Furthermore, the pharmaceutical composition has the advantages of convenient administration, easy absorption, rapid onset of action, good effect, low cost, no toxicity or side effects and the like.

The invention discloses a medicinal composition for the effective treatment of tumor diseases, which comprises gen-seng, ganoderma lucidum, Chinese blistering beetle and dried toad skin.

The invention discloses a plaster, and belongs to the technical field of application of traditional Chinese medicines. The plaster is prepared from the following raw medicines in parts by weight: 10-20 parts of toad skin, 15-30 parts of bungarus parvus, 15-30 parts of centipede, 15-30 parts of scorpion, 10-20 parts of pangolin scales, 5-15 parts of moschus, 15-30 parts of saussurea involucrate, 20-30 parts of pseudo-ginseng, 15-30 parts of frankincense, 15-30 parts of myrrh, 20-40 parts of dragon's blood, 20-40 parts of rhizoma cibotii, 20-40 parts of caulis spatholobi, 20-40 parts of common threewingnut root, 20-40 parts of radix aconiti, 20-30 parts of rhizoma gastrodiae, 20-30 parts of white mustard seed, 20-30 parts of fructus xanthii, 100-150 parts of minium and 800-1,000 parts of oleum sesami. The plaster has the significant advantages of being fast in effect, short in course of the treatment, remarkable in effect, low in cost and safe, free of toxic or side effect and the like.

The invention provides a cancer pain plaster composed of nux vomica, Hindu datura flower, pendulous monkshood root, dried Chinese toad skin, paniculate swallowwort root or herb, yanhusuo tuber, panax notoginseng, and an auxiliary material of borneol. One plaster comprises, preferably, 1.0g of nux vomica, 1.0g of Hindu datura flower, 1.0g of pendulous monkshood root, 1.0g of dried Chinese toad skin, 1.0g of paniculate swallowwort root or herb, 2.0g of yanhusuo tuber, 1.0g of panax notoginseng, and the auxiliary material of borneol. According to the technology, authentic pure traditional Chinese medicines are selected, and scientific formulation and rigorous production process are adopted. The materials are refined, and effect is concentrated. An effect can be provided after 20min of application, and a pain-relieving effect can last for 24h. Therefore, a substantial pain-relieving effect can be provided for continuous cancer pain. Especially, the plaster has relieving and stopping effects against long-term severe pains. When the plaster is repeatedly applied, no toxic or side effect is provided, and addiction is prevented. The plaster causes no irritation or allergy to skins, and is suitable to be used against various pains caused by various cancer primary tumors and metastases. With the plaster, patient pain can be relieved, symptoms can be relieved, and substantial pain relieving effects and concentrated pain relieving functions such as blood circulation activating, stasis removing, collateral dredging, qi regulating, and stagnation eliminating are provided.

The invention provides a selective separation and purification method of bufadienolide compounds. Positively charged XCharge C18 column is used for developing a novel high-performance liquid chromatographic separation method with high selectivity based on that at a low pH value, ionic properties of amino acid modified bufadienolides are different from ionic properties of bufadienolides which are not modified with amino acid. According to the selective separation and purification method, a mobile phase contains no buffer salt, so that it is convenient for sample preparation postprocessing; a toad skin 98% ethanol extract product is subjected to reversion phase chromatography preparation separation so as to obtain a fraction; and two kinds of compounds, including eight compounds, are obtained via reversed phase chromatography preparation. The selective separation and purification method is capable of realizing high efficiency preparation of amino acid modified bufadienolides and bufadienolides which are not modified with amino acid; and the selective separation and purification method is capable of solving a problem of trailing in separation process of amino acid modified bufadienolides; and excellent peaks are observed, and excellent separation effect is achieved. The selective separation and purification method is used for high efficiency systematic separation of bufadienolides, and is capable of providing substance base and technical support for anticancer active research of bufadienolides and signal-component new drug development.

The invention belongs to the field of traditional Chinese medicinal preparations for shingles, and provides a drug for treating the shingles and postherpetic neuralgia thereof to solve the problems that treatment methods in the prior art may cause adverse reaction of the whole body and have poor effect. The drug is made from goldthread, Chinese rhubarb, cortex phellodendri, raw pinellia ternate, arisaema heterophyllum blume, Chinese gall, dried alum, mirabilite, semen strychni, centipedes, realgar, paris polyphylla smith, frankincense, myrrh, flos daturae, toad skin, borneol, edible tulips, bee wax and linseed oil according to a certain ratio and a method. The drug for treating the shingles and the postherpetic neuralgia thereof has good analgesic effect, quick action and small side effect.