Bioactive glass ceramic material and preparation method and application thereof in oral care products

A technology of bioactive glass and ceramic materials, applied in the application field of oral care products, can solve problems such as differences in repair mechanism, and achieve the effects of promoting remineralization, simple preparation method, non-toxic and safe use

Active Publication Date: 2013-12-18
SICHUAN UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Both bioactive glass and nano-apatite are good artificial bone repair materials with good biocompatibility and are expected to become anti-dentin sensitive repair materials, but there are differences in the repair mechanism

Method used

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  • Bioactive glass ceramic material and preparation method and application thereof in oral care products
  • Bioactive glass ceramic material and preparation method and application thereof in oral care products
  • Bioactive glass ceramic material and preparation method and application thereof in oral care products

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1 Preparation of HX-BGC by powder calcination method

[0034] Choose SiO2 2 , CaHPO 4 2H 2 O, CaCO 3 , NaCO 3 , Sr(NO 3 ) 2 And NaF as raw material, ball mill grinding to micron-sized particles, pressing and pre-calcining, crushing to micron-sized particles, then sintering, controlling the furnace cooling process, and then crushing to micron and sub-micron-sized particles, that is, the raw material composition The ratio principle and conditions of pre-sintering, sintering, and controlled furnace cooling process are shown in Table 1.

[0035] Table 1 Experimental conditions for preparing HX-BGC by powder calcination method

[0036]

Embodiment 2

[0037] Example 2 Preparation of HX-BGC by High Temperature Melting Method

[0038] Choose SiO2 2 , CaHPO 4 2H 2 O, CaCO 3 , NaCO 3 , Sr(NO 3 ) 2 , CaF 2 It is the raw material, and the proportioning principle of each raw material is the same as that of Example 1. After ball milling and mixing uniformly, it is melted in a platinum crucible at 1400°C or 1460°C, poured into water to cool, crushed into 20-50 mesh particles, and subjected to microcrystallization treatment. Cool to room temperature, and then pulverize into micron and submicron particles.

[0039] The conditions of the microcrystallization treatment are to heat the cooled melt poured into water at a rate of 10°C / min to 600°C for nucleation for 2 hours to form crystal nuclei, and then hold at 900°C for 1 hour for crystallization treatment to form fine crystals;

[0040] Or heat up the cooled melt poured into water to 700°C for 1 hour at a rate of 20°C / min to form crystal nuclei, and then hold at 1000°C for 1 h...

Embodiment 3

[0042] Example 3 Preparation of HX-BGC by Co-precipitation Synthesis

[0043] Nano-SiO 2 Gel powder, Ca(NO 3 ) 2 4H 2 O, H 3 PO 4 , NaCO 3 , Sr(NO 3 ) 2 and NaF as raw materials; the Ca(NO 3 ) 2 4H 2 O, H 3 PO 4 , NaCO 3 , Sr(NO 3 ) 2 and NaF were prepared into 2.5mol / L, 1mol / L, 5mol / L, 2.5mol / L, and 1.5mol / L aqueous solutions with deionized water; the Ca(NO 3 ) 2 .4H 2 O, Sr(NO 3 ) 2 and NaF aqueous solution under the condition of stirring (100-300 rpm) to mix evenly, and evenly mix nano-SiO 2 Gel powder, slowly drop into H under stirring condition 3 PO 4 solution with NaCO 3 and ammonia solution to adjust the pH to 6.5-9 for co-precipitation reaction, aging for 3 days after the completion of the reaction, dehydration and draining, sintering, cooling, and then pulverizing to micron and submicron particles, that is, the ratio of raw materials and The sintering conditions are the same as in Example 1.

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Abstract

The invention relates to a bioactive glass ceramic material. The bioactive glass ceramic material belongs to a Na2O-CaO-SrO-SiO2-P2O5-F system, and comprises the following components in percentage by weight: 12-45% of SiO2, 10-35% of P2O5, 25-48% of CaO, 5-15% of Na2O, 3.5-4.9% of SrO, and 1.5-2.1% of F; and the main compositions of a crystalline phase in the bioactive glass ceramic material are hydroxyapatite, tricalcium phosphate and calcium sodium phosphate. The invention also provides a preparation method of the bioactive glass ceramic material, which comprises a powder calcinating method, a high-temperature melting method, and a coprecipitation synthesis method or a sol-gel method. The invention further provides the application of the bioactive glass ceramic material in oral care products. The bioactive glass ceramic material and a conventional oral care product carrier or a transfer agent are prepared into oral care products such as toothpastes, mouthwash, tooth powder, tooth gel, chewing gum, and the like, and the bioactive glass ceramic material can achieve an effect of effectively preventing dentine hypersensitivity and promoting the surface remineralization of teeth in the process of teeth cleaning.

Description

technical field [0001] The invention belongs to the field of bioactive glass ceramics, and in particular relates to a bioactive glass ceramic material whose crystalline phase is mainly composed of hydroxyapatite, tricalcium phosphate and sodium calcium phosphate and its preparation method and its application in toothpaste, tooth powder, etc. Sensitive oral care applications. Background technique [0002] Dentin hypersensitivity (DH) is a common and frequently-occurring disease in the oral cavity. According to hydrodynamics, reducing the diameter of dentinal tubules and closing the openings of dentinal tubules to reduce and avoid fluid flow in dentin is the fundamental way to treat dentin sensitivity. The current treatment concept of anti-dentin hypersensitivity is gradually changing to early diagnosis and minimally invasive treatment, and the mineralization restoration treatment of dentinal tubules is well in line with this development trend. In long-term practice, it has ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C03C10/02A61K8/25A61Q11/00
Inventor 廖运茂钟亦思邓嵘董海德
Owner SICHUAN UNIV
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