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Dentifrice Compositions Containing Calcium Silicate

a technology of calcium silicate and dental composition, applied in the field of dental care compositions, can solve the problems of excessive tooth nerve damage, tooth sensitivity, irritation and pain, etc., and achieve the effects of reducing or inhibiting tooth caries, reducing or inhibiting demineralization, and repairing or inhibiting pre-carious enamel lesions

Inactive Publication Date: 2013-09-26
COLGATE PALMOLIVE CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The invention is a composition that can be applied to the mouth to reduce dental caries, repair pre-carious lesions, promote remineralization of teeth, reduce hypersensitivity, reduce gingivitis, promote healing of mouth sores or cuts, inhibit microbial biofilm formation, reduce plaque accumulation, whiten teeth, reduce erosion, promote systemic health, immunize teeth against cariogenic bacteria, and clean the mouth and oral cavity. Specifically, the composition can help reduce hypersensitivity of the teeth.

Problems solved by technology

It is commonly understood that partially or fully exposed tubules can lead to tooth sensitivity, an irritating and painful condition.
The exposed tubules cause nerves within the tooth to be affected excessively by external oral stimuli because material and energy transfer between the exterior and interior of the tooth is accelerated through the tubules.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0092]Prototypes were prepared in a PCC and silica base with 13.86 wt. % arginine bicarbonate. Calcium silicate with average particle size less than 5 um was incorporated in the dentifrice. See Table 1 below for prototype formulations.

TABLE 1FormulaFormulaIngredientFormula IFormula IIIIIVISodium CMC0.720.50.50.5Xanthan gum0.1350.20.20.2Sodium Monofluorphosphate0.760.760.760.76Sodium Saccharin0.30.50.50.5Sodium Hydroxide00.250.250.3(50% Soln)Titanium Dioxide0.5111Tetrasodium Pyrophosphate0111Synthetic amorphous0444silica, thicknerHC Silica01005Synthetic amorphous0101010silica abrasiveSodium lauryl sulfate1.41.51.51.5Flavor1111Calcium Silicate10101010Glycerin054.2964.2959.24Water26.085555Sodium Silicate0.8000Precipitated calcium carbonate35.0000Sodium Bicarbonate0.3000Sorbitol23.0000

[0093]Hydroxyapatite Formation

[0094]A calcium silicate sample with a particle size less than 5 microns was immersed in a jar with PBS containing calcium and phosphate for seven days with continuous stirrin...

example 2

[0095]In vitro testing of the hydraulic conductance of several different compositions was conducted. The results are shown below. Human dentin segments were cut from extracted molars, cleared of pulpal tissue and mounted on acrylic blocks, etched and connected to a Flodec apparatus to measure fluid flow rate (hydraulic conductance) through dentin.

[0096]Treatments 1 and 2 were applied using a soft toothbrush for 1 minute. Following each of the 2 treatments, samples were rinsed with de-ionized (DI) water, connected to the Flodec apparatus, and the conductance was measured. Blocks were rinsed again and incubated in phosphate buffered saline (PBS) for at least 2 hours before the next treatment. Conductance was measured (70 cm water pressure) and reported as a % conductance relative to the etched baseline for each segment. After all treatments and measurements, the segments were incubated in PBS overnight, after which conductance was re-measured. The segments were challenged for one minu...

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PUM

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Abstract

An oral care composition includes an effective amount of calcium silicate particles. The calcium silicate particles have an average diameter of less than about 5 microns, such that they can occlude dentinal tubules of the teeth. An oral care method includes applying the composition to an oral cavity of a subject to reduce or inhibit hypersensitivity of the teeth and to achieve other benefits.

Description

FIELD OF THE INVENTION[0001]This invention relates to oral care compositions comprising dentin occluding particles and to methods of making and using such compositions.BACKGROUND OF THE INVENTION[0002]Dentin is a portion of the tooth internal to the enamel and cementum that has a radially striated appearance owing to a large number of fine canals or tubules known as the dentinal tubules. Tubules run from the pulp cavity to the periphery of the dentin and are generally about two microns in diameter at their base and somewhat narrower at their periphery. Tubules are not usually exposed to the environment in the oral cavity, as they are usually covered by enamel or cementum. The cementum in turn is often covered by the gums.[0003]It is commonly understood that partially or fully exposed tubules can lead to tooth sensitivity, an irritating and painful condition. In this theory, recession of the gum line exposes cementum to erosion. The eroded cementum in turn exposes the hollow dentinal...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K8/25A61Q11/00
CPCA61K8/044A61K8/25A61K2800/412C01P2006/12C01B33/24C01P2004/61C01P2004/62A61Q11/00A61K8/19
Inventor CHOPRA, SUMAN KUMARPATEL, RAHUL
Owner COLGATE PALMOLIVE CO
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