Preparation method and use of biomimetic anti-caries polypeptide

An anti-caries and pharmacy technology, applied in the field of bionic anti-caries peptides and its preparation, can solve the problems of complex gene recombination protein program, imperfect processing and modification system, and difficulty in obtaining high-purity products. It achieves the effect and is safe, reliable and good Safety and biocompatibility, cost-effective results
CN103408653AActive Publication Date: 2013-11-27SICHUAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SICHUAN UNIV
Publication Date
2013-11-27

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Abstract

The invention discloses a biomimetic anti-caries polypeptide and its preparation method and use. The invention discloses the biomimetic anti-caries polypeptide and its salt or ester. The biomimetic anti-caries polypeptide has an amino acid sequence shown in the formula of SEQ ID NO.1 or SEQ ID NO.2. The biomimetic anti-caries polypeptide mainly contains the amino acid sequence HA6-1 (SVSVGMKPSPRP) having the HA combination feature and the amino acid sequence QPX inducing early-stage caries remineralization, and can also contain the amino acid sequence TKREEVD acting on calcium ions and causing the HA nucleation. The biomimetic anti-caries polypeptide has small molecular weight, can improve absorption on the surface of enamel, can exert its effect better, can promote remineralization of early demineralized enamel (early decayed tooth), can be synthesized conveniently, and has good economical efficiency, good effects and high safety and reliability.
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Description

technical field

[0001] The invention relates to an anti-caries technology, in particular to a bionic anti-caries polypeptide and its preparation method and application. Background technique

[0002] Caries is the most common oral disease in humans. Due to the high incidence and wide prevalence of dental caries, which seriously affects oral and general health, the World Health Organization has listed it as one of the three major non-communicable diseases that human beings should prevent and treat, second only to cardiovascular diseases and tumors.

[0003] As a classic anti-caries agent, fluoride has been used in various forms over the past forty years, such as fluoridated drinking water, fluoridated milk or fluoridated table salt, topical fluoride application (fluoride toothpaste, Fluoride-containing gel, fluoride-containing mouthwash), etc., which can reduce the caries rate in the population to varying degrees, and are recognized as the most effective caries prevention mea...

Claims

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