Dentifrice Compositions Containing Calcium Silicate
a technology of calcium silicate and dental composition, applied in the field of dental care compositions, can solve the problems of excessive tooth nerve damage, tooth sensitivity, irritation and pain, etc., and achieve the effects of reducing or inhibiting tooth caries, reducing or inhibiting demineralization, and repairing or inhibiting pre-carious enamel lesions
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example 1
[0092]Prototypes were prepared in a PCC and silica base with 13.86 wt. % arginine bicarbonate. Calcium silicate with average particle size less than 5 um was incorporated in the dentifrice. See Table 1 below for prototype formulations.
TABLE 1FormulaFormulaIngredientFormula IFormula IIIIIVISodium CMC0.720.50.50.5Xanthan gum0.1350.20.20.2Sodium Monofluorphosphate0.760.760.760.76Sodium Saccharin0.30.50.50.5Sodium Hydroxide00.250.250.3(50% Soln)Titanium Dioxide0.5111Tetrasodium Pyrophosphate0111Synthetic amorphous0444silica, thicknerHC Silica01005Synthetic amorphous0101010silica abrasiveSodium lauryl sulfate1.41.51.51.5Flavor1111Calcium Silicate10101010Glycerin054.2964.2959.24Water26.085555Sodium Silicate0.8000Precipitated calcium carbonate35.0000Sodium Bicarbonate0.3000Sorbitol23.0000
[0093]Hydroxyapatite Formation
[0094]A calcium silicate sample with a particle size less than 5 microns was immersed in a jar with PBS containing calcium and phosphate for seven days with continuous stirrin...
example 2
[0095]In vitro testing of the hydraulic conductance of several different compositions was conducted. The results are shown below. Human dentin segments were cut from extracted molars, cleared of pulpal tissue and mounted on acrylic blocks, etched and connected to a Flodec apparatus to measure fluid flow rate (hydraulic conductance) through dentin.
[0096]Treatments 1 and 2 were applied using a soft toothbrush for 1 minute. Following each of the 2 treatments, samples were rinsed with de-ionized (DI) water, connected to the Flodec apparatus, and the conductance was measured. Blocks were rinsed again and incubated in phosphate buffered saline (PBS) for at least 2 hours before the next treatment. Conductance was measured (70 cm water pressure) and reported as a % conductance relative to the etched baseline for each segment. After all treatments and measurements, the segments were incubated in PBS overnight, after which conductance was re-measured. The segments were challenged for one minu...
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