166results about How to "Promote remineralization" patented technology

This invention relates to oral care compositions comprising a basic amino acid or salt thereof, and a small particle fraction: and to methods of using and of making these compositions.

This invention relates to oral care compositions comprising a basic amino acid or salt thereof, and an abrasive system comprising natural calcium carbonate and precipitated calcium carbonate; and to methods of using and of making these compositions.

An oral care composition includes an effective amount of a basic amino acid in free or salt form; and an effective amount of calcium silicate particles. The calcium silicate particles have an average diameter of less than about 5 microns, such that they can occlude dentinal tubules of the teeth. An oral care method includes applying the composition to an oral cavity of a subject to reduce or inhibit hypersensitivity of the teeth and to achieve other benefits.

Remineralizing dental cements contain source(s) of calcium and phosphate ions, adhesive resin monomers, reinforcing base resin monomers, and catalysts able to initiate the polymerization of the adhesive and reinforcing base resin monomers. Such dental cements can be used as orthodontic cements, crown and bridge cements, adhesives, sealants, cavity liners, and protective coatings. The release of calcium and phosphate ions and, optionally, fluoride ions, protects tooth structure from demineralization, a precursor of tooth decay.

The present application provides dental fillers, and methods of making and using dental fillers that include a treated surface that includes a phosphate salt. Dental compositions including such dental fillers can be useful for delivering ions to the oral environment. Dental compositions, and methods of using dental compositions that include a phosphate salt and a hardenable resin or a water-dispersible, polymeric film former are also provided.

This invention relates to compositions comprising a basic amino acid free or salt form and a soluble carbonate or bicarbonate salt.

The present invention provides tooth-whitening compositions comprising a bleaching agent and a baste amino acid, together with devices for application thereof, and methods of use therefor.

The present invention provides a novel composition of matter comprised of a mixture of two specific classes of compounds—Free-B-Ring flavonoids and flavans—for use in the prevention and treatment of diseases and conditions associated with mouth, gums and teeth. This composition of matter simultaneously inhibits cyclooxygenase (COX) and lipoxygenase (LOX) enzymatic activity and reduces cytokine production at the mRNA level in normal, aged and damaged periodontal cells and tissues. This invention further provides a method for the prevention and treatment of diseases and conditions of the mouth, gums and teeth. The method for preventing and treating diseases and conditions of the mouth, teeth and gums is comprised of administering to a host in need thereof a therapeutically effective amount of a composition comprising a mixture of Free-B-Ring flavonoids and flavans synthesized and/or isolated from a single plant or multiple plants, preferably in the Scutellaria, Oroxylum, Acacia or Uncaria genus of plants and pharmaceutically and/or cosmetically acceptable carriers. Finally the present invention provides a method for the prevention and treatment of diseases and conditions of the mouth, teeth or gums, including but not limited to periodontal diseases, such as gingivitis, periodontitis, pulpitis, periodontal conditions caused by the physical implantation of oral dentures, trauma, injuries, bruxism, neoplastic and other degenerative processes; material alba, pellicles, dental plagues, calculus, and stains. Use of the composition described herein also affords the benefit of maintaining optimum saliva production and pH, minimizing bacterial growth, reducing the formation of pellicles and plague, inhibiting tooth decalcification and tooth caries (decay), promoting remineralization, which yields healthy gums, whitening teeth, maintaining healthy oral hygiene and reducing oral malodour (halitosis).

The invention discloses a biomimetic anti-caries polypeptide and its preparation method and use. The invention discloses the biomimetic anti-caries polypeptide and its salt or ester. The biomimetic anti-caries polypeptide has an amino acid sequence shown in the formula of SEQ ID NO.1 or SEQ ID NO.2. The biomimetic anti-caries polypeptide mainly contains the amino acid sequence HA6-1 (SVSVGMKPSPRP) having the HA combination feature and the amino acid sequence QPX inducing early-stage caries remineralization, and can also contain the amino acid sequence TKREEVD acting on calcium ions and causing the HA nucleation. The biomimetic anti-caries polypeptide has small molecular weight, can improve absorption on the surface of enamel, can exert its effect better, can promote remineralization of early demineralized enamel (early decayed tooth), can be synthesized conveniently, and has good economical efficiency, good effects and high safety and reliability.

The invention discloses a compound toothpaste with functions of antisepsis, anti-inflammation, acid prevention and desensitization, and a preparation method of the compound toothpaste. The invention adopts natural propolis and traditional Chinese medicine with functions of analgesia, anesthesia and antiallergic effect as main effective preparations, is compounded with the traditional western medicine and is supplemented by biotechnology, so that the compound toothpaste with the functions of antisepsis, anti-inflammation, acid prevention and desensitization can be prepared. The compound toothpaste can be used for preventing and treating periodontitis, dental ulcer, enamel trauma, toothache and sensitivity of teeth, and is also capable of enhancing the self repairing capability of oral cavity tissue, enabling the gum to be healthy, improving the microcirculation, guaranteeing the oral cavity to be healthy and improving the comprehensive antiallergic capability of teeth.

A dental composition which, e.g., eliminates or substantially reduces the discomfort and pain associated with dentinal hypersensitivity and exhibits enhanced anticaries and remineralization benefits, which composition contains a first component containing a calcium source, a second component containing an anion source and at least one of the components containing a basic amino acid in free or salt form, and the first and second components being maintained separate from each other until dispensed and combined for application to teeth.

A method for preparing amorphous calcium phosphate (ACP) and oral care composition containing ACP prepared by the same are disclosed, wherein the method comprises the following steps: (a) cleaning and pulverizing the oyster shells; (b) sintering the oyster shells to obtain a calcium-containing powder; (c) dissolving the calcium-containing powder in water to obtain a calcium-containing solution; and (d) mixing the calcium-containing solution with a other phosphate-containing solution, to produce amorphous calcium phosphate.

The method of the present invention not only can simplify the process and reduce the cost, but also can solve the problem of environment pollution resulting from wasted oyster shells. In addition, the ACP prepared in accordance with the method of the present invention further comprises some trace elements, such as strontium (Sr) and fluoride (F), which can improve dental health.

The present application provides compositions comprising a divalent metal cation source or divalent metal cations dissolved in a substantially anhydrous liquid, and methods of making and using the compositions. Such compositions can be useful for remineralizing dental structures and/or providing other useful effects including an anticaries effect.

The present application provides dental compositions, and methods of making and using dental compositions that include a calcium and phosphorus releasing glass. Such dental compositions can be useful for delivering ions to the oral environment.

The present invention relates to improved complexes of amorphous calcium phosphate and/or amorphous calcium fluoride phosphate stabilised by phosphopeptides/phosphoproteins by addition of stannous ions. These complexes have anticariogenic properties useful to protect tooth structures as they remineralize (repair) early stages of dental caries and have other dental/medical applications (including anti-calculus, anti-erosion/corrosion and anti-dentinal hypersensitivity). Methods of making the complexes of the invention and of treatment or prevention of various dental conditions including dental caries, dental calculus, dental erosion/corrosion and dental hypersensitivity are also provided.

The present application provides dental fillers, and methods of making and using dental fillers that include a treated surface that includes phosphorus and a divalent cation. Dental compositions including such dental fillers can be useful for delivering ions to the oral environment.

The invention relates to a dental prosthetic material for promoting dentin remineralization. The dental prosthetic material for promoting dentin remineralization contains a polypeptide solution and a nanometer amorphous calcium phosphate suspension which are successively applied to the surface of a dentin surface, wherein the polypeptide solution and the nanometer amorphous calcium phosphate suspension are physically isolated before use; the polypeptide solution contains polypeptide and water, wherein the polypeptide has functions of adsorbing calcium ions and binding to type I collagen, and the polypeptide has a concentration of 0.5 to 0. 8 mg/ml; the nanometer amorphous calcium phosphate suspension contains nanometer amorphous calcium phosphate and water, wherein the concentration of nanometer amorphous calcium phosphate is 0.2 to 0.3 g/ml. The parental function polypeptide is combined with the nanometer amorphous calcium phosphate to be used, and the nanometer amorphous calcium phosphate can effectively realize the in situ remineralization on the dentin, with high degree of mineralization and bionic degree by setting the appropriate concentration ratio.

The invention provides three types of polypeptide modified tannic acid and a preparation method thereof. Experiments prove that the polypeptide modified tannic acid has a firm adsorption effect on hydroxyapatite and can conduct adsorption and aggregation on the surface of the hydroxyapatite to form a film, the polypeptide modified tannic acid can induce the hydroxyapatite to conduct deposition and crystallization on a worn tooth enamel block in simulated saliva and has the capacity of promoting remineralization of tooth enamel, and when the polypeptide modified tannic acid cooperates with ferric ion for use, the capacity of the polypeptide modified tannic acid for conducting remineralization on the tooth enamel in the simulated saliva can be further promoted; the polypeptide modified tannic acid can effectively prevent bacteria from being stuck to the tooth enamel and prevent bacteria stuck to the tooth enamel from being reproduced on the tooth enamel. The polypeptide modified tannic acid can serve as a tooth enamel in-situ remineralization inducer and a dental implant surface antibacterial material for application.

The invention relates to a preparation method for amorphous calcium phosphate nanospheres. The method comprises the following steps: first, calcium salt and phosphate are dissolved in an acidic solution, then stabilizing agents are added and a mixed solution is obtained; second, the mixed solution is sprayed into minimal liquid drop aerial fog by utilization of an air compression atomizer, the aerial fog goes through a spiral pipe in a nitrogen atmosphere with a certain flow velocity and then is blown into an alkaline buffer solution, and amorphous calcium phosphate nanosphere precipitate is obtained after filtering; third, the amorphous calcium phosphate nanosphere precipitate obtained from the second step is washed and dried, and amorphous calcium phosphate nanospheres are obtained. The diameters of the obtained amorphous calcium phosphate nanospheres are less 100nm, the diameters of part nanospheres are less than 40nm, which is convenient for promotion of remineralization of dentin collagen fibers. The Ca/p ratio is adjustable, the forms of the amorphous calcium phosphate nanospheres are regular spheres, and the amorphous calcium phosphate nanospheres can exist stably for about 200h in an aqueous solution and is suitable for medicine loading and participation in bionic mineralization. The devices are simple to assemble, preparation is simple and practical, and the preparation method facilitates final achievement of large scale production.